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Study of the efficacy of Korean Red Ginseng in the treatment of erectile dysfunction

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Asian Journal of Andrology 2007年第2期9卷 241-244页

作者： Enrico de Andrade Alexandre A. de mesquita Joaquim de Almeida Claro Priscila m. de Andrade Valdemar Ortiz mário Paranhos m.guel srougi Sector of Sexual medicine Division of Urological Clinic of Sāo Paulo University Sāo Paulo Brazil Discipline of Urology Sāo Paulo Federal University Sāo Paulo Brazil

Aim： To examine the treatment efficacy of Korean Red Ginseng （KRG） in impotent men with erectile dysfunction （ED）. methods： A total of 60 patients presenting mild or mild to moderate ED were enrolled in a double-blind, placebo-controlled study in which the efficacies of KRG and a placebo were compared. The patients received either 1 000 mg （3 times daily） of KRG or a placebo. Results： The five-item version of the International Index of Erectile Function （IIEF-5） score after the treatment was significantly higher in the KRG group compared with that before the treatment （from 16.4±2.9 to 21.0±6.3, P 〈 0.0001）. In contrast, there was no difference before and after the treatment in the placebo group （from 17.0±3.1 to 17.7±5.6, P 〉 0.05）. In the KRG group, 20 patients （66.6%）, reported improved erection, significant in the global efficacy question （P 〈 0.01）; in the placebo group there was no significance. Scores on questions 2 （rigidity）, 3 （penetration）, 4 and 5 （maintenance）, were significantly higher for KRG than those for the placebo when those questions were answered after 12 weeks of each treatment （P 〈 0.01）. When the score in the KRG group was compared to the placebo group after the treatment, there was a significant improvement in total score （IIEF-5 score） in questions 3 and 5 for the KRG-treated group （P 〈 0.001 and P 〈 0.0001, respectively）. The levels of serum testosterone, prolactine and cholesterol after the treatment were not statistically significant different between the KRG and the placebo group （P 〉 0.05）. Conclusion： Our data show that KRG can be an effective alternative to the invasive approaches for treating male ED.

关键词： penis impotence ginseng penile erection

Safety of intravitreal quinupristin/dalfopristin in an animal model

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International Journal of Ophthalmology(English edition) 2016年第3期9卷 373-378页

作者： Veronica E.Giordano Sergio E.Hernandez-Da mota Tania N.A dabache-guel Armando Castillejos-Cheve Sonia Corredor-Casas Samantha m.Salinas-Longoria Rafael Romero-Vera Juan m.Jimenez-Sierra Jose L.Guerrero-Naranjo Virgilio morales-Canton Department of Ophthalmology Retina and Vitreous Service Asociacion para Evitar la Ceguera en Mexico Vicente Garcia Torres 46 Coyoacan Barrio San Lucas Mexico City 04030 Mexico Ophthalmology Service Clinica David Boulevard Garcia de Leon 598 Nueva Chapultepec Morelia Michoacan 58280Mexico Department of Ophthalmology Glaucoma Service Asociacion para Evitar la Ceguera en Mexico Vicente Garcia Torres 46 Coyoacan Barrio San Lucas Mexico City 04030 Mexico Department of Ophthalmology Pathology Service Asociacion para Evitar la Ceguera en Mexico Vicente Garcia Tortes 46 Coyoacan Barrio San Lucas Mexico City 04030 Mexico

AIm： To determine whether different intravitreal doses of quinupristin/dalfopristin lead to electroretinographic or histological changes in the rabbit retina over one month period after injection. mETHODS： Eighteen New Zealand white rabbits were divided into three treatment groups （groups 1 to 3） and different intravitreal doses of quinupristin/dalfopristin were tested in each group. The right eye was injected with the drug and the left eye received intravitreal injection of 5% dextrose water and served as control eye. The doses delivered to each group were 0.1 mg/0.1 mL, 1 mg/0.1 mL and 10 mg/0.1 mL. Simultaneous, bilateral, dark-adapted electroretinography and clinical images of both eyes were obtained in all groups before injection （baseline） and after 7, 14, 21 and 28d, followed by enucleation for histological examination. RESULTS： Subjects in the group 1 showed no signs of toxicity in the electroretinogram when compared with groups 2 and 3 （Kruskall-Wallis test, P=0.000）. By day 7, no electrical response to light stimuli was recorded in the treated eyes in groups 2 and 3, consistent with severe damage due to retinal toxicity. Light microscopy revealedno significant histopathological changes in the group 1, while rabbits in groups 2 and 3 had signs of granulomatous inflammation in most cases. CONCLUSION： Intravitreal 0.1 mg/0.1 mL doses of quinupristin/dalfopristin do not lead to electroretinographic or histological signs of retinal toxicity compared with 1 mg/0.1 mL and 10 mg/O.1 mL in this rabbit model.

关键词： endophthalmitis quinupristin/dalfopristin retinal toxicity

前列腺动脉栓塞术在治疗良性前列腺增生引起的下尿路症状中的应用:10年经验

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国际医学放射学杂志 2020年第5期 619-619页

作者： F.C.Carnevale A.m.moreira A.m.de Assis A.A.Antunes V.C.de Paula Rodrigues m.srougi 贾鸣男 Department of Radiology University of S?o Paulo Medical School

摘要前列腺动脉栓塞术(PAE)治疗良性前列腺增生的长期经验有限。目的评估PAE对良性前列腺增生的疗效、安全性和长期效果。材料与方法本单中心回顾性研究纳入

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miRNA in bladder carcinogenesis:A review

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World Journal of Clinical Urology 2014年第3期3卷 238-248页

作者： Nelson Dip Sabrina T Reis Nayara I Viana Denis R morais Caio m moura Betina Katz Daniel K Abe Alexandre Iscaife Iran A Silva m.guel srougi Kátia Rm Leite Laboratory of medical Investigation Urology Department-LIM55 University of Sao Paulo Medical SchoolSao Paulo 01246-903 Brazil

Bladder cancer(BC)is the second urological malignancy in incidence,currently being one of the most neoplasms studied with profile and biology poorly *** the world,BC is responsible by about 386000 new cases and 150000 deaths annually with considerable economic impact and high costs for health *** its discovery more than 20 years,micro RNAs(miR NAs)have been recognized as molecules that work specifically in post-transcriptional control in majority of eukaryote *** NAs are a family of small noncoding RNAs of 19-25 nucleotides in length,expressedin a wide variety of organisms,comprising plants,worms and mammals,including *** have a fundamental role in physiological and pathological processes in organs and tissues in a context-dependent *** review brings new roles of protective and oncogenic miR NAs linked to carcinogenesis of urothelial carcinoma of the bladder,and associated with behavior of *** studies have demonstrated promising roles of miR NAs working as diagnostic and prognostic biomarkers or involved in target therapies,consolidating mi RNAs as crucial players in human *** review allowed a reflection about the true functions of mi RNAs in bladder *** only by their wide capacities of action,but also by abilities in define the cell *** future of anti-tumor target therapies will be based not in one,but in groups of miR NAs working together in several steps of carcinogenic process,being able to identify the disease,predicting behavior and effectively treat bladder cancer.

关键词： Bladder cancer Urothelial carcinoma miRNA Biomarkers