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RUFY4 deletion prevents pathological bone loss by blocking endo-lysosomal trafficking of osteoclasts

Bone Research 2024年第2期12卷 407-420页

作者： minhee Kim Jin Hee Park miyeon Go Nawon Lee Jeongin Seo hana Lee Doyong Kim Hyunil ha Taesoo Kim myeong Seon Jeong Suree Kim Taesoo Kim han Sung Kim Dongmin Kang Hyunbo Shim Soo Young Lee Department of Life Science Ewha Womans UniversitySeoul 03760South Korea The Research Center for Cellular Homeostasis Ewha Womans UniversitySeoul 03760South Korea Department of Biomedical Engineering Yonsei UniversityWonju 26493South Korea Km Convergence Research Division Korea Institute of Oriental MedicineDaejeon 34054South Korea Chuncheon Center Korea Basic Science InstituteChuncheon 24341South Korea Fluorescence Core Imaging Center and Bioimaging Data Curation Center Ewha Womans UniversitySeoul 03760South Korea multitasking macrophage Research Center Ewha Womans UniversitySeoul 03760South Korea

mature osteoclasts degrade bone matrix by exocytosis of active proteases from secretory lysosomes through a ruffled ***,the molecular mechanisms underlying lysosomal trafficking and secretion in osteoclasts remain largely ***,we show with GeneChip analysis that RUN and FYVE domain-containing protein 4(RUFY4)is strongly upregulated during *** lacking Rufy4 exhibited a high trabecular bone mass phenotype with abnormalities in osteoclast function in ***,deleting Rufy4 did not affect osteoclast differentiation,but inhibited bone-resorbing activity due to disruption in the acidic maturation of secondary lysosomes,their trafficking to the membrane,and their secretion of cathepsin K into the extracellular ***,RUFY4 promotes late endosome-lysosome fusion by acting as an adaptor protein between Rab7 on late endosomes and LAmP2 on primary ***,Rufy4-deficient mice were highly protected from lipopolysaccharide-and ovariectomy-induced bone ***,RUFY4 plays as a new regulator in osteoclast activity by mediating endo-lysosomal trafficking and have a potential to be specific target for therapies against bone-loss diseases such as osteoporosis.

关键词： osteoclast inhibited traffic

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morbidity and mortality of Acute Renal Failure in COVID-19 Patients in Intensive Care According to Waves/Variant: Case of the Grand Hôpital de l’Est Francilien Site de meaux

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Open Journal of Internal medicine 2024年第1期14卷 16-29页

作者： Khazy Anga Ariel makembi Éric Amisi Éric Delpierre Vivien Hong Tuan ha Wilfrid mbombo Jean Claude mubenga Dan Kankonde Chris Nsituavibidila Lionel Diyamona Noelly mukuna Gracia Likinda Tharcisse mabiala martin mukenga médard Bula-Bula Berthe Barhayiga Département d’Anesthésie Réanimation Université de Kinshasa Kinshasa République démocratique du Congo Service de Réanimation Grand H&ocircpital de l’Est Francilien Meaux France Département de médecine Interne Université de Kinshasa Kinshasa République démocratique du Congo Service d’Anesthésie Réanimation Centre Hospitalier Monkole Kinshasa République démocratique du Congo Department of Anaesthesia and Intensive Care H&ocircpital Général de Référence de Kinshasa Kinshasa République démocratique du Congo Department of Anaesthesia and Intensive Care Université Protestante du Congo Kinshasa République démocratique du Congo

Introduction: The incidence of acute renal failure (ARF) varies between 20% and 40% of cases for COVID-19 patients admitted to the intensive care unit, with very high mortality, but heterogeneous according to the different epidemic waves, probably due to the genetic variant phenomenon of the virus. The aim of this study is to determine the morbidity and mortality of COVID-19 patients admitted with ARF to the intensive care unit of the Grand H?pital Est Francilien (GHEF) according to the waves and variants. methods: Cross-sectional observational study of COVID-19 patients with ARF admitted to the intensive care unit of the GHEF site in meaux covering the period from march 1st 2020 to December, 31st 2021. Per-hospitalisation and outcome data were collected and analysed with SPSS version 25.0 software using the Chi-square or Fischer’s exact test or Student’s t-test and logistic regression for p Results: A total of 86 patients were included. The mean age was higher (70 ± 8.5) in patients in the fourth wave than in the other waves (p = 0.015), with male predominance in all waves without significant difference. Co-morbidities: hypertension, diabetes, heart disease, dyslipidaemia and arrhythmia complete with fibrillation were present in all waves. The majority of patients were classified as KDIGO 1 for the different waves (1st: 61.9%, 2nd: 86.5%, 3rd: 80%, and 4th: 75%), with the same trend according to variant (alpha: 80%, beta: 75%, delta: 81.3%, omicron: 75%). mortality by the wave was: 1st: 28.5%, 2nd: 37.5%, 3rd: 23% and 4th: 11%) and by variant: alpha: 24.2%, beta: 44.8%, delta: 20.7%, omicron: 10.3%). Overall mortality was 33.7%. Case fatality was higher in the fourth wave. Hypertension, shock, failure to recover renal function, acute lung oedema, ventilator-associated lung disease and hyperkalaemia were factors associated with mortality (p Conclusion: Acute renal failure is common in COVID-19 patients admitted to the intensive care unit, and m

关键词： mortality COVID-19 morbidity Renal Failure Intensive Care Unit

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KoNA:Korean Nucleotide Archive as A New Data Repository for Nucleotide Sequence Data

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Genomics, Proteomics & Bioinformatics 2024年第1期22卷 161-167页

作者： Gunhwan Ko Jae Ho Lee Young mi Sim Wangho Song Byung-ha Yoon Iksu Byeon Bang Hyuck Lee Sang-Ok Kim Jinhyuk Choi Insoo Jang Hyerin Kim Jin Ok Yang Kiwon Jang Sora Kim Jong-Hwan Kim Jongbum Jeon Jaeeun Jung Seungwoo Hwang Ji-Hwan Park Pan-Gyu Kim Seon-Young Kim Byungwook Lee Korea Bioinformation Center Korea Research Institute of Bioscience&BiotechnologyDaejeon 34141Republic of Korea

During the last decade,the generation and accumulation of petabase-scale high-throughput sequencing data have resulted in great challenges,including access to human data,as well as transfer,storage,and sharing of enormous amounts of *** promote data-driven biological research,the Korean government announced that all biological data generated from government-funded research projects should be deposited at the Korea BioData Station(K-BDS),which consists of multiple databases for individual data ***,we introduce the Korean Nucleotide Archive(KoNA),a repository of nucleotide sequence *** of July 2022,the Korean Read Archive in KoNA has collected over 477 TB of raw next-generation sequencing data from national genome *** ensure data quality and prepare for international alignment,a standard operating procedure was adopted,which is similar to that of the International Nucleotide Sequence Database *** standard operating procedure includes quality control processes for submitted data and metadata using an automated pipeline,followed by manual *** ensure fast and stable data transfer,a high-speed transmission system called GBox is used in ***,the data uploaded to or downloaded from KoNA through GBox can be readily processed using a cloud computing service called *** seamless coupling of KoNA,GBox,and Bio-Express enhances the data experience,including submission,access,and analysis of raw nucleotide *** not only satisfies the unmet needs for a national sequence repository in Korea but also provides datasets to researchers globally and contributes to advances in *** KoNA is available at https://***/kona/.

关键词： Korea BioData Station Nucleotide sequence Next-generation sequencing repository Genomics Deposition and access of big data

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Dysprosium oxide,alumina,and graphene oxide reinforced polycaprolactone thin films:Thermal stability,morphology,and cell viability

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Journal of Rare Earths 2024年第7期42卷 1337-1343,I0005页

作者： mohamed Tharwat Elabbasy mohamed R.Atteya mai A.Samak mousa Abdelrahman Tahani Almahmoud m.A.El-morsy A.A.menazea m.F.H.Abd El-Kader Department of Public Health College of Public Health and Health InformaticsUniversity of Ha'ilHa'il2440Saudi Arabia Food Control Department Faculty of Veterinary MedicineZagazig UniversityZagazig44519Egypt Department of Physical Therapy College of Applied Medical SciencesUniversity of Ha'ilHa'ilSaudi Arabia Department of Histology and Cell Biology Faculty of MedicineZagazig UniversityZagazig44519Egypt College of Nursing University of Ha'ilHa'ilSaudi Arabia College of Science and Humanities in Al-Kharj Physics DepartmentPlasma Technology and Material Science UnitPrince Sattam Bin Abdulaziz UniversityAl-kharj11942Saudi Arabia Physics Department Faculty of ScienceUniversity of DamiettaNew Damietta34517Egypt Spectroscopy Department Physics Research InstituteNational Research CentreDokki12622GizaEgypt Biophysics Department Faculty of ScienceCairo UniversityGizaEgypt

Developing a biomaterial for wound healing applications is still a ***,dysprosium oxide(Dy_(2)O_(3)),aluminum oxide(Al_(2)O_(3)),and graphene oxide(GO)were embedded in cast films based on polycaprolactone(PCL)to be examined for wound dressing *** techniques were used to characterize the fabricated films including X-ray diffraction(XRD),Fourier transform infrared spectroscopy(FTIR),Raman,and scanning electron microscopy(SEm),besides their biological *** thermogravimetric analysis(TGA)exhibits high thermal stability as the scaffold weight decreases slightly to 98.6%after raising the temperature from room temperature to 280℃.The cell viability was investigated and it is shown that the viable cells grow up to approximately 93%at 75μg/***,the cell attachment shows excellent behavior as the cells attach on most of the surface of the modified PCL which shows high biocompatibility.

关键词： Wound healing Polycaprolactone Dy_(2)O_(3) Al_(2)O_(3) Biocompatible Rare earths

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PCL/ha静电纺丝纤维涂层对可降解mg/ha复合材料的表面改性:力学性能、腐蚀和生物相容性

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Transactions of Nonferrous metals Society of China 2024年第5期34卷 1470-1486页

作者： m.ShamSI m.SEDIGHI A.BAGHERI School of mechanical Engineering Iran University of Science and TechnologyTehranIran

采用搅拌铸造和挤压法制备mg/ha复合材料,并在其表面采用静电纺丝法涂覆聚己内酯/羟基磷灰石(PCL/ha)纤维(2.5%和5%ha,质量分数),以提高其耐腐蚀性。力学性能测试结果表明,复合材料的压缩屈服强度从73mPa(纯镁)提高到151mPa,提高了107%... 详细信息

采用搅拌铸造和挤压法制备mg/ha复合材料,并在其表面采用静电纺丝法涂覆聚己内酯/羟基磷灰石(PCL/ha)纤维(2.5%和5%ha,质量分数),以提高其耐腐蚀性。力学性能测试结果表明,复合材料的压缩屈服强度从73mPa(纯镁)提高到151mPa,提高了107%。SEm、EDS和XRD分析表明,ha颗粒分布在多孔涂层中。极化曲线结果表明,涂层试样的耐腐蚀性能均优于未涂覆试样。PCL涂层使样品的腐蚀电流密度降低了两个数量级。通过极化和体外腐蚀试验证明了ha在涂层中的有效性。涂层和随后形成的Ca-P层阻碍了模拟体液与基体的接触和渗透,从而起到保护表面的作用。PCL/2.5%ha涂层样品的腐蚀速率最低,其平均值为0.98mm/a,与未涂层样品相比,在14天内减少了81%。根据3天mTT结果,使用PCL/2.5%ha涂层可使细胞活性从43%提高到121%。综上,涂覆PCL/2.5%ha纤维的mg/ha复合材料在生物可吸收植入物方面具有广阔的应用前景。

关键词：镁基复合材料复合涂层生物可降解羟基磷灰石聚己内酯纤维

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Post-fire recovery of Puya raimondii, vegetation and birds in the puna of Huascarán National Park, Perú

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Journal of mountain Science 2024年第1期21卷 20-32页

作者： mery L.SUNI Giovana P.VADILLO César ARANA Enoc JARA-PENA Letty SALINAS m.Estela PONCE Paul m.RAmSAY Plant Physiology Laboratory Faculty of Biological SciencesUniversidad Nacional Mayor de San MarcosLima 15081Peru Natural History museum Universidad Nacional Mayor de San MarcosLima 15072Peru Applied Phytology Laboratory Faculty of Biological SciencesUniversidad Nacional Mayor de San MarcosLima 15081Peru Department of Statistics Faculty of Mathematical SciencesUniversidad Nacional Mayor de San MarcosLima 15081Peru Department of Chemical and Biological Sciences Universidad de las Américas PueblaSan Andrés Cholula CP Cholula CP 72810Mexico

A large fire of 233 ha in Huascarán National Park in Peru provided an opportunity to compare plant and bird responses in burned and nearby unburned zones of the puna. Heights and live diameters of flagship Puya raimondii rosettes(assigned to four broad developmental phases), plant communities(66 species in 24 families and nine growth forms) and bird communities(77 species in six trophic guilds) were monitored after the fire. Although no mortality was observed, Puya raimondii plants were affected by the fire, losing approximately 60% of their photosynthetic area across all developmental phases, but recovered quickly during the first two years after fire. The comparison of Puya rosette recovery after fire was complicated by the changes in live rosette diameter for unburned plants, which showed plasticity of photosynthetic area linked to seasonal and annual fluctuations in precipitation in this relatively dry environment(decreased by 26% for mature adult plants over the study period). Fire caused an immediate change in the density, biomass and composition of vegetation. Although the species present remained similar, their abundances changed significantly immediately after the fire, with notable reductions in dominant tussock grasses. This provided opportunities for other plants, resulting in higher postfire diversity of plant species, genera, families and growth forms. In turn, the changes in vegetation after fire affected the composition of birds according to their trophic guild. Granivores largely disappeared,generalists were mostly unaffected, and other guilds showed a more complex response. As the vegetation recovered, most displaced birds returned within approximately one year.

关键词： Burning Plant biomass Trophic guilds Andes Giant rosette plants

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维生素D缺乏与糖尿病肾病相关性研究

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新疆医学 2024年第5期54卷 509-513,565页

作者：哈晓文姜鸿新疆维吾尔自治区人民医院肾病科乌鲁木齐830001

目的通过单中心研究评估不同疾病阶段糖尿病肾病(DKD)患者维生素D缺乏的患病率,同时探索导致DKD患者出现维生素D缺乏的潜在的危险因素及其相关性。方法纳入437名不同糖尿病肾病分期的患者及100名体检人员作为健康对照组,对比两组25-羟... 详细信息

目的通过单中心研究评估不同疾病阶段糖尿病肾病(DKD)患者维生素D缺乏的患病率,同时探索导致DKD患者出现维生素D缺乏的潜在的危险因素及其相关性。方法纳入437名不同糖尿病肾病分期的患者及100名体检人员作为健康对照组,对比两组25-羟基维生素D(25[OH]D)水平。根据25[OH]D水平分组,进行分析对比并进一步探究25[OH]D缺乏的独立风险因素。结果糖尿病肾病各期患者较健康对照组25[OH]D均有降低,BUN每升高1mmol/L,其25[OH]D缺乏的风险较前提高了近118%;TC每增高1mmol/L其患25[OH]D缺乏的风险则会提高近30%;高脂血症与25[OH]D缺乏的发生呈正相关,TG每增高1mmol/L,其发生25[OH]D缺乏的发生率增高近67%;HbA1c每升高1%其发生25[OH]D缺乏的风险增加近60%。eGFR每降低1mL/min/1.73m2其25[OH]D缺乏的发生率升高97.2%。结论血清25[OH]D水平有可能成为糖尿病肾病疾病进展情况的有力的预测因子。

关键词：糖尿病肾病 25-羟基维生素D 慢性肾脏病

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Effects of material and Dimension on TCF,Frequency,and Q of Radial Contour mode AlN-on-Si mEmS Resonators

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Journal of Electronic Science and Technology 2021年第4期19卷 319-334页

作者： Thi Dep ha with the Faculty of Electronics Technology Industrial University of Ho Chi Minh CityHo Chi Minh City 70000

This paper investigates the effects of material and dimension parameters on the frequency splitting,frequency drift,and quality factor(Q)of aluminium nitride(AlN)-on-n-doped/pure silicon(Si)microelectromechanical systems(mEmS)disk resonators through analysis and *** parameters include the crystallographic orientation,dopant,substrate thickness,and *** resonators operate in the elliptical,higher order,and flexural *** simulation results show that i)the turnover points of the resonators exist at 55°C,-50°C,40°C,and-10°C for n-doped silicon with the doping concentration of 2×1019 cm-3 and the Si thickness of 3.5μm,and these points are shifted with the substrate thickness and mode variations;ii)compared with pure Si,the modal-frequency splitting for n-doped Si is higher and increases from 5%to 10%for all studied modes;iii)Q of the resonators depends on the temperature and ***,the turnover,modal-frequency splitting,and Q of the resonators depend on the thickness and material of the substrate and the *** work offers an analysis and design platform for high-performance mEmS gyroscopes as well as oscillators in terms of the temperature compensation by n-doped Si.

关键词： Anisotropic contour mode doping gyroscope microelectromechanical systems(mEmS)resonator piezoelectric temperature coefficient of frequency(TCF) temperature compensation thin-film piezoelectric-on-substrate(TPoS)

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Biocompatibility evaluation in vitro. Part III: Cytotoxicity expression of human and animal osteoblasts on the biomaterials

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Journal of Central South University 2001年第3期13卷 147-155页

作者： RUAN Jian-ming 1,m.H. Grant 2 (1. State Key Laboratory for Powder metallurgy, Central South University, Changs ha 410083, China 2. Bioengineering Unit, Strathclyde University, Glasgow, G4 0NW, UK) State Key Laboratory for Powder metallurgy Central South University Changsha China Bioengineering Unit Strathclyde University Glasgow UK

Exclusion and inflammation in the clinic are observe d for various reas ons including material che- mical composition, physical properties as well a s macr o- and micro-structure of the implants, surface condition of the implants, and also patient dependent factors. Cytotoxicity expression of cells is a central issue i n current biocompatibility to screen the potential implant materials and drugs. This study was aimed at investigation reaction between the potential implant mat erials and surround tissue. Cytotoxicity of human and rat osteoblast in the mate rial extracts was determinated by testing standards such as GHS assay, mTT assay , alkaline phosphatase activity assay, LDH assay, and Lowry assay. Research resu lts demonstrated that compared with the control condition polystyrene culture pl a te both human and rat osteoblast cells have normal phenotypic expression in hydr oxyapatite extract, and this expression was statistically restricted in hydroxya patite-spinel extract. How- ever, this restrict, e.g. cytotoxicity could be partially eliminated by immersion treatment of the materials in culture medium.

关键词： biomaterial cytotoxicity biological molecular technique

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应用剪切波离散成像斜率值预测移植肾急性排异反应

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国际医学放射学杂志 2024年第5期 620-621页

作者： T.m.Kim H.Ahn J.Y.Cho A.han S.I .min J.ha 郑永利

目的评价剪切波离散成像斜率值预测移植肾功能不全的价值。方法回顾性分析2022年11月—2023年2月期间行肾移植的128例受试者资料[中位年龄，55(43～62)

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