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Ethnobotanical Survey of Appetite Suppressant Plants Used in Hauts-Bassins Areas of Burkina Faso

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Food and Nutrition Sciences 2022年第12期13卷 1001-1014页

作者： Emmanuel Zongo Roland Nâg-Tiero meda Yaya Gnanou Yaya Gnanou Sami Eric kam Benjamin Kouliga Koama Pataréyaoba Alassane Ouedraogo Eliasse Zongo Ollo Da Dramane Paré Georges Anicet Ouedraogo Laboratoire de Recherche et d’Enseignement en Santé et Biotechnologies Animales Université Nazi BONI Bobo-Dioulasso Burkina Faso Laboratoire de Biochimie Centre Hospitalier Universitaire Sourou SANOU Bobo-Dioulasso Burkina Faso Laboratoire de médicine et Pharmacopée Traditionnelle Institut de Recherche en Sciences de la Santé Direction Régionale de l’Ouest Bobo-Dioulasso Burkina Faso Laboratory of Biochemistry and Applied Chemistry (LABIOCA) UFR/SVT University of Ouagadougou Ouagadougou Burkina Faso

This study aimed to list the medicinal plants used as an appetite suppressant in Hauts-Bassins areas of Burkina Faso. An ethnobotanical survey was undertaken from September to November 2021 using a semi-structured questionnaire. To determine well-known families and species, some indices such as Family Importance Value (FIV) and Relative Frequency of Citation (RFC) were calculated respectively. Sixty-seven traditional healers (41 men and 26 women) have been interviewed. The age group from 41 to 60 years old was more represented (47.76%). Fifty-eight (58) plant species belonging to 29 families and 53 genera were recorded to have appetite suppressant properties. Fabaceae family (25%) was the most mentioned followed by Combretaceae (12%). The most mentioned species were Guierasenegalensis (7.64%), Parkiabiglobosa (6.18%), Annona senegalensis and Gardenia erubescens (5.35% for both). Leaves and fruits had the highest frequencies of use with 41% and 25% respectively. The decoction (49.62%) was the main preparation method. The oral route was the only mode of drug administration. These results would contribute to strengthening the database on the medicinal plants used as an appetite suppressant by the traditional healers in Burkina Faso.

关键词： Ethnobotanical Survey Appetite Suppressant Plants Hauts-Bassins Areas Burkina Faso

南亚季风长期动力:西藏新的高分辨率的古气候记录

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南亚季风长期动力:西藏新的高分辨率的古气候记录

Antralization at the edge of proximal gastric ulcers:Does Helicobacter pylori infection play a role?

中国古生物学会第20届学术年会

作者：唐领余沈才明 kam-biu Liu J.T.Overpeck 中国科学院南京地质古生物研究所 Louisiana State University Baton RougeLA 70803USA NOAA Paleoclimatology Program National Geophysical Date CenterBoulderCO.80303USA

1993-1995年中美科学家沿成都-康定-巴塘-八宿,波密-拉萨-那曲-嘉黎以及成都-兰州-格尔木-大柴旦3条路线进行野外考察和湖泊钻孔取样,共采集现代表土花粉样品202块(点),在6个小型湖泊中打钻取样,获得了18ka以来连续湖相沉积,累计岩芯25...

1993-1995年中美科学家沿成都-康定-巴塘-八宿,波密-拉萨-那曲-嘉黎以及成都-兰州-格尔木-大柴旦3条路线进行野外考察和湖泊钻孔取样,共采集现代表土花粉样品202块(点),在6个小型湖泊中打钻取样,获得了18ka以来连续湖相沉积,累计岩芯25m。这是恢复青藏高原末次最大盛冰期以来的古植被、古气候的理想材料。本研究花粉分析采样间距为2.5-4cm,磁化率、有机质含量和CaCO等取样间距为1cm,AmSC测年取样间距约为50cm。1现代花粉谱及转换函数

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World Journal of Gastroenterology 2003年第6期9卷 1265-1269页

作者： Harry Hua-Xinag Xia Shiu Kum Lam Wai man Wong Wayne Hsing Cheng Hu kam Chuen Lai Sau Hing Wong Suet Yi Leung Siu Tsan Yuen Nicholas A.Wright Benjamin Chun-Yu Wong Department of medicine The University of Hong KongHong Kong SARChina Department of Pathology The University of Hong KongHong Kong SARChina Histopathology Unit London Research InstituteCancer ResearchUK

AIm: To determine the prevalence of antralization at the edge of proximal gastric ulcers, and the effect ofH. pylori eradication on the mucosal appearances.mETHODS: Biopsies were taken from the antrum, body and the ulcer edge of patients with benign proximal gastric ulcers before and one year after treatment. Gastric mucosa was classified as antral, transitional or body type.H. pylori positive patients receivedeither triple therapy, or omeprazole.RESULTS: Patients with index ulcers in the incisura, body or fundus (n=116) were analyzed. Antral-type mucosa was more prevalent at the ulcer edge inH. pylori-positive patients ***-negative patients (93% vs 60%, OR=8.95,95%CI: 2.47-32.4, P=0.001). At one year, there was a significant reduction in the prevalence of antralization (from 93 % to 61%, P=0.004) at the ulcer edge in patients with H. pyloribeing eradicated. However, there was no difference in the prevalence of antralization at the ulcer edge in those with persistent infection.CONCLUSION: H. pylori infection is associated with antralization at the edge of proximal gastric ulcers, which may be reversible in some patients after eradication of the infection.

关键词：胃溃疡幽门螺杆菌感染胃粘膜活组织检查

基于教学模式视角的语言学习类大规模开放在线课程研究

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开放学习研究 2019年第5期24卷 9-15页

作者：黄德铭李锦昌张馨邈(译) 香港公开大学香港999077 北京大学医学继续教育学院在线教育中心

本论文从教学模式角度探讨大规模开放在线课程(mOOCs)为语言学习提供的机遇及其面临的挑战。mOOCs自2008年推出并逐渐兴起以来,被认为具有良好的教育发展前景,它们可以同时向大量学习者提供教学。目前mOOCs采用的主要教学模式是向学习... 详细信息

本论文从教学模式角度探讨大规模开放在线课程(mOOCs)为语言学习提供的机遇及其面临的挑战。mOOCs自2008年推出并逐渐兴起以来,被认为具有良好的教育发展前景,它们可以同时向大量学习者提供教学。目前mOOCs采用的主要教学模式是向学习者提供短视频及阅读材料进行自主学习、在线讨论(主要是学习者之间的课程内容讨论)以及自动评分的测验或考试,采用这种教学模式的mOOCs称为xmOOCs。然而,语言学习一般认为最重要的是提升语言技能,xmOOC教学模式对于语言学习的成效因而受到质疑。本研究分析语言学习类mOOCs的概况,包括从主流mOOC平台选取的123门语言学习类mOOCs,并根据课程采用的教学材料和学习活动类型对其教学模式进行分析。研究结果显示,这些mOOCs主要是教授英语的课程,其中80%的课程学习时长在6小时之内。大部分课程采用典型的xmOOC教学模式,其学习活动主要包括观看视频、阅读文本材料和进行自动评分测试。少于一半(43%)的课程设有在线讨论的学习环节,但其中仅有28%的课程有教学指导者参与讨论。尽管在技术上优化了课程模式,但目前语言学习类mOOCs与传统的语言学习远程课程在教学模式上没有明显的差异。然而,不可否认的是,计算机技术支持的语言学习以及mOOCs的庞大学习者群体形成的虚拟学习社区,为学习者提升语言技能提供了机遇。

关键词： mOOCs 语言学习教学模式

Protective effects of anti-ricin A-chain antibodies delivered intracellularly against ricin-induced cytotoxicity

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World Journal of Biological Chemistry 2010年第5期1卷 188-195页

作者： Frank martiniuk Seth Pincus Sybille müller Heinz Kohler kam-meng Tchou-Wong Department of medicine New York University School of Medicine550 First AvenueNew YorkNY 10016 United States Department of Research Children's Hospital200 Henry Clay AvenueNew OrleansLA 70118United States Immpheron Inc.5235 Athens-Boonesboro RoadLexingtonKY 40509United States markey Cancer Center University of Kentucky800 Rose StreetLexingtonKY 40536-0096United States Department of Environmental medicine New York University School of Medicine57 Old Forge RoadTuxedoNY 10987United States

AIm:To evaluate the ability of anti-ricin A-chain antibodies,delivered intracellularly,to protect against ricininduced cytotoxicity in RAW264.7 cells. mETHODS:Anti-deglycosylated ricin A-chain antibody and RAC18 anti-ricin A-chain monoclonal antibody were delivered intracellularly by encapsulating in liposomes or via conjugation with the cell-penetrating mTS-transport ***264.7 cells were incubatedwith these antibodies either before or after ricin *** changes in cytotoxicity were estimated by mTT ***-localization of internalized antibody and ricin was evaluated by fluorescence microscopy. RESULTS:Internalized antibodies significantly increased cell viability either before or after ricin exposure compared to the unconjugated *** microscopy confirmed the co-localization of internalized antibodies and ricin inside the cells. CONCLUSION:Intracellular delivery of antibodies to neutralize the ricin toxin after cellular uptake supports the potential use of cell-permeable antibodies for postexposure treatment of ricin intoxication.

关键词： Ricin inhibitors Antibody internalization Cell-penetrating peptide Cell-permeable antibodies Liposome-encapsulated antibodies

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青藏高原冰帽花粉记录的气候敏感性

青藏高原冰帽花粉记录的气候敏感性

Garcinol sensitizes human head and neck carcinoma to cisplatin in a xenograft mouse model despite downregulation of proliferative biomarkers

中国古生物学会孢粉学分会第九届一次学术年会

作者：唐领余李春海杨保邵亚军 kam-biu Liu 中国科学院南京地质古生物研究所中国科学院南京地理与湖泊研究所中国科学院寒区旱区环境及工程研究所 Dep.Oceanography and Coastal Sciences School of the Coast and EnvironmentalLouisiana State University

西藏中北部的Nijingangsan、Puruogangri、Dasuopu、Guliya以及青海祁连山Dunde冰帽的冰芯中保存的孢粉是青藏高原中北部上千年至百十年的全新世气候变化和相应植被变化的灵敏记录。冰层的孢粉分析表明总孢粉浓度与夏季降雨呈正相关,与... 详细信息

西藏中北部的Nijingangsan、Puruogangri、Dasuopu、Guliya以及青海祁连山Dunde冰帽的冰芯中保存的孢粉是青藏高原中北部上千年至百十年的全新世气候变化和相应植被变化的灵敏记录。冰层的孢粉分析表明总孢粉浓度与夏季降雨呈正相关,与夏季温度呈负相关。冰心记录的高孢粉浓度表明由于轨道作用力夏季季风可能超出了其现在的界限到达西藏西北及青海地区,代表草原成分的蒿、禾本科花粉增高达40%以上,气候环境相对暖湿;而花粉浓度低,且以藜科为代表的荒漠成分高含量,反映干旱环境。冰心记录显示距今11500以前西藏中西部高的藜科含量显示干旱环境,在青海祁连山地区11ka样品孢粉浓度低(200粒/L)同样意味着晚冰期的干旱环境(Yao,et.,2004;Liu,et.,1998);西藏中部11500-9500a BP之间蒿增加应是相对湿润的环境,9500-6500a BP禾本科增加草原发育,反映夏季风增强,季节降水增多;6500a BP以后禾本科减少反映回到干旱气候环境。中全新世相对的渐温期出现在2700-2200,1500-800和600-80年。中世纪暖期出现在距今790-620年,而小冰期出现在距今330-80年。Dunde冰心2000年以来花粉记录,显示3个干旱期(ad280-640,ad1200-1370,ad1926-1986)和3个湿润期,冷暖期之间出现是小冰期(ad1650和1926),这些结果与同时段氧同位素、树年及历史气候记录基本吻合;1900a BP以后呈现与现代相似的干旱环境。近500年来西藏西北部Puruogangri冰心花粉揭示冰芯中花粉记录与现代气象观测数据的相关性,草原和草甸成分的植物花粉的百分比之和可作为夏季温度变化的良好代用指标,而莎草科/(禾本科+蒿属)[Cy/(G+A)]和草甸植物花粉/草原植物花粉(m/S)比值可作为湿度变化的代用指标。在此基础上结合冰芯δ18O值及冰川积累量,揭示了西藏西北部1450—1640 ad主要发育荒漠植被,气候表现为寒冷特征。1640-1915 ad总体上以暖干气候为主,荒漠面积减小,草原植被扩大。1915-1980 ad气候稍变冷湿,草原植被范围减小,而荒漠植被扩大。1980-2002 ad气候暖干,荒漠植被范围急剧减小,期间主要发育草甸草原植被。而小冰期出现在距今330-80年。Nijingangsan冰心每年冰层的孢粉分析表明总孢粉浓度和冰川积累量与夏季降雨呈正相关,与夏季温度呈负相关;总的孢粉浓度就是冰帽周围草原与荒漠地区有效温度和植被密度的灵敏指示物。最近70年来(1936—2007)Nijingangsan冰心花粉反映研究区荒漠化严重。主要呈现在1995-2007,1965-1945期间最严重。仅1975-1945期间草原有所发展。综上所述,冰帽中如此显著的孢粉变化表明青藏高原植被对上百年的气候变化突发的敏感性。对比Qulccaya冰帽(Bolivia)的花粉研究,最近400年来从公元1500到1700由禾本科/菊科高比值代表的湿润期以及公元1700-1880以灌丛高含量指示的干旱期,与青藏高原冰心花粉记录的湿润或干旱期时间段基本同步,仅花粉组合上有区别。

关键词：孢粉气候冰帽青藏高原敏感性

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中国药理学与毒理学杂志 2015年第S1期29卷 80-80页

作者： Feng Li muthu K. Shanmugam Kodappully Sivaraman Siveen Fan Wang Tina H. Ong Ser Yue Loo mahadeva m.m. Swamy Somnath mandal Alan Prem Kumar Boon Cher Goh Tapas Kundu Kwang Seok Ahn Ling Zhi Wang kam man Hui Gautam Sethi Department of Pharmacology Yong Loo Lin School of Medicine National University of Singapore Singapore 117957 Cancer Science Institute of Singapore Centre for Translational Medicine Singapore 117957 Division of Cellular and molecular Research Humphrey Oei Institute of Cancer Research National Cancer Centre Singapore 169610 Genome Institute of Singapore Agency for Science Technology and Research (A*STAR) Singapore Jawaharlal Nehru Centre for advanced Scientific Research Molecular Biology and Genetics Unit Transcription and Disease Laboratory Bangalore 560064 India School of Biomedical Sciences Faculty of Health Sciences Curtin University Western Australia 6009 Australia Department of Biological Sciences University of North Texas Denton Texas 76203 Department of Haematology-Oncology National University Health System Singapore 117957 College of Korean medicine Kyung Hee University Seoul 130-701 Republic of Korea

OBJECTIVE Platinum compounds such as cisplatin and carboplatin are frequently used as the first-line chemotherapy for the treatment of the head and neck squamous cell carcinoma(HNSCC).In the present study,we investigated whether garcinol,apolyisoprenylated benzophenone can chemosensitize HNSCC to *** The effect of garcinol and cisplatin on HNSCC was assessed by mTT,Western blotting,real time PCR,FACS,immunohistochemistry,DNA binding assay and xenograft mouse *** We found that garcinol inhibited the viability of a panel of diverse HNSCC cell lines,enhanced the apoptotic effect of cisplatin,suppressed constitutive as well as cisplatin-induced NF-κB activation,and downregulated the expression of various oncogenic gene products(cyclin D1,Bcl-2,survivin and VEGF).In vivo study showed that administration of garcinol alone(0.5 mg·kg-1,ip five times/week)significantly suppressed the growth of the tumor,and this effect was further increased by *** the markers of proliferation index(Ki-67)and microvessel density(CD31)were downregulated in tumor tissues by the combination of cisplatin and *** pharmacokinetic results of garcinol indicated that good systemic exposure was achievable after ip administration of garcinol at 0.5and 2mg·kg-1 with mean peak concentration(cmax)of 1825.4 and 6635.7nmol·L-1 in the mouse serum,*** Overall,our results suggest that garcinol can indeed potentiate the effects of cisplatin by negative regulation of various inflammatory and proliferative biomarkers.

关键词： HNSCC chemoresistance NF-κB proliferation garcinol

Assessment of CH4 and C 2 surface emissions from Polesgo’s landfill(Ouagadougou, Burkina Faso) based on static chamber method

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advances in Climate Change Research 2019年第3期10卷 181-191页

作者： Kayaba HARO Issoufou OUARmA Bernard NANA Antoine BERE Guy Christian TUBREOUmYA Sie Zacharie kam Patricia LAVILLE Benjamin LOUBET Jean KOULIDIATI Laboratoire de Physique et de Chimie de I'Environnement Universite Joseph Kl-ZERBOOuagadougou03 BP 7021 Ouagadougou 03Burkina Faso INRA AgroParisTech VMR ECOSYSThiverval-GrignonF-78850France Institut des Sciences Ouagadougou01 BP 1757 Ouagadougou 01Burkina Faso

methane (CH4) and carbon dioxide (C02) surface emissions from Polesgo's landfill (Ouagadougou, Burkina Faso) were measured using the static chamber technique in 2017 and 2018. The Polesgo's landfill was composed of four zones: Phase I, II, Phase III, and SP. The surface of Phase I was fully covered and its conditions are better for surface emission measurements. As results concerning the Phase I zone, the geospatial means flux rates of CH4 (657 mg m-2 h l in 2017 and 1210 mg m 2 h_, in 2018, respectively) are measured higher than the tolerable value reported in literature. The emitted CH4 or C 02 have permitted to locate higher surface emissions which are related to the cover state. The calculated gas collection efficiency (27.4% in 2017 and 23.0% in 2018) is low compared to those reported for landfills integrating landfill gas (LFG) extraction system. The carbon footprint calculations (24,966 tC02-eq 2017 and 40,025 tC02-eq in 2018, respectively) shown that Polesgo's landfill is a significant source of greenhouse gases (GHG) and its important potential for organic recovery can contribute to reduce the carbon footprint.

关键词： municipal solid waste landfilling CH4 C 02 Collection efficiency Static chamber method Carbon footprint

Antioxidant and Antimicrobial Capacities of Two medicinal Plants Used against Urinary Infections in Burkina Faso

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advances in microbiology 2022年第12期12卷 671-683页

作者： Sami Eric kam Roland Nâg-Tiéro meda Soufiane Domalick Sanou Windmi Kagambega Clarisse Ouedraogo Franck Téounviel Somda Isaac Saamou Boni Eliasse Zongo Daniel Kobo Gnada Azouman Da Benjamin Kouliga Koama Hermann Yempabou Ouoba Georges Anicet Ouedraogo Laboratoire de Recherche et d’Enseignement en Santé et Biotechnologies Animales Université Nazi Boni Bobo-Dioulasso Burkina Faso Laboratoire de Recherche en Bactériologie INSP/Centre MURAZ Bobo-Dioulasso Burkina Faso Laboratoire de médicine et Pharmacopée Traditionnelle Institut de Recherche en Sciences de la Santé Direction Régionale de l’Ouest Bobo-Dioulasso Burkina Faso

Objective: This study aimed to evaluate the antioxidant and antimicrobial capacities of extracts from Euphorbia hirta L. and Terminalia avicennioides GUILL & PERR. methodology: The crude hydro-acetonic and aqueous extracts as well their fractionations were prepared. The total phenolic, flavonoids and tannins contents were assessed using the Folin-Ciocalteu, aluminum chloride and vanillin acid methods, respectively. The antioxidant and antibacterial activities were investigated using standard methods. Results: Euphorbia hirta showed significant contents of total phenolic and flavonoids in n-Butanol (145.14 ± 1.37 GAE/100mg extracts) and ethyl acetate (23.56 ± 0.68 mg QE/ 100mg extracts) fractions. Total tannins were high in hydro-acétonique extract (11.18 ± 0.31 mg TAE/100mg extracts) and aqueous fraction (11.12 ± 0.28 mg TAE/100mg extracts) of Terminalia avicennioides stem barks. Extracts and fractions of both plants demonstrated a strongly antioxidant capacity through the free radicals scavenging and the ferric ions reducing. Concerning antimicrobial screening the extracts of Terminalia avicennioides were effective against 16 causative pathogens of urinary tract infections. Bactericidal effect against Staphylococcus aureus ATCC 29213, Staphylococcus aureus and 2 methicillin-resistant Staphylococcus haemolyticus strains was found with aqueous fraction of Terminalia avicennioides leaves. This fraction also highlighted a synergetic effect with some antibiotics used against these bacterial strains. Conclusion: Terminalia avicennioides leaves could be recommended as an herbal drug formulation for the urinary infections management.

关键词： Antimicrobial Antioxidant Euphorbia hirta L. Terminalia avicennioides GUILL & PERR Urinary Infections