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The sexually dimorphic expression of glutamate transporters and their implication in pain after spinal cord injury

Neural Regeneration Research 2025年第11期20卷 3317-3329页

作者： Jennifer m.Colón-mercado Aranza I.Torrado-Tapias Iris K.Salgado Jose m.Santiago Samuel E.Ocasio Rivera Dina P.Bracho-Rincon Luis h.Pagan Rivera Jorge D.miranda Department of Physiology University of Puerto RicoMedical Sciences CampusSan JuanPRUSA National Institutes of health National Human Genome Research InstituteBethesdaMDUSA Universidad Central del Caribe School of MedicineBayamónPRUSA University of Puerto Rico Carolina CampusCarolinaPRUSA Institute of Neurobiology San JuanPRUSA

In addition to the loss of motor function,~60% of patients develop pain after spinal cord *** cellular-molecular mechanisms are not well understood,but the data suggests that plasticity within the rostral,epicenter,and caudal penumbra of the injury site initiates a cellularmolecular interplay that acts as a rewiring mechanism leading to central neuropathic *** can lead to the formation of new connections triggering abnormal sensory *** excitatory glutamate transporters are responsible for the reuptake of extracellular glutamate which makes them a critical target to prevent neuronal hyperexcitability and *** previous studies showed a sexually dimorphic therapeutic window for spinal cord injury after treatment with the selective estrogen receptor modulator *** this study,we investigated the anti-allodynic effects of tamoxifen in male and female rats with spinal cord *** hypothesized that tamoxifen exerts anti-allodynic effects by increasing the expression of glutamate transporters,leading to reduced hyperexcitability of the secondary neuron or by decreasing aberrant *** and female rats received a moderate contusion to the thoracic spinal cord followed by subcutaneous slow-release treatment of tamoxifen or matrix pellets as a control(placebo).We used von Frey monofilaments and the“up-down method”to evaluate mechanical *** treatment decreased allodynia only in female rats with spinal cord injury revealing a sexdependent *** expression profile of glutamatergic transporters(excitatory amino acid transporter 1/glutamate aspartate transporter and excitatory amino acid transporter 2/glutamate transporter-1)revealed a sexual dimorphism in the rostral,epicenter,and caudal areas of the spinal cord with a pattern of expression primarily on *** rodents showed a significantly higher level of excitatory amino acid transporter-1 expression while male rodents showed increased

关键词： allodynia central neuropathic pain EAAT-1/GLAST EAAT-2/GLT-1 glutamate transporters selective estrogen receptor modulator sexual dimorphism spinal cord injury trauma

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Effects of Bentonite,hydrogel and Biochar Amendments on Soil hydraulic Properties from Saturation to Oven Dryness

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Pedosphere 2019年第5期29卷 598-607页

作者： Osama m0hAWESh Wolfgang DURNER Department of Plant Production Faculty of AgricultureMutah UniversityKarak 61710 (Jordan) Division of Environmental Science and Technology Graduate School of AgricultureKyoto UniversityKyoto 6110011 (Japan) Institute of Geoecology Technical University of BraunschweigLanger Kamp 19cBraunschweig 38106 (Germany)

Effects of hydrogel, bentonite, and biochar as soil amendments on soil hydraulic properties and improving water availability from saturation to oven dryness were investigated. Soils were mixed with hydrogel (0.10%, 0.25%, and 0.50%), bentonite (0.5%, 1.0%, and 2.5%), and biochar (1.0%, 2.5%, and 5.0%) as soil amendments (weight:weight). Three methods (extended multistep outflow (XmSO), evaporation (EVA), and WP4 dewpoint potentiometer) were used to measure soil hydraulic properties from saturation to oven dryness. The cumulative XmSO results were more uniform across all the applied pressure steps for the amended soils. The EVA exhibited a shorter linear decrease during the first evaporation stage and a lower evaporation rate during the second evaporation stage. The WP4 results also exhibited that soil amendments increased the soil water content of the amended soils at low matric potentials. The results of soil water retention curves revealed that the unamended soil retained less water at any matric potential compared to the amended soils. Soil hydraulic conductivity decreased with increasing amount of soil amendments. The saturated hydraulic conductivity was higher for the unamended soil than the soils amended w计h 2.5% bentonite, 0.50% hydrogel, and 5.0% biochar by 11, 3, and 18 times, respectively. These results suggested that soil amendments improved soil water retentivity, which confirmed the appropriateness of these soil amendments for potential use in sandy soil improvements. however, field experiments and economical perception studies should be considered for further investigation.

关键词： evaporation extended multistep outflow soil amendment soil matric potential soil moisture soil water retentivity water availability WP4 dewpoint potentiometer

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Free vibration and buckling analysis of polymeric composite beams reinforced by functionally graded bamboo fbers

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Applied mathematics and mechanics(English Edition) 2024年第3期45卷 543-562页

作者： h.m.FEIZABAD m.h.YAS Department of mechanical Engineering Razi UniversityKermanshah ***Iran

Natural fibers have been extensively researched as reinforcement materials in polymers on account of their environmental and economic advantages in comparison with synthetic fibers in the recent *** fibers are renowned for their good mechanical properties,abundance,and short cycle *** beams are one of the fundamental structural components and are susceptible to mechanical loads in engineering applications,this paper performs a study on the free vibration and buckling responses of bamboo fiber reinforced composite(BFRC)beams on the elastic *** different functionally graded(FG)layouts and a uniform one are the considered distributions for unidirectional long bamboo fibers across the *** elastic properties of the composite are determined with the law of *** hamilton’s principle,the governing equations of motion are *** generalized differential quadrature method(GDQm)is then applied to the equations to obtain the *** achieved outcomes exhibit that the natural frequency and buckling load values vary as the fiber volume fractions and distributions,elastic foundation stiffness values,and boundary conditions(BCs)and slenderness ratio of the beam ***,a comparative study is conducted between the derived analysis outcomes for BFRC and homogenous polymer beams to examine the effectiveness of bamboo fibers as reinforcement materials,demonstrating the significant enhancements in both vibration and buckling responses,with the exception of natural frequencies for cantilever beams on the Pasternak foundation with the FG-◇fiber ***,the obtained analysis results of BFRC beams are also compared with those for carbon nanotube reinforced composite(CNTRC)beams found in the literature,indicating that the buckling loads and natural frequencies of BFRC beams are lower than those of CNTRC beams.

关键词： bamboo fiber free vibration buckling analysis functionally graded(FG)beam elastic foundation generalized differential quadrature method(GDQm)

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Analytical model for thermal lensing and spherical aberration in diode side-pumped Nd:YAG laser rod having Gaussian pump profile

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Chinese Physics B 2015年第12期24卷 334-341页

作者： m h moghtader Dindarlu m Kavosh Tehrani h Saghafifar A maleki Institute of Optics and Laser Malek-Ashtar University of Technology

In this paper, according to the temperature and strain distribution obtained by considering the Gaussian pump profile and dependence of physical properties on temperature, we derive an analytical model for refractive index variations of the diode side-pumped Nd：YAG laser rod. Then we evaluate this model by numerical solution and our maximum relative errors are 5% and 10% for variations caused by thermo–optical and thermo–mechanical effects; respectively. Finally, we present an analytical model for calculating the focal length of the thermal lens and spherical aberration. This model is evaluated by experimental results.

关键词： side-pumped laser rod Gaussian pump profile thermal effects thermal lens spherical aberration

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microstructure evolution of a recycled Al-Fe-Si-Cu alloy processed by tube channel pressing

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International Journal of minerals,metallurgy and materials 2018年第10期25卷 1166-1172页

作者： m.h.Farshidi m.Rifai h.miyamoto Department of materials Science and metallurgical Engineering Ferdowsi University of Mashhad Department of mechanical Engineering Doshisha University

Although excellent recyclability is one of the advantages of Al alloys, a recycling process can reduce different properties of these alloys by adding coarse AlFeSi particles into the alloys' microstructures. One of the well-known methods for modifying the microstructure of metallic materials is the imposition of severe plastic deformation(SPD). Nevertheless, the microstructure evolutions of recycled Al alloys containing extraordinary fractions of AlFeSi particles during SPD processing have seldom been considered. The aim of the present work is to study the microstructure evolution of a recycled Al–Fe–Si–Cu alloy during SPD processing. For this purpose, tubular specimens of the mentioned alloy were subjected to different numbers of passes of a recently developed SPD process called tube channel pressing(TCP); their microstructures were then studied using different techniques. The results show that coarse AlFeSi particles are fragmented into finer particles after processing by TCP. however, decomposition and dissolution of AlFeSi particles through TCP processing are negligible. In addition, TCP processing results in an increase in hardness of the alloy, which is attributed to the refinement of grains, to an increase of the dislocation density, and to the fragmentation of AlFeSi particles.

关键词： AlFeSi intermetallic particle severe plastic deformation microstructure tube channel pressing

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magnetic field induction and magnetic force distribution profiles in plasma focus discharge device

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Plasma Science and Technology 2021年第7期23卷 110-120页

作者： A A LAShIN T m ALLAm h A EL-SAYED Kamal m AhmED S A WARD h m SOLImANand m A ABOUELATTA Plasma and Nuclear Fusion Department Nuclear Research CentreEgyptian Atomic Energy AuthorityInshas 13759Egypt Faculty of Engineering Delta University for Science and TechnologyGamasa 11152Egypt Electrical Engineering Department Faculty of Engineering at ShoubraBenha UniversityCairo 11629Egypt

We report a simple-to-perform technique to investigate the distribution of the azimuthal magnetic field induction,Bθ,and the induced magnetic force acting on the plasma current sheath(PCS)in a plasma focus(PF)*** in situ measurement technique can undoubtedly be beneficial when other fast-imaging techniques are not *** are not *** work was conducted in the low-energy mather-type EAEA-PF1 device operated in *** axial distribution(Bθ)z along the coaxial electrodes system was measured with a four magnetic-probe set technique at different radial distances(r=2.625×10^(−2) to 4.125×10^(−2) m)within the annular space between the coaxial electrodes during the 1st and 2nd half cycles of the discharge current waveform,where inner electrode of coaxial electrode system has a+ve polarity and−ve polarity,***,radial and total magnetic force distribution profiles were estimated from Bθ*** of PCS shape in terms of its inclination(curvature)angle,θ,along the axial rundown phase and the correlation between the magnetic forces per unit volume acting on the PCS,the inclination angleθof the PCS,and the formation of a powerful PF action during the 1st and 2nd half cycles is carried *** of inclination angle,θ,on total magnetic force per unit volume acting on PCS axial motion was studied,separately,during the 1st and 2nd half cycles.

关键词： plasma focus azimuthal magnetic field magnetic force inclination angle plasma current sheath

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Approximate energies and thermal properties of a position-dependent mass charged particle under external magnetic fields

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Chinese Physics B 2017年第6期26卷 22-30页

作者： m Eshghi h mehraban S m Ikhdair Young Researchers and Elite Club Central Tehran BranchIslamic Azad UniversityTehranIran Faculty of Physics Semnan UniversitySemnanIran Department of Physics Faculty of ScienceAn-Najah National UniversityNablusWest BankPalestine Department of Electrical Engineering Near East UniversityNicosiaNorthern CyprusMersin 10Turkey

We solve the Schrodinger equation with a position-dependent mass（PDm） charged particle interacted via the superposition of the morse-plus-Coulomb potentials and is under the influence of external magnetic and Aharonov–Bohm（AB） flux fields. The nonrelativistic bound state energies together with their wave functions are calculated for two spatially-dependent mass distribution functions. We also study the thermal quantities of such a system. Further, the canonical formalism is used to compute various thermodynamic variables for second choosing mass by using the Gibbs formalism. We give plots for energy states as a function of various physical parameters. The behavior of the internal energy, specific heat, and entropy as functions of temperature and mass density parameter in the inverse-square mass case for different values of magnetic field are shown.

关键词： Schr?dinger equation morse-plus-Coulomb potentials position-dependent mass distribution functions perpendicular magnetic and Aharonov–Bohm flux fields

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Dynamic simulation of beam-like structure with a crack subjected to a random moving mass oscillator

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Earthquake Engineering and Engineering Vibration 2009年第3期8卷 447-458页

作者： m.m.Ettefagh m.h.Sadeghi m.Rezaee Vibration and modal Analysis Laboratory 51666-14766Department of Mechanical EngineeringUniversity of TabrizTabrizIran

In this paper, dynamic simulation of a beam-like structure with a transverse open crack subjected to a random moving mass oscillator is investigated. The simultaneous effect of a crack and a random oscillator has not been addressed up to now. The crack in the beam at different locations and with different depths is considered as one group of damage, each as an individual imperfection. In addition, bearing immobility is considered as another type of problem in the beam. mass, stiffness, damping and velocity of the oscillator are assumed to be random parameters. An improved perturbation technique is applied to reduce the simulation time. It was found that there is a maximum value of the variance of each uncertain parameter, in which the maximum reliability of the perturbation method can be achieved, and that this maximum value can be obtained by the Alpha-hilber monte-Carlo simulation method. The simulation results reveal that the mass and the velocity uncertainty cause high uncertainty in the deflection of the beam. Also, the pattern of the deflection is not affected by different random oscillator parameters, and as a result, the type of damage can be identified even with high uncertainty. moreover, the deflection in the nodes around the mid-span of the beam provides the best information regarding the imperfections, and consequently leads to the best sensor locations in an actual experiment.

关键词： bridge-vehicle interaction moving mass oscillator random parameters monte-Carlo simulation perturbation method

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Solvability of a class of PT-symmetric non-hermitian hamiltonians：Bethe ansatz method

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Chinese Physics B 2017年第6期26卷 14-21页

作者： m Baradaran h Panahi Department of Physics University of Guilan Rasht 41635-1914Iran

We use the Bethe ansatz method to investigate the Schrdinger equation for a class of PT-symmetric non-hermitian hamiltonians. Elementary exact solutions for the eigenvalues and the corresponding wave functions are obtained in terms of the roots of a set of algebraic equations. Also, it is shown that the problems possess sl（2） hidden symmetry and then the exact solutions of the problems are obtained by employing the representation theory of sl（2） Lie algebra. It is found that the results of the two methods are the same.

关键词： PT-symmetry Bethe ansatz method Lie algebraic approach quasi-exactly solvable

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A STABILITY ThEOREm FOR CONSTRAINED OPTImAL CONTROL PROBLEmS

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Journal of Computational mathematics 2004年第5期22卷 633-640页

作者： m.h.Farag DepartmentofmathematicsandComputerScienceFacultyofEducation lbriSultanateofOman

This paper presents the stability of difference approximations of an optimal control problem for a quasilinear parabolic equation with controls in the coefficients, boundary conditions and additional restrictions. The optimal control problem has been convered to one of the optimization problem using a penalty function technique. The difference approximations problem for the considered problem is obtained. The estimations of stability of the solution of difference approximations problem are proved. The stability estimation of the solution of difference approximations problem by the controls is obtained.

关键词： Optimal control Quasilinear Parabolic equations Penalty function methods Finite difference method Stability estimations

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