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Treatment of Helicobacter pylori infection in children:A systematic review

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World Journal of meta-Analysis 2020年第4期8卷 292-308页

作者： Filipe Antônio França da Silva Breno Bittencourt de Brito maria Luísa Cordeiro Santos Hanna Santos marques mariana miranda Sampaio Ronaldo Teixeira da Silva Júnior Jonathan Santos Apolonio Lorena Sousa de carvalho Camilo Santana Silva Luana Kauany de SáSantos márcio Vasconcelos Oliveira Gifone Aguiar Rocha Dulciene maria de magalhães Queiroz Fabrício Freire de melo Instituto multidisciplinar em Saúde Universidade Federal da BahiaVitória da Conquista 45029-094BahiaBrazil Campus Vitória da Conquista Universidade Estadual do Sudoeste da BahiaVitória da Conquista 45083-900BahiaBrazil Laboratory of Research in Bacteriology Faculdade de MedicinaUniversidade Federal de Minas Gerais(UFMG)Belo Horizonte 30130-100Minas GeraisBrazil

BACKGROUND Helicobacter pylori(***)infection is predominantly acquired in *** indicated,the most accepted treatment for *** eradication in this age group is first-line triple ***,the increasing resistance to clarithromycin and nitroimidazoles has been associated with treatment failure,and thus,alternative treatment regimens have been *** To perform a systematic review of randomized controlled trials on treatment regimens for *** infection in *** We surveyed relevant articles published in English from 2010 to April 2020 in the Pubmed and mEDLINE *** included“Helicobacter pylori“/”children or childhood“/”treatment or eradication.”The risk of bias was evaluated according to the Cochrane Handbook of Systematic Reviews for *** Among the 1144 records identified through the database,20 articles were *** studies compared the eradication rates of *** infection between standard triple therapies,changing only the main antibiotic *** studies evaluated the effectiveness of standard triple therapy with the addition of *** study investigated the relationship between the effectiveness in the eradication rates of standard triple therapy and vitamin E *** studies analyzed the eradication rates of sequential *** The findings suggest that although standard triple therapy is the most recommended regimen for children by the current guidelines,other therapeutic schemes have shown promising results and may also be recommended for clinical practice in the future.

关键词： Helicobacter pylori Children Pediatric treatment Standard triple therapy Probiotics Sequential therapy Eradication therapies

Resolutive Results with Oral Corticosteroids for Patients with COVID-19 in Pulmonary Inflammatory Phase. Successful Outpatient Experience during the Collapse of Belem Do Para Health System—Brazil

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Health 2021年第8期13卷 830-838页

作者： Roberto S. Zeballos Luciana N. L. Cruz Vânia C. R. Brilhante Adriana V. Lima Carlliane L. L. P. martins Karla N. A. Lima michele C. G. L. Leão Belinete L. Cruz Alessandra B. Dysarz Paulo C. B. Lobato Erika S. Almeida Rute A. P. Costa Klevison C. Araújo Augusto C. C. Almeida Leônidas B. D. Junior Kathia O. Harada Rita H. V. S. Araújo Elaine X. Prestes Ivete m. S. Souza Avany m. P. Pereira Antônio B. m. A. Rocha Iracema A. Estevão Fagnei I. C. carvalho Paulo m. P. melo Clinical Care Sao Paulo Brazil Instituto de Ciencias da Saude Faculdade de Medicina Universidade Federal do Para Belem Brazil Fundacao Publica Estadual Hospital de Clinicas Gaspar Vianna Belem Brazil Hospital da Policia militar do Para Belem Brazil Imunoclinic Belem Brazil Universidade Estadual do Para Fundacao Santa Casa de Misericordia do Para Belem Brazil Clinica Barros Cirurgia Plastica Belem Brazil Secretaria de Estado de Saude Publica Castanhal Brazil Centro de Tratamento Oncologico Belem Brazil Sociedade Brasileira de Valorizaç ã o das Sociedades medicas—SOBEmED S&#227 o Paulo Brazil Clinica de Nutrologia Sao Luiz Brazil Hospital Nipo Brasileiro de Olhos Belem Brazil Centro de Ciencias Biologicas e da Saude Universidade do Estado do Para Belem Brazil Hospital Regional do Baixo Amazonas Santarem Brazil Clinica Vallinoto Secretaria de Saude de Barcarena Barcarena Brazil Estrategia Saude da Familia Secretaria municipal de Saude de Ananindeua Centro Universitario do Estado do Para Belem Brazil A. m. P. Endocrinologia Belem Brazil Instituto Avertano Rocha Belem Brazil departamento de Neurocirurgia Hospital Militar de Area De Sao Paulo Sao Paulo Brazil

In the face of new diseases, medicine needs to reinvent itself in order to contain and control epidemics, such as the one we have recently faced, COVID-19, a disease with a wide spectrum of clinical severity. A new moment has been established, since the application of well-known, effective and safe medications for other diseases, has shown high success rates in the treatment of COVID-19. Thereunto, studies with early intervention are needed, which can change the unfavorable outcome of patients. In this article, we report the successful experience using an oral strategy during the collapse of Belem (Para, Brazil) Health System. Two hundred and ten patients were diagnosed with respiratory failure due to COVID-19, with no option of hospital treatment due to lack of beds and resources. These patients were then started on therapeutic regimen consisting of 40 mg prednisolone, 40 mg enoxaparin and macrolides (500 mg clarithromycin, 500 mg axetylcefuroxime) associated and followed in outpatient facilities. Two hundred and eight patients had an excellent therapeutic response and there were only two fatalities. These results push research boundaries, valuing outpatient treatment with early use of prednisolone in the initial pulmonary phase, preventing severe COVID-19 pneumonitis. Adoption of the proposed treatment intends to reduce the need for hospitalization, as well as lethality, with social robust benefits and incalculable economic savings since involves the use of accessible, safe and not expensive medications.

关键词： COVID-19 Corticosteroids Pulmonary Inflammatory Phase Collapse Brazil

Kinin B_2 receptor does not exert renoprotective effects on mice with glycerol-induced rhabdomyolysis

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World Journal of Nephrology 2014年第3期3卷 85-91页

作者： Pedro Paulo Gattai Fernando Francisco Pazello mafra Frederick Wasinski Sandro Soares Almeida marcos Ant?nio Cenedeze denise maria Avancini Costa malheiros Reury Frank Pereira Bacurau Carlos Castilho Barros Niels Olsen Saraiva Camara Ronaldo carvalho Araujo department of Biophysics Laboratory of Genetics and Exercise Metabolism Federal University of Sao Paulo-UNIFESP Sao Paulo CEP 04039-032 Brazil Federal University of Sao Paulo-UNIFESP Sao Paulo CEP 04039-032 Brazil Nephrology Division Laboratory of Clinical and Experimental Immunology Federal University of Sao Paulo–UNIFESP Sao Paulo CEP 04039-032 Brazil Renal Division Department of Clinical Medicine Laboratory of Renal Pathophysiology (LIM-16) Sao Paulo University-USP Sao Paulo CEP 04039-032 Brazil School of Arts Sciences and Humanities Sao Paulo University-USP Sao Paulo CEP 04039-032 Brazil Nutrition Faculty Federal University of Pelotas Rio Grande do Sul CEP 96010-610 Brazil department of Immunology Laboratory of Transplantation in Immunobiology Sao Paulo University-USP Sao Paulo CEP 05508-000 Brazil

AIm： To investigate a potential protective role of the kinin B2 receptor in a glycerol-induced rhabdomyolysis mouse model. mETHODS： We separated 28 C57Bl/6 male mice into 4 groups： untreated WT animals, untreated B2 knockout mice, glycerol-treated WT and glycerol-treated B2 knockout mice. Glycerol-treated animals received one intramuscular injections of glycerol solution （50% v/v, 7 mL/kg）. After 48 h, urine and blood samples were collected to measure creatinine and urea levels. Addi-tionally, kidney samples were extracted for histological evaluation, and the mRNA expression levels of kinin B1 and B2 receptors and infammatory mediators were measured by real-time polymerase chain reaction. RESULTS： Serum creatinine and urea levels showed differences between untreated wild-type and glycerol-treated wild-type mice （0.66 ± 0.04 vs 2.61 ± 0.53 mg/dL, P 〈 0.01; and 33.51 ± 2.08 vs 330.2 ± 77.7 mg/dL, P 〈 0.005）, and between untreated B2 knock-out mice and glycerol-treated knockout mice （0.56 ± 0.03 vs 2.23 ± 0.87 mg/dL, P 〈 0.05; and 42.49 ± 3.2 vs 327.2 ± 58.4 mg/dL, P 〈 0.01）, but there was no difference between the glycerol-treated wild-type and glycerol-treated knockout mice. Glycerol was able to in-duce a striking increase in kinin B2 receptor expression （〉 30 times, 31.34 ± 8.9） in kidney. Animals injected with glycerol had a higher degree of tubular injury than untreated animals. Wild-type and knockout mice treat-ed with glycerol intramuscularly present kidney injury, with impairment in renal function. However, B2 knock-out mice treated with glycerol did not show a different phenotype regarding kidney injury markers, when com-pared to the wild-type glycerol-treated group. CONCLUSION： We conclude that the kinin B2 receptordoes not have a protective role in renal injury.

关键词： Kinins acute kidney injury Animal models Rhabdomyolysis Skeletal muscle

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世界地震译丛 2008年第6期39卷 59-73页

作者： D. Lagoutte J. Y. Brochot D. de carvalho F. Eile F. Harivelo Y. Hobara L. madrias m. Parrot J. L. Pincon J. J. Berthelier D. Peschard E. Seran m. Gangloff J. A. Sauvaud J. P. Lebreton S. Stverak P. Travnicek J. Grygorczuk J. Slominski R. Wronowski S. Barbier P. Bernard A. Gaboriaud J. m. Wallut 董健（译）张景发（校）王喜珍复（校）不详中国地震局地壳应力研究所

demETER科学任务中心(SmC)已经建成,由法国环境物理与化学实验室(LPCE)负责运行,主要负责有效载荷工作指令的制定,向demETER卫星国际用户收集与分发卫星观测数据及其数据产品。成立科学任务中心的目的是最大限度地降低开发和探测成本,... 详细信息

demETER科学任务中心(SmC)已经建成,由法国环境物理与化学实验室(LPCE)负责运行,主要负责有效载荷工作指令的制定,向demETER卫星国际用户收集与分发卫星观测数据及其数据产品。成立科学任务中心的目的是最大限度地降低开发和探测成本,获得最大回报。本文描述了科学任务中心的数据处理系统、数据服务和有效载荷工作控制方法和相关的硬件和软件构架。

关键词：任务中心数据处理 demETER卫星卫星观测数据

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年轻视网膜中央静脉阻塞患者的临床进程

眼科新进展 2005年第3期25卷 200-200页

作者： Franco m.Recchia Cynthia A.carvalho-Recchia Tarek S.Hassan

目的描述55岁以下的视网膜中央静脉阻塞(CR-VO)患者的临床进程。设计和方法回顾性非比较性的连续病例分析。复习了67例患者的人口统计学、影像、临床和视力数据。对其中随访6个月以上(平均29.2个月)的病例资料进行了统计学分析。主要结... 详细信息

目的描述55岁以下的视网膜中央静脉阻塞(CR-VO)患者的临床进程。设计和方法回顾性非比较性的连续病例分析。复习了67例患者的人口统计学、影像、临床和视力数据。对其中随访6个月以上(平均29.2个月)的病例资料进行了统计学分析。主要结果测定最佳矫正视力和眼内新生血管形成的发病率。结果在连续的67例(男性55%,平均年龄45岁)患者中,视力平均为20/50。其中45例(67%)患者被查出至少有1种全身性疾病。在57例随访6个月以上的患者中,最终视力20/40(含)以上的占42%,20/50-20/100的占18%,20/200(含)以下的占40%.在CRVO发病的3-6个月内,绝大部分患者出现了视力减退。在发病的12个月以后,出现视力提高的极少见。就诊视力在20/40(含)以上的22例患者中,36%的患者在最近的1次检查中视力下降到了20/400甚至更低。就诊视力在20/200-20/400的10例患者中,8例视力提高到20/60甚至更高。就诊视力在数指或者更差的6例患者中,没有1例视力得到改善。在CRVO发病的1-9个月内,10例(18%)患者被诊断为眼内新生血管形成。其中前节新生血管形成的患者有6例(11%),包括3例(5%)新生血管性青光眼。新生血管形成的发生与患者的性别、年龄、有无伴随疾病、症状的持续时间和就诊视力均没有明显关系。结论年轻患者的CRVO有着多变的临床过程?

关键词：视网膜中央静脉阻塞新生血管患者视力 CRVO 进程

凝胶和聚乙烯醇混合生物降解膜——聚乙烯醇型号或浓度对薄膜某些物理属性的影响

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维纶通讯 2013年第2期33卷 54-61页

作者： G. G. D. Silva P. J. A. Sobral R. A. carvalho P. V. A. Bergo O. mendieta Taboada A. m. Q. B. Habitante1 宋文慧(译) 全夏(校译)

本文的目的是研制凝胶／PVA混合生物降解膜，该薄膜不加增塑剂。首先研究了五种不同醇解度的PVA对含PVA23．1％的薄膜物理属性的影响，然后选择了一种型号的PVA研究其浓度对薄膜机械性能、色度、浊度、光洁度和水溶性的影响。被研究的... 详细信息

本文的目的是研制凝胶／PVA混合生物降解膜，该薄膜不加增塑剂。首先研究了五种不同醇解度的PVA对含PVA23．1％的薄膜物理属性的影响，然后选择了一种型号的PVA研究其浓度对薄膜机械性能、色度、浊度、光洁度和水溶性的影响。被研究的五种牌号的PVA生成的薄膜有不同的性能，但和PVA醇解度没有直接的关联性。因此，第二部分选择醇解度为91．8％PVACelvold．18作为研究对象，因为他们制备的薄膜有更高的拉力强度。PVA浓度影响所有被研究的薄膜的性能，通过DSC和FTIR分析对这些结果进行了解释，DSC和F-11R表明凝胶和不同浓度PVA之间有一些相互影响，这会影响薄膜的结晶度。

关键词：生物聚合物蛋白质机械性能色度溶解度

Evaluation of Quantum Chemical methods and Basis Sets Applied in the molecular modeling of Artemisinin

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Computational molecular Bioscience 2013年第3期3卷 66-79页

作者： Cleydson B. R. dos Santos Cleison C. Lobato Josinete B. Vieira Davi S. B. Brasil Alaan U. Brito Williams J. C. macêdo José Carlos T. carvalho José C. Pinheiro Laboratory of modelling and Computational Chemistry Federal University of Amapá Macapá Brazil Laboratory of Theoretical and Computational Chemistry Institute of Exact and Natural Sciences Federal University of Pará Belém Brazil Postgraduate Program in Biotechnology and Biodiversity-Network BIONORTE Campus Universitário Marcos Zero Macapá Brazil

In this paper, we evaluate semiempirical methods (Am1, Pm3, and ZINDO), HF and DFT (B3LYP) in different basis sets to determine which method best describes the sign and magnitude of the geometrical parameters of artemisinin in the region of the endoperoxide ring compared to crystallographic data. We also classify these methods using statistical analysis. The results of PCA were based on three main components, explaining 98.0539% of the total variance, for the geometrical parameters C3O13, O1O2C3, O13C12C12a, and O2C3O13C12. The DFT method (B3LYP) corresponded well with the experimental data in the hierarchical cluster analysis (HCA). The experimental and theoretical angles were analyzed by simple linear regression, and statistical parameters (correlation coefficients, significance, and predictability) were evaluated to determine the accuracy of the calculations. The statistical analysis exhibited a good correlation and high predictive power for the DFT (B3LYP) method in the 6-31G** basis set.

关键词： Artemisinin molecular modeling Quantum Chemical methods Statistical Analysis B3LYP/6-31G**

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细长正交异性钢桥面板的疲劳寿命评估

钢结构 2008年第6期23卷 85-85页

作者： Ronaldo C. Battista michèle S. Pfeil Eliane m.L. carvalho

在多种焊接节点中产生的疲劳裂缝,也产生在大量细长正交异性钢桥面板中。一部分裂缝在桥梁投入使用短短几年之后便会出现,所以对于桥面焊接节点的疲劳寿命评估较复杂。这同时也是局部压应力会随着很多因素而随机变化的原因,尤其是那些... 详细信息

在多种焊接节点中产生的疲劳裂缝,也产生在大量细长正交异性钢桥面板中。一部分裂缝在桥梁投入使用短短几年之后便会出现,所以对于桥面焊接节点的疲劳寿命评估较复杂。这同时也是局部压应力会随着很多因素而随机变化的原因,尤其是那些在车胎、公路和钢结构的动力交互作用面上。提出并讨论了可观测裂缝的主要成因,以及具有梯形横截面和纵肋的正交异性桥面上典型焊接和几何细部的极限疲劳寿命的评估结果。以一现存长跨钢桥的桥面为例进行分析。该桥面曾经通过增加钢筋混凝土覆层,采用剪力螺栓连接到钢板面而加固。这些措施是为了防止后续更大的维修工作,并且提高钢桥面的疲劳寿命预期值。采用数值模型、试验性应变测量对疲劳寿命进行评估,还考虑了在该桥32年的使用年限中所有结构上的可变因素、交通流量、车载荷载。

关键词：钢桥正交异性钢桥面板疲劳裂缝车胎-结构交互面

经睫状体平坦部玻璃体切割术切除内界膜治疗持续性糖尿病性黄斑水肿

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世界核心医学期刊文摘（眼科学分册） 2005年第8期1卷 21-21页

作者： Recchia F.m. Ruby A.J. carvalho Recchia C.A. 王永强 Associated Retinal Consultants PC 3535 W. 13 Mile Rd Royal Oak MI 48073 United States Dr.

PURPOSE: To evaluate the benefit of pars plana vitrectomy (PPV) and removal of the internal limiting membrane (ILm) in eyes with diffuse diabetic macular edem a refractory to laser ***: Prospective, consecutive, interve ntional case series. mETHODS: Diabetic patients with biomicroscopic, angiographi c, and tomographic evidence of diabetic macular edema persisting for at least 3 months after numerous sessions of macular photocoagulation were evaluated for in clusion. Patients with biomicroscopic evidence of epiretinal membrane or taut po sterior hyaloid, previous vitreoretinal surgery, or active proliferative diabeti c retinopathy were excluded. The main outcome measures were macular thickness, a s measured by optical coherence tomography (OCT) and visual acuity (VA). RESULTS : PPV with ILm removal was performed in 11 eyes of 10 patients (four men, six wo men; mean age=58.2 years). Six-month follow-up data were available for 10 eyes (91%). At 6 months postoperatively, central macular thickness had improved by at least 20%in eight of 11 eyes (mean preoperative thickness of 421 μm compare d with mean postoperative thickness of 188 μm; P=.007). mean VA improved from 2 0/352 to 20/94 at 6 months (P=.002). By the most recent visit (range=6-20 month s postoperatively), VA had improved by at least 2 Snellen lines in 6 of 10 eyes treated with surgery alone. CONCLUSIONS: The early results of this ongoing study suggest that PPV with ILm removal may provide anatomic and visual benefit in so me eyes with chronic diabetic macular edema unresponsive or unamenable to additi onal laser photocoagulation.

关键词：玻璃体切割术内界膜睫状体平坦部治疗持续性生物显微镜玻璃体手术激光光凝术断层扫描玻璃体牵拉视网膜前膜