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Psychiatric morbidity of Chikungunya among Children in Bangladesh

Health 2018年第1期10卷 90-94页

作者： Sanjana Zaman m.ham.ad delwer hossain hawlader Ariful Bari Chowdhury Gias U. Ahsan Institute of Child Health Mirpur Dhaka Bangladesh North South University Dhaka Bangladesh

Chikungunya occurred as a major epidemic form in Bangladesh in 2017 after a gap of 6 years. The first outbreak of Chikungunya was identified in Bangladesh in 2008. Another outbreak occurred at Dhaka in 2011. But the current outbreak is huge and effecting almost two third of the population. methods: This was a retrospective case series study, consisted of 60 children, among which 35 were male and 25 female, ages ranging from 5 to 15 years. Those children were recruited from child health care clinic with a history of two to five days’ high grade fever. All patients recruited were Igm antibody for Chikungunya positive (after 5th day of onset of fever) and on the other hand antibody for Dengue was negative. Two patients were excluded from the study due to Cerebral Palsy and Claustrophobia. Finally 58 patients were assessed. Informed written consent was obtained from all the legal guardians before data collection. Results: All patients presented with a history of two to five days’ high grade fever. The fever was preceded by a maculopapular rash over the trunk and extremities, headache, myalgia and arthralgia. Delirium (non-specified) was most prevalent psychiatric symptoms 45 (77%). Other psychiatric symptoms were Panic Disorder (56%), Phobic Disorder (36%), Neurasthenia or Fatigue syndrome (27%), Hypersomnia (13%) and Claustrophobia (5%). Conclusion: This study suggested that psychiatric morbidity among pediatric Chikungunya patients is very common. Knowledge of the pathogenesis is required to reduce the psychiatric complications and to prevent the morbidity. There is an emergence to invent the prophylactic vaccination, proper and early diagnosis of Chikungunya.

关键词： Chikungunya Dengue Psychiatric Symptoms Children Bangladesh

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High Prevalence of Vitamin D Deficiency among Bangladeshi Children: An Emerging Public Health Problem

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Health 2017年第12期9卷 1680-1688页

作者： Sanjana Zaman m.ham.ad delwer hossain hawlader Animesh Biswas mahmudul Hasan mobashera Jahan Gias U Ahsan Department of Public Health North South University Dhaka Bangladesh Center for Injury Prevention and Research Dhaka Bangladesh

Background: Recent studies suggested that vitamin D deficiency among children is widespread worldwide. most of the Asian countries are suffering from high prevalence of vitamin D deficiency, especially in children. However, the vitamin D deficiency of Bangladeshi children has not been investigated yet. The objective of the study was to assess the prevalence of vitamin D deficiency among children in Dhaka city, Bangladesh. methods: A cross-sectional study was designed. Children aged 0 month to 16 years attended Pediatrics’ clinics with minor illness were conveniently recruited. After obtaining informed written consent, venous blood was taken and serum 25(OH)D levels were determined by direct enzyme-linked immunosorbent assay. Descriptive statistics were performed for age, sex, biochemical parameters. Socio-economic status (SES) was estimated using a wealth index, producing a weighted score. Scores were categorized into quintiles, with category 1 representing the poorest and category 5 the richest. Serum 25(OH)D was categorized: deficient as Results: 31.88% children of 0 - 1 year had deficient serum 25(OH)D level and 52.17% children had insufficient level. Among 2 - 5 years’ group, 38.16% were deficient and 50% were insufficient. Among the 6 - 11 years group, 41.02% were deficient and 52.56% were insufficient. Among 12 - 16 years group, 46.75% were deficient and 51.95% were insufficient. That means, serum 25-hydroxyvitamin D deficiency and insufficiency rate is found very high among Bangladeshi children. Conclusions: The prevalence of vitamin D deficiency and insufficiency among children in Bangladesh is high. The study recommended that vitamin D supplementation in Bangladeshi children should be formally launched from first day of birth up to adolescence.

关键词： Prevalence Serum 25(OH)D Vitamin D Children Deficiency Bangladesh

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Effective antimicrobial therapies of urinary tract infections among children in low-and middle-income countries:A systematic review

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Pediatric Investigation 2023年第2期7卷 102-110页

作者： Rifat Ara Sarker m.ham.ad Nasrullah Zarrin Tasnim Sadia Afrin m.ham.ad delwer hossain hawlader Km Saif-Ur-Rahman Infectious Disease Division icddrbDhakaBangladesh maternal and Child Health Division icddrbDhakaBangladesh Public Health Professional Development Society(PPDS) DhakaBangladesh Health System and Population Studies Division icddrbDhakaBangladesh Department of Public Health North South UniversityDhakaBangladesh Evidence Synthesis Ireland and Cochrane Ireland University of GalwayGalwayIreland College of medicine Nursing and Health SciencesUniversity of GalwayGalwayIreland

Importance:Urinary tract infection(UTI)is one of the most common infections encountered in infancy and *** the emerging problem of antibiotic resistance in recent years,the use of antibiotics for better management of UTIs is ***:This study aims to explore the efficacy and adverse effects of the available antimicrobial agents that are used in pediatric UTIs in low-and middle-income countries(LmICs).methods:Five electronic databases were searched to identify relevant *** reviewers independently performed screening,data extraction,and quality assessment of the available *** controlled trials providing antimicrobial interventions in both male and female participants within the age range of 3 months to 17 years in LmICs were ***:Six randomized controlled trials from 13 LmICs were included in this review(four trials explored the efficacy).Due to high heterogeneity across the studies,a meta-analysis was not *** than attrition and reporting bias,the risk of bias was moderate to high due to poor study *** differences in the efficacy and adverse events of different antimicrobials were not found to be statistically ***:This review indicates the necessity for additional clinical trials on children from LmICs with more significant sample numbers,adequate intervention periods,and study design.

关键词： Antimicrobial agents Children Efficacy LmICs Urinary tract infection

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Descriptive Epidemiology of multidrug Resistance Tuberculosis (mDR-TB) in Bangladesh

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Journal of Tuberculosis Research 2018年第4期6卷 292-301页

作者： Abu Bakar Siddik m.ham.ad maqsud hossain Sanjana Zaman Basana marma Gias Uddin Ahsan m.ham.ad Rashed Uzzaman Arman hossain m.ham.ad delwer hossain hawlader School of Health and Life Sciences North South University Dhaka Bangladesh Genome Research Institute North South University Dhaka Bangladesh Department of Public Health North South University Dhaka Bangladesh Plan International Bangladesh Dhaka Bangladesh School of Business and Economics North South University Dhaka Bangladesh

Background: The number of reported mDR-TB cases has been increasing in recent years. Objectives: To describe the epidemiological profile of mDR-TB cases in Bangladesh. Design: This was a descriptive cross-sectional study. Settings: The study was conducted among the multi drug resistant tuberculosis patient admitted in the National Institute of Diseases of the Chest and Hospital (NIDCH) Dhaka, Bangladesh. Samples: 148 confirmed cases of mDR-TB. materials and methods: Hospital admitted mRD-TB cases were randomly chosen from the above mentioned hospital. Semi-structured and pretested questionnaire were introduced by researcher. Clinical and treatment data i.e. duration of TB drug intake, report of sputum, X-ray and blood test etc. were extracted from the hospital record. Results: Study found, majority of the participants (56.1%) were in the age group of 16 - 30 years. 64.2% of the study subjects were married. majority of the participants education were whether under primary or primary level. 24.3% participant’s family member and 14.5% of neighbor were having TB. most common comorbidity were diabetes, pulmonary infection, hearing loss, psychiatric symptoms, chest pain, joint pain etc. 63.5% respondent had high degree of AFB for sputum positivity and more than 98% had positive finding in X-ray chest. On an average ESR was low and also few cases of extremely low ESR were found. 71.6% were under twenty four months regimen. Conclusion: We can conclude that, many possible factors for mDR-TB. There is an urgent need for further study to confirm the exact factors in Bangladesh and address those immediately.

关键词： mDR-TB Risk Factors Descriptive Study Epidemiology Bangladesh

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Prevalence of Gilbert Syndrome in Bangladesh

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Open Journal of Blood Diseases 2018年第1期8卷 1-9页

作者： Sanjana Zaman Hiroko Fukushima Ryoko Suzuki m.ham.ad delwer hossain hawlader Shoji Yoshimatsu Yu Kanai Gias U. Ahsan Takashi Fukushima Department of Child Health Faculty of Medicine University of Tsukuba Tsukuba Japan Department of Public Health North South University Dhaka Bangladesh Department of Pediatrics University of Tsukuba Hospital Tsukuba Japan Department of Pediatrics National Hospital Organization Minami Kyoto Hospital Kyoto Japan

Background: Gilbert syndrome (GS) is characterized by an elevated serum bil-irubin due to a polymorphism in Uridine Diphosphate Glucuronosyl Transferase (UGT1A1) gene. Several studies have found high prevalence of Gilbert Syn-drome in some Asian countries but still haven’t explored in Bangladesh. Aim of this study was to determine the allele frequencies of two different variants of UGT1A1 polymorphisms (UGT1A1 6 and UGT1A1 28) among Bangladeshi population. materials and method: Total 150 unrelated volunteer from outpa-tient unit of the Central Hospital Limited, and Bangabandhu Sheikh mujib medical University, Dhaka were enrolled in this study. Peripheral blood was obtained from each subject and DNA extraction was done by Genomic DNA Isolation Kit. Polymorphisms of UGT1A1*6 (c.211G>A) was genotyped using the Taqman Assay-on-Demand SNP Typing System and UGT1A1*28 (c.-53_-52TA) promoter repeat number polymorphism was determined by PCR method on an ABI PRISm 3130 Genetic Analyzer. Results: 57.3% of the study participants were male, mean age of them was 4.05 years. minor allele fre-quency (mAF) was 0.442 (44.2%) for UGT1A1*28 and 0.047 (4.7%) for UGT1A1*6. Conclusion: This is the first ever study conducted among Bangla-deshi population to identify the Gilbert syndrome and found very high prevalence. Drugs those who are conjugated by UGT1A1 may lead to worse adverse event due to UGT1A1 polymorphism. Infants having decreased UGT1A1 enzyme activity develop neonatal jaundice and its further complication like Ker-nicterus. Higher incidence of Gilbert syndrome among Bangladeshi might be the alert for the clinicians treating neonatal jaundice.

关键词： Gilbert Syndrome Uridine Diphosphate Glucuronosyl Transferase

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Quality of life of COVID-19 recovered patients:a 1-year follow-up study from Bangladesh

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Infectious Diseases of Poverty 2023年第4期12卷 101-102页

作者： m.ham.ad delwer hossain hawlader md Utba Rashid md Abdullah Saeed Khan mowshomi mannan Liza Sharmin Akter m.ham.ad Ali hossain Tajrin Rahman Sabrina Yesmin Barsha Alberi Afifa Shifat mosharop Hossian Tahmina Zerin mishu Soumik Kha Sagar Ridwana maher manna Nawshin Ahmed Sree Shib Shankar Devnath Debu Irin Chowdhury Samanta Sabed mashrur Ahmed Sabrina Afroz Borsha Faraz Al Zafar Sabiha Hyder Abdullah Enam Habiba Babul Naima Nur miah md.Akiful Haque Shopnil Roy K.m.Tanvir Hassan m.ham.ad Lutfor Rahman m.ham.ad Hayatun Nabi Koustuv Dalal Department of Public Health North South University Dhaka Bangladesh International Centre for Diarrhoeal Disease Research Bangladesh Dhaka Bangladesh National Institute of Preventive and Social medicine Dhaka Bangladesh Ibn Sina medical College Hospital Dhaka Bangladesh Public Health Promotion and Development Society (PPDS) Dhaka Bangladesh Covid Vaccine Coordination Cell Directorate General of Health Services (DGHS) Dhaka Bangladesh Institute of Statistical Research and Training (ISRT) University of Dhaka Dhaka Bangladesh School of Health Sciences Division of Public Health Science Mid Sweden University Sundsvall Sweden

BackgroundThe COVID-19 pandemic posed a danger to global public health because of the unprecedented physical,mental,social,and environmental impact affecting quality of life(QoL).The study aimed to find the changes in QoL among COVID-19 recovered individuals and explore the determinants of change more than 1 year after recovery in low-resource ***-19 patients from all eight divisions of Bangladesh who were confirmed positive by reverse transcription-polymerase chain reaction from June 2020 to November 2020 and who subsequently recovered were followed up twice,once immediately after recovery and again 1 year after the first *** follow-up study was conducted from November 2021 to January 2022 among 2438 individuals using the World Health Organization Quality of Life Brief Version(WHOQOL-BREF).After excluding 48 deaths,95 were rejected to participate,618 were inaccessible,and there were 45 cases of incomplete *** statistics,paired-sample analyses,generalized estimating equation(GEE)analysis,and multivariable logistic regression analyses were performed to test the mean difference in participants’QoL scores between the two *** participants(n=1710,70.1%)were male,and one-fourth(24.4%)were older than *** average physical domain score decreased significantly from baseline to follow-up,and the average scores in psychological,social,and environmental domains increased significantly at follow-up(Padjusting for other factors,we found that older age groups(Pmale(Padmission during COVID-19 illness(Pmore chronic diseases(Pmale sex[adjusted odd ratio(aOR)=1.3,95%confidence interval(CI)1.0–1.6]were associated with reduced social domain scores on multivariable logistic regression *** or semi-urban peo

关键词： Quality of life Health-related quality of life Reverse transcription-polymerase chain reaction COVID-19 Bangladesh

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在惰性气体环境中热泵干燥食品

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干燥技术与设备 2013年第1期11卷 52-60页

作者： m.N.A.hawlader 郝博(译) 赵丽娟(校) 马来西亚伊斯兰国际大学机械工程系吉隆坡马来西亚53100 天津科技大学机械工程学院天津300222

在传统的食品干燥技术中,干燥介质是空气,干燥能力由变化的温度控制。通常,干燥过程在高温下进行,空气中氧的存在影响食品的营养物质。想要在低温条件下提高干燥能力,可以通过热泵来改善干燥环境。热泵是闭环系统,冷凝器产生的热控制干... 详细信息

在传统的食品干燥技术中,干燥介质是空气,干燥能力由变化的温度控制。通常,干燥过程在高温下进行,空气中氧的存在影响食品的营养物质。想要在低温条件下提高干燥能力,可以通过热泵来改善干燥环境。热泵是闭环系统,冷凝器产生的热控制干燥温度,蒸发器除去干燥室的水分,干燥介质在低温低湿下运行。由于整个系统在闭路下操作,为了去除空气中氧对食品的影响,采用氮气、二氧化碳等惰性气体代替空气作为干燥介质。本文主要研究:采用氮气、二氧化碳和空气干燥一些热敏性水果,如番石榴和木瓜,探讨对食品营养物质和颜色的影响,并与冷冻干燥、真空干燥的结果进行对比。

关键词：干燥惰性气体环境热敏材料水果营养物质和颜色

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抗坏血酸的微胶囊包裹:工艺过程对产品特性的影响

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食品与机械 1999年第5期 14-15页

作者： m.S.Uddin,m.N.A.hawlader,H.J.Zhu 新加坡国立大学新加坡国立大学新加坡国立大学

抗坏血酸微胶囊通过热相分离、融化分散、溶剂分离和喷雾干燥的方法制备.使用了不同的涂布材料,如乙基纤维素(EC)、巴西棕榈蜡、胶、淀粉和β-环状糊精.用扫描电子显微镜检查(SEm)、释放测试和大小分布对产品进行评价.结果表明:微胶囊... 详细信息

抗坏血酸微胶囊通过热相分离、融化分散、溶剂分离和喷雾干燥的方法制备.使用了不同的涂布材料,如乙基纤维素(EC)、巴西棕榈蜡、胶、淀粉和β-环状糊精.用扫描电子显微镜检查(SEm)、释放测试和大小分布对产品进行评价.结果表明:微胶囊包裹的抗坏血酸可防止抗坏血酸颜色变化,并且一般可遮盖其酸味;在热相分离时,EC的分子量(mw)对微胶囊包裹过程中的微胶囊聚合具有重大的影响.微胶囊的聚合作用随着EC的mw的增加而下降,释放速度在很大程度上受到EC的mw和聚异丁烯(PIB)添加量的影响.

关键词：抗坏血酸微胶囊包裹

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