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Neurocircuit regeneration by extracellular matrix reprogramming

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Neural Regeneration Research 2025年第8期20卷 2300-2301页

作者： Shengzhang Su ian N.Levasseur Kimberly m.Alonge Department of medicinal Chemistry University of WashingtonSeattleWAUSA Department of Chemistry University of WashingtonSeattleWAUSA Department of medicine University of Washington Medicine Diabetes InstituteSeattleWAUSA

The brain's extracellular matrix(ECm),which is comprised of protein and glycosaminoglycan(GAG)scaffolds,constitutes 20%-40% of the human brain and is considered one of the largest influencers on brain cell functioning(Soles et al.,2023).Synthesized by neural and glial cells,the brain's ECm regulates a myriad of homeostatic cellular processes,including neuronal plasticity and firing(miyata et al.,2012),cation buffering(moraws ki et al.,2015),and glia-neuron interactions(Anderson et al.,2016).Considering the diversity of functions,dynamic remodeling of the brain's ECm indicates that this understudied medium is an active participant in both normal physiology and neurological diseases.

关键词： matrix programming

Crossover of large to small radius polaron in ionic crystals

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Chinese Physics B 2016年第11期25卷 434-440页

作者： m i Umo Department of Physics University of Calabar PMB 1115 Nigeria

The crossover of large to small radius polaron is studied in terms of the inverse-relaxation time and *** is found that the small radius polaron exists at higher temperature than the large radius polaron.A formula which relates the inverse-relaxation time to the ratio of arbitrary temperature and Debye temperature of the crystal is *** polaron crossover temperatures in NaCl and KBr are found from plotted *** straight line emerging at the Debye temperature T_d of a graph reflects the increase of the inverse relaxation time for increasing temperature up to the collapse of the small radius *** relationship between the small and large radius polarons is found and known ratios of the effective and the bare masses of the electrons for the two substances are used to validate our *** small radius polaron＇s mass is later compared with the mass obtained from the hopping formula and is found to be approximately ***,we point out that the crossover temperature is material-specific since it depends on the Debye and the effective dielectric function.

关键词： relaxation radius crossover inverse straight ionic validate arbitrary phonon dielectric

Egypt Shows World How to Tackle Hepatitis C

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Engineering 2024年第7期38卷 2-4页

作者： Alla katsnelson Senior Technology Writer

in October 2023,Egypt received recognition for a feat that cheered public health experts around the world:it became the first country awarded the World Health Organization(WHO)“Gold Tier”certification for its progress in eliminating viral hepatitis caused by the hepatitis C virus(HCV)[1].it is also the first time in history that a country has nearly eliminated a chronic illness caused by a *** that achievement itself is remarkable,especially impressive is the speed with which Egypt accomplished this public health *** just 14 years,from 2008 to 2022,Egypt’s prevalence of HCV viral hepatitis fell from 10%to 0.38%[1],and deaths due to the disease dropped by 51%[2].modeling suggests the country’s aggressive elimination program,which has tested more than 60 million people and treated more than 4 million[1],will have prevented almost 250000 HCV-related deaths by 2030[3].

关键词： Egypt eliminating eliminated

Transport mechanism in chemically reactive hybrid nanofluid flow containing gyrotactic micro-organisms over a curved oscillatory surface

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Applied mathematics and mechanics(English Edition) 2025年第1期46卷 177-192页

作者： m.NAVEED m.imRAN T.ASGHAR Z.ABBAS Department of mathematics Division of Science and TechnologyUniversity of Education Department of mathematics The Islamia University of Bahawalpur

This paper examines the transport analysis, including both heat transfer and mass transfer, in hybrid nanofluid flow containing gyrotactic microorganisms towards a curved oscillatory surface. The influence of magnetic fields is also inspected in terms of their physical characteristics. To depict the phenomena of transport, modified versions of both Fick's and Fourier's laws are used. Additionally, the characteristics of both heterogeneous and homogeneous chemical reactions are also incorporated. Utilizing a curvilinear coordinate system, the flow problem is formulated as partial differential equations(PDEs)for momentum, concentration, microorganism field, and energy. An analytical solution to the obtained flow equations is achieved utilizing the homotopy analysis method(HAm).The effects of significant flow parameters on the pressure and microorganism fields, velocity, oscillation velocity, concentration, and temperature distributions are shown via graphs. Furthermore, the variations in skin friction, mass transfer rate, heat transfer rate, and local motile number due to different involved parameters are presented in tables and are analyzed in detail. Graphical results indicate that the curves of velocity and temperature fields are enhanced as the values of the solid volume fraction variables *** is also verified that the concentration rate field decreases as the values of the homogeneous reaction strength parameter and the radius of curvature parameter increase, and it increases with the Schmidt number and the heterogeneous reaction strength *** outcomes show a favorable response of the motile number to advanced values of the Peclet number, the Schmidt number, the microorganism difference parameter, and the bio-convective Lewis number.

关键词： hybrid nanofluid oscillating curved stretchable sheet gyrotactic microorganism Cattaneo-Christov heat and mass flux chemical reaction analytical solution O368

Prognostic impact of inflammatory and nutritional biomarkers in pancreatic cancer

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World Journal of Clinical Oncology 2025年第1期16卷 5-9页

作者： macarena Teja maría i Garrido Abrahams Ocanto Felipe Counago Department of Radiation Oncology GenesisCare-San Francisco de Asís University HospitalMadrid 28002Spain Department of Radiation Oncology GenesisCare-Vithas La Milagrosa University HospitalMadrid 28010Spain National Director GenesisCare SpainMadrid 28043Spain Department of medicine School of MedicineHealth and SportEuropean University of MadridMadrid 28670Spain

Pancreatic cancer is usually associated with a poor *** is the main curative treatment but pancreatic operations are aggressive and new tools that help clinicians to predict surgical and prognostic outcomes are *** et al recently published a retrospective,single centre cohort study evaluating the impact of seven nutritional and inflammatory markers in pancreatic cancer surgical patients:The albumin-to-globulin ratio,prognostic nutritional index(PNi),systemic immune-inflammation index(Sii),neutrophil-to-lymphocyte ratio(NLR),platelet-to-lymphocyte ratio(PLR),nutritional risk index,and the geriatric nutritional risk index.A significant correlation was found between the PNi,Sii,NLR,and PLR and a hospital discharge of less than 15 *** a univariable analysis,PNi,Sii,NLR and PLR were significantly related to recurrence-free survival and,in a multivariable analysis PNi was associated with overall *** meta-analyses corroborate the results in terms of prognosis but individual studies are discordant on their ***,the cut-off values for these markers vary significantly between studies and there are no clinical trials comparing them to identify the most relevant *** are limitations when implementing nutritional and inflammatory biomarkers into clinical practice and further studies are needed in order to answer these questions.

关键词： inflammatory biomarkers Nutritional biomarkers Pancreatic cancer Prognosis Surgical complications

Regression analysis of squeezing-induced hybrid nanofluid flow in Darcy-Forchheimer porous medium

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Applied mathematics and mechanics(English Edition) 2025年第1期46卷 193-208页

作者： K.mUHAmmAD m.SARFRAZ Department of Humanities and Sciences School of Electrical Engineering and Computer Science National University of Sciences and Technology Department of mathematics Quaid-i-Azam University

This article presents a mathematical model addressing a scenario involving a hybrid nanofluid flow between two infinite parallel plates. One plate remains stationary, while the other moves downward at a squeezing velocity. The space between these plates contains a Darcy-Forchheimer porous medium. A mixture of water-based fluid with gold(Au) and silicon dioxide(Si O2) nanoparticles is formulated. in contrast to the conventional Fourier's heat flux equation, this study employs the Cattaneo-Christov heat flux equation. A uniform magnetic field is applied perpendicular to the flow direction, invoking magnetohydrodynamic(mHD) effects. Further, the model accounts for Joule heating, which is the heat generated when an electric current passes through the fluid. The problem is solved via NDSolve in mATHEmATiCA. Numerical and statistical analyses are conducted to provide insights into the behavior of the nanomaterials between the parallel plates with respect to the flow, energy transport, and skin *** findings of this study have potential applications in enhancing cooling systems and optimizing thermal management strategies. it is observed that the squeezing motion generates additional pressure gradients within the fluid, which enhances the flow rate but reduces the frictional drag. Consequently, the fluid is pushed more vigorously between the plates, increasing the flow velocity. As the fluid experiences higher flow rates due to the increased squeezing effect, it spends less time in the region between the plates. The thermal relaxation, however, abruptly changes the temperature, leading to a decrease in the temperature fluctuations.

关键词： convective boundary condition Darcy-Forchheimer medium hybrid nanofluid Joule heating magnetohydrodynamic (mHD) numerical solution squeezing flow regression analysis O361 O175.2

Vertical seismic absorber utilizing inertance and negative stiffness implemented with gas springs

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Earthquake Engineering and Engineering Vibration 2023年第1期22卷 225-241页

作者： Kalogerakou m Paradeisiotis A Antoniadis i Dynamics and Structures Laboratory School of Mechanical EngineeringNational Technical University of Athens15780 AthensGreece

A novel implementation of negative stiffness elements(NSEs)is proposed,utilizing industrial grade nitrogen gas springs as pre-stressed stiffness elements in a configuration with lever *** NSE is combined with an inerter to form a stiff dynamic absorber(SDA)for vertical seismic protection of structures with base *** SDA is optimized to minimize vertical accelerations while ensuring static structural integrity,excellent damping performance and containment of relative *** introduction of gas springs in place of conventional linear springs addresses important practical limitations through features of non-linearity and industrial grade *** proposed implementation is dimensioned for a 50-ton structure and evaluated numerically for 25 actual earthquake records,in comparison with a linear SDA model and an equivalent conventional damper(CD).individual and averaged results of acceleration and displacement time histories demonstrate vastly superior response compared to CD regarding induced accelerations for similar *** equivalency with the linear SDA model indicates the stability of the gas spring implementation while guaranteeing predictability,tested endurance,proper tolerances,and off-axis motion resistance without requiring additional guiding components,as opposed to conventional *** features render the proposed implementation a promising solution for the realization of NSEs in seismic protection.

关键词： negative stiffness gas springs vertical seismic protection KDamper inerter

New Hope for HiV microbicide

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科技英语学习 2009年第6期 16-18页

作者： Alla katsnelson 林波

最近出版的《自然》杂志报道说，最新的艾滋病研究发现，一种在化妆品和食品行业广泛应用的合成物质——甘油一月桂酸酯——可以有效阻止艾滋病的传播。研究人员将该化学物质制成溶剂，其药效已在猴子实验中得到了一定的证实，但它是否... 详细信息

最近出版的《自然》杂志报道说，最新的艾滋病研究发现，一种在化妆品和食品行业广泛应用的合成物质——甘油一月桂酸酯——可以有效阻止艾滋病的传播。研究人员将该化学物质制成溶剂，其药效已在猴子实验中得到了一定的证实，但它是否能够推而广之运用在人类身上，仍需进一步的实验研究。

关键词：艾滋病化学物质研究预防 HiV

Anomalous reactivity of thermo-bioconvective nanofluid towards oxytactic microorganisms

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Applied mathematics and mechanics(English Edition) 2020年第5期41卷 711-724页

作者： S.i.ABDELSALAm m.m.BHATTi Basic Science Department Faculty of EngineeringThe British University in EgyptAl-Shorouk CityCairo 11837Egypt instituto de matemáticas-Juriquilla Universidad Nacional Autónoma de MéxicoBlvd.Juriquilla 3001Quer´etaro 76230M´exico College of mathematics and Systems Science Shandong University of Science and TechnologyQingdao 266590Shandong ProvinceChina

The peristaltic flow of a non-Newtonian nanofluid with swimming oxytactic microorganisms through a space between two infinite coaxial conduits is investigated. A variable magnetic field is applied on the flow. The bioconvection flow and heat transfer in the porous annulus are formulated, and appropriate transformations are used, leading to the non-dimensionalized ruling partial differential equation model. The model is then solved by using the homotopy perturbation scheme. The effects of the germane parameters on the velocity profile, temperature distribution, concentration distribution, motile microorganism profile, oxytactic profile, pressure rise, and outer and inner tube friction forces for the blood clot and endoscopic effects are analyzed and presented *** is noticed that the pressure rise and friction forces attain smaller values for the endoscopic model than for the blood clot model. The present analysis is believed to aid applications constituting hemodynamic structures playing indispensable roles inside the human body since some blood clotting disorders, e.g., haemophilia, occur when some blood constituents on the artery wall get confined away from the wall joining the circulation system.

关键词： oxytactic swimming microorganism swimming variable magnetic field blood clotting endoscopy non-Newtonian fluid