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P53-mDm2在普萘洛尔诱导血管瘤内皮细胞凋亡中的作用

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现代口腔医学杂志 2018年第1期32卷 6-10页

作者：姚天华李全雁李立峰杜婧婷 krishna Regmi 葛苏蒙屠军波西安交通大学口腔医院.陕西省颅颌面精准医学研究重点实验室陕西710004 山东省泰安市口腔医院牙周粘膜科西安交通大学口腔医院口腔颌面外科陕西710004

目的初步研究P53、mDm2与普萘洛尔诱导血管瘤内皮细胞凋亡的关系,为血管瘤的治疗提供新的思路和靶点。方法体外培养血管瘤内皮细胞,实验设计为2组,加药组和空白对照组,加药组以100umol/L的普萘洛尔处理细胞,空白对照组不予以特殊处理。... 详细信息

目的初步研究P53、mDm2与普萘洛尔诱导血管瘤内皮细胞凋亡的关系,为血管瘤的治疗提供新的思路和靶点。方法体外培养血管瘤内皮细胞,实验设计为2组,加药组和空白对照组,加药组以100umol/L的普萘洛尔处理细胞,空白对照组不予以特殊处理。倒置显微镜、电镜下观察形态学变化,流式细胞术检测细胞凋亡率,RTPCR、Western-blot检测mDm2、P53 mRNA水平和蛋白水平上的变化。结果用普萘洛尔处理后,大部分细胞形态有紧密排列的"铺路石"形态逐渐变圆。透射电镜观察到细胞呈现凋亡相,对照组无明显变化;加药组细胞凋亡率为14.67%,空白对照组4.87%,具有统计学差异。RT-PCR、Western-blot结果一致,与空白对照组相比,P53、mDm2均升高,具有统计学差异。结论 100umol/L普萘洛尔能够诱发体外培养的血管瘤内皮细胞凋亡,能促使体外培养的血管瘤内皮细胞中P53与mDm2呈现高表达。

关键词：普萘洛尔血管瘤内皮细胞细胞凋亡 P53/mDm2

Reviving Fertility:Phytochemicals as Natural Allies in the Fight against Non-genetic male Infertility

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Clinical Complementary medicine and Pharmacology 2024年第1期4卷 112-128页

作者： Vivek P.Chavda Shreya S Sonak Pankti C.Balar Krupa Vyas Pranali Palandurkar Komal mule krishna Patel Vivek Hala Dixa A.Vaghela Devarshi Acharya Akta Vaishnav Jimil Gandhi Vasso Apostolopoulos Department of Pharmaceutics and Pharmaceutical Technology L M College of PharmacyAhmedabadGujarat 380008India Bharati Vidyapeeth University’s Poona College of Pharmacy ErandwaneKothrudPune 411038India Pharmacy section L M College of PharmacyAhmedabadGujarat 380008India University Department of Pharmaceutical Sciences R.T.m Nagpur 440033India Department of Pharmaceutics Khyati College of PharmacyAhmedabad 380009India IICISST Sardar Patel UniversityVallabh Vidyanagar 388120India Institute for Health and Sport Immunology and Translational ResearchVictoria UniversityMelbourneVIC 3030Australia Immunology Program Australian Institute for Musculoskeletal ScienceMelbourneVIC 3021Australia

Background:male infertility poses a growing challenge to the healthcare system,with its prevalence on the *** lifestyle,food,and addictions such as smoking,alcoholism,*** the *** several approaches are being investigated to prevent and treat this condition,each therapeutic approach has its *** medications continue to play a crucial role in the healthcare *** recent years,there has been a shift towards determining the efficacy of phytochemicals(or,herbal drugs)as ***:To evaluate the effect of various herbs,plant,metabolites,or a part of plant in management of non-genetic male ***:The male infertility-associated keywords were searched in Pubmed,excluding those non-English writen papers.A total of 146 pertinent and closely connected records were included for full reading and inclusion in the systemic ***:The manuscript focuses on individual herbal drug components,their active ingredients,their role in improving the condition and quality of life,and decreasing the prevalence of male ***:Herbal medicinal plants show promising outcomes to treat male *** alternatives are appealing and have regained *** future holds promise for some of these herbal treatments to advance with many showing improved outcomes in males with infertility issues.

关键词： male infertility Plant-based management Phytochemical Herbal drug Traditional Chinese medicine

Geochemistry and petrogenesis of Rajahmundry trap basalts of krishna-Godavari Basin,India

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Geoscience Frontiers 2015年第3期6卷 437-451页

作者： C.manikyamba Sohini Ganguly m.Santosh Abhishek Saha G.Lakshminarayana CSIR-National Geophysical Research Institute Department of Geology University of Calcutta School of Earth Sciences and Resources China University of Geosciences midwest Group Banjara Hills

The Rajahmundry Trap Basalts （RTB） are erupted through fault-controlled fissures in the krishna-Godavari Basin （K-G Basin） of Godavari Triple Junction, occurring as a unique outcrop sandwiched between Cretaceous and Tertiary sediments along the east coast of India. Detailed geochemical studies have revealed that RTB are mid-Ti （1.74-1.92） to high-Ti （2.04-2.81） basalts with a distinct quartz tholeiitic parentage. mgO （6.2-13.12 wt.%）, mg# （29-50） and Zr （109-202 ppm） suggest that these basalts evolved by fractional crystallization during the ascent of the parent magma along deep-seated fractures. mod- erate to high fractionation of HREE, as indicated by （Gd/Yb）N ratios （1.71-2.31） of RTB, suggest their generation through 3-5% melting of a Fe-rich mantle corresponding to the stability fields of spinel and garnet peridotite at depths of 60-100 km. Low K2O/P2O5 （0.26-1.26）, high TiO2/P2O5 （6.74-16.79）, La/Nb （0.89-1.45）, Nb/Th 〉 8 （8.35-13）, negative anomalies at Rb reflect minimum contamination by granitic continental crust. （Nb/La）Pm ratios （0.66-1.1） of RTB are attributed to endogenic contamination resulted through recycling of subducted oceanic slab into the mantle. Pronounced Ba enrichment with relative depletion in Rb indicates assimilation of Infra- and Inter-trappean sediments of estuarine to shallow marine character. Geochemical compositions such as A1203/TiO2 （3.88-6.83）, medium to high TiO2 （1.74 -2.81 wt.%）, positive Nb anomalies and LREE enrichment of these RTB attest to their mantle plume origin and indicate the generation of parent magma from a plume-related enriched mantle source with Em 1 signature. Ba/Th （46-247）, Ba/La （3.96-28.51） and Th/Nb （0.08-0.13） ratios suggest that the source enrichment process was marked by recycling of subduction-processed oceanic crust and lithospheric components into the mantle. Zr/Hf （37-41） and Zr/Ba （0.51-3.24） indicate involvement of an asthenospheric mantle source. The Rajahmundry basalts show affinity towards FOZO （

关键词： Rajahmundry Trap Basalts (RTB) Fault-controlled fissures Fractional crystallization Enriched mantle source Plume-lithosphere interaction

An Optimized Novel Trust-Based Security mechanism Using Elephant Herd Optimization

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Computer Systems Science & Engineering 2023年第3期44卷 2489-2500页

作者： Saranya Veerapaulraj m.Karthikeyan S.Sasipriya A.S.Shanthi Tamilnadu College of Engineering CoimbatoreIndia krishna College of Engineering CoimbatoreIndia

Routing strategies and security issues are the greatest challenges in Wireless Sensor Network(WSN).Cluster-based routing Low Energy adaptive Clustering Hierarchy(LEACH)decreases power consumption and increases net-work lifetime *** WSN is a challenging issue faced by *** systems are very helpful in detecting interfering nodes in *** have successfully applied Nature-inspired metaheuristics Optimization Algorithms as a decision-making factor to derive an improved and effective solution for a real-time optimization *** metaheuristic Elephant Herding Optimizations(EHO)algorithm is formulated based on ele-phant herding in their *** considers two herding behaviors to solve and enhance optimization *** on Elephant Herd Optimization,a trust-based security method is built in this *** proposed routing selects routes to destination based on the trust values,thus,finding optimal secure routes for transmitting *** results have demonstrated the effectiveness of the proposed EHO based *** Average Packet Loss Rate of the proposed Trust Elephant Herd Optimization performs better by 35.42%,by 1.45%,and by 31.94%than LEACH,Elephant Herd Optimization,and Trust LEACH,respec-tively at Number of Nodes *** the proposed routing is efficient in selecting secure routes,the average packet loss rate is significantly reduced,improving the network’s *** is also observed that the lifetime of the network is enhanced with the proposed Trust Elephant Herd Optimization.

关键词： Wireless sensor network low energy adaptive clustering hierarchy trust systems elephant herding optimizations algorithm trust-based elephant herd optimization

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地中海及其邻区的上地幔速度结构

地球物理学进展 1992年第1期7卷 105-105页

作者： V.G.krishna 柯忍

本文仔细地分析了深达500km的229个深震的P波和S波走时资料,取得了地中海及其邻区的上地幔速度结构.用Kaila(1969)分析法得到卡拉布里亚孤—第勒尼安海、西地中海—南西班牙、巴尔干半岛的西缘和东缘以及东喀尔巴阡山脉的Vrancea区的中... 详细信息

本文仔细地分析了深达500km的229个深震的P波和S波走时资料,取得了地中海及其邻区的上地幔速度结构.用Kaila(1969)分析法得到卡拉布里亚孤—第勒尼安海、西地中海—南西班牙、巴尔干半岛的西缘和东缘以及东喀尔巴阡山脉的Vrancea区的中、深源地震区的“震源深度上”的P波和S波速度.显示出直到150km深度的地段,其横向速度变化约为3%一4%.巴尔干边缘的尸波速度为最高.在卡拉布里亚孤一第勒尼安海深震区,p波速度由40 km深度上8.01 km/s增加到2,0 km深度上的8.14 km/5.尸波速度从具变化率为0,0055一,的210 km较深部起迅速地增加,到500 km深度上.达到9.62 km/5.该区的S波速度由40k。深度上的458 km/s增加到400 km深度上的4.73 km/:,没有任何关于快速的速度增加带的象征.然而,发现了卡拉布里亚孤一第勒尼安海深震区的S波速度比由面波频散研究导出的邻区的上地慢顶部150一200 km区段的平均S波速度4.34 km/s高出约6%.与此类似,西地中海和巴尔干边缘的中源地震区,其S波速度比邻区上地慢相应的平均值高约5%.这些差异本质上是因为存在一条轮廓清晰的扩展到中欧大部地区的次盖层(sub一lid))低S波速通道引起的.本文确定的卡拉布里亚弧一第勒尼安海深震区的尸波速度模型显然与EKw的p波速度模型(England等,1 077)和mR的速度模型(mager一Rosa和mue]ler.1 973)+分一致,这两个模型适用于南一中欧下方的上地慢区域、把南一中欧的尸波速度模型,包括本文提出的模型,与适合于东欧地台下方的上地慢p波速度模型,即sNF(Hurtig等,1979),KCA(King和Caxeagnile,197e)和m^(masse和Alexander,1974)模型相比较,揭示出这两区的上地慢具有强烈的横向速度不均匀性.南一中欧的速度比东欧地台的速度约低5%,这种情况到至少250 km的深度上都存在.这些结果与stromeyer(1 978)给出的欧洲温度一深度函数一致,Stromcyer(1 978)指出中欧的这些深度上的温度比东欧地台的高400一500℃.本文确定的卡拉布里亚孤一第勒尼安海深震区,从40一400 km深度,其S波速度(4,6一4.7 km/s)几乎不变.也是与所预计的中欧下方的邻近上地慢区具较高温度相一致.在本研究中,尸波和S波速度模型,直到深达500 km都未发现“400 km间断”,这可能是因为在南一中欧,它在520一540 km这个比较大的深度上,而其它几个模型给出,在东欧地台区它在380一420 km的深度上,比较之下相对较浅.另一方面,210一500 km深度上的高尸波速度梯度可以说明不存在“明显的”400 km间断。

关键词：波速度速度模型速度结构上地幔横向速度变化速度比第勒尼安海地台频散面波

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肺癌全基因组测序

国际病理科学与临床杂志 2013年第4期33卷 277-285页

作者： marissa Daniels Felicia Goh Casey m. Wright krishna B. Sriram Vandana Relan Belinda E. Clarke Edwina E. Duhig Rayleen V. Bowman Ian A Yang Kwun m. Fong 孙岚何建行 Thoracic Research Laboratory Department of Thoracic Medicine The Prince Charles Hospital UQ Thoracic Research Centre School of Medicine The University of Queensland Pathology Queensland Department of Anatomical PathologyThe Prince Charles Hospital 重庆市璧山县人民医院肿瘤科重庆402760 广州医学院第一附属医院心胸外科广州510120 广州呼吸疾病研究所广州510120

肺癌是全球肿瘤发病率和病死率的主因,且预后很差。加强对肿瘤生物学的认识对肺癌研究至关重要。被誉为"下一代测序技术"的NGS技术(next-generation sequencing)是一种针对全基因组鉴定的有力工具,可以对致癌体细胞突变进行全面检测。... 详细信息

肺癌是全球肿瘤发病率和病死率的主因,且预后很差。加强对肿瘤生物学的认识对肺癌研究至关重要。被誉为"下一代测序技术"的NGS技术(next-generation sequencing)是一种针对全基因组鉴定的有力工具,可以对致癌体细胞突变进行全面检测。大多数的NGS技术是基于平台特异性DNA文库进行多重聚合酶链反应(polymerase chain reaction,PCR),从而对目的基因扩增后测序。这种技术适用于高通量测序,可以检测出肿瘤中出现的全部基因组变异。缺点是这种技术需要在时间、实验设备、计算机数据分析、生物信息技术等各方面的大量投入。NGS技术已广泛应用于全基因组、外显子组、转录组和表观基因组的研究中,为肺癌研究和医疗模式带来改变。这项新技术的开展将转变当前对致癌信号通路的认识,可为癌症诊疗提供新的分子靶点。肺癌体细胞突变已有NGS技术的分析报道,但大规模基因组研究仍在进行中。个体化治疗策略将改善那些潜在获益患者的治疗方式,避免"无辜"患者受无效治疗带来的高额费用和不良反应。NGS的组织化、计算机化和生物信息化技术推动了科技的进步,同时,患者知情权和数据发布的相关伦理问题也浮现出来。信号通路中,驱动基因(driver gene)突变和传递基因(passenger gene)突变的区别,需要对测序结果进行细致解读。解读准确与否取决于DNA提取的样本类型、样本处理技术和样本含量。肿瘤异质性也会降低肿瘤基因突变的检测效能。NGS技术将推动对肿瘤基因突变的基础和临床研究,而且,也可应用于单细胞和游离的循环DNA,未来还将用于从体液和肿瘤亚群中获取的DNA样本。如果能进一步降低费用、提高检验速度和精度,NGS技术无疑将会成为肺癌研究的绝佳选择。

关键词：高通量核苷酸测序 DNA序列分析肺肿瘤非小细胞肺癌小细胞肺癌

多次覆盖的深地震反射剖面炮集产生的单边折射数据的模拟与反演:推导浅层速度结构的方法

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世界地震译丛 2007年第5期38卷 65-73页

作者： V. V. Rao K. Sain V. G. krishna 刘越（译）谢汝一（译）梁慧云（校）不详中国地震局地球物理勘探中心

地壳尺度多次覆盖的近垂直深地震反射剖面产生大量的单边炮集,因浅层折射波的交互覆盖而产生众多的数据集。我们介绍一种推导浅层速度结构的方法,该方法是通过模拟和反演单边地震折射初至走时数据来实现的。我们将该方法应用于在印度地... 详细信息

地壳尺度多次覆盖的近垂直深地震反射剖面产生大量的单边炮集,因浅层折射波的交互覆盖而产生众多的数据集。我们介绍一种推导浅层速度结构的方法,该方法是通过模拟和反演单边地震折射初至走时数据来实现的。我们将该方法应用于在印度地盾西北新元古代马尔瓦尔盆地进行的炮检距为100m、长12km的剖面上获得的数据集。该方法表明,在描述浅层折射层深度、陡的倾角和速度方面是成功的,即使缺少常规的相遇折射剖面也如此。研究揭示出马尔瓦尔盆地的2层沉积建造、默拉尼火山岩和复杂基底地形,并测量出了所估算模型参数的分辨率和不确定性。发现近道选排的地震截面图在性质上与导出的盆地结构特征相一致。在布格重力剖面上观测到的相对高和低的异常进一步证实了导出的这一速度模型。本文提出的方法对那些只能获得单边、多次覆盖的地震剖面数据集的近海等地区是非常有用的。

关键词：深地震反射剖面浅层速度结构多次覆盖折射波反演模拟数据集地震折射

Bayes-Q-Learning Algorithm in Edge Computing for Waste Tracking

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Intelligent Automation & Soft Computing 2023年第5期36卷 2425-2440页

作者： D.Palanikkumar R.Ramesh Kumar mehedi masud mrim m.Alnfiai mohamed Abouhawwash Department of Computer Science and Engineering Dr.NGP Institute of TechnologyCoimbatore641048India Department of Information Technology Sri Krishna College of TechnologyCoimbatore641042India Department of Computer Science College of Computers and Information TechnologyTaif UniversityP.O.Box 11099Taif21944Saudi Arabia Department of Information Technology College of Computers and Information TechnologyTaif UniversityTaif P.O.Box 11099Taif21944Saudi Arabia Department of mathematics Faculty of ScienceMansoura UniversityMansoura35516Egypt Department of Computational mathematics Scienceand Engineering(CMSE)Michigan State UniversityEast LansingMI48824USA

The major environmental hazard in this pandemic is the unhygienic dis-posal of medical *** wastage is not properly managed it will become a hazard to the environment and *** medical wastage is a major issue in the city,municipalities in the aspects of the environment,and *** efﬁcient supply chain with edge computing technology is used in managing medical *** supply chain operations include processing of waste collec-tion,transportation,and disposal of *** research works have been applied to improve the management of *** main issues in the existing techniques are ineffective and expensive and centralized edge computing which leads to failure in providing security,trustworthiness,and *** over-come these issues,in this paper we implement an efﬁcient Naive Bayes classiﬁer algorithm and Q-Learning algorithm in decentralized edge computing technology with a binary bat optimization algorithm(NBQ-BBOA).This proposed work is used to track,detect,and manage medical *** minimize the transferring cost of medical wastage from various nodes,the Q-Learning algorithm is *** accuracy obtained for the Naïve Bayes algorithm is 88%,the Q-Learning algo-rithm is 82%and NBQ-BBOA is 98%.The error rate of Root mean Square Error(RmSE)and mean Error(mAE)for the proposed work NBQ-BBOA are 0.012 and 0.045.

关键词： Binary bat algorithm naïve bayes supply chain edge medical wastage

应用T2WI诊断移行带前列腺癌:主观特征与定量形态分析的比较

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国际医学放射学杂志 2019年第3期 368-368页

作者：孔蒙娟 S.krishna N.Schieda m.D.F.mcInnes T.A.Flood R.E.Thornhill Department of medical Imaging The Ottawa HospitalThe University of Ottawa

目的评价mR T2WI对移行带（TZ）前列腺癌（PCa）与前列腺增生（BPH）的鉴别诊断价值。方法经伦理委员会批准,将22个TZ PCa与30个BPH结节(间质性增生结节

关键词：移行带前列腺癌 T2WI 形态分析