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Sleep as a window to understand and regulate Alzheimer's disease:emerging roles of thalamic reticular nucleus

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Neural Regeneration Research 2025年第6期20卷 1711-1712页

作者： Haoqi Sun Shiqian Shen Robert J.Thomas m.Brandon Westover Can Zhang Department of Neurology Beth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Center for Translational Pain Research Department of AnesthesiaCritical Care and Pain MedicineMassachusetis General HospitalHarvard Medical SchoolBostonMAUSA Division of Pulmonary Critical Care and Sleep MedicineDepartment of MedicineBeth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Genetics and Aging Research Unit McCance Center for Brain HealthMass General Institute for Neurodegenerative DiseaseDepartment of NeurologyMassachusetts General HospitalHarvard Medical SchoolBostonMAUSA

Introduction:Alzheimer 's disease(AD) is a common neurodegenerative disorder and the primary cause of dementia. Considerable evidence supports the “amyloid hypothesis,” stating that the pathogenesis of AD is primarily caused by the deposition of amyloid-β(Aβ), which drives tau phosphorylation, neuroinflammation, and neurodegeneration in the brain. The amyloid hypothesis is strengthened by the significant and moderate benefit of lecanemab, a humanized antibody through an anti-amyloid mechanism,showing slowed clinical decline(van Dyck et al.,2023). The recent positive results of anti-amyloid trials have brought back focus on the amyloid hypothesis through biochemical, genetic, and pharmacological approaches(Zhang, 2023).

关键词： Alzheimer inflammation hypothesis

Impacts of Revised Quantum Electrodynamics on Fundamental Physics

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Journal of Electromagnetic Analysis and Applications 2018年第5期10卷 106-118页

作者： Bo lehnert Alfvén Laboratory Royal Institute of Technology Stockholm Sweden

A revised quantum electrodynamic theory by the author is reconsidered, in respect to the basic concepts established by m. Planck and H.B.G. Casimir on the Zero Point Energy (ZPE) and by A. Einstein on Special Relativity. Attention is given to the new properties of its field equations and their applications. These equations include results not being available from conventional theory and the Standard model. This concerns the internal structure of elementary particles, such as the photon, the electron, muon and tauon, the Z boson, and the so called Higgs particle detected in the experiments at the laboratory of CERN. A possible unification of electrodynamics and the strong nuclear force is further provided by the theory. Finally, there are aspects on the expanding universe represented by a new interpretation of dark matter and dark energy in terms of the ZPE.

关键词： Quantum Electrodynamics Standard model and Beyond Zero Point Energy Higgs Particle Unification of Electrodynamics and the Strong Force Expanding Universe Dark matter and Dark Energy

On the Cosmical Zero Point Energy Density

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Journal of modern Physics 2016年第10期7卷 1112-1119页

作者： Bo lehnert Alfvén Laboratory Royal Institute of Technology Stockholm Sweden

The frequency spectrum of the cosmical Zero Point Energy (ZPE) and its total density are so far unknown in their details. In the present complementary investigation, a revised theory forms the basis for studies of this concept in two respects. It first applies to the observable universe considered as an entity, as well as to included subregions such as the galaxies with supermassive black holes. Second, experiments are proposed on the maximum Casimir force arising between two metal plates of different materials and with a vanishing air gap in their spacing. This serves the purpose of making an indirect determination of the ZPE energy density in the laboratory, i.e. at the Earth’s orbit. The ZPE energy density is interpreted as dark matter density and its pressure gradient as dark energy force density.

关键词： Zero Point Energy Casimir Force Dark matter Dark Energy

Solution‑Processed Thin Film Transparent Photovoltaics:Present Challenges and Future Development

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Nano-micro Letters 2025年第2期17卷 566-600页

作者： Tianle Liu munerah m.S.Almutairi Jie ma Aisling Stewart Zhaohui Xing mengxia Liu Bo Hou Yuljae Cho Um-SJTU Joint Institute Shanghai Jiao Tong UniversityShanghai 200240People’s Republic of China School of Physics and Astronomy Cardiff UniversityCardiff CF243AAWalesUK Department of Electrical and Computer Engineering Yale UniversityNew HavenCT 06511USA Energy Sciences Institute Yale UniversityWest HavenCT 06516USA Future Photovoltaics Research Center Global Institute of Future TechnologyShanghai Jiao Tong UniversityShanghai 200240People’s Republic of China

Electrical energy is essential for modern society to sustain economic *** soaring demand for the electrical energy,together with an awareness of the environmental impact of fossil fuels,has been driving a shift towards the utilization of solar ***,traditional solar energy solutions often require extensive spaces for a panel installation,limiting their practicality in a dense urban *** overcome the spatial constraint,researchers have developed transparent photovoltaics(TPV),enabling windows and facades in vehicles and buildings to generate electric *** TPV advancements are focused on improving both transparency and power output to rival commercially available silicon solar *** this review,we first briefly introduce wavelength-and non-wavelengthselective strategies to achieve *** of merit and theoretical limits of TPVs are discussed to comprehensively understand the status of current TPV *** we highlight recent progress in different types of TPVs,with a particular focus on solution-processed thin-film photovoltaics(PVs),including colloidal quantum dot PVs,metal halide perovskite PVs and organic *** applications of TPVs are also reviewed,with emphasis on agrivoltaics,smart windows and ***,current challenges and future opportunities in TPV research are pointed out.

关键词： Transparent semiconductors Solution-processable transparent solar cell Emerging solar cell materials Buildingintegrated photovoltaics

Intrinsic Particle Charges and the Strong Force

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Journal of modern Physics 2017年第7期8卷 1053-1066页

作者： Bo lehnert Alfvén Laboratory Royal Institute of Technology Stockholm Sweden

Starting from a revised quantum electrodynamic theory by the author, an attempt is made to elaborate a particle model of quarks which in their turn form triangular neutron and proton configurations. These “quark particles” are found to be electrically neutral but contain intrinsic electrical charges of both polarities, being an order of magnitude larger than the elementary charge, e. The main interaction force between two such particles is further found to have an attractive short-range character, and it becomes nearly two orders of magnitude larger than the repulsive force which would arise from two interacting elementary charges. The spatial potential distribution of this force corresponds to an inner barrier, an intermediate well, and an outer barrier. The well is found to have a depth being nearly equal to the binding energy 8 meV of the neutron. The distribution of the barriers and the well makes a stable position possible for the mutual particle distance. The deduced radii of the outer shell and of the core are further of the same magnitude as the known nuclear radii of the neutron and proton. All these deduced characteristic features are the same as those of the known strong force concept. This raises the question whether the present results could provide a first step in a unification of the electromagnetic and the strong nuclear forces.

关键词： Quantum Electrodynamics Zero Point Energy Intrinsic Particle Charges Strong Force

Some Consequences of Zero Point Energy

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Journal of Electromagnetic Analysis and Applications 2014年第10期6卷 319-327页

作者： Bo lehnert Alfvén Laboratory Royal Institute of Technology Stockholm Sweden

Both theory and experiments indicate that the vacuum is not a state of empty space, but is populated by electromagnetic fluctuations at a lowest nonzero level, the Zero Point Energy (ZPE). This debouches into considerable changes of fundamental physics, as shown by a revised quantum electrodynamic theory (RQED) applied to elementary particles, and by a revised ZPE frequency spectrum applied to the expanding universe. The Standard model based on a vacuum state of empty space is thus replaced by RQED, thereby resulting in massive elementary particles from the beginning, independently of the theory by Higgs. Also the basic properties of the Higgs-like particle detected at CERN can be reproduced by RQED. It further leads to new fundamental results beyond the theories by Dirac and Higgs, such as to a deduced value of the elementary net charge, magnetic confinement of charged particle configurations, intrinsic local particle charges, photon spin with a very small but nonzero photon rest mass, and needle-like particle-wave properties which contribute to the understanding of the photoelectric effect and two-slit experiments. The real macroscopic pressure due to the revised ZPE frequency distribution further influences the dynamics of the expanding universe, by the ZPE photon pressure gradient acting as dark energy, and the ZPE photon energy density acting as dark matter. This results in a model being consistent with the observed scale, the rate of expansion, and the stability of a flat expanding observable universe.

关键词： Zero Point Energy Quantum Electrodynamics Standard model and Beyond Expanding Universe Dark Energy Dark matter

Advancing healthcare through laboratory on a chip technology:Transforming microorganism identification and diagnostics

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World Journal of Clinical Cases 2025年第3期13卷 9-19页

作者： Carlos m Ardila Department of Basic Sciences Biomedical Stomatology Research GroupUniversidad de Antioquia U de AMedellín 0057Colombia

In a recent case report in the World Journal of Clinical Cases,emphasized the crucial role of rapidly and accurately identifying pathogens to optimize patient treatment ***-on-a-chip(LOC)technology has emerged as a transformative tool in health care,offering rapid,sensitive,and specific identification of *** editorial provides a comprehensive overview of LOC technology,highlighting its principles,advantages,applications,challenges,and future *** studies from the field have demonstrated the practical benefits of LOC devices in clinical diagnostics,epidemiology,and food *** studies have underscored the superiority of LOC technology over traditional methods,showcasing improvements in speed,accuracy,and *** future integration of LOC with biosensors,artificial intelligence,and data analytics promises further innovation and *** call to action emphasizes the importance of continued research,investment,and adoption to realize the full potential of LOC technology in improving healthcare outcomes worldwide.

关键词： Laboratory-on-a-chip microorganism identification Diagnostics Point-ofcare testing Biosensors

minimum mass of a Composite Boson

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Journal of modern Physics 2015年第14期6卷 2074-2079页

作者： Bo lehnert Alfvén Laboratory Royal Institute of Technology Stockholm Sweden

A model of the Z boson is elaborated from a revised quantum electrodynamic theory (RQED) by the author. The electromagnetic steady field is derived from a separable generating function with a convergent radial part, resulting in a vanishing net electric charge and a nonzero spin and rest mass. From the superposition of the solutions of two Z bosons with antiparallel spin directions, a model is further formed of a composite boson, the computed mass mC of which becomes connected with the mass of 91 GeV for each Z boson. This results in a composite boson which is likely to become identical with the heavy particle recently detected at CERN. Both these particles are thus lacking of net electric charge, magnetic field and spin, are purely electrostatic and highly unstable, and have masses close to the value of 125 GeV.

关键词： Quantum Electrodynamics Zero Point Energy Standard model and Beyond

Revised Quantum Electrodynamics in a Condensed Form

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Journal of modern Physics 2016年第11期7卷 1316-1319页

作者： Bo lehnert Alfvén Laboratory Royal Institute of Technology Stockholm Sweden

This theory aims beyond the possibilities being available from the Standard model. Examples are given by the directly obtained rest masses of the elementary particles, the deduced values of the elementary charge and of the mass of the boson detected by CERN which are close to their experimental data, and by an incorporated spin of the photon.

关键词： Quantum Electrodynamics Zero Point Energy Standard model and beyond