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World Journal of Gastroenterology 2014年第9期20卷 2143-2158页

作者： maryconi m Jaurigue mitchell S Cappell Division of Gastroenterology and Hepatology Department of Internal MedicineWilliam Beaumont Hospital Royal Oak MI 48073 United States Oakland University William Beaumont School of medicine Royal Oak MI 48073 United States

Alcoholism results in about 2.5 million deaths annually worldwide, representing 4% of all mortality. Although alcoholism is associated with more than 60 diseases, most mortality from alcoholism results from alcoholic liver disease (ALD). ALD includes alcoholic steatosis, alcoholic hepatitis, and alcoholic cirrhosis, in order of increasing severity. Important scoring systems of ALD severity include: Child-Pugh, a semi-quantitative scoring system useful to roughly characterize clinical severity; model for end-stage liver disease, a quantitative, objective scoring system used for prognostication and prioritization for liver transplantation; and discriminant function, used to determine whether to administer corticosteroids for alcoholic hepatitis. Abstinence is the cornerstone of ALD therapy. Psychotherapies, including twelve-step facilitation therapy, cognitive-behavioral therapy, and motivational enhancement therapy, help support abstinence. Disulfiram decreases alcohol consumption by causing unpleasant sensations after drinking alcohol from accumulation of acetaldehyde in serum, but disulfiram can be hepatotoxic. Adjunctive pharmacotherapies to reduce alcohol consumption include naltrexone, acamprosate, and baclofen. Nutritional therapy helps reverse muscle wasting, weight loss, vitamin deficiencies, and trace element deficiencies associated with ALD. Although reduced protein intake was previously recommended for advanced ALD to prevent hepatic encephalopathy, a diet containing 1.2-1.5 g of protein/kg per day is currently recommended to prevent muscle wasting. Corticosteroids are first-line therapy for severe alcoholic hepatitis (discriminant function ≥ 32), but proof of their efficacy in decreasing mortality remains elusive. Pentoxifylline is an alternative therapy. Complications of advanced ALD include ascites, spontaneous bacterial peritonitis, esophageal variceal bleeding, hepatic encephalopathy, hepatorenal syndrome, hepatopulmonary syndrome, and portopu

关键词： Alcoholic liver disease Alcoholic steatosis Alcoholic hepatitis Alcoholic cirrhosis Alcoholism Liver disease Corticosteroids Pentoxifylline Liver transplantation

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Temperature dependence of InAs/GaAs quantum dots solar photovoltaic devices

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Journal of Semiconductors 2014年第5期35卷 21-25页

作者： E.Garduno-Nolasco m.missous D.Donoval J.Kovac m.mikolasek School of Electrical and Electronic Engineering.The University of manchester Institute of Electronics and Photonics Slovak University of Technology

This paper presents the temperature dependence measurements characterisation of several InAs/GaAs quantum dots （QDs） solar cell devices. The devices with cylindrical geometry were fabricated and characterised on-wafer under 20 suns in a temperature range from 300°K to 430°K. The temperature dependence parameters such as open circuit voltage, short circuit density current, fill factor and efficiency are studied in detail. The increase of temperature produces an enhancement of the short circuit current. However, the open circuit voltage is degraded because the temperature increases the recombination phenomena involved, as well as reducing the effective band gap of the semiconductor.

关键词： quantum dots solar cells III-V semiconductors inter-dot doping efficiency temperature depen- dence

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Glycogen storage diseases:An update

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World Journal of Gastroenterology 2023年第25期29卷 3932-3963页

作者： Ersin Gümüs Hasan Ozen Department of Pediatric Gastroenterology Hepatology and NutritionHacettepe University Faculty of MedicineIhsan Dogramaci Children’s HospitalAnkara 06230Turkey

Glycogen storage diseases(GSDs),also referred to as glycogenoses,are inherited metabolic disorders of glycogen metabolism caused by deficiency of enzymes or transporters involved in the synthesis or degradation of glycogen leading to aberrant storage and/or *** overall estimated GSD incidence is 1 case per 20000-43000 live *** are over 20 types of GSD including the *** heterogeneous group of rare diseases represents inborn errors of carbohydrate metabolism and are classified based on the deficient enzyme and affected *** primarily affect liver or muscle or both as glycogen is particularly abundant in these ***,besides liver and skeletal muscle,depending on the affected enzyme and its expression in various tissues,multiorgan involvement including heart,kidney and/or brain may be *** GSDs share similar clinical features to some extent,there is a wide spectrum of clinical ***,the goal of treatment is to maintain glucose homeostasis by dietary management and the use of uncooked *** addition to nutritional interventions,pharmacological treatment,physical and supportive therapies,enzyme replacement therapy(ERT)and organ transplantation are other treatment approaches for both disease manifestations and longterm *** lack of a specific therapy for GSDs has prompted efforts to develop new treatment strategies like gene *** early diagnosis and aggressive treatment are related to better prognosis,physicians should be aware of these conditions and include GSDs in the differential diagnosis of patients with relevant manifestations including fasting hypoglycemia,hepatomegaly,hypertransaminasemia,hyperlipidemia,exercise intolerance,muscle cramps/pain,rhabdomyolysis,and muscle ***,we aim to provide a comprehensive review of *** review provides general characteristics of all types of GSDs with a focus on those with liver involvement.

关键词： Glycogen storage disease Liver muscle Hypoglycemia

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Are therapeutic diets an emerging additional choice in autism spectrum disorder management?

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World Journal of Pediatrics 2018年第3期14卷 215-223页

作者： m.Gogou G.Kolios 2nd Department of Pediatrics School of MedicineUniversity General Hospital AHEPAAristotle University of ThessalonikiThessaloníkiGreece Laboratory of Pharmacology School of MedicineDemocritus University of ThraceAlexandroupolisGreece

Background A nutritional background has been recognized in the pathophysiology of autism and a series of nutritional interventions have been considered as complementary therapeutic options. As available treatments and interventions are not effective in all individuals, new therapies could broaden management options for these patients. Our aim is to provide current literature data about the effect of therapeutic diets on autism spectrum disorder. Data sources A systematic review was conducted by two reviewers independently. Prospective clinical and preclinical stud-ies were considered. Results Therapeutic diets that have been used in children with autism include ketogenic and gluten/casein-free diet. We were able to identify 8 studies conducted in animal models of autism demonstrating a beneficial effect on neurophysiological and clinical parameters. Only 1 clinical study was found showing improvement in childhood autism rating scale after implemen-tation of ketogenic diet. With regard to gluten/casein-free diet, 4 clinical studies were totally found with 2 of them showing a favorable outcome in children with autism. Furthermore, a combination of gluten-free and modified ketogenic diet in a study had a positive effect on social affect scores. No serious adverse events have been reported. Conclusions Despite encouraging laboratory data, there is controversy about the real clinical effect of therapeutic diets in patients with autism. more research is needed to provide sounder scientific evidence.

关键词： Autism Children Gluten/casein-free diet Ketogenic diet Therapeutic diet

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Thermodynamic study of CN^- ion inhibition of Jack bean urease using the extended solvation theory

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Chinese Chemical Letters 2009年第11期20卷 1389-1392页

作者： G.Rezaei Behbehani A.A.Saboury m.mohebbian S.Tahmasbi Sarvestani m.Poorheravi Chemistry Department Imam Khomeini International UniversityQazvinIran Institute of Biochemistry and Biophysics University of TehranTehranIran Chemistry Department Payame Noor University(PNU)AbharIran

Cyanide ion was studied as an inhibitor of Jack bean urease at 300 K in 30 mmol/L tris buffer, pH 7. The inhibition was investigated by isothermal titration calorimetry （ITC）. The extended solvation model was used for CN^- ＋ JBU interaction over the whole range of CN^- concentrations. The binding parameters recovered from the solvation model were attributed to the cyanide ion interaction. It was found that cyanide ion acted as a non-cooperative inhibitor ofurease, and there is a set of 12 ± 0.12 identical and independent binding sites for CN- ions. The dissociation equilibrium constant is 749.99 umol/L. The molar enthalpy of binding is AH= -13.60 kJ mol^-1.

关键词： Jack bean urease Cyanide ion Isothermal titration calorimetry Binding parameters Inhibitor

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Fire Hawk Optimizer with Deep Learning Enabled Human Activity Recognition

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Computer Systems Science & Engineering 2023年第6期45卷 3135-3150页

作者： mohammed Alonazi mrim m.Alnfiai Department of Information Systems College of Computer Engineering and SciencesPrince Sattam bin Abdulaziz UniversityAl-Kharj16273Saudi Arabia Department of Information Technology College of Computers and Information TechnologyTaif UniversityTaif P.O.Box 11099Taif21944Saudi Arabia

Human-Computer Interaction(HCI)is a sub-area within computer science focused on the study of the communication between people(users)and computers and the evaluation,implementation,and design of user interfaces for computer *** has accomplished effective incorporation of the human factors and software engineering of computing systems through the methods and concepts of cognitive *** is an aspect of HCI dedicated to guar-anteeing that human–computer communication is,amongst other things,efficient,effective,and sustaining for the ***,Human activity recognition(HAR)aim is to identify actions from a sequence of observations on the activities of subjects and the environmental *** vision-based HAR study is the basis of several applications involving health care,HCI,and video *** article develops a Fire Hawk Optimizer with Deep Learning Enabled Activ-ity Recognition(FHODL-AR)on HCI driven *** the presented FHODL-AR technique,the input images are investigated for the identification of different human *** feature extraction,a modified SqueezeNet model is intro-duced by the inclusion of few bypass connections to the SqueezeNet among Fire ***,the FHO algorithm is utilized as a hyperparameter optimization algorithm,which in turn boosts the classification *** detect and cate-gorize different kinds of activities,probabilistic neural network(PNN)classifier is *** experimental validation of the FHODL-AR technique is tested using benchmark datasets,and the outcomes reported the improvements of the FHODL-AR technique over other recent approaches.

关键词： Activity recognition fire hawks optimizer deep learning usability human computer interaction

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Two-warehouse inventory model for non-instantaneous deteriorating items with optimal credit period and partial backlogging under inflation

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Journal of Control and Decision 2016年第2期3卷 132-150页

作者： m.Palanivel R.Uthayakumar Department of mathematics The Gandhigram Rural Institute-Deemed UniversityDindigulIndia

This paper analyses an inventory model for non-instantaneous deteriorating items under a two-warehouse system with the effect of inflation and time value of *** propose the model from the seller’s prospective by incorporating the fact that granting the trade credit from the seller to its buyer not only increases sales and revenue but also opportunity cost and default ***,in this model,shortages are allowed and partially *** backlogging rate is dependent on the waiting time for the next *** purpose of this study is to determine the optimal credit period and the optimal order quantity such that the total profit of the seller is *** numerical examples are presented for illustrating the proposed inventory ***,sensitivity analysis of the optimal solutions with respect to major parameters is carried out and some managerial inferences are obtained.

关键词： two-warehouse non-instantaneous partial backlogging trade credit inflation

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Semi-global leader-following output consensus of heterogeneous systems subject to actuator position and rate saturation

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Autonomous Intelligent Systems 2021年第1期1卷 91-103页

作者： Panpan Zhou Ben m.Chen Department of mechanical and Automation Engineering The Chinese University of Hong KongShatinN.T.Hong Kong

We study in this paper a semi-global leader-following output consensus problem for multiple heterogeneous linear systems in the presence of actuator position and rate saturation over a directed *** each follower,via the low gain feedback design technique and output regulation theory,both a state feedback consensus protocol and an output feedback consensus protocol are *** the output feedback case,different distributed observers are designed for the informed followers and uninformed followers to estimate the state of the leader and the follower *** show that the semi-global leader-following output consensus of heterogeneous linear systems can be achieved by the two consensus protocols if each follower is reachable from the leader in the directed communication topology.

关键词： multi-agent system Output consensus Low gain feedback

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Real-Time multi-Feature Approximation model-Based Efficient Brain Tumor Classification Using Deep Learning Convolution Neural Network model

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Computer Systems Science & Engineering 2023年第9期46卷 3883-3899页

作者： Amarendra Reddy Panyala m.Baskar Department of Computer Science and Engineering School of ComputingSRM Institute of Science and TechnologyKattankulathurChengalpattuChennai603203TamilnaduIndia Department of Information Technology MLR Institute of TechnologyHyderabad500043TelanganaIndia Department of Computing Technologies School of ComputingSRM Institute of Science and TechnologyKattankulathurChengalpattuChennai603203TamilnaduIndia

The deep learning models are identified as having a significant impact on various *** same can be adapted to the problem of brain tumor ***,several deep learning models are presented earlier,but they need better classification *** efficient multi-Feature Approximation Based Convolution Neural Network(CNN)model(mFACNN)is proposed to handle this *** method reads the input 3D magnetic Resonance Imaging(mRI)images and applies Gabor filters at multiple *** noise-removed image has been equalized for its quality by using histogram ***,the features like white mass,grey mass,texture,and shape are extracted from the *** features are trained with deep learning Convolution Neural Network(CNN).The network has been designed with a single convolution layer towards dimensionality *** texture features obtained from the brain image have been transformed into a multi-dimensional feature matrix,which has been transformed into a single-dimensional feature vector at the convolution *** neurons of the intermediate layer are designed to measure White mass Texture Support(WmTS),Graymass Texture Support(GmTS),Whitemass Covariance Support(WmCS),Graymass Covariance Support(GmCS),and Class Texture Adhesive Support(CTAS).In the test phase,the neurons at the intermediate layer compute the support as mentioned above values towards various classes of *** on that,the method adds a multi-Variate Feature Similarity measure(mVFSm).Based on the importance ofmVFSm,the process finds the class of brain image given and produces an efficient result.

关键词： CNN deep learning brain tumor classification mFA-CNN mVFSm 3D mRI texture Gabor

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Husbandry practices and gut health outcomes in weaned piglets:A review

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Animal Nutrition 2017年第3期3卷 205-211页

作者： Balachandar Jayaraman Charles m.Nyachoti Department of Animal Sciences University of Manitoba

The immediate post-weaning period is one of the most stressful phases in a pig's life, and during this period, piglets are usually exposed to environmental, social and psychological stressors which have direct or indirect effects on gut health and overall growth performance. In this review, the impact of husbandry practices on gut health outcomes and performance of piglets is discussed. Husbandry practices in the swine barn generally include nutrition and management practices, maintenance of hygienic standards and disease prevention protocols, and animal welfare considerations. Poor husbandry practices could result in reduced feed intake, stress and disease conditions, and consequently affect gut health and performance in weaned piglets. Reduced feed intake is a major risk factor for impaired gut structure and function and therefore a key goal is to maximize feed intake in newly weaned piglets. In weaned piglets, crowding stress could reduce pig performance, favor the proliferation of pathogenic bacteria resulting in diarrhea, stimulate immune responses and interfere with beneficial microbial activities in the gut. Sanitation conditions in the swine barn plays an important role for optimal piglet performance, because unclean conditions reduced growth performance, shifted nutrient requirements to support the immune system and negatively affected the gut morphology in weaned piglets. Appropriate biosecurity measures need to be designed to prevent disease entry and spread within a swine operation,which in turn helps to keep all pigs and piglets healthy. Collectively, husbandry practices relating to feeding and nutrition, animal welfare, biosecurity and disease prevention are important determinants of gut health and piglet performance. Thus, it is suggested that adopting high husbandry practices is a critical piece in strategies aimed at raising pigs without the use of in-feed antibiotics.

关键词： Gut health Husbandry practices Weaned piglets

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