检索结果-南通市图书馆

FK506 contributes to peripheral nerve regeneration by inhibiting neuroinflammatory responses and promoting neuron survival

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第7期20卷 2108-2115页

作者： Yuhui Kou Zongxue Jin Yusong Yuan Bo ma Wenyong Xie na Han Department of Trauma and Orthopedics Peking University People’s HospitalBeijingChina national Center for Trauma medicine Peking University People’s HospitalBeijingChina Key laboratory of Trauma and Neural Regeneration(Peking University) Ministry of EducationBeijingChina Trauma medicine Center Peking University People’s HospitalBeijingChina Department of Orthopedics China-Japan Friendship HospitalBeijingChina

FK506(Tacrolimus)is a systemic immunosuppressant approved by the *** and Drug ***506 has been shown to promote peripheral nerve regeneration,however,its precise mechanism of action and its pathways remain *** this study,we established a rat model of sciatic nerve injury and found that FK506 improved the morphology of the injured sciatic nerve,increased the numbers of motor and sensory neurons,reduced inflammatory responses,markedly improved the conduction function of the injured nerve,and promoted motor function *** findings suggest that FK506 promotes peripheral nerve structure recovery and functional regeneration by reducing the intensity of inflammation after neuronal injury and increasing the number of surviving neurons.

关键词： FK506 inflammation motor neurons nerve regeneration neuron peripheral nerve injury sensory neurons

maximizing biomass utilization: An integrated strategy for coproducing multiple chemicals

在线全文

学校读者我要写书评

暂无评论

Journal of Energy Chemistry 2025年第1期100卷 180-191页

作者： Byeongchan Ahn Sua Jo Jonggeol na J.Jay liu Young-Ju Kim Wangyun Won Department of Chemical and Biological Engineering Korea University Department of Chemical Engineering (Integrated process) Kyung Hee University Department of Chemical Engineering and materials Science Ewha Womans University Department of Chemical Engineering Pukyong National University Resources Engineering Plant Research Department Korea Institute of Geoscience and Mineral Resources

lignocellulosic biomass is one of the viable solutions to alleviate the global warming. However, the limited utilization of biomass majorly focused on cellulose and hemicellulose restricts the economic and environmental feasibilities. To cope with this issue, we proposed an integrated process of co-producing 1,6-hexanediol（1,6-HDO） with tetrahydrofuran and adipic acid from biomass, referred to as Strategy A. To compare the impacts of lignin upgrading and feedstock, Strategy B, which co-produces tetrahydrofuran alone, and Strategy C, which is the traditional route to produce 1,6-HDO from fossil fuels, were used. Heat networks are also designed to reduce operating costs and indirect carbon emissions due to energy consumption, saving 87% and 83% of the heat and cooling requirements, respectively, in Strategy A. The market competitiveness of Strategy A was evaluated by determining the minimum selling price through techno-economic analysis, and sustainability was thoroughly investigated by quantifying the environmental impacts through both midpoint and endpoint life-cycle assessments（lCAs）.Strategy A was found to be the most favorable both economically（USRDSCHARDOllAR3,402/ton） and environmentally（-26.9 kg CO2eq.）. This indicates that lignin valorization is not only economically but also environmentally preferred. Finally, changes in economic and environmental feasibilities depending on economic, process, and environmental parameters were investigated using sensitivity and uncertainty analyses. The results of these analyses provide valuable insight into bio-based chemical production.

关键词： Carbon capture and utilization

Tunable non-markovian and quantum coherence in the single-qubit dephasing noise channel

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Science China(Physics,mechanics & Astronomy) 2025年

作者： na-na Zhang Chao-Yi Wu Xu Zhou Qi-Yuan liu Cheng-Ge liu Yong-Rui Guo Ren-Pu li School of Optoelectronic Engineering Chongqing University of Posts and Telecommunications Department of Physics Applied Optics Beijing Area Major Laboratory Beijing Normal University

In this paper, we construct a single-qubit dephasing noise channel based on the nuclear magnetic resonance（NmR） system by employing the bath-engineering technology, and achieve the construction of the tunable non-markovian environment in the dephasing noise channel. Our findings indicate that for the single-qubit system, the transition of system dynamics from markovian to non-markovian can be achieved by adjusting the base frequency of the noise power spectrum. However, the base frequency corresponding to this phase transition point is not fixed, and there is a certain relationship between it and the total evolution time of the single-qubit system. Through our research, we discovered a fundamental relationship: if the single-qubit system dynamics undergoe a transition from markovian to non-markovian at ω0within 0-2t ms, shortening the evolution time to 0-t ms results in an increase of the phase transition point to 2ω0. This insight offers crucial guidance for artificially crafting non-markovian environments across arbitrary time scales in single-qubit systems, and it is not limited by the type of noise. Apart from system dynamics, quantum coherence is also a focal point of our research. We find that when the system dynamics exhibit non-markovian behavior, the quantum coherence of the single-qubit system experiences revivals. Notably, the timing of these coherence revivals aligns with the instants of the non-markovianity enhancement. Therefore, our research also serves as a pivotal foundation for the artificial manipulation and realization of quantum coherence revivals within diverse single-qubit systems.

关键词：

Emerging role of A-kinase anchoring protein 5 signaling in reward circuit function

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第10期20卷 2913-2914页

作者： William J.Flerlage mark l.Dell’Acqua Brian m.Cox Fereshteh S.Nugent Uniformed Services University of the Health Sciences Department of Pharmacology and Molecular TherapeuticsBethesdaMDUSA Department of Pharmacology University of Colorado School of MedicineAnschutz Medical CampusAuroraCOUSA

There is a strong evidence supporting the hypothesis of synaptic dysfunction as a major contributor to neural circuit and network disruption underlying emotional and mood dysregulation in psychiatric disorders(Simmons et al.,2024).Diverse sets of distinct molecular signaling pathways converge on the synapse to regulate synaptogenesis,synaptic function,and synaptic plasticity in brain regions and circuits through complex interactions organized by numerous multivalent protein scaffolds,including the family of proteins known as A-kinase anchoring proteins(AKAPs).

关键词： function supporting

Inhibitory gamma-aminobutyric acidergic neurons in the anterior cingulate cortex participate in the comorbidity of pain and emotion

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第10期20卷 2838-2854页

作者： lu Guan mengting Qiu na li Zhengxiang Zhou Ru Ye liyan Zhong Yashuang Xu Junhui Ren Yi liang Xiaomei Shao Jianqiao Fang Junfan Fang Junying Du Department of Neurobiology and Acupuncture Research Third School of Clinical MedicineZhejiang Chinese Medical UniversityHangzhouZhejiang ProvinceChina Key laboratory for Research of Acupuncture Treatment and Transformation of Emotional Diseases Third School of Clinical MedicineZhejiang Chinese Medical UniversityHangzhouZhejiang ProvinceChina Fuchun Community Health Service Center of Fuyang District HangzhouZhejiang ProvinceChina

Pain is often comorbid with emotional disorders such as anxiety and *** of the anterior cingulate cortex has been implicated in pain and pain-related negative emotions that arise from impairments in inhibitory gamma-aminobutyric acid *** review primarily aims to outline the main circuitry(including the input and output connectivity)of the anterior cingulate cortex and classification and functions of different gamma-aminobutyric acidergic neurons;it also describes the neurotransmitters/neuromodulators affecting these neurons,their intercommunication with other neurons,and their importance in mental comorbidities associated with chronic pain *** understanding on their role in pain-related mental comorbidities may facilitate the development of more effective treatments for these ***,the mechanisms that regulate gamma-aminobutyric acidergic systems remain *** is also unclear as to whether the mechanisms are presynaptic or *** exploration of the complexities of this system may reveal new pathways for research and drug development.

关键词： anterior cingulate cortex anxiety chronic pain circuit communication comorbidity depression gamma-aminobutyric acidergic neurons parvalbumin neurons synaptic transmission

mesospheric tide comparisons at low latitudes observed by two collocated meteor radars

在线全文

学校读者我要写书评

暂无评论

Earth and Planetary Physics 2025年第1期9卷 54-68页

作者： Jian li Wen Yi XiangHui Xue Jie Zeng Hailun Ye JianYuan Wang JinSong Chen na li TingDi Chen Chinese Academy of Sciences(CAS)Key laboratory of Geospace Environment Department of Geophysics and Planetary SciencesUniversity of Science and Technology of ChinaHefei 230026China CAS Center for Excellence in Comparative Planetology Anhui Mengcheng Geophysics National Observation and Research StationUniversity of Science and Technology of ChinaHefei 230026China Hefei national laboratory University of Science and Technology of ChinaHefei 230026China Collaborative Innovation Center of Astronautical Science and Technology Harbin 150001China national Key laboratory of Electromagnetic Environment China Research Institute of Radiowave PropagationQingdao 266107China Yunnan Kunming Electromagnetic Environment national Observation and Research Station Qujing Kunming 655000China

Accurate knowledge of mesospheric winds and waves is essential for studying the dynamics and climate in the mesosphere and lower thermosphere(mlT)*** this study,we conduct a comparative analysis of the mesosphere tidal results obtained from two adjacent meteor radars at low latitudes in Kunming,China,from November 2013 to December *** two radars operate at different frequencies of 37.5 mHz and 53.1 mHz,***,overall good agreement is observed between the two radars in terms of horizontal winds and tide *** results show that the dominant tidal waves of the zonal and meridional winds are diurnal and semidiurnal ***,we conduct an exhaustive statistical analysis to compare the tidal amplitudes and vertical wavelengths recorded by the dual radar systems,which reveals a high degree of alignment in tidal *** investigation includes variances and covariances of tidal amplitudes,which demonstrate remarkable consistency across measurements from both *** finding highlights clear uniformity in the mesospheric tidal patterns observed at low latitudes by the two neighboring meteor *** of the comparative analysis specifically underscore the significant correlation in vertical wavelength measurements,validating the robustness of radar observations for tidal research.

关键词： mesosphere and lower thermosphere region meteor radar mesospheric winds tides

Beginning from the end:the presynaptic terminal as a pathomechanism hub in frontotemporal dementia and amyotrophic lateral sclerosis

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第11期20卷 3217-3218页

作者： laura Huggon Emma l.Clayton UK Dementia Research Institute at King’s College london LondonUK Department of Basic and Clinical Neuroscience Institute of Psychiatry Psychology&NeuroscienceKing’s College LondonLondonUK

Frontotemporal dementia and amyotrophic lateral sclerosis:Frontotemporal dementia(F T D)and amyo t rophic lateral sclerosis(AlS)are neurodegenerative diseases with significant overlapping *** these neurodegenerative diseases affect different neuronal populations(with FTD affecting neurons of the frontal and temporal lobes,and AlS affecting upper and lower motor neurons),these two diseases are complexly *** and AlS exist on a disease spectrum,with shared genetic causes,clinical presentations,and pathologies.

关键词： diseases amyotrophic sclerosis

基于粒子群优化算法的农业机器人控制策略研究

在线全文

学校读者我要写书评

暂无评论

农机化研究 2025年第1期47卷 205-209页

作者：王娜吴延凯许娜河南工业职业技术学院河南南阳473000

介绍了粒子群优化算法的概念,并由数学模型、边界约束和环境约束对农业机器人优化约束模型进行了分析,实现了对农业机器人的动态避障和路径规划。仿真实验表明:针对复杂的作业环境,农业机器人可以进行最优避障路径规划,且算法收敛速度较... 详细信息

介绍了粒子群优化算法的概念,并由数学模型、边界约束和环境约束对农业机器人优化约束模型进行了分析,实现了对农业机器人的动态避障和路径规划。仿真实验表明:针对复杂的作业环境,农业机器人可以进行最优避障路径规划,且算法收敛速度较快,能够满足设计要求,证明系统具有一定的可行性。

关键词：农业机器人粒子群优化约束模型避障路径规划

维普期刊数据库博看期刊

multiple sclerosis is at a checkpoint: advancing the program

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第3期20卷 811-812页

作者： Brandon C.Smith Jessica l.Williams Department of Neurosciences Lerner Research InstituteCleveland ClinicClevelandOHUSA Department of Biological Geologicaland Environmental SciencesCleveland State UniversityClevelandOHUSA

multiple sclerosis(mS) is a chronic inflammatory and demyelinating disease of the central nervous system(CNS). Patients with mS experience sensory and motor function loss due to myelin and/or axon damage perpetuated b... 详细信息

关键词： Hauser sclerosis damage