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Brain.derived n.urotrophic factor s.gn.lin. in.the n.uromus.ular jun.tion.durin. developmen.al axon.l competition.an. s.n.ps. elimin.tion

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n.ural Regen.ration.Res.arch 2025年第2期20卷 394-401页

作者： Jos.p Tomàs.Víctor Cilleros.mañé Laia Jus.-Borràs.marta Balan.à-s.gura Aleks.n.ra Polis.chuk Laura n.0}al marta Tomàs.Carolin. s.lvera-s.món.man.l m.s.n.afé maria A.Lan.za Un.tat d’His.ologia i n.urobiologia(UHn.urob) Facultat de Medicina i Ciències de la SalutUniversitat Rovira i VirgiliReusSpain

Durin. the developmen. of the n.rvous.s.s.em,there is.an.overproduction.of n.uron. an. *** competition.between.n.ighborin. n.rve en.in.s.an. s.n.ps.s.performin. differen. activity levels.leads.to their elimin.tion.or *** have exten.ively s.udied the in.olvemen. of the brain.derived n.urotrophic factor-Tropomyos.n.related kin.s. B receptor n.urotrophic retrograde pathway,at the n.uromus.ular jun.tion.in.the axon.l developmen. an. s.n.ps. elimin.tion.proces. vers.s.the s.n.ps. *** purpos. of this.review is.to des.ribe the n.urotrophic in.luen.e on.developmen.al s.n.ps. elimin.tion.in.relation.to other molecular pathways.that we an. others.have foun. to regulate this.*** particular,we s.mmarize our publis.ed res.lts.bas.d on.tran.mitter releas. an.lys.s.an. axon.l coun.s.to s.ow the differen. in.olvemen. of the pres.n.ptic acetylcholin. mus.arin.c autoreceptors.coupled to down.tream s.rin.-threon.n. protein.kin.s.s.A an. C(PKA an. PKC)an. voltage-gated calcium chan.els.at differen. n.rve en.in.s.in.developmen.al *** dyn.mic chan.es.that occur s.multan.ous.y in.s.veral n.rve termin.ls.an. s.n.ps.s.con.erge acros. a pos.s.n.ptic s.te,in.luen.e each other,an. require careful s.udies.to in.ividualize the mechan.s.s.of s.ecific *** des.ribe an.activity-depen.en. balan.e(related to the exten. of tran.mitter releas.)between.the pres.n.ptic mus.arin.c s.btypes.an. the n.urotrophin.mediated TrkB/p75n.R pathways.that can.in.luen.e the timin. an. fate of the competitive in.eraction. between.the differen. axon.*** down.tream dis.lacemen. of the PKA/PKC activity ratio to lower values.both in.competin. n.rve termin.ls.an. at pos.s.n.ptic s.tes.plays.a relevan. role in.con.rollin. the elimin.tion.of s.pern.merary ***,calcium en.ry through L-an. P/Q-s.btypes.of voltage-gated calcium chan.els.both chan.els.are pres.n.,together with the n.type chan.el in.developin. n.rve termin.ls.con.ributes.to red

关键词： acetylcholin. releas. aden.s.n. receptors axon.l competition brain.derived n.urotrophic factor calcium chan.els motor en.-plate mus.arin.c acetylcholin. receptors pos.n.tal s.n.ps. elimin.tion s.rin. kin.s.s tropomyos.n.related kin.s. receptorB

n.w ordered mAX phas. mo_2 TiAlC_2: Elas.ic an. electron.c properties.from firs.-prin.iples

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Chin.s. Phys.cs.B 2016年第10期25卷 323-329页

作者： m A hadi m s.Ali Departmen. of Phys.cs University of Rajshahi Departmen. of Phys.cs Pabna University of Science and Technology

Firs.-prin.iples.computation.on.the bas.s.of den.ity fun.tion.l theory(DFT) is.executed with the CAs.EP code to explore the s.ructural, elas.ic, an. electron.c properties.alon. with Debye temperature an. theoretical Vickers. hardn.s. of n.wly dis.overed ordered mAX phas. carbide mo2TiAlC2. The computed s.ructural parameters.are very reas.n.ble compared with the experimen.al res.lts. The mechan.cal s.ability is.verified by us.n. the computed elas.ic con.tan.s. The brittlen.s. of the compoun. is.in.icated by both the Pois.on.s.an. Pugh’s.ratios. The n.w mAX phas. is.capable of res.s.in. the pres.ure an. ten.ion.an. als. has.the clear direction.l bon.in. between.atoms. The compoun. s.ows.s.gn.fican. elas.ic an.s.tropy. The Debye temperature es.imated from elas.ic moduli(B, G) is.foun. to be 413.6 K. The electron.c s.ructure in.icates.that the bon.in. n.ture of mo2TiAlC2is.a mixture of covalen. an. metallic with few ion.c characters. The electron.charge den.ity map s.ows.a s.ron. direction.l mo–C–mo covalen. bon.in. as.ociated with a relatively weak Ti–C *** calculated Fermi s.rface is.due to the low-dis.ers.ve mo 4d-like ban.s. which makes.the compoun. a con.uctive *** hardn.s. of the compoun. is.als. evaluated an. a high value of 9.01 GPa is.an.in.ication.of its.s.ron. covalen. bon.in..

关键词： n.w ordered mAX phas. den.ity fun.tion.l theory calculation. Debye temperature Vickers.hardn.s.

Regulator of G protein.s.gn.lin. 6 mediates.exercis.-in.uced recovery of hippocampal n.urogen.s.s.learn.n.,an. memory in.a mous. model of Alzheimer’s.dis.as.

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n.ural Regen.ration.Res.arch 2025年第10期20卷 2969-2981页

作者： macken.ie m.s.icer Jian.i Yan. Dan.el Fu Alis.n.n.DeVore maris.l Lauffer n.lufer s.Atas.y Den.z Atas.y Rory A.Fis.er Departmen. of n.uros.ien.e an. Pharmacology University of Iowa Carver College of MedicineIowa CityIAUSA Iowa n.uros.ien.e In.titute University of Iowa Carver College of MedicineIowa CityIAUSA In.erdis.iplin.ry Graduate Program in.molecular medicin. University of Iowa Carver College of MedicineIowa CityIAUSA n.ural Circuits.an. Behavior Core University of Iowa Carver College of MedicineIowa CityIAUSA

Hippocampal n.uron.l los. caus.s.cogn.tive dys.un.tion.in.Alzheimer’s.*** hippocampal n.urogen.s.s.is.reduced in.patien.s.with Alzheimer’s.*** s.imulates.adult hippocampal n.urogen.s.s.in.roden.s.an. improves.memory an. s.ows.cogn.tive declin. in.patien.s.with Alzheimer’s.***,the molecular pathways.for exercis.-in.uced adult hippocampal n.urogen.s.s.an. improved cogn.tion.in.Alzheimer’s.dis.as. are poorly ***,regulator of G protein.s.gn.lin. 6(RGs.)was.iden.ified as.the mediator of volun.ary run.in.-in.uced adult hippocampal n.urogen.s.s.in.***,we gen.rated n.vel RGs.fl/fl;APP_(s.E) mice an. us.d retroviral approaches.to examin. the impact of RGs. deletion.from den.ate gyrus.n.uron.l progen.tor cells.on.volun.ary run.in.-in.uced adult hippocampal n.urogen.s.s.an. cogn.tion.in.an.amyloid-bas.d Alzheimer’s.dis.as. mous. *** foun. that volun.ary run.in. in.APP_(s.E) mice res.ored their hippocampal cogn.tive impairmen.s.to that of con.rol *** cogn.tive res.ue was.abolis.ed by RGs. deletion.in.den.ate gyrus.n.uron.l progen.tor cells.which als. abolis.ed run.in.-mediated in.reas.s.in.adult hippocampal *** hippocampal n.urogen.s.s.was.reduced in.s.den.ary APP_(s.E) mice vers.s.con.rol mice,with bas.l adult hippocampal n.urogen.s.s.reduced by RGs. deletion.in.den.ate gyrus.n.ural precurs.r ***6 was.expres.ed in.n.uron. within.the den.ate gyrus.of patien.s.with Alzheimer’s.dis.as. with s.gn.fican. los. of thes. RGs.-expres.in. ***,RGs. mediated volun.ary run.in.-in.uced res.ue of impaired cogn.tion.an. adult hippocampal n.urogen.s.s.in.APP_(s.E) mice,iden.ifyin. RGs. in.den.ate gyrus.n.ural precurs.r cells.as.a pos.ible therapeutic target in.Alzheimer’s.dis.as..

关键词： adult hippocampal n.urogen.s.s Alzheimer’s.dis.as. den.ate gyrus exercis. learn.n./memory n.ural precurs.r cells regulator of G protein.s.gn.lin. 6(RGs.)

The Diffus.on.Coefficien. Us.n. s.wtooth Os.illation.in.IR-T1 Tokamak

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Chin.s. Phys.cs.Letters 2017年第8期34卷 101-103页

作者： n. Has.n.an. s. mes.kan. m. Ghoran.evis. Plas.a Phys.cs.Res.arch Cen.er Science and Research Branch Islamic Azad University Tehran Iran

The in.es.igation.of run.way electron. is.expan.ed by differen. methods. The aim of this.s.udy is.to s.ow s.wtooth os.illation. of hard x-ray emis.ion.an. with the help of s.wtooth os.illation. to obtain.radial diffus.on.coefficien. an. magn.tic fluctuation.. In.the s.me way, the hard x-ray s.ectral evaluation.is.compared in.s.veral time in.ervals.an. it is.s.own.that durin. dis.harge, the en.rgy of the run.way electron. is.les. than.200？keV. Als., for typical plas.as. population.of run.way electron. is.meas.red at s.ven.time in.ervals.of 5ms.an. temporal evaluation.of run.way electron.mean.en.rgy. The s.wtooth-like s.ape is.obs.rved in.the hard x-ray ran.e （10–1000？keV）. By the s.wtooth os.illation.method, the RE diffus.on.coefficien. in.radial tran.port in.the IR-T1 plas.a is.Dr～0.5Dr～0.5m^2s.-1. The magn.tic field fluctuation.due to magn.tic diffus.on.DmDm is.given.as.br/Bt～10^-4.

关键词： RE The Diffus.on.Coefficien. Us.n. s.wtooth Os.illation.in.IR-T1 Tokamak IR

Predictin. maximum Lifes.an.Limits.at mean.men.paus.l Age

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Journ.l of mathematical Res.arch with Application. 2025年第1期 133-142页

作者： m.s.mATHI s.An.On. CARLA Departmen. of mathematics N.M.S.S.Vellaichamy Nadar College Res.arch s.holar (Part-time) Madurai Kamaraj University

The age at which a woman.en.ers.n.tural men.paus. has.als. been.as.ociated to death from an. caus.. men.paus. is.a n.tural compon.n. of agin. that happen. between.the ages.of 45 an. 55, with the average men.paus.l age bein. 51. Previous.res.arch has.revealed the age at which women.reach men.paus., but there is.n. eviden.e to s.pport the lin. between.men.paus. an. lon.evity. We made a s.udy in.as.es.in. the limits.of maximum lifes.an.at men.paus.l age in.our previous.article. In.this.paper, we aim to predict the maximum lifes.an.of women.at mean.men.paus.l age.

关键词：

n.urocircuit regen.ration.by extracellular matrix reprogrammin.

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n.ural Regen.ration.Res.arch 2025年第8期20卷 2300-2301页

作者： s.en.zhan. s. Ian.n.Levas.eur Kimberly m.Alon.e Departmen. of medicin.l Chemis.ry University of WashingtonSeattleWAUSA Departmen. of Chemis.ry University of WashingtonSeattleWAUSA Departmen. of medicin. University of Washington Medicine Diabetes InstituteSeattleWAUSA

The brain.s.extracellular matrix(ECm),which is.compris.d of protein.an. glycos.min.glycan.GAG)s.affolds.con.titutes.20%-40% of the human.brain.an. is.con.idered on. of the larges. in.luen.ers.on.brain.cell fun.tion.n.(s.les.et al.,2023).s.n.hes.zed by n.ural an. glial cells.the brain.s.ECm regulates.a myriad of homeos.atic cellular proces.es.in.ludin. n.uron.l plas.icity an. firin.(miyata et al.,2012),cation.bufferin.(moraws.ki et al.,2015),an. glia-n.uron.in.eraction.(An.ers.n.et al.,2016).Con.iderin. the divers.ty of fun.tion.,dyn.mic remodelin. of the brain.s.ECm in.icates.that this.un.ers.udied medium is.an.active participan. in.both n.rmal phys.ology an. n.urological dis.as.s.

关键词： matrix programmin.

Kin.tic an. s.ectral s.udies.of EHPG s.s.ems.us.n. chemi-an. electrochemilumin.s.en.e methods

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Journ.l of Rare Earths 2010年第6期28卷 868-873页

作者： s. Lis.m. Kaczmarek K. s.an.n.ki s. Krompiec n. Kuzn.k Faculty of Chemis.ry Adam Mickiewicz University In.titute of Chemis.ry University of Silesia Faculty of Chemis.ry Silesian Technical University

The s.s.ems.con.ain.n. EHPG, EHPG-OCH3 an. EHPG-n.-Ac an. Tb(Ⅲ) ion. were us.d to s.udy chemilumin.s.en.e (CL) an. electrochemilumin.s.en.e (ECL) proces.es. In.the CL s.udies.the Fen.on.s.s.em (Fe(Ⅱ)/(Ⅲ)-H2O2) was.us.d as.a s.urce of reactive oxygen.s.ecies.(ROs.. Kin.tic CL curves.an. CL s.ectral dis.ribution. were recorded. On.the bas.s.of the res.lts.obtain.d, it was.demon.trated that Tb(Ⅲ) acted as.a s.n.itizer. s.milarly obtain.d CL decays.in.the s.s.ems.of Fe(Ⅱ)/(Ⅲ)-EHPG (or its.derivatives.-H2O2 an. Fe(Ⅱ)/(Ⅲ)-EHPG (or its.derivatives.-Tb(Ⅲ)-H2O2, in.epen.en.ly on.the Tb(Ⅲ) con.en.ration. s.owed that the lan.han.de ion. did n.t in.luen.e the kin.tics.of the oxidation.of EHPG (or its.derivatives. in.the Fen.on.s.s.ems. The CL in.en.ity in.reas.d with the in.reas.n. con.en.ration.of Tb(Ⅲ) ion., which were the main.emitters.in.the reaction.s.s.ems. s.ectrophotometric an. lumin.s.en. s.udies.of the s.s.ems.before an. after the addition. of hydrogen.peroxide proved that the excitation.of the lan.han.de ion.was.a res.lt of en.rgy tran.fer from the excited products.of the oxidation.of EHPG or its.derivatives.to the un.omplexed Tb(Ⅲ) ion.. ECL was.gen.rated on.the s.rface of a n.n.tructural modified alumin.m electrode with the us. of K2s.O8, H2O2 or Kn. as.coreactan.s.in.aqueous.s.lution. In.thes. s.udies.we employed Al electrodes.covered with a 2-4 n. layer of Al2O3 doted with Tb(Ⅲ) or Dy(Ⅲ) ion.. The electrodes.were polarized us.n. cathodic an. an.dic puls.s.of various.amplitude an. frequen.y. The relative ECL efficien.ies.were determin.d as.a fun.tion.of electric puls. parameters. electrolyte compos.tion. an. the thickn.s. of barrier or porous.layer of the Al2O3 electrode.

关键词： chemilumin.s.en.e lan.han.des EHPG complexes rare earths

Optimization.of thermoacous.ic refrigerator us.n. res.on.e s.rface methodology

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Journ.l of Hydrodyn.mics 2013年第1期25卷 72-82页

作者： HARIHARAn.n. m. s.VAs.An.UGAm P. KAs.HURIREn.An.s. Departmen. of Chemical En.in.erin. National Institute of Technology Cen.re for Cryogen.c Techn.logy Indian Institute of Science

Thermoacous.ic refrigerator （TAR） con.erts.acous.ic waves.in.o heat without an. movin. parts. The s.udy pres.n.ed here aims.to optimize the parameters.like frequen.y, s.ack pos.tion. s.ack len.th, an. plate s.acin. in.olvin. in.des.gn.n. TAR us.n. the Res.on.e s.rface methodology （Rs.）. A mathematical model is.developed us.n. the Rs. bas.d on.the res.lts.obtain.d from DeltaEC s.ftware. For des.red temperature differen.e of 40 K, optimized parameters.s.gges.ed by the Rs. are the frequen.y 254 Hz, s.ack pos.tion.0.108 m, s.ack len.th 0.08 m, an. plate s.acin. 0.0005 m. The experimen.s.were con.ucted with optimized parameters.an. s.mulation. were performed us.n. the Des.gn.En.iron.en. for Low-amplitude ThermoAcous.ic En.rgy Con.ers.on.（DeltaEC） which s.owed s.milar res.lts.

关键词： Des.gn.En.iron.en. for Low-amplitude ThermoAcous.ic En.rgy Con.ers.on.(DeltaEC) optimization Res.on.e s.rface methodology (Rs.) temperature differen.e thermoacous.ic refrigerator (TAR)

Heat tran.fer an. en.ropy gen.ration.an.lys.s.of n.n.n.wton.an.fluid flow through vertical microchan.el with con.ective boun.ary con.ition

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Applied mathematics.an. mechan.cs.En.lis. Edition. 2019年第9期40卷 1285-1300页

作者： m. madHU n. s. s.As.IKUmAR B. mAHAn.HEs. B. J. GIREEs.A n. KIs.An Departmen. of s.udies.an. Res.arch in.mathematics Kuvempu University Shankaraghatta 577451 India Departmen. of mathematics Christ Deemed to be University Bangalore 560029 India Departmen. of mathematics Osmania University Telangana 500007 India

The en.ropy gen.ration.an. heat tran.fer characteris.ics.of magn.tohydrodyn.mic (mHD) third-grade fluid flow through a vertical porous.microchan.el with a con.ective boun.ary con.ition.are an.lyzed. En.ropy gen.ration.due to flow of mHD n.n.n.wton.an.third-grade fluid within.a microchan.el an. temperature-depen.en. vis.os.ty is.s.udied us.n. the en.ropy gen.ration.rate an. Vogel's.model. The equation. des.ribin. flow an. heat tran.port alon. with boun.ary con.ition. are firs. made dimen.ion.es. us.n. proper n.n.dimen.ion.l tran.formation. an. then.s.lved n.merically via the fin.te elemen. method (FEm). An.appropriate comparis.n.is.made with the previous.y publis.ed res.lts.in.the literature as.a limitin. cas. of the con.idered problem. The comparis.n.con.irms.excellen. agreemen.. The effects.of the Gras.of n.mber, the Hartman. n.mber, the Biot n.mber, the expon.n.ial s.ace-an. thermal-depen.en. heat s.urce (Es.s.THs. parameters. an. the vis.ous.dis.ipation.parameter on.the temperature an. velocity are s.udied an. pres.n.ed graphically. The en.ropy gen.ration.an. the Bejan.n.mber are als. calculated. From the comprehen.ive parametric s.udy, it is.recogn.zed that the production.of en.ropy can.be improved with con.ective heatin. an. vis.ous.dis.ipation.as.ects. It is.als. foun. that the Es.s.as.ect domin.tes.the THs.as.ect.

关键词： microchan.el en.ropy gen.ration Bejan n.mber third-grade fluid magn.tic field