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measurement of the integrated luminosity of the Phase 2 data of the Belle Ⅱ experiment

Chinese Physics C 2020年第2期44卷 1-12页

作者： F.Abudinén I.Adachi P.Ahlburg H.Aihara N.Akopov A.Aloisio F.Ameli L.Andricek N.Anh Ky D.m.Asner H.Atmacan T.Aushev V.Aushev T.Aziz K.Azmi V.Babu S.Baehr S.Bahinipati A.m.Bakich P.Bambade Sw.Banerjee S.Bansal V.Bansal m.Barrett J.Baudot A.Beaulieu J.Becker P.K.Behera J.V.Bennett E.Bernieri F.U.Bernlochner m.Bertemes m.Bessner S.Bettarini V.Bhardwaj F.Bianchi T.Bilka S.Bilokin D.Biswas G.Bonvicini A.Bozek m.Bračko P.Branchini N.Braun T.E.Browder A.Budano S.Bussino m.Campajola L.Cao G.Casarosa C.Cecchi D.Červenkov m.-C.Chang P.Chang R.Cheaib V.Chekelian Y.Q.Chen Y.-T.Chen B.G.Cheon K.Chilikin H.-E.Cho K.Cho S.Cho S.-K.Choi S.Choudhury D.Cinabro L.Corona L.m.Cremaldi S.Cunliffe T.Czank F.Dattola E.De La Cruz-Burelo G.De Nardo m.De Nuccio G.De Pietro R.de Sangro m.Destefanis S.Dey A.De Yta-Hernandez F.Di Capua S.Di Carlo J.Dingfelder Z.Doležal I.Domínguez Jiménez T.V.Dong K.Dort S.Dubey S.Duell S.Eidelman m.Eliachevitch T.Ferber D.Ferlewicz G.Finocchiaro S.Fiore A.Fodor F.Forti A.Frey B.G.Fulsom m.Gabriel E.Ganiev m.Garcia-Hernandez R.Garg A.Garmash V.Gaur A.Gaz U.Gebauer A.Gellrich J.Gemmler T.Geßler R.Giordano A.Giri B.Gobbo R.Godang P.Goldenzweig B.Golob P.Gomis P.Grace W.Gradl E.Graziani D.Greenwald C.Hadjivasiliou S.Halder K.Hara T.Hara O.Hartbrich K.Hayasaka H.Hayashii C.Hearty m.T.Hedges I.Heredia de la Cruz m.Hernández Villanueva A.Hershenhorn T.Higuchi E.C.Hill H.Hirata m.hoek S.Hollitt T.Hotta C.-L.Hsu Y.Hu K.Huang T.Iijima K.Inami G.Inguglia J.Irakkathil Jabbar A.Ishikawa R.Itoh m.Iwasaki Y.Iwasaki S.Iwata P.Jackson W.W.Jacobs D.E.Jaffe E.-J.Jang H.B.Jeon S.Jia Y.Jin C.Joo J.Kahn H.Kakuno A.B.Kaliyar G.Karyan Y.Kato T.Kawasaki H.Kichimi C.Kiesling B.H.Kim C.-H.Kim D.Y.Kim S.-H.Kim Y.K.Kim Y.Kim T.D.Kimmel K.Kinoshita C.Kleinwort B.Knysh P.Kodyš T.Koga I.Komarov T.Konno S.Korpar D.Kotchetkov N.Kovalchuk T.m.G.Kraetzschmar P.Križan R.Kroeger J.F.Krohn P.Krokovny W.Kuehn T.Kuhr m.Kumar R.Kumar K.Kumara S.Kurz A.Kuzmin Y.-J.Kwon S.Lacaprara Y.-T.Lai C.La Licata K.Lalwani L.Lanceri J.S.Lange K.Lautenbach I.-S.Le Beihang University Beijing 100191 Brookhaven National Laboratory UptonNew York 11973 Budker Institute of Nuclear Physics SB RAS Novosibirsk 630090 Centro de Investigacion y de Estudios Avanzados del Instituto Politecnico Nacional Mexico City 07360 Faculty of mathematics and Physics Charles University12116 Prague Chiba University Chiba 263-8522 Consejo Nacional de Ciencia y Tecnología Mexico City 03940 Deutsches Elektronen–Synchrotron 22607 Hamburg Duke University DurhamNorth Carolina 27708 Earthquake Research Institute University of TokyoTokyo 113-0032 Forschungszentrum Jülich 52425 Jülich Department of Physics Fu Jen Catholic UniversityTaipei 24205 Key Laboratory of Nuclear Physics and Ion-beam Application(mOE)and Institute of modern Physics Fudan UniversityShanghai 200443 II.Physikalisches Institut Georg-August-Universität Göttingen37073 Göttingen Gifu University Gifu 501-1193 The Graduate University for Advanced Studies(SOKENDAI) Hayama 240-0193 Gyeongsang National University Jinju 52828 Department of Physics and Institute of Natural Sciences Hanyang UniversitySeoul 04763 High Energy Accelerator Research Organization(KEK) Tsukuba 305-0801 J-PARC Branch KEK Theory CenterHigh Energy Accelerator Research Organization(KEK)Tsukuba 305-0801 Indian Institute of Science Education and Research mohali SAS Nagar140306 Indian Institute of Technology Bhubaneswar Satya Nagar 751007 Indian Institute of Technology Hyderabad Telangana 502285 Indian Institute of Technology madras Chennai 600036 Indiana University BloomingtonIndiana 47408 Institute for High Energy Physics Protvino 142281 Institute of High Energy Physics Vienna 1050 Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049 Institute of Particle Physics(Canada) VictoriaBritish Columbia V8W 2Y2 Institute of Physics Hanoi Instituto de Fisica Corpuscular Paterna 46980 INFN Laboratori Nazionali di Frascati I-00044 Frascati INFN Sezione di Napoli I-80126 Napoli INFN Sezione di Padova I-35131 Padova INFN Sezione di Perugia I-06123 Perugia

From April to July 2018,a data sample at the peak energy of the T(4 S) resonance was collected with the Belle Ⅱ detector at the SuperKEKB electron-positron *** is the first data sample of the Belle Ⅱ *** Bhabha and digamma events,we measure the integrated luminosity of the data sample to be(496.3±0.3±3.0) pb-1,where the first uncertainty is statistical and the second is *** work provides a basis for future luminosity measurements at Belle Ⅱ.

关键词： luminosity Bhabha digamma Belle II

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超算与机器学习辅助高渗透性海水反渗透膜系统优化设计

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Science Bulletin 2023年第4期68卷 397-407,M0004页

作者：罗玖李明恒 Eric m.V.hoek 衡益 School of Computer Science and Engineering Sun Yat-sen UniversityGuangzhou 510006China National Supercomputing Center in Guangzhou(NSCC-GZ) Guangzhou 510006China Guangdong Province Key Laboratory of Computational Science Guangzhou 510006China Department of Chemical and materials Engineering California State Polytechnic UniversityPomona CA 91768USA Department of Civil&Environmental Engineering California NanoSystems Institute and Institute of the Environment&SustainabilityUniversity of CaliforniaLos Angeles(UCLA)Los Angeles CA 90095USA Energy Storage&Distributed Resources Division Lawrence Berkeley National LaboratoryBerkeley CA 94720USA

当前,高渗透性反渗透膜材料的研究引起了广泛的关注,然而高渗透导致的浓差极化与膜污染加剧等瓶颈问题限制了高性能膜材料的应用发展.本工作采用机器学习结合超级计算提出了针对先进反渗透膜材料的组件进水隔网(亚毫米级)与系统(米级)... 详细信息

当前,高渗透性反渗透膜材料的研究引起了广泛的关注,然而高渗透导致的浓差极化与膜污染加剧等瓶颈问题限制了高性能膜材料的应用发展.本工作采用机器学习结合超级计算提出了针对先进反渗透膜材料的组件进水隔网(亚毫米级)与系统(米级)的多尺度优化设计新方法.在进料含盐度35,000 ppm,回收率50%典型工况下,对标目前国际先进海水反渗透淡化工艺,本文提出的优化方案能使淡水制备比能耗(1.66 k Wh/m^(3))降低27.5%,所需膜面积减少约37.2%,系统最大浓差极化因子控制在工程允许范围以内(<1.20),可有效缓解高渗透膜系统中膜污染问题,为高性能膜材料精准设计提供理论依据、计算工具和大数据支撑,有重要的应用潜力.本文提出的机器学习结合超算的多尺度设计新研究范式,突破了基于“试错法”的传统单一尺度组件设计限制,高通量并行计算规模可扩展至93,120核以上,较串行算法计算效率提升3000倍以上,可大幅度缩短高性能膜组件的设计周期.

关键词： Reverse osmosis desalination High permeability membrane multiscale design optimization multilayer artificial neural networks Supercomputing Enhancement of mass transfer

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Taxation And Corruption In Transition Countries In Central And Eastern Europe

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公共经济与政策研究 2009年第1期 171-182页

作者： m. PETER VAN DER hoek Erasmus University

This paper focuses on the relationship between taxation and corruption in transition countries in Central and Eastern Europe. It seems plausible that negative relationships exist between corruption and tax effort and between corruption and foreign direct investments. However,research regarding corruption faces serious measurement problems due to the phenomenon’s very nature. A preliminary look at the available data provides some weak empirical evidence of a possible relationship between tax effort and corruption on the one hand and between foreign direct investments and corruption on the other. Further research into these subjects seems warranted.

关键词： tax capacity tax effort corruption

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“The Expo-tunity”Shanghai World Expo 2010:ain Goals for a Long-Lasting Contribution to the Development of the City

“The Expo-tunity”Shanghai World Expo 2010:ain Goals for a ...

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中国地理学会2006年学术年会

作者： Xiangfeng ma R．m．van hoek 上海师范大学旅游学院荷兰鹿特丹大学

本文引入大型活动三个阶段对城市发展的影响的欧洲理论,结合上海2010年世界博览会的案例研究及在上海对政府、工商界等各界人士的现场调研,应对上海2010年世博会可持续性发展的研究课题,提出了自己的解决对策。

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Calcineurin Inhibitors in the Treatment of Adult Autoimmune Hepatitis:A Systematic Review

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Journal of Clinical and Translational Hepatology 2022年第6期10卷 1155-1166页

作者： martine AmC Baven-Pronk Joffre m.Hew,Jr maaike Biewenga maarten E.Tushuizen Aad P.van den Berg Gerd Bouma Johannes T.Brouwer Bart van hoek 无 Department of Gastroenterology and Hepatology Groene Hart HospitalGoudaNetherlands Department of Gastroenterolo-gy and Hepatology Leiden University Medical CenterLeidenNetherlands Department of Gastroenterology and Hepatology University Medical Center GroningenGroningenNetherlands Department of Gastroenterology and Hepatology Amsterdam University medical Center Location VUAmsterdamNetherlands Reinier de Graaf medical Center Delft DelftNetherlands Dutch Autoimmune Hepatitis Study Group

Background and Aims:A considerable number of au-toimmune hepatitis(AIH)patients completely or partially fail on first-line *** studies on the use of calcineurin inhibitors(CNIs)in the treatment of AIH have been published without focusing on *** aim was to assess the efficacy of CNIs in the treatment of adult AIH patients,specifically focusing on indication:first-line intolerant and with first-line insufficient response(failure to achieve or maintain remission),and with second versus third-line ***:A literature search included studies on the use of CNIs in adult *** with past or present use of CNIs from the Dutch AIH group cohort were *** primary endpoint was biochemical remission while using *** endpoints were biochemical response,treatment failure,and adverse ***:Twenty studies from the literature and nine Dutch patients were included describing the use of cyclosporine in 59 and tacrolimus in 219 adult AIH *** CNI remission rate was 53%in patients with insufficient response to first-line treatment and 67%in patients intolerant to first-line *** were used as second-line treatment in 73%with a remission rate of 52%and as third-line treatment in 22%with a remission rate of 26%.Cyclosporine was discontin-ued in 13%and tacrolimus in 11%of patients because of adverse ***:CNIs as rescue treatment in adult AIH patients are reasonably effective and safe both with insufficient response or intolerance to previous *** studies are needed.

关键词： Autoimmune hepatitis Cyclosporine Tacrolimus Calcineurin inhibi-tor

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Integration and Innovation of the Urban Water Cycle： The Waternet Experience

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Journal of Environmental Science and Engineering 2011年第5期5卷 533-544页

作者： J.P. van der hoek J.A.m.H. Hofman T.C.R. van Someren Department of Water management Delft University of Technology Delft 2628 CN the Netherlands Strategic Centre Waternet Amsterdam 1096 AC the Netherlands KWR Watercycle Research Institute Nieuwegein 3433 PE the Netherlands School of Environment Beijing Normal University Beijing 100875 China Ynnovate Hilversum 1213 LC 5the Netherlands

Waternet is the first water cycle company in the Netherlands, responsible for drinking water treatment and distribution, wastewater collection and treatment, and water system management and control in and around Amsterdam. Waternet started on 1 January 2006 to overcome the disadvantages of the rather fragmented organisation of the Dutch public water sector. The water cycle concept offers better opportunities to meet the future challenges in the water sector. The first four years of operation of Waternet show very promising results with respect to efficiency, customer orientation and quality improvement. To further develop the water cycle concept and to find sustainable solutions for the challenges the water sector is confronted with, Waternet focuses on six strategic innovation areas the coming years： water resources and water system; closing the water cycle; sustainability; new sanitation concepts; new products and services; management innovations.

关键词： Water cycle sustainable development water management water services.

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Identification of common and distinct origins of human serum and breastmilk IgA1 by mass spectrometry-based clonal profiling

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Cellular & molecular Immunology 2023年第1期20卷 26-37页

作者： Kelly A.Dingess max hoek Danique m.Hvan Rijswijk Sem Tamara maurits Aden Boer Tim Veth mirjam J.A.Damen Arjan Barendregt michelle Romijn Hannah G.Juncker Britt Jvan Keulen Gestur Vidarsson Johannes Bvan Goudoever Albert Bondt Albert J.R.Heck Biomolecular mass Spectrometry and Proteomics Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical SciencesUniversity of UtrechtPadualaan 8Utrecht 3584 CHThe Netherlands Netherlands Proteomics Center Padualaan 8Utrecht 3584 CHThe Netherlands Amsterdam UmC Vrije UniversiteitUniversity of AmsterdamEmma Children’s HospitalAmsterdam Reproduction&Development Research InstituteDepartment of PediatricsAmsterdamthe Netherlands Department of Experimental Immunohematology Sanquin Research and Landsteiner LaboratoryAmsterdam UMCUniversity of AmsterdamAmsterdamNetherlands

The most abundant immunoglobulin present in the human body is IgA. It has the highest concentrations at the mucosal lining and in biofluids such as milk and is the second most abundant class of antibodies in serum. We assessed the structural diversity and clonal repertoire of IgA1-containing molecular assemblies longitudinally in human serum and milk from three donors using a mass spectrometry-based approach. IgA-containing molecules purified from serum or milk were assessed by the release and subsequent analysis of their Fab fragments. Our data revealed that serum IgA1 consists of two distinct structural populations, namely monomeric IgA1 (∼80%) and dimeric joining (J-) chain coupled IgA1 (∼20%). Also, we confirmed that IgA1 in milk is present solely as secretory (S)IgA, consisting of two (∼50%), three (∼33%) or four (∼17%) IgA1 molecules assembled with a J-chain and secretory component (SC). Interestingly, the serum and milk IgA1-Fab repertoires were distinct between monomeric, and J-chain coupled dimeric IgA1. The serum dimeric J-chain coupled IgA1 repertoire contained several abundant clones also observed in the milk IgA1 repertoire. The latter repertoire had little to no overlap with the serum monomeric IgA1 repertoire. This suggests that human IgA1s have (at least) two distinct origins;one of these produces dimeric J-chain coupled IgA1 molecules, shared in human serum and milk, and another produces monomeric IgA1 ending up exclusively in serum.

关键词： Antigen binding fragment Immunoglobulin A1 Clonal repertoires human milk Serum

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THE ENVIRONmENTAL ImPACT OF FLOODING OF A DENSELY POPULATED POLDER DISTRICT IN THE NETHERLANDS

THE ENVIRONMENTAL IMPACT OF FLOODING OF A DENSELY POPULATED ...

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第19届国际灌排大会

作者： Louis C.P.m.Stuyt Eline E.van der hoek Johan E.A.Reinders Ellen G.m.Hermans menzo de muinck Keizer Centre for Water and Climate （CWK） Alterra Wageningen URP.O.Box 47NL-6700 AA WageningenThe Netherlands.

＜正＞model studies into the consequences of flooding events are usually focused on damage to buildings, infrastructure, economic losses and casualties thus ignoring the risk of environmental damage. In this project, a model study was made to assess the environmental consequences of the release of pollutants during the flooding of a polder district in the Netherlands following a river dike breach. A conceptual framework was established for the sequence of events or ’chain reaction’ during a flood. A dike breach is formed, the scour of the flood waters and/or high water levels may damage or destroy objects like homes, industrial complexes and farms;damaged objects release hazardous substances that will be dispersed in the flood waters including suspended matter and the released chemicals will affect people and ecosystems in the inundated area. The analyses were made in the 50,000 ha case study area ’Krimpen’, located in the western Netherlands near the cities of Rotterdam, Delft and The Hague. The simulated period of flooding was ten days. The failure of objects where hazardous chemicals are stocked was linked to water height and velocity. The release and migration of pollutants like volatile aromatics, germs, sum PAH, PCB, LNAPL, DNAPL, heavy metals, nutrients and pesticides was simulated with an innovative, integrated modelling tool. The assessed impact of the pollutants on the environment was found to be substantial. Small yet numerous sources like cars may release substantial amounts of toxic chemicals to the flood waters and suspended sediments during and after the flood, while large installations like chemical plants only give problems near the dike breach where high flow velocities prevail. The simulated concentrations of toxic substances frequently exceeded the legal threshold levels.

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严重节理化或风化岩体的边坡稳定性分析

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国外金属矿采矿 1982年第5期 27-41页

作者： Evert hoek 盛安加拿大Golder咨询公司理事博士

本文介绍了一个用于计算严重节理化或风化岩体的经验准则。这一准则引入了完整岩石材料强度这一概念,并采用了两个表示节理化岩体内颗粒互嵌特性的无量纲参数m和s。讨论了岩体分类法在计算这两个参数值时的应用。本文还利用计算实例举... 详细信息

本文介绍了一个用于计算严重节理化或风化岩体的经验准则。这一准则引入了完整岩石材料强度这一概念,并采用了两个表示节理化岩体内颗粒互嵌特性的无量纲参数m和s。讨论了岩体分类法在计算这两个参数值时的应用。本文还利用计算实例举例说明了非线性破坏准则在分析边坡过程中的应用。

关键词：风化岩体法向应力正应力节理化岩体完整岩石不连续面间断面边坡稳定性分析岩体破坏最小主应力土边坡圆弧破坏面地质力学分类法材料常数理化

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自然原因死亡率和颗粒物成分长期暴露：多中心ESCAPE项目中19个欧洲队列的分析

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环境与职业医学 2016年第3期33卷 303-311页

作者： Rob Beelen Gerard hoek Ole Raaschou-Nielsen 汪源郑轻舟金泰廙机构不详

[背景]已有研究表明,在死亡率和颗粒物空气污染长期暴露之间存在关联,而估计颗粒物元素成分对死亡率影响的队列研究很少。[目的]研究自然原因死亡率和长期暴露于颗粒物元素成分之间的关联。[方法]遵循严格的标准化方案,并使用19个欧洲... 详细信息

[背景]已有研究表明,在死亡率和颗粒物空气污染长期暴露之间存在关联,而估计颗粒物元素成分对死亡率影响的队列研究很少。[目的]研究自然原因死亡率和长期暴露于颗粒物元素成分之间的关联。[方法]遵循严格的标准化方案,并使用19个欧洲队列研究中死亡率和混杂因素的数据。描述住宅暴露于优先选择的8种颗粒物（Pm）成分的特征。使用土地利用回归模型估计粒级≤2.5μm（Pm2.5）和≤10μm（Pm10）的颗粒物中铜、铁、钾、镍、硫、硅、钒和锌的年平均浓度,并在meta分析之后,按照统一的标准,使用Cox比例风险模型对队列特异的死亡率和空气污染之间的关联进行统计分析。[结果]研究包括291 816名参与者,其中25 466在随访期间（平均随访时间14.3年）死于自然原因。几乎所有元素的风险比都呈阳性,并且Pm2.5硫的风险比具有统计学显著性（每200 ng/m3为1.14,95%CI：1.06～1.23）。在一个双污染物模型中,校正Pm2.5总质量之后,死亡率与Pm2.5硫之间的关联保持稳定,而与Pm2.5总质量的关联性降低。[结论]长期暴露于Pm2.5硫与自然原因引起的死亡率有关联。这个关联在校正了其他污染物和Pm2.5之后依然稳定。

关键词： ESCAPE 空气污染统计学显著性估计值模型分析模型估计年平均浓度土地利用随机效应回归模型

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