检索结果-南通市图书馆

青春期阴毛早现患儿及雄激素增高症少女黑皮素-4受体(mC4R)基因突变分析

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

世界核心医学期刊文摘（妇产科学分册） 2005年第4期1卷 50-50页

作者： Roldan martin m.B. White C. Kammerer C. Witchel S.F. 朱国栋

To determine if variants in the melanocortin-4 receptor (m-C4R) gene are associated with premature pubarche (PP) in children and hyperandrogenism (ha) in adolescent girls, we performed single-strand conformational polymorphism (S-SCP) in 75 children (69 girls/six boys) with PP, 53 adolescent girls with ha, and 95 healthy adult control subjects. DNA sequence analysis of the conformers identified by SSCP revealed variants in six patients (two silent and one missense) and in none of the control subjects.

关键词：基因突变分析 mC4R 带型错义突变

羊膜移植联合丝裂霉素C进行穹隆部重建治疗重症瘢痕性眼表疾病

在线全文

学校读者我要写书评

暂无评论

世界核心医学期刊文摘（眼科学分册） 2005年第10期1卷 57-57页

作者： Tseng S.C.G. Di Pascuale m.A. Liu D.T.-S. 王永强 Ocular Su rface Center 7000 SW 97th Avenue Miami FL 33173 United States Dr.

Purpose: To investigate whether intraoperative application of mitomycin C may enhance the success of amniotic membrane transplantation in symblepharon lysis a nd fornix reconstruction in severe cicatricial ocular surface diseases. Design: Noncomparative interventional case series. Participants: Sixteen patients (8 fem ale, 8male; 18 eyes)with amean age of 41±23.4 years (range, 3-79) and sufferin g from severe chemical/thermal burns (7 eyes), multiple recurrent pterygia and p seudopterygia (5 eyes), Stevens-Johnson syndrome (4 eyes), and ocular cicatrici al pemphigoid (2 eyes) were consecutively enrolled. All except for 2 eyes had ha d prior surgical attempts of surgical reconstruction, including 6 eyes with a mu cous membrane graft (mmG), but still presented with symblepharon and persistent ocular surface inflammation. Intervention: After excision of subconjunctival fib rovascular tissues, 0.04%mitomycin C was applied for 5 minutes in the deep forn ix before amniotic membrane transplantation. main Outcome measures: Deeper forni x, noninflamed ocular surface, and full motility. Results: The mean epithelial h ealing time was 4.2±1.9 weeks. During the follow-up of 14.16±5.2 months, all eyes showed a marked reduction of conjunctival inflammation, a deep fornix, and a continuous tear meniscus. Of 12 eyes with motility restriction, 2 eyes with mu ltiple recurrent pterygia and 1 eye with severe thermal burn showed recurrence o f partial motility restriction 2 months after surgery. The vision of 9 eyes was successfully restored by an additional keratolimbal allograft with subsequent pe netrating keratoplasty (6 eyes). Conclusion: Intraoperative application of mitom ycin C is an effective means to reduce chronic and deep-seated conjunctival inf lammation, and helps amniotic membrane restore a deep fornix after symblepharon lysis, even in eyes that had a failed mmG. Restoration of deep fornix and tear m eniscus is an important prerequisite to achieve successful reconstruction

关键词：羊膜移植瘢痕性穹隆部眼表疾病复发性翼状胬肉睑球粘连同种异体角膜缘热烧伤眼球运动受限黏膜移植术

双向腔肺动脉吻合术患者在Fontan手术前的诊断性评估:应用非侵入性手段已足够?

在线全文

学校读者我要写书评

暂无评论

世界核心医学期刊文摘（心脏病学分册） 2005年第1期1卷 48-48页

作者： Ro P.S. Rychik J. Cohen m.S. J.J. Rome 高登峰 Division of Cardiology Th e Children's Hosp. of Philadelphia Philadelphia PA United StatesDr.

Objectives This study was designed to determine if a subset of patients who ha ve undergone bidirectional cavopulmonary anastomosis could be identified in whic h catheterization was of little benefit before completion of the Fontan procedur e. Background Diagnostic evaluation before Fontan procedure has typically includ ed cardiac catheterization. However, the overall management strategy for patient s with functional single ventricle has evolved to include staging bidirectional cavopulmonary anastomosis in most, and it has become uncommon to exclude patient s from Fontan based on catheterization data. methods Patients who underwent bidi rectional cavopulmonary anastomosis and had complete echocardiograms and cathete rizations within three months of each other between January 1992 and October 199 7 were evaluated with a series of clinical and echocardiographic characteristics to identify a subset in whom catheterization was predicted to be of little adde d value (“no-cath”group). The predictive value and sensitivity of these crite ria in excluding patients who required additional intervention, were excluded fr om Fontan, or died within 30 days of Fontan was determined. Results A total of 9 9 patients who underwent bidirectional cavopulmonary anastomosis at 6.7 months ( range 2.9 months to 14 years) were studied; 46 met criteria for the “no-cath” group. Noninvasive criteria stratified all patients who died (n=5) or did not pr oceed to Fontan (n =1) and 9 of 11 who required additional interventions to the “cath”group. Thus, the negative predictive value of these criteria was 93%. C onclusions Our data suggest that catheterization before Fontan could be avoided in a large percentage of patients without adversely affecting outcome; prospecti ve evaluation of this strategy is warranted.

关键词：动脉吻合术 Fontan手术导管组功能性单心室心导管检查超声检查结果超声心动图阴性预测值附加效应介入术

2009-2011年广州地区甲型H1N1流感病毒对奥司他韦耐药性分析

在线全文

学校读者我要写书评

暂无评论

中华结核和呼吸杂志 2014年第1期37卷 16-20页

作者：关文达杨子峰伍时冠王玉涛陈荣昌钟南山徐国荣李铭源罗翌李小波押谷仁鈴木陽呼吸疾病国家重点实验室广州医科大学广州医科大学附属第一医院呼吸科 510120 香港中文大学生物化学系澳门大学中华医药研究院广东省中医院急诊科广东省出入境检验检疫局检验检疫技术中心卫生检疫实验室日本东北大学大学院醫學系研究科微生物学分野

目的分析2009--2011年广州地区甲型HINl流感病毒对奥司他韦的耐药情况。方法选取2009年7月至2011年4月从广州地区分离的甲型HlNl流感病毒192株，通过对病毒的血凝素和神经氨酸酶基因进行序列测定，并利用数据库和软件进行生物信息学分... 详细信息

目的分析2009--2011年广州地区甲型HINl流感病毒对奥司他韦的耐药情况。方法选取2009年7月至2011年4月从广州地区分离的甲型HlNl流感病毒192株，通过对病毒的血凝素和神经氨酸酶基因进行序列测定，并利用数据库和软件进行生物信息学分析；测定病毒对奥司他韦的敏感度，分析广州地区甲型H1N1流感病毒的耐药情况和变异规律。结果192株中1株神经氨酸酶基因发生$247N神经氨酸酶耐药突变，对奥司他韦的敏感活性（IC）50为0。45nmol／L，比野生株下降了2．5倍。进化分析结果表明该耐药株未在广州地区流行，且与2011年初澳大利亚和新加坡流行的$247N耐药株不处于同一进化分支。结论广州地区甲型HlNl流感病毒对奥司他韦耐药的比例低，但需要加强耐药株的监测，防控来自境外输人性耐药株的传播。

关键词：流感病毒A型,HlNl亚型奥司他韦耐药性

注射方式对二维实体肿瘤中药物输运影响的数值研究

在线全文

学校读者我要写书评

暂无评论

医用生物力学 2006年第4期21卷 309-316页

作者：浏丹许世雄吴洁卫晶晶 Long Quan Collins mW Carola Koenig 蒋雨平 Padhani AR 复旦大学力学与工程科学系上海200433 Brunel Institute for Bioengineering School of Engineering and Design Brunel University UxBridge Middlesex UK 复旦大学附属华山医院上海200040 Paul Strickland Scanner Centre Mount Vernon Hospital Middlesex HA6 2RN UK

目的研究药物注射方式对二维实体肿瘤中药物输运的影响,确定较适当的注射方式。方法根据数值生成的肿瘤二维血管网,研究药物的输运。采用肿瘤中各部位药物浓度维持在最小药物浓度mEC水平以上的时间曲面下体积VUS来衡量药物的效果。对不... 详细信息

目的研究药物注射方式对二维实体肿瘤中药物输运的影响,确定较适当的注射方式。方法根据数值生成的肿瘤二维血管网,研究药物的输运。采用肿瘤中各部位药物浓度维持在最小药物浓度mEC水平以上的时间曲面下体积VUS来衡量药物的效果。对不同的施药注射方式进行了探讨。结果mEC较小时各种注射方式效果接近;mEC较大时,比较适合采用短时间集中注射方式。结论对肿瘤进行药物注射策略选取时,应根据肿瘤具体特性,以及药物施加方式对肿瘤细胞产生的不同作用来组合设计相应的优化施药方案。

关键词：二维实体肿瘤药物输运注射方式数值研究

在线全文

学校读者我要写书评

暂无评论

腐植酸和植物促生菌对甘蔗幼苗生长的影响

腐植酸 2019年第2期 49-49页

作者： R.Lotfi H.m.Kalaji G.R.Valizadeh 李发远(译) 段旭锦(译) 李海平(译) 不详山西农业大学园艺学院

试验假设,与单独施用腐植酸(ha)和植物促生菌(PGPB)相比,二者结合可以提高甘蔗幼苗产量。通过温室甘蔗扦插试验,评价了ha和PGPB结合作为农业应用的潜力。4个处理分别为对照、PGPB、ha、ha+PGPB。试验结束时(种植后60天),对植物进行生物... 详细信息

试验假设,与单独施用腐植酸(ha)和植物促生菌(PGPB)相比,二者结合可以提高甘蔗幼苗产量。通过温室甘蔗扦插试验,评价了ha和PGPB结合作为农业应用的潜力。4个处理分别为对照、PGPB、ha、ha+PGPB。试验结束时(种植后60天),对植物进行生物学特征评价。结果表明:与单独施用ha和PGPB处理相比。

关键词：植物甘蔗腐植酸评价幼苗试验

Turbo-taxonomy to assemble a megadiverse lichen genus:seventy new species of Cora(Basidiomycota:Agaricales:Hygrophoraceae),honouring David Leslie hawksworth’s seventieth birthday

在线全文

学校读者我要写书评

暂无评论

Fungal Diversity 2017年第3期84卷 139-207页

作者： Robert Lücking manuela Dal Forno Bibiana moncada Luis Fernando Coca Leidy Yasmín Vargas-mendoza André Aptroot Laura Juliana Arias Betty Besal Frank Bungartz Diego mauricio Cabrera-Amaya marcela E.S.Cáceres José Luis Chaves Sionara Eliasaro martha Cecilia Gutiérrez Jesús E.Hernández marin maría de los Ángeles Herrera-Campos maría E.Holgado-Rojas harald Jonitz martin Kukwa Fabiane Lucheta Santiago madriñán marcelo Pinto marcelli Suzana maria de Azevedo martins Joel A.mercado-Díaz Jorge Alberto molina Eduardo A.morales Peter R.Nelson Freddy Nugra Francisco Ortega Telma Paredes Ayda Lucía Patiño Rouchi Nadine Peláez-Pulido Rosa Emilia Pérez Pérez Gary B.Perlmutter Eimy Rivas-Plata Javier Robayo Camilo Rodríguez Diego Fernando Simijaca Edier Soto-medina Adriano Afonso Spielmann Alejandra Suárez-Corredor Jean-marc Torres Carlos Alberto Vargas Alba Yánez-Ayabaca Gothamie Weerakoon Karina Wilk marcela Celis Pacheco mauricio Diazgranados Grischa Brokamp Thomas Borsch Patrick m.Gillevet masoumeh Sikaroodi James D.Lawrey Botanical Garden and Botanical museum Berlin KöniginLuise-Straße 6-814195 BerlinGermany Science Education The Field Museum1400 South Lake ShoreChicagoIL 60605USA Department of Botany Smithsonian InstitutionNational Museum of Natural History10th St Constitution Ave NWWashingtonDC 20560USA Department of Environmental Science and Policy George Mason UniversityFairfaxVA 22030-4444USA Licenciatura en Biologı´a Universidad Distrital Francisco Jose´de CaldasCra.4 No.26D-54Torre de LaboratoriosHerbarioBogota´D.C.Colombia Herbario Universidad de Caldas(FAUC) Edificio BicentenarioCalle 65No.26-10ManizalesA.A.275CaldasColombia ABL Herbarium G.v.d.Veenstraat 1073762 XK SoestThe Netherlands Biologı´a Universidad del Quindı´oCarrera 15 Calle 12 NorteArmeniaQuindı´oColombia 120 Chavis Avenue LexingtonVA 24450USA Charles Darwin Foundation Puerto AyoraSanta Cruz IslandGala´pagosEcuador Schedestraße 8 53113 BonnGermany Jardı´n Bota´nico de Bogota´Jose´Celestino mutis Avenida Calle 63 No.68-95Bogota´D.C.Colombia Departamento de Biocieˆncias Universidade Federal de SergipeAvenida Vereador Olı´mpio Grandes/n.ItabaianaCEP:49.500-000 SergipeBrazil Laboratorio de Hongos Instituto Nacional de Biodiversidad(INBio)Apdo.22-3100Santo Domingo de HerediaCosta Rica Departamento de Botaˆnica Universidade Federal do Parana´Campus Polite´cnicoSetor de Cieˆncias Biolo´gicasAv.Cel.Francisco H.dos Santoss/nJardim das Ame´ricas81531-980 CuritibaPRBrazil Ingenierı´a Ambiental Universidad Distrital Francisco Jose´de CaldasCarrera 5 Este No.15-82Av.CircumvalarBogota´D.C.Colombia Instituto Experimental Jardı´n Bota´nico Dr.Tobı´as Lasser Centro de Investigacio´n y DesarrolloUniversidad Central de VenezuelaAve.Salvador AllendeJardı´n Bota´nico de CaracasApartado#2156Caracas 1010-AVenezuela Departamento de Bota´nica Instituto de Biologı´aUniversidad Nacional Auto´noma de Me´xicoApartado Postal 70-36704510 Ciudad De Me´xicoMexico Facultad de Ciencias Escuela Profesional de Biologı´aUniv

Following a large-scale phylogenetic study of the lichenized genus Cora(Basidiomycota:Agaricales:Hygrophoraceae),we formally describe 70 new species,honouring the seventieth birthday of David Leslie hawksworth,one of the preeminent figures in mycology and lichenology in the past 50 *** on an updated phylogeny using the ITS fungal barcoding locus,we now recognize 189 taxa in a genus that until recently was considered to represent a single species;including this contribution,92 of these are formally recognized,including five taxa based on historical names or collections that have not been *** of Cora can be recognized by a combination of morphological(size,colour,lobe configuration,surface hairs,hymenophore size and shape),anatomical(thallus thickness,cortex structure,photobiont type,hyphal papillae),and ecogeographical features(substrate,habitat,distribution),and a keytable allowing the identification of all accepted taxa is *** new species are:Cora accipiter moncada,madrin˜a´n&Lücking ***.,*** moncada,Soto-medina&Lücking ***.,*** moncada,Dal Forno&Lücking ***.,*** Dal Forno,Chaves&Lücking ***.,*** moncada,***ı´guez&Lücking ***.,*** Lücking,moncada&*** ***.,*** moncada,Ya´nez-Ayabaca&Lücking ***.,*** moncada,Patin˜o&Lücking ***.,*** Lücking,***&Dal Forno ***.,*** Holgado,Rivas Plata&Perlmutter ***.,*** Dal Forno,Eliasaro&Spielmann ***.,*** Nugra,Dal Forno&Lücking ***.,*** Lücking,martins&Lucheta ***.,*** moncada,R.-***´rez&Lücking ***.,*** moncada,***.&Lücking ***.,*** moncada,CabreraAmaya&Lücking ***.,*** moncada,R.-***´rez&***.,*** Lücking,***&Dal Forno ***.,*** moncada,***´rez-Corredor&Lücking ***.,*** moncada,***&Lücking ***.,***

关键词： Bolivia Citizen science Chile mexico Puerto Rico Sri Lanka

肠毒性甲氧西林耐药金黄色葡萄球菌的预防及治疗

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中华医学信息导报 2008年第13期23卷 11-11页

作者： Y Yoshida Y Sumiyama S Kusachi Y Arima H Tanaka J Sato T Saito J magao Y Saida m Watanabe 张波（译）日本东京

目的：外毒素类超抗原如中毒性休克毒素1是日本院内耐甲氧西林金黄色葡萄球菌（ha-mRSA）的主要致病因子，葡萄球菌肠毒性涉及脓毒症休克及mRSA肠炎。为控制mRSA肠毒素感染，我们研究了稳态肠道菌群。

关键词：甲氧西林耐药金黄色葡萄球菌中毒性休克耐甲氧西林金黄色葡萄球菌肠炎治疗预防外毒素类 mRSA

高致病性人禽流感H5N1透皮疫苗免疫佐剂的初步筛选

在线全文

学校读者我要写书评

暂无评论

现代免疫学 2009年第4期29卷 288-295页

作者：孙艳丽孙艳花马安伦鹿文葆陈惠方王希良军事医学科学院微生物流行病研究所病原做生物生物安全国家重点实验室北京100071 苏州大学附属第一医院江苏省血液研究所苏州215006 蒙特利尔大学Notre-Dame医院外科实验室蒙特利尔H2L4M1加拿大

用不同的佐剂与高致病性人禽流感H5N1全病毒疫苗混合,通过透皮途径免疫BALB/c小鼠并评价其免疫应答效果,从而初步筛选出较好的透皮免疫佐剂。实验选用CT、CpG ODN1826、CpG ODN2006、mF59四种不同的佐剂按适当的比例与高致病性人禽流感H... 详细信息

用不同的佐剂与高致病性人禽流感H5N1全病毒疫苗混合,通过透皮途径免疫BALB/c小鼠并评价其免疫应答效果,从而初步筛选出较好的透皮免疫佐剂。实验选用CT、CpG ODN1826、CpG ODN2006、mF59四种不同的佐剂按适当的比例与高致病性人禽流感H5N1灭活全病毒抗原混合制成透皮疫苗,透皮免疫BALB/c小鼠,检测血清IgG抗体效价、血清中和抗体效价,以及肺、鼻灌洗液中特异性IgG和IgA抗体效价,并对脾淋巴细胞分泌的IFN-γ和IL-4细胞因子水平进行评估。结果显示,在CpG ODN1826单独使用或与CT合用组血清IgG抗体效价较无佐剂组均有显著升高(Pha组血清IgG抗体效价最高,同时血清中和抗体效价也验证了这一点,肺、鼻灌洗液中,均可检测到特异性IgA、IgG。佐剂组与无佐剂组、PBS组、空白对照组相比较,脾淋巴细胞分泌IFN-γ和IL-4的水平均见提高(Pha组与滴鼻组相比无统计学意义(P=0.2267)。结果表明,在高致病性人禽流感H5N1病毒透皮疫苗的小鼠模型中,CT与CpG ODN1826是较好的的透皮免疫佐剂,能够诱导机体Th2型和Th1型免疫应答,同时诱导了黏膜免疫应答的产生,这为进一步研究提供了基础。

关键词：高致病性人禽流感疫苗霍乱毒素免疫佐剂透皮免疫免疫应答