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Neural Regeneration Research 2025年第4期20卷 1094-1095页

作者： Natalia Kulesskaya Kira m.Holmström Henri j.Huttunen Herantis Pharma Plc EspooFinland

Neurotrophic factors as a therapeutic approach in neurodegenerative diseases:A major unmet need in the field of central nervous system diseases is disease-modifying *** for decades there have been various symptomatic treatments available to alleviate the symptoms of the disease,disease-modification,*** that stop,significantly delay,or reverse the progression of the disease,has been turned out to a difficult goal to achieve.

关键词： diseases treatment therapeutic

Sleep as a window to understand and regulate Alzheimer's disease:emerging roles of thalamic reticular nucleus

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Neural Regeneration Research 2025年第6期20卷 1711-1712页

作者： Haoqi Sun Shiqian Shen Robert j.Thomas m.Brandon Westover Can Zhang Department of Neurology Beth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Center for Translational Pain Research Department of AnesthesiaCritical Care and Pain MedicineMassachusetis General HospitalHarvard Medical SchoolBostonMAUSA Division of Pulmonary Critical Care and Sleep MedicineDepartment of MedicineBeth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Genetics and Aging Research Unit McCance Center for Brain HealthMass General Institute for Neurodegenerative DiseaseDepartment of NeurologyMassachusetts General HospitalHarvard Medical SchoolBostonMAUSA

Introduction:Alzheimer 's disease(AD) is a common neurodegenerative disorder and the primary cause of dementia. Considerable evidence supports the “amyloid hypothesis,” stating that the pathogenesis of AD is primarily caused by the deposition of amyloid-β(Aβ), which drives tau phosphorylation, neuroinflammation, and neurodegeneration in the brain. The amyloid hypothesis is strengthened by the significant and moderate benefit of lecanemab, a humanized antibody through an anti-amyloid mechanism,showing slowed clinical decline(van Dyck et al.,2023). The recent positive results of anti-amyloid trials have brought back focus on the amyloid hypothesis through biochemical, genetic, and pharmacological approaches(Zhang, 2023).

关键词： Alzheimer inflammation hypothesis

TRANSIENT ANALYSIS OF COmPOSITE PLATES BY A LOCAL RADIAL BASIS FUNCTIONS-FINITE DIFFERENCE TECHIQUE

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Acta mechanica Solida Sinica 2012年第1期25卷 22-36页

作者： C.m.C.Roque D.cunha A.j.m.Ferreira INEGI Faculdade de Engenharia da Universidade do PortoRua Dr.Roberto Frias Departamento de Engenharia mecnica Faculdade de Engenharia da Universidade do PortoRua Dr.Roberto Frias

The use of local numerical schemes,such as finite differences produces much better conditioned matrices than global collocation radial basis functions ***,finite differ-ence schemes are limited to special *** scattered points,a combination of finite differences and radial basis functions would be a possible *** this paper,we use a higher-order shear deformation plate theory and a radial basis function-finite difference technique for predicting the transient behavior of thin and thick composite *** numerical experiments on beams and composite plates,the accuracy and efficiency of this collocation technique is demonstrated.

关键词： meshless beam composite plate

Emerging role of A-kinase anchoring protein 5 signaling in reward circuit function

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Neural Regeneration Research 2025年第10期20卷 2913-2914页

作者： William j.Flerlage mark L.Dell’Acqua Brian m.Cox Fereshteh S.Nugent Uniformed Services University of the Health Sciences Department of Pharmacology and Molecular TherapeuticsBethesdaMDUSA Department of Pharmacology University of Colorado School of MedicineAnschutz Medical CampusAuroraCOUSA

There is a strong evidence supporting the hypothesis of synaptic dysfunction as a major contributor to neural circuit and network disruption underlying emotional and mood dysregulation in psychiatric disorders(Simmons et al.,2024).Diverse sets of distinct molecular signaling pathways converge on the synapse to regulate synaptogenesis,synaptic function,and synaptic plasticity in brain regions and circuits through complex interactions organized by numerous multivalent protein scaffolds,including the family of proteins known as A-kinase anchoring proteins(AKAPs).

关键词： function supporting

Comparison of Classical models for Evaluating the Heat Requirements of Olive(Olea europeae L.) in Portugal

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journal of Integrative Plant Biology 2006年第6期48卷 664-671页

作者： Helena Ribeiro mário cunha Ilda Abreu Autonomous Section of Agricultural Sciences Faculty of Sciences University of Porto4485-661 VairaoPortugal Department of Botany Faculty of SciencesUniversity of Porto1191-4150 PortoPortugal Institute of Agricultural Sciences and Technology 4485-661 VairaoPortugal Department of Botany Faculty of Sciences University of Porto1191-4150 PortoPortugal Institute for molecular and Cell Biology 823-4150 PortoPortugal

The aim of the present study was to compare the accuracy and reproducibility of six statistical models for the calculation of olive （Olea europeae L.） heat requirements to trigger the onset of flowering in three Portuguese regions： Reguengos de monsaraz, Valenga do Douro, and Braga. Other alms were to ascertain the date on which the heat-accumulation period started and the threshold temperatures above which the development of reproductive structures starts in olives. The starting and peak dates for the regional O. europeae flowering season were estimated by monitoring airborne pollen from 1998 to 2004 using ＂Cour＂- type samplers. The threshold temperature values calculated for the three regions were very similar （9.0 ℃ for Valenca do Douro, 9.2 ℃ for Reguengos de monsaraz, and 9.7 ℃ for Braga）. The accumulated daily mean temperature model had less interannual and inter-regional variation, showing best predictive results for 2004, with absolute differences between the observed and predicted dates of 4 d in Reguengos de monsaraz and 2 d In Valenca do Douro and Braga for the onset of flowering date and of 2 d In Reguengos de monsaraz, 7 d in Valenca do Douro, and 4 d in Braga for peak flowering dates. This model was the most accurate, reproducible, and operational to calculate heat requirements for olives to flower, with an average mean temperature accumulation of 1 446 ℃ In Reguengos, 1 642 ℃ in Valenga do Douro, and 1 703℃ In Braga to reach the onset of flowering. The best initial date for this accumulation was 1 january.

关键词： flowering season heat requirements olives pollen Portugal

Temporal dynamics of neonatal hypoxic-ischemic encephalopathy injuries on magnetic resonance imaging

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Neural Regeneration Research 2025年第11期20卷 3144-3150页

作者： Holly Flyger Samantha j.Holdsworth Alistair j.Gunn Laura Bennet Hamid Abbasi mātai medical Research Institute Tairāwhiti GisborneNew Zealand Department of Anatomy&medical Imaging Faculty of Medical and Health SciencesThe University of AucklandAucklandNew Zealand Center for Brain Research The University of AucklandAucklandNew Zealand Auckland Bioengineering Institute The University of AucklandAucklandNew Zealand

moderate to severe perinatal hypoxic-ischemic encephalopathy occurs in~1 to 3/1000 live births in high-income countries and is associated with a significant risk of death or neurodevelopmental *** assessment is important to help identify highrisk infants,to help families,and to support appropriate interventions.A wide range of monitoring tools is available to assess changes over time,including urine and blood biomarkers,neurological examination,and *** present,magnetic resonance imaging is unique as although it is expensive and not suited to monitoring the early evolution of hypoxic-ischemic encephalopathy by a week of life it can provide direct insight into the anatomical changes in the brain after hypoxic-ischemic encephalopathy and so offers strong prognostic information on the long-term outcome after hypoxic-ischemic *** review investigated the temporal dynamics of neonatal hypoxic-ischemic encephalopathy injuries,with a particular emphasis on exploring the correlation between the prognostic implications of magnetic resonance imaging scans in the first week of life and their relationship to long-term outcome prediction,particularly for infants treated with therapeutic hypothermia.A comprehensive literature search,from 2016 to 2024,identified 20 pertinent *** review highlights that while the optimal timing of magnetic resonance imaging scans is not clear,overall,it suggests that magnetic resonance imaging within the first week of life provides strong prognostic *** challenges limit the timing consistency,particularly the need for intensive care and clinical ***,although most reports examined the prognostic value of scans taken between 4 and 10 days after birth,there is evidence from small numbers of cases that,at times,brain injury may continue to evolve for weeks after *** suggests that in the future it will be important to explore a wider range of times after hypo

关键词： magnetic resonance imaging neonatal hypoxic-ischemic encephalopathy neurodevelopmental outcomes prognostic biomarkers in neuroimaging scan timing therapeutic hypothermia

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Food Bioscience 2022年第6期50卷 1450-1467页

作者： Yuxin Qin Nenad Naumovski Chaminda Senaka Ranadheera Nathan m.D'cunha School of Agriculture and Food Faculty of Veterinary and Agricultural ScienceThe University of MelbourneParkvilleVictoria3010Australia Discipline of Nutrition and Dietetics School of Rehabilitation and Exercise SciencesFaculty of HealthUniversity of CanberraBruceACT2601Australia Functional Foods and Nutrition Research (FFNR) Laboratory University of CanberraNgunnawal CountryACT2617Australia Department of Nutrition and Dietetics School of Health Science and EducationHarokopio University17671AthensGreece

Sweet potato (Ipomoea batatas ) thrives in a wide range of climates and is high in fibre, vitamins and minerals. There is increasing evidence that sweet potato consumption can positively affect human health. This systematic review aimed to summarise nutritional-related health outcomes of sweet potato intake among healthy people and people with chronic diseases by reviewing human intervention trials. A total of 22 articles met the inclusion criteria, which examined the effects of sweet potato on vitamin A intakes and status (n = 8), glycemic markers and anthropometric parameters (n = 6), hepatic biomarkers (n = 3) and blood pressure (n = 1), iron absorption (n = 1), constipation (n = 1), nitrogen balance (n = 1), and sex hormones (n = 1). In the included studies, sweet potato consumption appears to improve vitamin A status, blood glucose levels, blood pressure, iron absorption, constipation, liver function and nitrogen balance. However, the evidence base is limited and future research in long-term, well-designed, randomised controlled trials are needed to establish cause-and-effect relationships with these health effects of sweet potato consumption. The functional properties of the bioactive compounds in sweet potatoes require further investigation to establish their ability to manage chronic disease when consumed in high amounts.

关键词： Sweet potato Ipomoea batatas Vitamin A Blood glucose Blood pressure Systematic review

Arctic sea-ice extent: No record minimum in 2023 or recent years

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Atmospheric and Oceanic Science Letters 2025年第1期18卷 52-55页

作者： Ola m.johannessen Tor I.Olaussen Nansen Scientific Society BergenNorway Nansen Environmental and Remote Sensing Center BergenNorway

Arctic sea-ice extent reaches its minimum each year in September. On 11 September 2023 the minimum was 4.969 million square kilometers(***^(2)). This was not a record low, which occurred in 2012, when the minimum was 4.175 ***^(2), 0.794 ***^(2) less than the minimum in 2023. However, the ice extent had decreased by 0.432 ***^(2) compared with 2022. Nevertheless, the summer melting in 2023 was remarkably less than expected when considering the strong heat waves in the atmosphere and ocean, with record temperatures set around the world. In general, there is a high correlation between the long-term decrease in sea-ice extent and the increasing CO_(2) in the atmosphere, where the increase of CO_(2) in recent decades explains about 80% of the decrease in sea ice in September, while the remainder is caused by natural variability.

关键词： Sea ice Arctic minimum ice Climate

Diagnosing non-hepatocellular carcinoma malignancies on CT/mRI and contrast enhanced ultrasound: the Liver Imaging Reporting and Data System approach

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Hepatoma Research 2020年第4期6卷 60-69页

作者： Kathryn jFowler Guilherme moura cunha Tae Kyoung Kim Department of Diagnostic Radiology University of California at San DiegoSan DiegoCA 92130USA University of Toronto Joint Department of Medical ImagingUniversity Health Network/Mount Sinai Hospital/Women’s College HospitalToronto M5G 2N2Canada

The Liver Imaging Reporting and Data System(LI-RADS)provides a stepwise algorithmic approach that is proven to be highly accurate in diagnosing hepatocellular carcinoma(HCC)in patients at *** essential and early step in the algorithm is the diagnosis of malignancies other than HCC,such as cholangiocarcinoma and combined tumors,by application of LR-m features and *** LR-m category captures most non-HCC malignancies and some atypical *** exclusion of non-HCC malignancies is important for maintaining the high specificity of the LR-5,definite HCC *** review provides an overview of the approach to diagnosing non-HCC malignancies using LI-RADS CT/mRI and contrast enhanced ultrasound algorithms.

关键词： magnetic resonance imaging computer tomography contrast-enhanced ultrasound