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Effects of Traditional Herbal Formulae on Human CYP450 Isozymes

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Chinese Journal of Integrative medicine 2017年第1期23卷 62-69页

作者： Seong Eun Jin Hyekyung ha Hyeun-Kyoo Shin K-Herb Research Center Korea Institute of Oriental MedicineDaejeon 34054Republic of Korea

Objective：To assess the effects of traditional herbal formulae Sijunzi Decoction（四君子汤,Sagunja-tang,SJZD）,Siwu Decoction（四物汤,Samul-tang,SWD）,Bawu Decoction（八物汤,Palmul-tang,BWD）and Shiquan Dabu Decoction（十全大补汤,Sipjeondaebo-tang,SDD）on the activities of human cytochrome P450（CYP450）,a drug-metabolizing ***：Herbal formula water extracts were filtered and lyophilized after the powder extracts were dissolved in distilled *** activities of major human CYP450isozymes（CYP3A4,CYP2C19,CYP2D6 and CYP2E1）were measured using in vitro fluorescence-based enzyme *** inhibitory effects of the herbal formulas on the activities of CYP450 were characterized as half maximal inhibition concentration（IC50）***：All the tested herbal formulae inhibited CYP2C19activity（IC50：SJZD,83.28μg/m L;SWD,235.54μg/m L;BWD,166.82μg/m L;SDD,178.19μg/m L）;SJZD（IC50=196.46μg/m L）,SWD（IC50=333.42μg/m L）and SDD（IC50=163.42μg/m L）inhibited CYP2E1-mediated metabolism;whereas BWD exhibited comparatively weak inhibition of CYP2E1（IC50=501.78μg/m L）.None of the four herbal formulas significantly affected CYP3A4 or ***：These results suggest that SJZD,SWD,BWD and SDD could potentially inhibit the metabolism of co-administered synthetic drugs whose primary route of elimination is via *** addition,clinically relevant pharmacokinetic interactions could occur when SJZD,SWD or SDD is co-administered with drugs metabolized by *** findings provide information for the safety and effective clinical use of these four classic herbal formulas.

关键词： cytochrome P450 Sijunzi Decoction Siwu decoction Bawu Decoction Shiquan Dabu Decoction,herb-drug interactions

Experimental Investigation of Flexible hawkmoth-like Wings on the Wing-wake Interaction in Hovering Flight

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Journal of Bionic Engineering 2018年第1期15卷 139-153页

作者： YeongGyun Ryu Jo Won Chang Joon Chung Dong-ha Kim Department of Aerospace Engineering Ryerson University Toronto Ontario M5B 2K3 Canada Department of Aeronautical Science and Flight Operation Korea Aerospace University 76 Hanggongdaehak-ro Deogyang-gu Goyang-si Gyeonggi-do 10540 Republic of Korea Aerodynamics Group Korean Air R&D Center Daejeon Metropolitan City 34054 Republic of Korea

To study wing-wake interaction for various wing flexibilities, force measurements and digital particle image velocimetry were carried out on flapping hawkmoth-like wings in a water tank. Wing thickness was employed as a design variable for the wing flexi- bility distributions. Abrupt flap-down and phase delay in flexible wings influenced the behaviors of the Leading-Edge Vortex （LEV） and Trailing-Edge Vortex （TEV）, generated by the previous stroke. While the rigid wing exhibited a detached LEV at the end of the stroke, wing with specific flexibilities obtained attached LEVs. The attached LEVs induced a relatively rapid flow toward the wing surface as a result of encountering the TEV, and the flow caused a higher lift peak. On the other hand, the wings with larger wing deformations generated distinctive changes in LEV and TEV behaviors. The flap-down helped the TEV form closer to the wing surface, and it thus caused a downwash rather than wing-wake interaction. Furthermore, the most flexible wing had a newly-formed pair of LEVs above the wing during the wing reversal, thereby being not able to generate the wing-wake interaction. These results help to understand the different vortex structures generated by flexible wings during the wing reversal and the corresponding effects of wing-wake interaction.

关键词： hovering flight flexible hawkmoth wings wing-wake interaction Digital Particle Image Velocimetry (DPIV)

On the System Performance of mobile Edge Computing in an Uplink NOmA WSN With a multiantenna Access Point Over Nakagami-m Fading

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IEEE/CAA Journal of Automatica Sinica 2022年第4期9卷 668-685页

作者： Van-Truong Truong Van Nhan Vo Dac-Binh ha Chakchai So-In the Faculty of Electrical-Electronic Engineering Duy Tan University the Institute of Research and Development Duy Tan University the Faculty of Information Technology Duy Tan University IEEE the Applied Network Technology(ANT)Laboratory Department of Computer ScienceCollege of ComputingKhon Kaen University

In this paper,we study the system performance of mobile edge computing(mEC)wireless sensor networks(WSNs)using a multiantenna access point(AP)and two sensor clusters based on uplink nonorthogonal multiple access(NOmA).Due to limited computation and energy resources,the cluster heads(CHs)offload their tasks to a multiantenna AP over Nakagami-m *** proposed a combination protocol for NOmA-mEC-WSNs in which the AP selects either selection combining(SC)or maximal ratio combining(mRC)and each cluster selects a CH to participate in the communication process by employing the sensor node(SN)*** derive the closed-form exact expressions of the successful computation probability(SCP)to evaluate the system performance with the latency and energy consumption constraints of the considered *** results are provided to gain insight into the system performance in terms of the SCP based on system parameters such as the number of AP antennas,number of SNs in each cluster,task length,working frequency,offloading ratio,and transmit power ***,to determine the optimal resource parameters,i.e.,the offloading ratio,power allocation of the two CHs,and mEC AP resources,we proposed two algorithms to achieve the best system *** approach reveals that the optimal parameters with different schemes significantly improve SCP compared to other similar *** use monte Carlo simulations to confirm the validity of our analysis.

关键词： mobile edge computing(mEC) Nakagami-m fading offloading selection combining(SC)/maximal ratio combining(mRC) successful computation probability(SCP) uplink nonortho-gonal multiple access(NOmA) wireless sensor networks(WSNs)

mesomorphic behavior of new azomethine liquid crystals having terminal iodo group

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Chinese Chemical Letters 2011年第3期22卷 260-263页

作者： Sie-Tiong ha Teck-Leong Lee Guan-Yeow Yeap masato m.Ito Ayumu Saito masaaki Watanabe Department of Chemical Science Faculty of ScienceUniversiti Tunku Abdul RahmanJln UniversitiBandar Barat31900 KamparPerakMalaysia Liquid Crystal Research Laboratory School of Chemical SciencesUniversiti Sains Malaysia11800 MindenPenangMalaysia Faculty of Engineering Soka University1-236 Tangi-choHachiojiTokyo 192-8577Japan

A series of azomethine esters,3-hydroxy-4-{[（4-iodophenyl）imino]methyl}phenyl alkanoates possessing even number of carbon atoms at the terminal alkanoyloxy chain（C_（n-1）H_（2n-1）COO-,n = 4,6,8,10,12,14） was synthesized.n-Butanoyloxy was found non-mesogenic,whilst n-hexanoyloxy to n-tetradecanoyloxy exhibited enantiotropic smectic A phase with fan-shaped *** was found that the length of terminal alkanoyloxy chain influenced the mesomorphic properties.

关键词： Liquid crystals Azomethine ester Enantiotropic Smectic A

harmful effects of pyrethroid ester insecticide on the male reproductive system mainly through affecting testicular function and inflammatory markers

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BIOCELL 2020年第1期44卷 111-115页

作者： ha ABDEL mAKSOUD mk mAHFOUZ mi SOLImAN mohamed G ELhaRRIF m ABBASS ma EL-BADRY Department of Biochemistry Benha UniversityBenhaEgypt Department of Basic medical Sciences Shaqra UniversityShaqraaSaudi Arabia

Pyrethroid esters are widely used as insecticides worldwide. In this study, we aimed to evaluate the harmful effect of deltamethrin on the male reproductive system through the assessment of reproductive hormones, inflammatorymarkers, and testicular function. To achieve our aim, eighty male 7-9-week-old, Wistar rats were taken, weighed, and divided into four experimental groups. The first group was kept as a control group, and the other three groups were given deltamethrin orally at different concentrations (0.87, 8.7, and 17.4 mg/kg body weight) for nine weeks. The resultsindicated that deltamethrin administration associated with a significant decrease in reproductive hormones, especially FSH, LH, and significant elevation in the interleukin 2 (IL2), interleukin 6 (IL6), histamine, and cortisol levels. Also, thesignificance of inhibition of sperm motility and viability, decreased testis weights, sperm count, and fructose in semen were noted. These findings clarify the harmful effect of deltamethrin on the male reproductive system by producing a significant alteration in reproductive hormones, inflammatory markers as well as testicular function.

关键词： Deltamethrin Reproductive hormones Inflammatory markers

Going only half the way:cell cycle exit after the G1 restriction point

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Signal Transduction and Targeted Therapy 2024年第1期9卷 1-2页

作者： Lisa muller Tony Gutschner mechthild hatzfeld Department of Pathobiochemistry Institute of Molecular MedicineMartin Luther University Halle-WittenbergCharles Tanford Protein Research CenterHalleGermany Department of RNA Biology and Pathogenesis Institute of Molecular MedicineMartin Luther University Halle-WittenbergCharles Tanford Protein Research CenterHalleGermany

In a recent article published in Nature,James *** et *** that cyclin A2 levels determine whether cells will make an entrance into mitosis or whether cells will leave the cell cycle after having passed the G1/restriction(R)-point implicating that the decision is fully reversible(Fig.1).This ground-breaking study could impact future approaches for cancer treatment by targeting the mitotic clock.

关键词： point cycle

Vertically aligned nanocomposite films by self-assembled epitaxial nucleation for super-broadband transparent conductors

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Infomat 2023年第4期5卷 14-24页

作者： Youngkyoung ha Judith L.macmanus-Driscoll Shinbuhm Lee Department of Physics and Chemistry DGISTDaeguRepublic of Korea Department of Emerging materials Science DGISTDaeguRepublic of Korea Department of materials Science and metallurgy University of CambridgeCambridgeUK

Designing super-broadband transparent conductors is challenging because of the exclusive nature of conductivity and infrared ***,using a one-step process,we created vertically aligned nanocomposite conducting films with high transparency across a super-broad wavelength *** aligned transparent Ba_(3)V_(2)O_(8)nanocolumns with lateral-100-nm widths enable high transmittance(>50%,even at a 4-μm wavelength)for all incident light and outperform that of Sn-doped In_(2)O_(3),while the conducting SrVO_(3)matrix retains low resistivity(mΩcm at room temperature).A combined study of scanning transmission electron microscopy,scattering scanning nearfield infrared microscopy,and X-ray diffraction revealed that spontaneous phase separation of Ba_(3)V_(2)O_(8)nanocolumns in a SrVO_(3)matrix film occurs via self-assembled epitaxial *** vertically aligned nanocomposite films provide a fertile platform for next-generation optoelectronics.

关键词： epitaxial nucleation spontaneous phase separation SrVO_(3)-Ba_(3)V_(2)O_(8) super-broadband transparent conductors vertically aligned nanocomposite films

Convolutional Neural Network-Based Regression for Predicting the Chloride Ion Diffusion Coefficient of Concrete

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Computers, materials & Continua 2022年第3期70卷 5059-5071页

作者： Hyun Kyu Shin ha Young Kim Sang Hyo Lee Architectural Engineering Hanyang University ERICAAnsan15588Korea Graduate School of Information Yonsei UniversitySeoul03722Korea Division of Smart Convergence Engineering Hanyang University ERICAAnsan15588Korea

The durability performance of reinforced concrete(RC)building structures is significantly affected by the corrosion of the steel reinforcement due to chloride penetration,thus,the chloride ion diffusion coefficient should be investigated through experiments or theoretical equations to assess the durability of an RC *** study aims to predict the chloride ion diffusion coefficient of concrete,a heterogeneous material.A convolutional neural network(CNN)-based regression model that learns the condition of the concrete surface through deep learning,is developed to efficiently obtain the chloride ion diffusion *** the model implementation to determine the chloride ion diffusion coefficient,concrete mixes with w/c ratios of 0.33,0.40,0.46,0.50,0.62,and 0.68,are cured for 28 days;subsequently,the surface image data of the specimens are ***,the proposed model predicts the chloride ion diffusion coefficient using the concrete surface image data and exhibits an error of approximately 1.5E−12 m^(2)/*** results suggest the applicability of proposed model to the field of facility maintenance for estimating the chloride ion diffusion coefficient of concrete using images.

关键词： Chloride ion diffusion coefficient convolutional neural network deep learning

Hydroxyapatite composites with carbon allotropes:Preparation,properties,and applications

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Particuology 2024年第5期88卷 239-265页

作者： Boris I.Kharisov Oxana V.Kharissova Lucy T.González Yolanda Peña méndez Igor E.Uflyand Idalia Gómez de la Fuente Universidad Autónoma de Nuevo León Ave.UniversidadCiudad UniversitariaSan Nicolás de los GarzaNuevo León 66455Mexico Tecnologico de monterrey Escuela de Ingeniería y CienciasMonterreyNuevo Leon 64890Mexico Department of Chemistry Southern Federal UniversityRostov-on-DonRussia

Hydroxyapatite(ha)and its composites with inorganic additives,dopants,and polymers is a rapidly developing branch in the materials *** particular,carbon allotropes are widely used in these composites being widely applied for medical *** a gap of insufficient generalization of recent achievements in the field of the ha/Carbon composites,in this review we present the state of the art of the field of ha composites and hybrids with classic carbon allotropes and *** composites are known for carbon nanotubes,nanofibers,graphene and its oxidized forms,as well as,in a lesser grade,for graphite,fullerenes,nanodiamonds,carbon nanofoams,*** composites can be fabricated by a variety of classic and less-common methods,such as co-precipitation(with or without ultrasonic treatment),CVD,hot isostatic pressing,hydrothermal,spark plasma sintering,biomimetic mineralization,thermal and plasma spray,electrochemical and electrophoretic deposition,self-assembling,3D printing,electrospinning,and lyophilisation,among *** of various synthesis techniques can be also carried out for composite *** or synthetic ha can be used as it is for further interaction with carbon allotropes or it can be first prepared and then reacted with carbon counterpart;similarly,carbon allotropes can be introduced into the interaction with ha directly or they can be first synthesized,in particular from *** biocompatible composites can be produced in the form of coatings,powders,and scaffolds and can additionally contain quantitative amounts of third phases,frequently natural or synthetic *** these composites,especially with O-containing functionalizing groups,ha disadvantages could be considerably decreased with simultaneous enhancement of mechanical properties,becoming similar to human bone,chemical stability and biocompatibility,as well as possessing antibacterial ***→G reduction and higher ha decoration were obs

关键词： Hydroxyapatite Carbon nanotubes Graphene Quantum dots Fullerenes Nanodiamonds