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甲状腺过氧化物酶抗体检测方法的建立及临床应用

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中华核医学杂志 2003年第2期23卷 90-91页

作者：邵新华刘树业张卫民李涛周津东天津市第三中心医院检验科 300170 天津医科大学总医院内分泌科

目的　建立血清甲状腺过氧化物酶抗体放射免疫检测方法 ,探讨其对甲状腺疾病的临床意义。方法　采用1 2 5I氯胺 T法标记人甲状腺过氧化物酶 ,选择不同的实验条件 ,进而确定实验方法。测定 37例正常对照者和 92例甲状腺疾病患者血清甲... 详细信息

目的　建立血清甲状腺过氧化物酶抗体放射免疫检测方法 ,探讨其对甲状腺疾病的临床意义。方法　采用1 2 5I氯胺 T法标记人甲状腺过氧化物酶 ,选择不同的实验条件 ,进而确定实验方法。测定 37例正常对照者和 92例甲状腺疾病患者血清甲状腺过氧化物酶抗体。结果　甲状腺疾病患者血清甲状腺过氧化物酶抗体水平显著高于对照组 (F =4 .6 12 ,P <0 .0 5 ) ,各种甲状腺疾病的阳性检出率分别为 :Graves病 6 6 .7% ,桥本甲状腺炎 95 .2 % ,原发性粘液水肿 72 .7%。结论　该方法特异性强 ,重复性好 ,非特异性结合率低。

关键词：甲状腺疾病过氧化物酶抗体检测方法建立临床应用放射免疫检测

1例与感觉神经节病变相关的hashimoto脑病患者

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世界核心医学期刊文摘（神经病学分册） 2006年第3期2卷 20-20页

作者： Tselis A.C. Gorman m. 高中宝 Departments of Neurology and Neurosurgery Yale University School of Medicine P.O. Box 208018 New Haven CT 06520-8018 United States

We report a case of hashimoto’s encephalopathy with prominent unsteadiness of gait. Nerve conduction studies and electromyographic findings were consistent with a sensory ganglionopathy. Symptoms and clinical findings resolved with high-dose corticosteroid therapy and paralleled the levels of anti-microsomal antibodies. Sensory ganglionopathy seems to be another aspect of the broad clinical syndrome labeled hashimoto’s encephalopathy.

关键词：感觉神经节 hashimoto 脑病患者微粒体抗体神经传导肌电图检查皮质激素治疗

嗜酸性筋膜炎发现后30年——我们真正了解吗?11例患者报道及文献回顾

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世界核心医学期刊文摘（皮肤病学分册） 2006年第11期2卷 53-53页

作者： Antic m. Lautenschlager S. Itin P.H. 张路坤 Department of Dermatology University of Basel Petersgraben 4 CH-4031 Basel Switzerland

Background: Eosinophilic fasciitis (EF) is a rare fibrosing disorder associated with peripheral eosinophilia and scleroderma-like induration of the distal extremities which affects substantially quality of life. Although the disease has been described 30 years ago, the etiology and pathomechanisms are still obscure, and consensus for therapy is lacking. Numerous case reports of patients with EF exist but series are scarce. Patients and methods: Eleven patients with EF from the Department of Dermatology, Kantonsspital Aarau, the University Hospital Basel and the OutpatientClinic of Dermatology, Triemli Hospital Zurich, Switzerland, were retrospectively studied. Results:In 4 patients the initial diagnosis was not recognized by the referring non dermatologists. The median age was 55 years, excluding the youngest patient ever diagnosed with EF (age =1 year). All patients showed an induration of the skin, which led to painful contractures in the joints in 3 cases. All but 2 patients demonstrated edema. A slight predominance of the upper extremities was observed. Sclerodactyly was noticed in 1 patient. Three patients reported an initial trauma at the affected site. Two patients were tested positive for borreliosis. One patient subsequently developed aplastic anemia and hashimoto thyroiditis. Visceral or extracutaneous involvement was absent. Eight patients had a full or partial recovery under corticosteroids whereas in 2, improvement could be achieved only with cyclosporine, azathioprine or cyclophosphamide. Conclusions: The diagnosis of EF can be established by clinical, laboratory and histological findings. In general, corticosteroids are highly efficacious in EF and only a minority of patients need other immunosuppressive or cytostatic drugs.

关键词：文献回顾嗜酸性筋膜炎硫唑嘌呤嗜酸性细胞皮肤科医师皮肤硬肿疼痛性大学医院初次就诊病理