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Insights from an academic endeavor into central nervous system drug discovery

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Neural Regeneration Research 2025年第6期20卷 1717-1718页

作者： Lieve van Veggel An m.Voets Tim Vanmierlo Rudy Schreiber BIOmED Biomedical Research Institute Faculty of Medicine and Life SciencesHasselt UniversityHasseltBelgium Department of Psychiatry and Neuropsychology Division of Translational NeuroscienceEuropean Graduate School of NeuroscienceSchool for Mental Health and NeuroscienceMaastricht UniversityMaastrichtThe Netherlands Section of Psychopharmacology Neuropsychology and PsychopharmacologyFaculty of Psychology and NeuroscienceMaastricht UniversityMaastrichtThe Netherlands University mS Center(UmSC) Hasselt-PeltBelgium

Historically,"big pharma"did most central nervous system drug discovery R&D ***,in modern times their"management reductionism"resulted in disappointing pipelines and pharma resided to(late)development,regulatory approval,and marketing(Thong,2015).This had significant consequences for financing and executing research,resulting in a larger role for funding by governments and patient-organizations and a shift of research to academia(mazzucato,2013).

关键词： academic approval consequences

Teleportation of unknown states of a qubit and a single-mode field in strong coupling regime without Bell-state measurement

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Communications in Theoretical Physics 2023年第2期75卷 73-79页

作者： F Jahanbakhsh m k Tavassoly Optics and Laser Group Faculty of PhysicsYazd UniversityYazd 89195-741Iran

In this paper,we develop the teleportation scheme in[Zheng in Phys Rev A 69,064302,2004],in the sense that,we work in the strong atom-field coupling regime wherein the rotating wave approximation(RWA)is no longer *** achieve the purpose,a scheme consisting of a qubit interacting with a single-mode quantized field is described via the Rabi model(counter rotation terms are taken into account).Our first aim is to teleport an unknown atomic state of a qubit(which interacts with the quantized field in a cavity)to a second qubit(exists in another distant cavity field),beyond the RWA and without the Bell-state measurement *** the continuation,in a similar way,we teleport an unknown state of a single-mode field *** fact,it is shown that,in this regime,after applying some particular conditions,containing the interaction time of atom-field in the cavities,adjusting the involved frequencies,as well as the atom-field coupling in the model,if a proper measurement is performed on the state of the first qubit(the related field in the cavity),the unknown states of the qubit(field)can be teleported from the first qubit(cavity field)to the second qubit(cavity field),*** show that in both considered cases,the teleportation protocol is successfully performed with the maximum possible fidelity,1,and the acceptable success probability,0.25.

关键词： strong atom-field coupling Rabi model quantum teleportation success probability fidelity

Neurocircuit regeneration by extracellular matrix reprogramming

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Neural Regeneration Research 2025年第8期20卷 2300-2301页

作者： Shengzhang Su Ian N.Levasseur kimberly m.Alonge Department of medicinal Chemistry University of WashingtonSeattleWAUSA Department of Chemistry University of WashingtonSeattleWAUSA Department of medicine University of Washington Medicine Diabetes InstituteSeattleWAUSA

The brain's extracellular matrix(ECm),which is comprised of protein and glycosaminoglycan(GAG)scaffolds,constitutes 20%-40% of the human brain and is considered one of the largest influencers on brain cell functioning(Soles et al.,2023).Synthesized by neural and glial cells,the brain's ECm regulates a myriad of homeostatic cellular processes,including neuronal plasticity and firing(miyata et al.,2012),cation buffering(moraws ki et al.,2015),and glia-neuron interactions(Anderson et al.,2016).Considering the diversity of functions,dynamic remodeling of the brain's ECm indicates that this understudied medium is an active participant in both normal physiology and neurological diseases.

关键词： matrix programming

Determination of stress intensity factors in half-plane containing several moving cracks

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Applied mathematics and mechanics(English Edition) 2013年第12期34卷 1535-1542页

作者： k.mALEkZADEH FARD m.m.mONFARED k.NOROUZIPOUR Department of Structural Analysis and Simulations Space Research CenterKaraj-Tehran High Way Institute for Advanced Studies in Basic Sciences

The dynamic stress intensity factors in a half-plane weakened by several finite moving cracks are investigated by employing the Fourier complex transformation. Stress analysis is performed in a half-plane containing a single dislocation and without dislocation. An exact solution in a closed form to the stress fields and displacement is ob- tained. The Galilean transformation is used to transform between coordinates connected to the cracks. The stress components are of the Cauchy singular kind at the location of dislocation and the point of application of the the influence of crack length and crack running force. Numerical examples demonstrate velocity on the stress intensity factor.

关键词： moving crack stress intensity factor half-plane Cauchy singularity

Barut-Girardello and Gilmore-Perelomov coherent states for pseudoharmonic oscillators and their nonclassical properties: Factorization method

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Chinese Physics B 2013年第8期22卷 421-428页

作者： m k Tavassoly H R Jalali Atomic and molecular Group Faculty of Physics Yazd UniversityYazd Iran Photonics Research Group Engineering Research Center Yazd UniversityYazd Iran The Laboratory of Quantum Information Processing Yazd UniversityYazd Iran

In this paper we try to introduce the ladder operators associated with the pseudoharmonic oscillator, after solving the corresponding Schrrdinger equation by using the factorization method. The obtained generalized raising and lowering operators naturally lead us to the Dirac representation space of the system which is much easier to work with, in comparison to the functional Hilbert space. The SU（1, 1） dynamical symmetry group associated with the considered system is exactly established through investigating the fact that the deduced operators satisfy appropriate commutation relations. This result enables us to construct two important and distinct classes of Barut-Girardello and Gilmore-Perelomov coherent states associated with the system. Finally, their identities as the most important task are exactly resolved and some of their nonclassical properties are illustrated, numerically.

关键词： pseudoharmonic oscillator factorization method Barut-Girardello coherent states Gilmore-Perelomov coherent states nonclassical properties

Synthesis and Crystal Structure of a New Potassium Yttrium Diphosphate Dihydrate kYP_2O_7·2H_2O

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Chinese Journal of Structural Chemistry 2008年第10期27卷 1199-1204页

作者： Férid m Horchani-Naifer k Unité de Recherches de matériaux de Terres Rares Centre National de Recherches en Sciences des MatériauxB.P.95 Hammam-Lif 2050Tunisie

The dihydrated potassium yttrium diphosphate, kYP2O7·2H2O, has been synthesized for the first time. Single-crystal XRD study has allowed the determination of its structure and correct formula. It crystallizes in the monoclinic system, space group P21/c, with the cell parameters a = 7.7069（3）, b = 10.5801（4）, c = 10.0204（5）A,β = 93.24（3）A, V= 815.76（6）A^3, Z= 4, mr = 337.98, F（000） = 656, Dc = 2.752 g/cm^3 and/t = 8.073 mm^-1. The single-crystal structure was solved from 1856 unique reflections with the final R = 0.0365 and wR = 0.0772, refined with 119 parameters. The atomic arrangement of kYP2O7·2H2O is built by the P2O7 groups, the YO7 and the kO10 polyhedrons which are connected by corner and edge-sharing to form a three-dimensional framework. Water molecules are directly bonded to the Y and k atoms, and they are located in channels running along the a direction.

关键词： crystal structure yttrium diphosphate infrared spectrum TGA-DTA analysis

Peristaltic transport of mHD Williamson fluid in an inclined asymmetric channel through porous medium with heat transfer

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Journal of Central South University 2015年第8期22卷 3189-3201页

作者： k.Ramesh m.Devakar Department of mathematics Visvesvaraya National Institute of Technology

The intention of this investigation is to study the effects of heat transfer and inclined magnetic field on the peristaltic flow of Williamson fluid in an asymmetric channel through porous medium. The governing two-dimensional equations are simplified under the assumption of long wavelength approximation. The simplified equations are solved for the stream function, temperature, and axial pressure gradient by using a regular perturbation method. The expression for pressure rise is computed numerically. The profiles of velocity, pressure gradient, temperature, heat transfer coefficient and stream function are sketched and interpreted for various embedded parameters and also the behavior of stream function for various wave forms is discussed through graphs. It is observed that the peristaltic velocity increases from porous medium to non-porous medium, the magnetic effects have increasing effect on the temperature, and the size of the trapped bolus decreases with the increasing of magnetic effects while the trend is reversed with the increasing of Darcy number. moreover, limiting solutions of our problem are in close agreement with the corresponding results of the Newtonian fluid model.

关键词： Williamson fluid heat transfer inclined magnetic field porous medium inclined asymmetric channel

microstructural evolution and mechanical properties of nanostructured Cu-Al-Ni shape memory alloys

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International Journal of minerals,metallurgy and materials 2012年第4期19卷 333-338页

作者： m. Izadinia k. Dehghani mining and metallurgical Engineering Department Amirkabir University of Technology

The melt spinning technique, with an applied cooling rate of about 106 k/s, was used to produce a nanostructured Cu＋13.2Al＋ 5.1Ni （in wt%） shape memory alloy. The properties of nanostructured ribbons were then compared with those of conventional coarse struc- ture. The microstructural evolution was characterized using scanning electron microscopy （SEm）, atomic force microscopy （AFm） and X-ray diffraction （XRD） techniques. microhardness measurements indicate a two-fold increase in hardness because of the produced nanos- lructure. Comparing to its coarse structure, the nanostructured Cu-A1-Ni shape memory alloy exhibited the enhanced mechanical properties including a ductility of 6.5% and a pronounced plateau in the stress-strain curve.

关键词： copper allosy shape memory effect melt spinning mechanical properties microstructural evolution

Ultrasound effects on zinc recovery from EAF dust by sulfuric acid leaching

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International Journal of minerals,metallurgy and materials 2015年第4期22卷 353-362页

作者： k.Brunelli m.Dabalà Department of Industrial Engineering University of Padua

In this work, an ultrasound-assisted leaching process was studied for the recovery of zinc from electric arc furnace （EAF） dust, in which zinc was mainly present in the form of franklinite （60%）. HydrometaUurgy is emerging as a preferred process for the recovery of a va- riety of metals, and the use of ultrasound could offer advantages over the conventional leaching process, especially for the dissolution of franklinite. Franklinite is a refractory phase that is difficult to leach and represents the main obstacle in conventional hydrometallurgy proc- essing. Atmospheric leaching with different sulfuric acid concentrations （0.2-2.0 m） at two temperatures （323 and 353 k） was performed. The tests were conducted using both conventional and ultrasound-assisted leaching. After the leaching tests, the solid residues were charac- terized by scanning electron microscopy （SEm） and X-ray diffraction （XRD） techniques, whereas the leach liquor was analyzed by induc- tively coupled plasma spectroscopy OCP）. The use of ultrasound facilitated the dissolution of franklinite at low acid concentrations and re- suited in a greater zinc recovery under all of the investigated operating conditions.

关键词： zinc recovery ultrasound electric arc furnaces dust leaching