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鹿特丹地区膳食脂肪酸和帕金森病发病风险关系的研究

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世界核心医学期刊文摘（神经病学分册） 2005年第10期1卷 47-48页

作者： De Lau L.m.L. bornebroek m. Witteman J.C.m. m.m.b. breteler 史利利 Department of Epidemiology and biostatistics Erasmus Medical Center PO Box 1738 3 000 DR Rotterdam Netherlands Dr.

background: Unsaturated fatty acids are important constituents of neuronal ce ll membranes and have neuroprotective, antioxidant, and anti- inflammatory prop erties. Objective: To determine if a high intake of unsaturated fatty acids migh t be associated with a lower risk of Parkinson disease (PD). methods: In the Rot terdam Study, a prospective population- based cohort study of people ages ≥ 55 , the association between intake of unsaturated fatty acids and the risk of inci dent PD was evaluated among 5,289 subjects who were free of dementia and parkins onism and underwent complete dietary assessment at baseline. PD was assessed thr ough repeated in- person examination, and the cohort was continuously monitored by computer linkage to medical records. The data were analyzed using Cox propor tional hazards regression models. Results: After a mean follow- up of 6.0 years , 51 participants with incident PD were identified. Intakes of total fat, monoun saturated fatty acids (mUFAs), and polyunsatu rated fatty acids (PUFAs) were significantly associated with a lower risk of PD, with an adjusted hazard ratio per SD increase of energy- adjusted intake of 0.69 (95% CI 0.52 to 0.91) for total fat, of 0.68 (95% CI 0.50 to 0.94) for mUFAs, and 0.66 (95% CI 0.46 to 0.96) for PUFAs. No associations were found f or dietary saturated fat, cholesterol, or trans- fat. Conclusion: These finding s suggest that high intake of unsaturated fatty acids might protect against Park inson disease.

关键词：帕金森病发病风险患病风险神经细胞膜队列研究患者病历无痴校正值连续监测试验结果

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血压、白质损伤和颞叶内侧萎缩之间的联系

世界核心医学期刊文摘（神经病学分册） 2005年第6期1卷 42-43页

作者： Den Heijer T. Launer L.J. Prins N.D. m.m.b. breteler 邓剑平 Dept. of Epidemiol. and biostatist. Erasmus MC 3000 DR Rotterdam Netherlands Dr.

background: blood pressure level is associated with the risk of clinical Alzheimer disease (AD), yet the underlying mechanisms are unclear. High blood pressure levels may cause cerebral small- vessel pathology, which contributes to cognitive decline in patients with AD. Alternatively, in persons with high blood pressure, increased numbers of neurofibrillary tangles and amyloid plaques at autopsy have also been observed, suggesting direct links between blood pressure and AD. Abstract:Objective: To investigate the association of blood pressure and markers of small- vessel disease (white matter lesions [WmLs] on mRI)- with hippocampal and amygdalar atrophy on mRI - potential in vivo indicators of Alzheimer pathology. methods: In 1995 to 1996, 511 nondemented elderly subjects (age 60 to 90) underwent mRI. The extent of WmLs was assessed, and volumes of the hippocampus and amygdala were measured. blood pressure levels were assessed at the time of mRI and 5 years before the mRI. Results: Higher diastolic blood pressure 5 years before mRI predicted more hippocampal atrophy in persons untreated for hypertension (per SD increase - 0.10 mL [95% CI - 0.19 to - 0.02, p = 0.02]). Conversely, in persons treated for hypertension, a low diastolic blood pressure was associated with more severe atrophy. Persons with more WmLs on mRI more often had severe atrophy of the hippocampus and amygdala. Conclusion: blood pressure and indicators of small- vessel disease in the brain may be associated with atrophy of

关键词：颞叶内侧神经纤维缠结阿尔茨海默病小血管病变杏仁核淀粉样变潜在机制

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脑白质损害与痴呆的发病风险

世界核心医学期刊文摘（神经病学分册） 2005年第3期1卷 11-12页

作者： Prins N.D. Van Dijk E.J. Den Heijer T. m.m.b. breteler 黄卫东 Dept. of Epidemiol. and biostatist. Erasmus Medical Cent er PO Box 1738 3000 DR Rotterdam Netherlands Dr.

Objective: To smtudy the association between white matter lesions (WmL) in spe cific locations and the risk of dementia. Design: The Rotterdam Scan Study, a pr ospective population based cohort study. We scored periventricular and subcortic al WmL on magnetic resonance imaging and observed participants until January 200 2 for incident dementia. Setting: General population. Participants: We included 1077 people aged 60 to 90 years who did not have dementia at baseline. main Outc ome measure: Incident dementia by Diagnostic and Statistical manual of mental Di sorders, Third Edition (DSm III R) criteria. Results: During a mean follow up of 5.2 years, 45 participants developed dementia. Higher severity of periventric ular WmL increased the risk of dementia, whereas the association between subcort ical WmL and dementia was less prominent. The adjusted hazard ratio of dementia for each standard deviation increase in periventricular WmL severity was 1.67 (9 5%confidence interval, 1.25-2.24). This increased risk was independent of othe r risk factors for dementia and partly independent of other structural brain cha nges on magnetic resonance imaging. Conclusion: White matter lesions, especially in the periventricular region, increase the risk of dementia in elderly people.

关键词：脑白质发病风险统计手册精神障碍诊断队列研究无痴标准分析脑结构

脑小血管疾病与信息处理速度、执行功能和记忆力的下降

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世界核心医学期刊文摘(神经病学分册) 2006年第1期 60-60页

作者： Prins N.D. Van Dijk E.J. Den Heijer T. m.m.b. breteler 夏峰 Department of Epidemiology Erasmus Medical Center PO Box 1738 3000 DR Rotterdam Netherlands Dr.

Cerebral small-vessel disease is common in older people and may contribute to the development of dementia. The objective of the present study was to evaluate the relationship between measures of cerebral small-vessel disease on mRI and the rate of decline in specific cognitive domains in participants from the prospective, population-based Rotterdam Scan Study. Participants were 60-90 years of age and free from dementia at baseline in 1995-1996. White matter lesions (WmL), cerebral infarcts and generalized brain atrophy were assessed on the baseline mRI. We performed neuropsychological testing at baseline and repeatedly in 1999-2000 and in 2001-2003. We used random-effects models for repeated measures to examine the association between quantitative mRI measures and rate of decline in measures of global cognitive function, information processing speed, executive function and memory. There were a total of 2266 assessments for the 832 participants in the study, with an average time from the initial to last assessment of 5.2 years. Increasing severity of periventricular WmL and generalized brain atrophy and the presence of brain infarcts on mRI were associated with a steeper decline in cognitive function. These structural brain changes were specifically associated with decline in information processing speed and executive function. The associations between mRI measures of cerebral small-vessel disease and cognitive decline did not change after additional adjustment for vascular risk factors or depressed mood. After exclusion of participants with an incident stroke, some of the associations of periventricular WmL, brain infarcts and generalized brain atrophy with measures of information processing speed and executive function were no longer significant. This may indicate that stroke plays an intermediate role in the relationship between cerebral small-vessel disease and cognitive decline. Our results suggest that in older people cerebral small-vessel disease may contribut

关键词：执行功能脑萎缩脑梗死脑小血管疾病记忆力信息处理计算机应用

mitochondria–cGAS–STING axis is a potential therapeutic target for senescence-dependent inflammaging-associated neurodegeneration

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Neural Regeneration Research 2025年第3期20卷 805-807页

作者： Josém.Izquierdo Centro de biología molecular Severo Ochoa(Cbm) Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid(CSIC-UAM)MadridSpain

The word “senescence” comes from the Latin senescens, meaning “to begin to age”, and is characterized by a long-lasting but reversible block in proliferation, resulting from stress-induced cell cycle arrest of pre... 详细信息

关键词： Latin potential lasting

普通人群中帕金森综合征和帕金森病的发病率:鹿特丹研究

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世界核心医学期刊文摘（神经病学分册） 2005年第3期1卷 53-53页

作者： De Lau L.m.L. Giesbergen P.C.L.m. De Rijkm.C. m.m.b. breteler 姚庆和 Dept. of Epidemiol. and biostatist. Erasmus Medical Cent er P.O. Box 1738 3000 DR Rotterdam Netherlands Dr.

Objective: To investigate the incidence of parkinsonism and Parkinson disease (PD) in the general population using inperson screening along with clinical data . methods: In the Rotterdam study, a prospective population based cohort study of people aged ≥55 years, the authors assessed age and sex specific incidence r ates of parkinsonism and PD among 6,839 participants who were free of parkinsoni sm at baseline. Case finding involved in person screening at baseline and two f ollow up visits, and additional information was obtained through continuous mon itoring of the cohort by computer linkage to general practitionersand pharmacy records. Results: After a mean follow up period of 5.8 years, 132 subjects wit h incident parkinsonism were identified, of whom 67 (51%) had PD. The incidence of parkinsonism and PD increased with age, with incidence rates for PD increasi ng from 0.3 per 1000 person years in subjects aged 55 to 65 years, to 4.4 per 1 000 person years for those aged ≥85 years. The overall age adjusted incidence rate of any parkinsonism was not different in men and women, but men seem to ha ve a higher risk for PD (male to female ratio, 1.54; 95%CI, 0.95 to 2.51). Co nclusion: Incidence rates for parkinsonism and Parkinson disease were higher tha n those reported by most previous studies, possibly because of the authorsinte nsive case finding methods involving in person screening.

关键词：帕金森综合征用药资料临床数据队列研究总体发病率基线水平

The impact of alpha-fetoprotein (AFP), child-turcotte-pugh (CTP) score and disease staging on the survival of hepatocellular carcinoma (HCC) patients: a retrospective cohort from single oncology center

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Oncology research 2025年第1期33卷 149-160页

作者： Nasser mulla Yousef Katib Asim m Almughamsi Duaa S Alkhayat mohamed mosaad Samir T Alfotih Rawan Alaofi Department of Internal medicine Faculty of Medicine Taibah University Madinah 42278 Saudi Arabia. Department of Radiology Faculty of Medicine Taibah University Madinah 42278 Saudi Arabia. Department of Surgery Faculty of Medicine Taibah University Madinah 42278 Saudi Arabia. Department of Endemic and Infectious Diseases Suez Canal University Ismailia 41522 Egypt. King Salman bin Abdulaziz medical City Madinah 42311 Saudi Arabia. Prince mohammed bin Abdulaziz Hospital Madinah 41511 Saudi Arabia.

background:Hepatocellular carcinoma (HCC) is the most common cause of cancer-related death in Saudi Arabia. Our study aimed to investigate the patterns of HCC and the effect of TNm staging, Alfa-fetoprotein (AFP), and Child-Turcotte Pugh (CTP) on patients' overall survival (OS).methods:A retrospective analysis was conducted on 43 HCC patients at a single oncology center in Saudi Arabia from 2015 to 2020. All patients had to fulfill one of the following criteria: (a) a liver lesion reported as definitive HCC on dynamic imaging and/or (b) a biopsy-confirmed diagnosis.Results:The mean patient age of all HCC cases was 66.8 with a male-to-female ratio of 3.3:1. All patients were stratified into two groups: viral HCC (n = 22, 51%) and non-viral HCC (n = 21, 49%). Among viral-HCC patients, 55% were due to HbV and 45% due to HCV. Cirrhosis was diagnosed in 79% of cases. Age and sex did not significantly statistically differ in OS among viral and non-viral HCC patients (-value > 0.05). About 65% of patients had tumor size >5 cm during the diagnosis, with a significant statistical difference in OS (-value = 0.027). AFP was >400 ng/ml in 45% of the patients. There was a statistically significant difference in the OS in terms of AFP levels (-value = 0.021). A statistically significant difference was also observed between the CTP score and OS (-value = 0.02). CTP class b had the longest survival. bSC was the most common treatment provided to HCC patients followed by sorafenib therapy. There was a significant statistical difference in OS among viral and non-viral HCC patients (-value = 0.008).Conclusions:The most common predictors for OS were the underlying cause of HCC, AFP, and tumor size. being having non-viral etiology, a tumor size >5 cm, an AFP > 400 ng/mL, and a CTP score class C were all negatively associated with OS.

关键词： Alpha-fetoprotein (AFP) Child-turcotte-pugh Hepatocellular carcinoma Pattern Progression free survival

Phase diagrams and magnetic properties of the mixed spin-1 and spin-3/2 Ising ferromagnetic thin film: monte Carlo treatment

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Chinese Physics b 2019年第2期28卷 414-419页

作者： b boughazi m boughrara m Kerouad Laboratoire Physique des matériaux et modélisation des Systémes(LP2mS) UnitéAssociée au CNRST-URAC:08Faculty of SciencesUniversity Moulay Ismail

Phase diagrams and magnetic properties of the mixed spin-1 and spin-3/2 Ising film with different single-ion anisotropies are investigated, by the use of monte Carlo simulation based on heat bath algorithms. The effects of the crystal-fields and the surface coupling on the phase diagrams are investigated in detail and the obtained phase diagrams are presented. Depending on the Hamiltonian parameters, the system exhibits both second-and first-order phase transitions besides tricritical point, triple point, and isolated critical end point.

关键词： monte Carlo simulation thin film phase diagrams magnetic properties

On a biseparability criterion of bipartite qudit state

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Chinese Physics b 2019年第8期28卷 42-49页

作者： b benzimoun m Daoud LPHE-modeling and Simulation Faculty of SciencesUniversity Mohammed ⅤRabatMorocco Department of Physics Faculty of Sciences-Ain ChockUniversity Hassan ⅡCasablancaMorocco Abdus Salam International Centre for Theoretical Physics TriesteItaly

In this paper,we propose a new approach to tackle the separability problem for bipartite qudit *** is based on the majorana representation which allows to represent a N-spinors(qudit)as a symmetric state of N spin-1/*** also discuss how we can exploit such representation and the notion of the biseparability of multipartite qubit states in the sense to establish new criteria of the separability problem based on the PPT and concurrence.

关键词： separability bipartite qubit state partial separability majorana representation