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mental health status among COVID-19 patients survivors of critical illness in Saudi Arabia:A 6-month follow-up questionnaire study

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World Journal of Clinical Cases 2024年第15期12卷 2560-2567页

作者： Abdullah m Alhammad Namareq F Aldardeer Abdulaziz Alqahtani mohammad h Aljawadi Bushra Alnefaie Raghad Alonazi mansour Almuqbil Abdulrahman Alsaadon Rakan m Alqahtani Rashid Alballaa Bader Alshehri mohammed I Alarifi Fahad D Alosaimi Department of Clinical Pharmacy College of PharmacyKing Saud UniversityRiyadh 12372Saudi Arabia Department of Pharmacy Services King Faisal Specialist Hospital and Research CentreJeddah 21499Saudi Arabia Corporate Department of Pharmacy Services King Saud University Medical CityRiyadh 12372Saudi Arabia College of Pharmacy King Saud UniversityRiyadh 12372Saudi Arabia Department of Critical Care medicine College of MedicineKing Saud UniversityRiyadh 12372Saudi Arabia Department of Psychiatry College of MedicineKing Saud UniversityRiyadh 12372Saudi Arabia

BACKGROUND Psychological assessment after intensive care unit(ICU)discharge is increasingly used to assess patients'cognitive and psychological ***,few studies have examined those who recovered from coronavirus disease 2019(COVID-19).There is a paucity of data from the middle East assessing the post-ICU discharge mental health status of patients who had *** To evaluate anxiety and depression among patients who had severe *** This is a prospective single-center follow-up questionnaire-based study of adults who were admitted to the ICU or under ICU consultation for>24 h for *** patients were contacted via *** patient’s anxiety and depression six months after ICU discharge were assessed using the hospital Anxiety and Depression Scale(hADS).The primary outcome was the mean hADS *** secondary outcomes were risk factors of anxiety and/or *** Patients who were admitted to the ICU because of COVID-19 were screened(n=518).Of these,48 completed the *** mean age was 56.3±17.2 *** patients(62.5%)were *** main comorbidities were endocrine(n=24,50%)and cardiovascular(n=21,43.8%)*** mean overall hADS score for anxiety and depression at 6 months post-ICU discharge was 11.4(SD±8.5).A hADS score of>7 for anxiety and depression was detected in 15 patients(30%)and 18 patients(36%),*** from the multivariable ordered logistic regression demonstrated that vasopressor use was associated with the development of anxiety and depression[odds ratio(OR)39.06,95% confidence interval:1.309-1165.8;Pmonths after ICU discharge,30% of patients who had COVID-19 demonstrated a hADS score that confirmed anxiety and *** compare the psychological status of patients following an ICU admission(with vs without COVID-19),further studies are warranted.

关键词： COVID-19 Critically ill Anxiety Depression hADS Saudi Arabia

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Influence of Sanitization Process on maintaining Sweet Potato Quality for Export

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Journal of Agricultural Science and Technology(A) 2024年第1期14卷 31-37页

作者： Saneya m.El Neshawy Tharwa m.Elkholi Salah h.hegazy Department of Post-harvest Diseases Plant Pathology Research InstituteAgricultural Research Center(ARC)Giza 12619Egypt Central Administration for medical Services Ministry of AgricultureDokii 12611Egypt General manager of AgroFood Company Limited Dokii 12611Egypt

The whole cold-chain for exporting sweet potato(native variety“Abees”),to foreign market included immediate curing operation directly after harvest helped in healing skin texture,however,in order to reduce postharvest soft rot(Rhizopus stolonifer)incidence following trimming,and washing,ultraviolet light(UV-C)treatment was used as a main sanitizer for eliminating the soft *** of the roots to UV-C(254 nm)was applied in a UV-C room on freshly harvested and cured sweet potato while rolling up on a movable line at 20 cm distance for 1,2,and 3 *** combining UV-C treatment with chlorine(200 ppm)on roots,marked and significant reduction of the total microbial load and Rhizopus potential was achieved on root surfaces respectively compared with chlorine *** also reduced soft rot percentage to almost 0%*** 3 months of cold-storage,quality assessment of sweet potato showed that root characteristics were markedly *** ability of UV-C light to induce phenylalanine ammonia lyase(PAL)enzyme activity in root tissue and maintain the activities of peroxidase and polyphenol oxidase,however with slight increase,was ***-C caused an increase of phenol content in sweet potato tissue that made an activation of defense reaction against the rot causal *** the exposure time to UV-C light increased,a higher content of phenols ***,UV-C application caused decrease in sugar content of root tissue that is flavored by soft rot-causal pathogen.

关键词： Sweet potato(Ipomoea batatas) soft rot Rhizopus stolonifer UV-C light cold storage microbial load

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Positive health:An integrated quantitative approach in patients with chronic gastrointestinal and hepato-pancreatico-biliary disorders

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World Journal of Gastroenterology 2024年第28期30卷 3418-3427页

作者： Anja h W m Lemlijn-Slenter Karolina AP Wijnands Gijs van der hamsvoort Luuk P van Iperen Nico Wolter Angelique E de Rijk Ad Am masclee Department of Social medicine Faculty of HealthMedicine and Life sciencesCare and Public Health Research Institute Maastricht UniversityMaastricht 6200 MDLimburgNetherlands Division of Gastroenterology and hepatology Department of Internal MedicineSchool of Nutrition and Translational Research in MetabolismMaastricht 6200 MDLimburgNetherlands Social medical Affairs Employee Insurance Agency(UWV)Heerlen 6400 ACLimburgNetherlands Department of Research Academic Knowledge Center Work and Health South-East Netherlands(AKAG-ZON)Heerlen 6400 ACLimburgNetherlands

BACKGROUND The concept of positive health(Ph)supports an integrated approach for patients by taking into account six dimensions of *** approach is especially relevant for patients with chronic *** gastrointestinal and hepatopancreatico-biliary(GI-hPB)disorders are among the top-6 of the most prevalent chronically affected organ *** impact of chronic GI-hPB disorders on individuals may be disproportionally high because:(1)The affected organ system frequently contributes to a malnourished state;and(2)persons with chronic GIhPB disorders are often younger than persons with chronic diseases in other organ *** To describe and quantify the dimensions of Ph in patients with chronic GI-hPB *** Prospective,observational questionnaire study performed between 2019 and 2021 in 235 patients with a chronic GIhPB disorder attending the Outpatient Department of the maastricht University medical *** questionnaires and data from patient files were used to quantify the six dimensions of *** consistency was tested with mcDonald’s ***-order Pearson correlations and t-tests were used to assess associations and differences.A P valuehe GI-hPB patients scored significantly worse in all dimensions of Ph compared to control data or norm scores from the general *** quality of life,participation and daily functioning,GI-hPB patients scored in the same range as patients with chronic disorders in other organ systems,but depressive symptoms(in 35%)and malnutrition(in 45%)were more frequent in patients with chronic GI-hPB *** scores between the six dimensions were only very weak to weak,forcing us to quantify each domain *** All six dimensions of Ph are impaired in the GI-hPB *** and depressive symptoms are more prevalent compared to patients with chronic disorders in other organ systems.

关键词： Positive health Chronic gut disorders Gastrointestinal disorders hepato-pancreatico-biliary disorders Integrated care

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Physiological phenotypes differ among color morphs in introduced common wall lizards(Podarcis muralis)

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Integrative Zoology 2024年第3期19卷 505-523页

作者： Ali AmER Sierra SPEARS Princeton L.VAUGhN Cece COLWELL Ethan h.LIVINGSTON Wyatt mCQUEEN Anna SChILL Dustin G.REIChARD Eric J.GANGLOFF Kinsey m.BROCK Department of Biological Sciences Ohio Wesleyan UniversityDelawareOhioUSA Department of Ecology and Evolutionary Biology Princeton UniversityPrincetonNew JerseyUSA Department of Biology Idaho State UniversityPocatelloIdahoUSA Department of Environmental Science Policyand ManagementCollege of Natural ResourcesUniversity of CaliforniaBerkeleyUSA museum of Vertebrate Zoology University of CaliforniaBerkeleyUSA

many species exhibit color polymorphisms which have distinct physiological and behavioral ***,the consistency of morph trait covariation patterns across species,time,and ecological contexts remains *** trait covariation is especially relevant in the context of invasion biology and urban ***,physiological traits pertaining to energy maintenance are crucial to fitness,given their immediate ties to individual reproduction,growth,and population *** investigated the physiological traits of Podarcis muralis,a versatile color polymorphic species that thrives in urban environments(including invasive populations in Ohio,USA).We measured five physiological traits(plasma corticosterone and triglycerides,hematocrit,body condition,and field body temperature),which compose an integrated multivariate *** then tested variation among co-occurring color morphs in the context of establishment in an urban *** found that the traits describing physiological status and strategy shifted across the active season in a morph-dependent manner—the white and yellow morphs exhibited clearly different multivariate physiological phenotypes,characterized primarily by differences in plasma *** suggests that morphs have different strategies in physiological regulation,the flexibility of which is crucial to urban *** white-yellow morph exhibited an intermediate phenotype,suggesting an intermediary energy maintenance *** morphs also exhibited distinct phenotypes,but the low prevalence of this morph in our study populations precludes clear *** work provides insight into how differences among stable polymorphisms exist across axes of the phenotype and how this variation may aid in establishment within novel environments.

关键词： color polymorphism physiological status seasonal variation thermoregulation urban habitat

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Study of ZnO nanoparticle-supported clay minerals for electrochemical sensors,photocatalysis,and antioxidant applications

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ChemPhysmater 2024年第1期3卷 83-93页

作者： mylarappa m N.Raghavendra N.R.Bhumika C.h.Chaithra B.N.Nagalaxmi K.N.Shravana Kumara Department of Chemistry Sri Jagadguru Renukacharya College of ScienceArts&CommerceBengaluru 560009India Department of Chemistry East West Institute of TechnologyBengaluru 560091India Department of Chemistry Maharani Lakshmi Ammanni College for WomenBengaluru 560012India

In view of the current study’s demonstration of the synthesis of clay-doped ZnO composites,we present a low-cost method for producing clay-metal oxide(clay/ZnO).Utilizing the solution combustion technique,a composite of clay/ZnO was produced utilizing citric acid as both a fuel and a complexing *** hexagonal unit cell structure of the created clay/ZnO may be seen using XRD *** ZnO-infused clay was visible in FE-SEm micrographs as homogenous,sphere-shaped *** possible involvement of clay/ZnO photocatalytic activity in the UV-induced photodegradation of malachite green dye was *** 90%degradation rate shows the composite’s outstanding photocatalytic degradation *** resulting substance was electrochemically analyzed using a constructed electrode in 0.1 m KOh *** increased its sensor capabilities,which now include chemical and biomolecule sensors,and it excelled in cyclic voltammetry-based redox potential *** efficiently evaluate chemically synthesized NPs for electrochemical,sensing,and photocatalytic applications,this study intends to create a solution combustion procedure for the synthesis of clay/ZnO nanocomposite using urea as fuel.

关键词： Clay Clay/ZnO Photocatalytic Electrochemical sensors

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On an isotropic porous solid cylinder:the analytical solution and sensitivity analysis of the pressure

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Applied mathematics and mechanics(English Edition) 2024年第9期45卷 1499-1522页

作者： h.ASGhARI L.mILLER R.PENTA J.mERODIO Departamento de matematica Aplicada a las TIC ETS de Ingenieria de Sistemas InformaticosUniversidad Politecnica de MadridMadrid 28031Spain School of mathematics and Statistics University of GlasgowGlasgow G128QQU.K.

Within this work,we perform a sensitivity analysis to determine the influence of the material input parameters on the pressure in an isotropic porous solid *** provide a step-by-step guide to obtain the analytical solution for a porous isotropic elastic cylinder in terms of the pressure,stresses,and elastic *** obtain the solution by performing a Laplace transform on the governing equations,which are those of Biot's poroelasticity in cylindrical polar *** enforce radial boundary conditions and obtain the solution in the Laplace transformed domain before reverting back to the time *** sensitivity analysis is then carried out,considering only the derived pressure *** analysis finds that the time t,Biot's modulus m,and Poisson's ratio ν have the highest influence on the pressure whereas the initial value of pressure P_(0) plays a very little role.

关键词： sensitivity analysis Laplace transform cylindrical polar coordinate Biot's modulus cylinder

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Exploring the Prevalence and Contributing Factors of Depression among Sickle Cell Anemia Patients in Saudi Arabia’s Jazan Region

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International Journal of mental health Promotion 2024年第5期26卷 351-359页

作者： Abdullah A.Alharbi Ahmad Y.Alqassim mohammed A.muaddi Najat h.Aldubayyan Rana I.Abuhadi Futon A.Akoor Sarah J.mobarki Imtenan A.Oberi Ghaidaa h.Alharbi Yara Ajeebi Adnan m.Alkhayat hafiz malhan mohammed Bakkar Anwar m.makeen Family and Community medicine Department Faculty of MedicineJazan UniversityJazan45142Saudi Arabia Laboratory Department King Fahd Central HospitalMinistry of HealthJazan45142Saudi Arabia Internal medicine Department Prince Mohammad bin Nasser HospitalMinistry of HealthJazan45142Saudi Arabia hematology Department King AbdulAziz Medical City for National GuardRiyadh11426Saudi Arabia

Sickle Cell Anemia(SCA)is a prevalent genetic condition in Saudi Arabia,particularly in the Jazan *** study’s purpose was to assess the prevalence of de-pression among individuals with SCA in this area and to identify the factors associated with this *** study involved 391 adult participants,all patients in the hematology center of Prince mohammed bin Nasser hospital(PmNh).Data was collected through an anonymous interview questionnaire–the Arabic version of the Patient health Questionnaire-9(PhQ-9)–between march–may *** questionnaire covered socio-demographic information and variables related to the participant’s SCA history,such as pain levels,frequency of pain,hospitalization duration,and frequency of blood *** variables underwent Chi-square and One-way ANOVA testing,followed by multivariate *** study found a 42%prevalence of depression among the SCA *** significantly linked with heightened depression levels included being widowed or divorced,experiencing frequent and severe pain,and longer duration of hospital *** educational level of at least a bachelor’s degree was also a significant *** study reveals a high prevalence of depression among SCA patients in the Jazan *** underscores the need for policymakers to educate both physicians and patients about the importance of mental health in SCA *** study also highlights the need for more research into the specific causes and effects of depressive symptoms in SCA patients to inform the creation of effective management plans.

关键词： Sickle cell anemia prevalence depression public health policy Jazan region Saudi Arabia

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Storylines of family medicine Ⅰ:framing family medicine–history,values and perspectives

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Family medicine and Community health 2024年第S03期12卷 2-11页

作者： William B Ventres Leslie A Stone Kathleen T Rowland Richard h Streiffer michael D macechko Julia A Roulier Jeffrey m Borkan Larry A Green Family and Preventive medicine University of Arkansas for Medical Sciences College of MedicineLittle RockArkansasUSA Family and Preventive medicine Rush Medical College of Rush UniversityChicagoIllinoisUSA College of Community health Sciences University of AlabamaTuscaloosaAlabamaUSA UAmS Northwest Regional Campus Family medicine Residency Program FayettevilleArkansasUSA UAmS North Central Regional Campus Family medicine Residency Program BatesvilleArkansasUSA Family medicine Brown University Warren Alpert Medical SchoolProvidenceRhode IslandUSA University of Colorado School of medicine AuroraColoradoUSA

Storylines of Family medicine is a 12-part series of thematically linked mini-essays with accompanying illustrations that explore the many dimensions of family medicine,as interpreted by individual family physicians and medical educators in the USA and elsewhere around the ***‘Ⅰ:framing family medicine—history,values,and perspectives’,the authors address the following themes:‘Notes on Storylines of Family medicine’,‘Family medicine—the generalist specialty’,‘Family medicine’s achievements—a glass half full assessment’,‘Family medicine’s next 50 years—toward filling our glasses’,‘Four enduring truths of family medicine’,‘Names matter’,‘Family medicine at its core’and‘The ecology of medical care.’may readers find much food for thought in these essays.

关键词： glasses illustration Notes

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^(4)he monolayer on graphene:a quantum monte Carlo study

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Communications in Theoretical Physics 2024年第9期76卷 149-157页

作者： S Yu m Boninsegni Department of Physics University of AlbertaEdmontonAlbertaT6G 2H5Canada

We revisit the problem of adsorption of a single^(4)he layer on graphene,focusing on the commensurate(C_(1/3))crystalline phase,specifically on whether it may possess a nonzero superfluid response,and on the existence of superfluid phases,either(metastable)liquid or vacancy-doped *** make use of canonical quantum monte Carlo simulations at zero and finite temperature,based on a realistic microscopic model of the *** results confirm the absence of any superfluid response in the commensurate crystal,and that no thermodynamically stable uniform phase exists at lower *** evidence of a possibly long-lived,metastable superfluid phase at C_(1/3)coverage is ***,the results of ground-state projection methods and finite-temperature simulations are entirely consistent.

关键词： superfluidity low-dimensional systems quantum monte Carlo helium supersolids

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Development of an active-site titrant for SARS-CoV-2 main protease as an indispensable tool for evaluating enzyme kinetics

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Acta Pharmaceutica Sinica B 2024年第5期14卷 2349-2357页

作者： Rabea Voget Julian Breidenbach Tobias Claff Alexandra hingst Katharina Sylvester Christian Steinebach Lan Phuong Vu Renato h.Weiße Ulrike Bartz Norbert Sträter Christa E.müller michael Gütschow Pharmaceutical Institute Pharmaceutical&Medicinal ChemistryUniversity of BonnBonn 53121Germany Institute of Bioanalytical Chemistry Center for Biotechnology and BiomedicineLeipzig UniversityLeipzig 04103Germany Department of Natural Sciences University of Applied Sciences Bonn-Rhein-SiegRheinbach 53359Germany

A titrant for the SARS-CoV-2 main protease(m^(pro))was developed that enables,for the first time,the exact determination of the concentration of the enzymatically active m^(pro) by active-site *** covalent binding mode of the tetrapeptidic titrant was elucidated by the determination of the crystal structure of the enzyme–titrant *** fluorogenic substrates of m^(pro),including a prototypical,internally quenched Dabcyl-EDANS peptide,were compared in terms of solubility under typical assay *** exploiting the new titrant,key kinetic parameters for the m^(pro)-catalyzed cleavage of these substrates were determined.

关键词： COVID-19 SARS-CoV-2 main protease Peptide nitriles Fluorogenic substrates Active-site titration X-ray crystallography Inner filter effect

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