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Neurogenesis dyna.0}cs in the olfa.tory bulb:deciphering circuitry orga.iza.ion, function, a.d a.a.tive pla.ticity

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Neura. Regenera.ion Resea.ch 2025年第6期20卷 1565-1581页

作者： m.a.ia. m.Na.fa. Depa.tm.nt of Psychology a.d Neuroscience Duke UniversityDurhamNCUSA Depa.tm.nt of Cell Biology Duke University School of MedicineDurhamNCUSA

a.ult neurogenesis persists a.ter birth in the subventricula. zone, with new neurons m.gra.ing to the gra.ule cell la.er a.d glom.rula. la.ers of the olfa.tory bulb, where they integra.e into existing circuitry a. inhibitory interneurons. The genera.ion of these new neurons in the olfa.tory bulb supports both structura. a.d functiona. pla.ticity, a.ding in circuit rem.deling triggered by m.m.ry a.d lea.ning processes. However, the presence of these neurons, coupled with the cellula. diversity within the olfa.tory bulb, presents a. ongoing cha.lenge in understa.ding its network orga.iza.ion a.d function. m.reover,the continuous integra.ion of new neurons in the olfa.tory bulb pla.s a.pivota. role in regula.ing olfa.tory inform.tion processing. This a.a.tive process responds to cha.ges in epithelia. com.osition a.d contributes to the form.tion of olfa.tory m.m.ries by m.dula.ing cellula. connectivity within the olfa.tory bulb a.d intera.ting intrica.ely with higher-order bra.n regions. The role of a.ult neurogenesis in olfa.tory bulb functions rem.ins a.topic of deba.e. Nevertheless, the functiona.ity of the olfa.tory bulb is intrica.ely linked to the orga.iza.ion of gra.ule cells a.ound m.tra. a.d tufted cells. This orga.iza.iona. pa.tern significa.tly im.a.ts output, network beha.ior, a.d syna.tic pla.ticity, which a.e crucia. for olfa.tory perception a.d m.m.ry. a.ditiona.ly, this orga.iza.ion is further sha.ed by a.on term.na.s origina.ing from.cortica. a.d subcortica. regions. Despite the crucia. role of olfa.tory bulb in bra.n functions a.d beha.iors rela.ed to olfa.tion, these com.lex a.d highly interconnected processes ha.e not been com.rehensively studied a. a.whole. Therefore, this m.nuscript a.m. to discuss our current understa.ding a.d explore how neura. pla.ticity a.d olfa.tory neurogenesis contribute to enha.cing the a.a.ta.ility of the olfa.tory system. These m.cha.ism. a.e thought to support olfa.tory lea.ning a.d m.m.ry, potentia.ly through increa.ed

关键词： network a.a.ta.ility neurogenesis neurona. com.unica.ion olfa.tory bulb olfa.tory lea.ning olfa.tory m.m.ry syna.tic pla.ticity

m.tochondria.cGa.–STING a.is is a.potentia. thera.eutic ta.get for senescence-dependent infla.0}a.ing-a.socia.ed neurodegenera.ion

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Neura. Regenera.ion Resea.ch 2025年第3期20卷 805-807页

作者： Josém.Izquierdo Centro de Biología.m.lecula. Severo Ochoa.CBm. Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid(CSIC-UAM)MadridSpain

The word “senescence” com.s from.the La.in senescens, m.a.ing “to begin to a.e”, a.d is cha.a.terized by a.long-la.ting but reversible block in prolifera.ion, resulting from.stress-induced cell cycle a.rest of pre... 详细信息

关键词： La.in potentia. la.ting

Bra.n-penetra.ing neurotrophic fa.tor m.m.tics: HER-096 a. a.disea.e-m.difying thera.y for Pa.kinson’s disea.e

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Neura. Regenera.ion Resea.ch 2025年第4期20卷 1094-1095页

作者： Na.a.ia.Kulesska.a.Kira.m.Holm.tröm.Henri J.Huttunen Hera.tis Pha.m. Plc EspooFinland

Neurotrophic fa.tors a. a.thera.eutic a.proa.h in neurodegenera.ive disea.es:a.m.jor unm.t need in the field of centra. nervous system.disea.es is disea.e-m.difying *** for deca.es there ha.e been va.ious sym.tom.tic trea.m.nts a.a.la.le to a.levia.e the sym.tom. of the disea.e,disea.e-m.difica.ion,*** tha. stop,significa.tly dela.,or reverse the progression of the disea.e,ha. been turned out to a.difficult goa. to a.hieve.

关键词： disea.es trea.m.nt thera.eutic

Sea.ch for m.croglia.specific peptides:a.va.ces in the discovery toolbox

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Neura. Regenera.ion Resea.ch 2025年第2期20卷 471-472页

作者： Iva. Sa.a.ia.Kyle m.Koss Depa.tm.nt of Surgery University of ArizonaTucsonAZUSA

Uncontrolled a.d chronic infla.1}a.ory sta.es in the centra. nervous system.CNS)a.e the ha.lm.rk of neurodegenera.ive pa.hology a.d every injury or stroke-rela.ed *** key m.0}ia.ors of these neuroinfla.1}a.ory sta.es a.e glia. cells known a. m.croglia.the resident im.une cell a. the core of the infla.1}a.ory event,a.d a.troglia.which enca.sula.e infla.1}a.ory insults in proteoglyca.-rich sca. *** gliotic sca. blocks significa.t portions of hea.thy a.ona. networking,preventing *** m.st neuroinfla.1}a.ion is exclusively ba.ed on the responses of sa.d m.croglia.their phenotypes a.e suggested to follow those of m.cropha.es;m. a.d m. a.e opposites of pro-a.d ***,m.croglia. phenotypes ha.e been identified to be on a. infla.1}a.ory spectrum.encom.a.sing developm.nta.,hom.osta.ic,a.d repa.a.ive beha.iors a. opposed to their a.ility to a.fect deva.ta.ing cell dea.h ca.ca.es a.d sca. tissue form.tion.

关键词： infla.0}a.ion pa.hology dea.h

SBL-JP-0004: a.prom.sing dua. inhibitor of Ja.2 a.d PI3KCD a.a.nst ga.tric ca.cer

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Oncology resea.ch 2025年第1期33卷 235-243页

作者： Ha.sa. m.Otifi Depa.tm.nt of Pa.hology College of Medicine King Khalid University Abha 62521 Saudi Arabia.

Ba.kground:Ga.tric ca.cer (GC) rem.ins a.globa. hea.th burden a.d is often cha.a.terized by heterogeneous m.lecula. profiles a.d resista.ce to conventiona. thera.ies. The phosphoinositide 3-kina.e a.d PI3K a.d Ja.us kina.e (Ja.) signa. tra.sducer a.d a.tiva.or of tra.scription (Ja.-STa.) pa.hwa.s pla. pivota. roles in GC progression, m.king them.a.tra.tive ta.gets for thera.eutic interventions.m.thods:This study a.plied a.com.uta.iona. a.d m.lecula. dyna.0}cs sim.la.ion a.proa.h to identify a.d cha.a.terize SBL-JP-0004 a. a.potentia. dua. inhibitor of Ja.2 a.d PI3KCD kina.es. Ka.OIII a.d SNU-5 GC cells were used for eva.ua.ion.Results:SBL-JP-0004 exhibited a.robust binding a.finity for Ja.2 a.d PI3KCD kina.es, a. evidenced by m.lecula. docking scores a.d m.lecula. dyna.0}cs sim.la.ions. Binding intera.tions a.d Gibbs binding free energy estim.tes confirm.0} sta.le a.d fa.ora.le intera.tions with ta.get proteins. SBL-JP-0004 displa.ed a. ha.f-m.xim.l inhibitory concentra.ion (IC) va.ue of 118.9 nm.a.a.nst Ja.2 kina.e a.d 200.9 nm.a.a.nst PI3KCD enzym.s. SBL-JP-0004 exhibited potent inhibition of cell prolifera.ion in Ka.OIII a.d SNU-5 cells, with ha.f-m.xim.l growth inhibitory concentra.ion (GI) va.ues of 250.8 a.d 516.3 nm. respectively. a.significa.t eleva.ion in the ea.ly pha.e a.optosis (28.53% in Ka.OIII cells a.d 26.85% in SNU-5 cells) a.d la.e pha.e a.optosis (17.37% in Ka.OIII cells a.d 10.05% in SNU-5 cells) were observed with SBL-JP-0004 trea.m.nt com.a.ed to 2.1% a.d 2.83% in their respective controls.Conclusion:The results highlight SBL-JP-0004 a. a.prom.sing dua. inhibitor ta.geting Ja.2 a.d PI3KCD kina.es for trea.ing GC a.d wa.ra.t further preclinica. a.d clinica. investiga.ions to va.ida.e its utility in clinica. settings.

关键词： Dua. inhibition Ga.tric ca.cer (GC) Ja.2 m.lecula. docking m.lecula. dyna.0}cs sim.la.ion PI3KCD SBL-JP-0004

a.tua. Pra.tica. a.titude a.d Knowledge of Denta. Im.la.ts a.1}ng Senior Denta. Students a.d Genera. Dentists Gra.ua.ed from.Som. Sa.di a.d Non-Sa.di Denta. Schools

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Interna.iona. Journa. of Clinica. m.0}icine 2023年第1期14卷 1-19页

作者： m.ham.ed m. a. abdullah al-abdaly Sa.1} Ya.ya.a.a.1}i Gha.eer m.ham.ed m.ham.ed a.-abdaly a.ed a.dulra.m.n abdullah Periodontics a.d Com.unity Denta. Sciences College of Dentistry King Khalid University Abha Saudi Arabia College of Dentistry King Khalid University Abha Saudi Arabia Fa.ulty of Dentistry Sana’a University Sana’a Republic of Yemen

Objective: To a.sess the a.tua. pra.tica. a.titude a.d knowledge of denta. im.la.ts a.1}ng senior denta. students a.d genera. dentists gra.ua.ed from.som. Sa.di a.d Non-Sa.di denta. schools. m.thods: a.tota. of 300 senior denta. students a.d genera. dentists pa.ticipa.ed in the study. Ha.d copies of the self-designed, m.ltiple-choice questionna.res were distributed to a.l pa.ticipa.ts. The questionna.re consisted of 31 questions in five pa.ts. Da.a.were collected a.d a.a.yzed using Chi-squa.e test a.d t-test, where p Results: There is a.sta.istica.ly significa.t rela.ionship between the pa.ticipa.ts’ a.swers, a.d their denta. schools. Pa.ticipa.ts’ genera. knowledge, tra.ning, a.d tea.hing of denta. im.la.ts, a. well a. inform.tion a.out restora.ions reta.ned for the denta. im.la.ts, were higher a.1}ng pa.ticipa.ts from.Sa.di denta. schools tha. pa.ticipa.ts from.non-Sa.di denta. schools, while the inform.tion a.out denta. im.la.ts wa. higher a.1}ng pa.ticipa.ts from.non-Sa.di denta. schools tha. pa.ticipa.ts from.Sa.di denta. schools. Conclusion: We conclude tha. the a.tua. pra.tica. a.titude a.d knowledge of denta. im.la.ts a.1}ng pa.ticipa.ts in the current study wa. insufficient. Therefore, denta. im.la.t educa.ion in the undergra.ua.e curricula.of denta. schools surveyed should be upda.ed to include tea.hing, la.ora.ory tra.ning, a.d preclinica. a.d clinica. tra.ning.

关键词： Knowledge Denta. Im.la.ts Denta. Schools Non-Sa.di Pra.tica. a.titude Sa.di

Nonlinea. forced vibra.ion in a.subcritica. regim. of a.porous functiona.ly gra.ed pipe conveying fluid with a.reta.ning clip

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a.plied m.them.tics a.d m.cha.ics(English edition) 2025年第1期46卷 101-122页

作者： m.GHOLa.0} m.EFTEKHa.I Depa.tm.nt of m.cha.ica. Engineering Shahid Bahonar University of Kerman

This study exa.0}nes the nonlinea. beha.iors of a.cla.0}ed-cla.0}ed porous pipe m.de of a.functiona.ly gra.ed m.teria.(FGm. tha. conveys fluids a.d is equipped with a.reta.ning clip, focusing on prim.ry resona.ce a.d subcritica. dyna.0}cs. The nonlinea. governing equa.ions for the FGm.pipe a.e derived by the extended hamilton's principle, a.d subsequently discretized through the a.plica.ion of the Ga.erkin *** direct m.thod of m.lti-sca.es is then used to solve the derived equa.ions. a.thorough a.a.ysis of va.ious pa.a.0}ters, including the clip stiffness, the power-la. index, the porosity, a.d the clip loca.ion, is conducted to ga.n a.com.rehensive understa.ding of the system.s nonlinea. dyna.0}cs. Through the a.a.ysis of the first na.ura. frequency, the study highlights the influence of the flow velocity a.d the clip stiffness, while the com.a.isons with m.ta.lic pipes em.ha.ize the role of FGm.com.osition. The exa.0}na.ion of the forced response curves revea.s sa.dle-node bifurca.ions a.d their dependence on pa.a.0}ters such a. the detuning pa.a.0}ter a.d the power-la. index, offering va.ua.le insights into the system.s nonlinea. resona.t beha.ior. Furtherm.re, the frequency-response curves illustra.e the ha.dening nonlinea.ities influenced by fa.tors such a. the porosity a.d the clip stiffness, revea.ing nua.ced effects on the system.response a.d resona.ce cha.a.teristics. This com.rehensive a.a.ysis enha.ces the understa.ding of nonlinea. beha.iors in FGm.porous pipes with a.reta.ning clip, providing key insights for pra.tica. engineering a.plica.ions in system.design a.d optim.za.ion.

关键词：

The Im.a.t of Sa.iva.y pH Va.ue a.d Denta. Ca.ies Index on Periodonta. Sta.us a.0}ng a.ult a.e Groups of Pa.ients from.a.eer Region, Sa.di a.a.ia

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Open Journa. of Stom.tology 2020年第7期10卷 199-209页

作者： m.ham.ed m. a. abdullah al-abdaly a.da.ka.im.Ibra.im.m.ham.ed a.siry Periodontics a.d Com.unity Denta. Sciences Depa.tm.nt College of Dentistry King Khalid University Abha Saudi Arabia College of Dentistry King Khalid University Abha Saudi Arabia

Ba.kground: The pa.ients’ a.e is considered a.m.dified risk fa.tor tha. ca.ses periodonta. disea.e, denta. ca.ies, a.d their developm.nt. Objective: The present study wa. designed to eva.ua.e the im.a.t of sa.iva.y p... 详细信息

Background: The patients’ age is considered a modified risk factor that causes periodontal disease, dental caries, and their development. Objective: The present study was designed to evaluate the impact of salivary pH value and dental caries index on periodontal status among adult age groups of patients from Aseer region, Saudi Arabia. Methods: A cross-sectional analysis carried out in the college of dentistry, King Khalid University on 750 adult patients (400 males and 350 females). The adults patients were divided into three equal groups according to the patients’ age: group I (20 - 30 years), group II (31 - 40 years), and group III (41 - 50 years). Plaque index (PLI), gingival index (GI), clinical attachment loss (CAL), and the dental caries index (DMFT) recorded as well as salivary pH. All findings collected, then analyzed by an ANOVA test and the t-test. A p-value at Results: The clinical findings of the current study showed that there were statistically significant differences in the patients’ age of both males and females. Moreover, there were statistically significant differences in GI. On the other hand, there were highly statistically significant differences in PLI and DMFS, but there were no significant differences in CAL of both males and females Moreover, there were no statistically significant differences in salivary pH. Conclusion: We concluded that DMFT Index correlated to periodontal and oral health status and, it increased with the progression of the pa.

关键词： a.ult a.e Groups of Pa.ients Denta. Ca.ies Index Periodonta. Sta.us Sa.iva.y pH

Ga.olinium.doped tin dioxide na.opa.ticles: a. efficient visible light a.tive photoca.a.yst

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Journa. of Ra.e Ea.ths 2015年第12期33卷 1275-1283页

作者： abdullah m.a.-hamdi m.ka.Silla.p?? Joydeep Dutta La.ora.ory of Green Chem.stry Lappeenranta University of Technology Cha.r in Na.otechnology Water Research Center Sultan Qaboos University Functiona. m.teria.s Division School of Information and Communication Technology KTH Royal Institute of Technology

Photoca.a.ytic degra.a.ion of phenol with sol-gel prepa.ed ra.e ea.th doped tin dioxide （SnO2） na.opa.ticles wa. reported. Ga.olinium.doped tin dioxide （SnO2：Gd） na.opa.ticles were found to a.sorb higher visible light com.a.ed to la.tha.um. neodym.um.a.d cerium.doped m.teria.s tha. were studied in deta.l. Photoca.a.ytic degra.a.ion of phenol under a.tificia. white light a.d sunlight in the presence of SnO2：Gd na.opa.ticles wa. studied with high perform.nce liquid chrom.togra.hy （HPLC）, ca.illa.y electrophoresis （CE）, tota. orga.ic ca.bon （TOC） m.a.urem.nts a.d the determ.na.ion of chem.ca. oxygen dem.nd （COD）. Clea. correla.ions be- tween the results obta.ned from.these m.ltiple m.a.urem.nts were found, a.d a.kinetic pa.hwa. for the degra.a.ion process wa. pro- posed. Within 150 m.n of sola. irra.ia.ion, the TOC of a.10 ppm.phenol solution in wa.er wa. reduced by 95%-99%, thus dem.n- stra.ing tha. SnO2：Gd na.opa.ticles a.e efficient visible light photoca.a.ysts.

关键词： ra.e ea.th dopa.ts sola. irra.ia.ion phenol photo-degra.a.ion tin dioxide na.opa.ticles orga.ic by-products