检索结果-南通市图书馆

microRNA-502-3p regulates GABAergic synapse function in hippocampal neurons

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2024年第12期19卷 2698-2707页

作者： Bhupender Sharma melissa mTorres Sheryl Rodriguez Laxman Gangwani Subodh Kumar Center of Emphasis in Neuroscience Department of Molecular and Translational MedicinePaul L.Foster School of MedicineTexas Tech University Health Sciences CenterEl PasoTXUSA Bond Life Sciences Center and Department of Veterinary Pathobiology University of MissouriColumbiaMOUSA L.Frederick Francis Graduate School of Biomedical Sciences Texas Tech University Health Sciences CenterEl PasoTXUSA

Gamma-aminobutyric acid(GABA)ergic neurons,the most abundant inhibitory neurons in the human brain,have been found to be reduced in many neurological disorders,including Alzheimer's disease and Alzheimer's disease-related *** previous study identified the upregulation of microRNA-502-3p(miR-502-3p)and downregulation of GABA type A receptor subunitα-1 in Alzheimer's disease *** study investigated a new molecular relationship between miR-502-3p and GABAergic synapse *** vitro studies were perfo rmed using the mouse hippocampal neuronal cell line HT22 and miR-502-3p agomiRs and *** silico analysis identified multiple binding sites of miR-502-3p at GABA type A receptor subunitα-1 *** assay confirmed that miR-502-3p targets the GABA type A receptor subunitα-1 gene and suppresses the luciferase ***,quantitative reve rse transcription-polymerase chain reaction,miRNA in situ hybridization,immunoblotting,and immunostaining analysis confirmed that overexpression of miR-502-3p reduced the GABA type A receptor subunitα-1 level,while suppression of miR-502-3p increased the level of GABA type A receptor subunitα-1 ***,as a result of the overexpression of miR-502-3p,cell viability was found to be reduced,and the population of necrotic cells was found to be *** whole cell patch-clamp analysis of human-GABA receptor A-α1/β3/γ2L human embryonic kidney(HEK)recombinant cell line also showed that overexpression of miR-502-3p reduced the GABA current and overall GABA function,suggesting a negative correlation between miR-502-3p levels and GABAergic synapse ***,the levels of proteins associated with Alzheimer s disease were high with miR-502-3p overexpression and reduced with miR-502-3p *** present study provides insight into the molecular mechanism of regulation of GABAergic synapses by *** propose that micro-RNA,in particular miR-502-3p,could be a potential the

关键词： Alzheimer's disease GABAergic synapse gamma-aminobutyric acid type A receptor subunitα-1(GABRα1) microRNA-502-3p(miR-502-3p) miRNA in situ hybridization Patch-clamp

维普期刊数据库

Tia Juana油田注蒸汽—溶剂生产试验

在线全文

学校读者我要写书评

暂无评论

油气田开发工程译丛 1991年第12期 11-20页

作者：张文玉 Bracho,lg

本文介绍委内瑞拉Tia Juana油田LSJ－4057号井同时注蒸汽及溶剂所取得的结果。根据室内试验选用工业柴油作为试验溶剂。整个生产试验阶段相当于该井的蒸汽吞吐第二周期，在整个三阶段注入施工中，共注入5015m^3蒸汽（冷水当量），包括29... 详细信息

本文介绍委内瑞拉Tia Juana油田LSJ－4057号井同时注蒸汽及溶剂所取得的结果。根据室内试验选用工业柴油作为试验溶剂。整个生产试验阶段相当于该井的蒸汽吞吐第二周期，在整个三阶段注入施工中，共注入5015m^3蒸汽（冷水当量），包括298m^3溶剂。该井处理后初产量平均为47．8m^3/d，比邻井平均初产量高出63．3％。30个月的累计产量比邻井高出85．9％。

关键词：油田注蒸汽注溶剂蒸汽吞吐 Tia Juana油田

Percutaneous management in hepatic alveolar echinococcosis:A sum of single center experiences and a brief overview of the literature

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Surgery 2023年第3期15卷 398-407页

作者： Suat Eren Sonay Aydın mecit Kantarci Volkan Kızılgöz Akın Levent Düzgün CanŞenbil Okan Akhan Department of Radiology Faculty of MedicineAtatürk UniversityErzurum 25100Turkey Department of Radiology Faculty of MedicineErzincan Binali Yıldırım UniversityErzincan 24100Turkey Department of Radiology Hacettepe UniversityAnkara 06090Turkey

BACKGROUND Hepatic alveolar echinococcosis(HAE)is a serious zoonotic infection that affects *** may have a tumor-like appearance at *** treatment of HAE patients is extremely relaxing for *** is a significant human zoonotic infection caused by the fox tapeworm Echinococcus multilocularis *** possesses the characteristics of an invasive tumor-like lesion due to its infiltrative growth pattern and protracted incubation *** disease is endemic over central Europe,Asia,and North *** To characterize HAE patients who were treated percutaneously,their outcomes,and the major technical features of percutaneous treatment in *** Patients who were treated with percutaneous cyst drainage and/or percutaneous biliary drainage were included in the *** abnormal coagulation values and solid or non-infected HAE with minor necrotic change were *** Thirty-two patients underwent percutaneous cyst drainage,two patients underwent percutaneous biliary drainage,and four patients underwent percutaneous biliary drainage *** radiology is utilized to drain echinococcal necrosis and abscesses within/without the liver,as well as diseased and clogged bile *** Percutaneous drainage of cyst contents and/or biliary channels using a minimally invasive technique is a very *** cyst drainage with albendazole therapy improves quality of life in patients who are unable to undergo surgery,even when the mass resolves with long-term treatment.

关键词： Interventional Radiology Treatment Alveolar echinococcosis Liver

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

网页美容术

电脑知识与技术 2004年第25期 69-70页

作者： lg

想让你的网页看起来更有个性吗 ? 笔者在使用D ream w eaverm X 制作网页的同时 , 总结了一些心得 ,今天拿来和各位朋友分享 ,希望可以通过本文 ,让朋友们对 D ream w eaver m X 的应用... 详细信息

想让你的网页看起来更有个性吗 ? 笔者在使用D ream w eaverm X 制作网页的同时 , 总结了一些心得 ,今天拿来和各位朋友分享 ,希望可以通过本文 ,让朋友们对 D ream w eaver m X 的应用更加得心应手。 1、秀气的 9 磅字为什么别人网页上的文字是那样的秀气 ? 而我们页面上的文字却有些 … … ,其实很简单 ,只是他们利用CSS 样式表定义了字体的大小罢了。只要通过快捷键“Shift+F11”打开样式表“CSS 样式 ”编辑器 ,然后在窗口中单击鼠标右键执行“新建 CSS 样式 ”命令 ,图 1 所示。之后选择一个保存路径即可。最后在弹出的对话框中 ,把 “字体 ”下面的 “大小 ”选项设置成 “”即可实现大小 ...

关键词： CSS 选项

Incidental congenital coronary artery vascular fistulas in adults:Evaluation with adenosine-13N-ammonia PET-CT

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

World Journal of Cardiology 2018年第10期10卷 153-164页

作者： Salah Am Said Aly Agool Arno Hm moons mounir WZ Basalus Nils RL Wagenaar Rogier lg Nijhuis Jutta m Schroeder-Tanka Riemer HJA Slart Department of Cardiology Hospital Group TwenteAlmelo-Hengelo 7555 DLOverijsselThe Netherlands Department of Nuclear medicine Hospital Group TwenteAlmelo-Hengelo 7555 DLOverijsselThe Netherlands Department of Cardiology Slotervaart HospitalAmsterdam 1066 ECNorth HollandThe Netherlands Department of Cardiology Hospital Onze Lieve Vrouwe GasthuisLocation WestAmsterdam 1061 AENorth HollandThe Netherlands Department of Nuclear medicine and molecular Imaging University Medical Center GroningenGroningen 9713 GZThe Netherlands Faculty of Science and Technology Biomedical Photonic ImagingUniversity of TwenteEnschede 7522 NBThe Netherlands

AIm To assess the functionality of congenital coronary artery fistulas(CAFs) using adenosine stress ^(13)N-ammonia positron emission tomography computed tomography(PET-CT).mETHODS Congenital CAFs were incidentally detected during coronary angiography(CAG) procedures in 11 adult patients(six males and five females) with a mean age of 64.3 years(range 41-81). Patients were collected from three institutes in the Netherlands. The characteristics of the fistulas(origin, pathway and termination), multiplicity of the origins and pathways of the fistulous vessels were assessed by CAG. Five patients underwent adenosine pharmacologic stress ^(13)N-ammonia PET-CT to assess myocardial perfusion and the functional behavior of the fistula. RESULTS Eleven patients with 12 CAFs, 10 unilateral and one bilateral, originating from the left anterior descending coronary artery(n = 8), right coronary artery(n = 2) and circumflex(n = 2). All fistulas were of the vascular type, terminating into either the pulmonary artery(n = 11) or coronary sinus(n = 1). The CAG delineated the characteristics of the fistula(origin, pathway and termination). multiplicity of the origins and pathways of the fistulous vessels were common in most fistulas(8/12, 67% and 9/12, 75%, respectively). multiplicity was common among the different fistula components(23/36, 64%). Adenosine pharmacologic stress ^(13)N-ammonia PET-CT revealed normal myocardial perfusion and ejection fraction in all but one patient, who showed a reduced ejection *** PET-CT may be helpful for assessing the functional status of congenital CAFs in selected patients regarding clinical decision-making. Studies with a larger patient series are warranted.

关键词： Coronary angiography Coronary-pulmonary artery fistulas Adenosine ammonia positron emission tomography computed tomography Coronary vascular fistulas Congenital coronary artery fistulas

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

5-HT3受体亚型的药理和功能

国际药学研究杂志 1987年第4期 223-225页

作者： Richardson BP ,Enge lg ,许守玺

约于30年前已证实,5-HT 通过两种不同的机理引起豚鼠回肠收缩,即直接活化平滑肌细胞或间接引起壁内胆碱神经释放ACh。1957年Gaddum 等又证明,苯氧苄胺(Dibenzyline;D)能阻滞平滑肌细胞上的5-HT 受体;吗啡(m)则抑制5-HT 兴奋神经元和释放... 详细信息

约于30年前已证实,5-HT 通过两种不同的机理引起豚鼠回肠收缩,即直接活化平滑肌细胞或间接引起壁内胆碱神经释放ACh。1957年Gaddum 等又证明,苯氧苄胺(Dibenzyline;D)能阻滞平滑肌细胞上的5-HT 受体;吗啡(m)则抑制5-HT 兴奋神经元和释放ACh 所引起的收缩作用。因而设想,平滑肌细胞上5-HT受体是D 受体,而胆碱神经上5-HT 受体是m受体,这是首次从药理学角度证明存在不同的5-HT 受体亚型,但苯氧苄胺和吗啡都不能在

关键词： HT3 激动剂拮抗剂受体亚型豚鼠回肠功能

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

前牙折断片粘结修复技术：病例报告

中国口腔医学继续教育杂志 2011年第2期14卷 114-116页

作者： Kina m Ribeiro lg monteiro S Jr de Andrada mA 侯晓玫（译）董雯（审）不详首都医科大学口腔医学院牙体牙髓科北京市崇文区天坛西里4号100050

前牙外伤可引起牙齿颜色和形态的改变．使美观受到影响。前牙折断片粘结修复技术可以恢复牙齿美观，同时恢复功能和外形，适于折断片完整的病例。本文报道了1例前牙折断片粘结修复病例，体现了该方法不须磨除剩余牙体组织以及获得理想... 详细信息

前牙外伤可引起牙齿颜色和形态的改变．使美观受到影响。前牙折断片粘结修复技术可以恢复牙齿美观，同时恢复功能和外形，适于折断片完整的病例。本文报道了1例前牙折断片粘结修复病例，体现了该方法不须磨除剩余牙体组织以及获得理想的美观效果等优点。

关键词：粘结修复技术前牙折断病例报告美观效果牙齿颜色前牙外伤恢复功能牙体组织

Biosynthesis of silver nanoparticles by using mangrove plant extract and their potential mosquito larvicidal property

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian Pacific Journal of Tropical medicine 2011年第10期4卷 799-803页

作者： m Gnanadesigan m Anand S Ravikumar m maruthupandy V Vijayakumar S Selvam m Dhineshkumar AK Kumaraguru School of Energy Environmental and Natural ResourcesDepartment of Marine and Coastal StudiesMadurai Kamaraj UniversityMadurai-625021Tamil NaduIndia School of marine Sciences Department of Oceanography and Coastal Area StudiesAlagappa UniversityThondi CampusThondi-623409Ramanathapuram DistrictTamil NaduIndia School of Chemistry Department of Inorganic ChemistryMadurai Kamaraj UniversityMadurai-625021Tamil NaduIndia School of Chemistry Department of Industrial ChemistryAlagappa UniversityKaraikudi-630003Tamil NaduIndia

Objective:To identify the larvicidal activities of silver nano particles synthesised with Rhizophora mucronata（***） leaf extract against the larvae of Aedes aegypti（***） and Culex quinquefasciatus（***）.methods:In vitro larvicidal activities such as LC50 and LC90 were assessed for the *** and *** larval ***, characterisation such as UV,XRD,FTIR and AFm analysis were carried out for the synthesised silver nano ***:The LC50 value of the synthesised silver nano particle was identified as 0.585 and 0.891 mgg/L for *** and *** larvae respectively. Further,the lg90 values are also identified as 2.615 and 6.291 mg/L for *** and Cx. quinquefasciatus species *** synthesised silver nanoparticles have maximum absorption at 420 nm with the average size of 60-95 *** XRD data showed 20 intense values with various degrees such as 37.10°,47.66°,63.97°and 70.01°.The FTIR data showed prominent peaks in（3 426.89,2 925.49,2 869.56,2 346.95,1 631.49,1 031.73,669.18 and 455.12） different ***:The biosynthesis of silver nanoparticles with leaf aqueous extract of R. mucronata provides potential source for the larvicidal activity against mosquito borne diseases.

关键词： Biosynthesis mangroves Larvicidal

Climate-influenced vector-borne diseases in Africa: a call to empower the next generation of African researchers for sustainable solutions

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

贫困所致传染病(英文) 2024年第2期13卷 1-10页

作者： Obame-Nkoghe Judica?l Agossou Adjoavi Esse mboowa Gerald Kamgang Basile Caminade Cyril Duke Dawn C. Githeko Andrew Karanja Ogega Obed m. Elloué Nestor Engone Sarr Fatou Bintou Nkoghe Dieudonné Kengne Pierre Ndam Nicaise T. Paupy Christophe Bockarie moses Otomo Patricks Voua molecular and Cellular Biology Laboratory (LabmC) Biology Department University of Science and Technology of Masuku BP Franceville Gabon Ecology and Health Research Unit Interdisciplinary Center for Medical Research of Franceville BP Franceville Gabon Department of Zoology and Entomology Faculty of Natural and Agricultural Sciences University of the Free State Private Bag x13 Phuthaditjhaba Republic of South Africa Laboratory of Pharmacology and Improved Traditional medicines Department of Animal Physiology Faculty of Science and Technology University of Abomey-Calavi BP Cotonou Benin The African Center of Excellence in Bioinformatics and Data-Intensive Sciences Infectious Diseases Institute College of Health Sciences Makerere University P. O Box Kampala Uganda Africa Centers for Disease Control and Prevention African Union Commission Roosevelt Street P.O. Box WKAddis Ababa Ethiopia Centre for Research in Infectious Diseases P.O. Box Yaoundé Cameroon Earth System Physics Department The Abdus Salam International Centre for Theoretical Physics Trieste Italy Africa Research Excellence Fund Charterhouse Street London EC1MHR UK Community Health Support Program P.O. Box Kisumu Kenya The African Academy of Sciences Nairobi Kenya Center for Phylosophical Studies and Research (CERP) Omar Bongo University (UOB) BP Libreville Gabon UmRED Health Training and Research Unit University of Iba Der Thiam of Thiès BP Thiès Senegal National Parasitic Diseases Control Program Ministry of Health Libreville Gabon mIVEGEC Univ. Montpellier CNRS IRD Montpellier France mERIT IRD Paris Cité University Paris France Department of Parasitology Noguchi Memorial Institute for Medical Research University of Ghana LG Accra Ghana School of Community Health Sciences Njala University Bo Sierra Leone

We look at the link between climate change and vector-borne diseases in low- and middle-income countries in Africa. The large endemicity and escalating threat of diseases such as malaria and arboviral diseases, intensified by climate change, disproportionately affects vulnerable communities globally. We highlight the urgency of prioritizing research and development, advocating for robust scientific inquiry to promote adaptation strategies, and the vital role that the next generation of African research leaders will play in addressing these challenges. Despite significant challenges such as funding shortages within countries, various pan-African-oriented funding bodies such as the African Academy of Sciences, the Africa Research Excellence Fund, the Wellcome Trust, the U.S. National Institutes of Health, and the Bill and melinda Gates Foundation as well as initiatives such as the African Research Initiative for Scientific Excellence and the Pan-African mosquito Control Association, have empowered (or are empowering) these researchers by supporting capacity building activities, including continental and global networking, skill development, mentoring, and African-led research. This article underscores the urgency of increased national investment in research, proposing the establishment of research government agencies to drive evidence-based interventions. Collaboration between governments and scientific communities, sustained by pan-African funding bodies, is crucial. Through these efforts, African nations are likely to enhance the resilience and adaptive capacity of their systems and communities by navigating these challenges effectively, fostering scientific excellence and implementing transformative solutions against climate-sensitive vector-borne diseases.

关键词： Climate change Vector-borne diseases Africa Environmental justice Research and development Pan-African funding initiatives