检索结果-南通市图书馆

Amifostine对环磷酰胺衍生物所致正常造血祖/干细胞毒性的保护作用

在线全文

学校读者我要写书评

暂无评论

引用

中国实验血液学杂志 1995年第4期3卷 406-410页

作者：陈虎 Luc Douay m-C Giarratana N-C Gorin 北京北太平路医院血液科 Cell Culture Laboratory CHU Saint-Antoine 27 Rue de Chaligny 75012 Paris France

为了估价Amifostine(WR-2721)对正常造血干细胞的保护作用,我们用不同剂量的环磷酰胺衍生物(4-HC,ASTA-Z)对13例正常造血干细胞进行了体外处理,并测定其PCm-CFU-Gm,5R-CFU-Gm和LTO-IC的LD_(95),发现在处理前经过WR-2721孵育的13例中10例... 详细信息

为了估价Amifostine(WR-2721)对正常造血干细胞的保护作用,我们用不同剂量的环磷酰胺衍生物(4-HC,ASTA-Z)对13例正常造血干细胞进行了体外处理,并测定其PCm-CFU-Gm,5R-CFU-Gm和LTO-IC的LD_(95),发现在处理前经过WR-2721孵育的13例中10例LD_(95)明显增加(P<0.05),显示了明确的保护效果,而在9例白血病祖细胞组中,这种保护效果却没有被发现。相反,经过WR-2721孵育9例白血病祖细胞对化疗的敏感性都有不同程度的增加。

关键词： Amifostine 骨髓移植造血祖/干细胞白血病

学龄前儿童和学龄儿童的免疫接种率和适时接种情况

在线全文

学校读者我要写书评

暂无评论

引用

世界核心医学期刊文摘（儿科学分册） 2006年第6期2卷 21-22页

作者： Heininger U. Zuberbühler m. 王经纬 University Children's Hospital (UKBB) P.O. Box 4005 Basel Switzerland

Whereas immunization coverage has been repeatedly assessed in the Swiss population, little is known about the timely administration of universally recommended immunizations in Switzerland and elsewhere. The goal of this study was to determine compliance with official standard immunization recommendations in pre-school and school-a-ged children in Basel, Switzerland, focusing on coverage rates and timely administration. Of a cohort of children entering kindergarten and third-grade primary school in Basel in 2001, 310 and 310, respectively, were identified in proportion to the overall ageappropriate populations in the four city districts. Foreign-born children were excluded. The data were extracted from immunization records provided voluntarily by parents. Coverage for three doses of diphtheria, tetanus, and poliomyelitis vaccines was > 95%and mulative coverage for measles, mumps, and rubella (mmR) was mmunizations were administered with significant delays. Coverage for the first three doses of DTP combination vaccines did not reach 90%before 1 year of age and, for the first dose of mmR, a plateau just below 80%was not reached before 3 years of age. Delayed administration of immunizations in childhood, as well as complete lack of booster doses in a significant fraction of children, with important implications for public health have been discovered in this study. This may lead to fatal disease in individuals, epidemics in the community, and threatens national and international targets of disease elimination, such as measles and congenital rubella syndrome.

关键词：免疫接种率学龄前儿童学龄儿童接种情况适时母乳喂养持续时间 T1Dm 患病风险保护性因素

对接受维生素A治疗的视网膜色素变性患者加用二十二碳六烯酸效果的进一步分析:亚群分析

在线全文

学校读者我要写书评

暂无评论

引用

世界核心医学期刊文摘（眼科学分册） 2005年第2期1卷 17-18页

作者： Berson E.L. Rosner B. Sandberg m.A. 张磊 Berman-Gund Labo ratory 243 Charles St Boston MA 02114 United States Dr.

Objective: To determine whether docosahexaenoic acid will slow the course of r etinal degeneration in subgroups of patients with retinitis pigmentosa who are r eceiving vitamin A. Design: Acohort of 208 patients with retinitis pigmentosa, a ged 18 to 55 years, were randomly assigned to 1200 mg of docosahexaenoic acid pl us 15000 IU/d of vitamin A given as retinyl palmitate (DHA +A group) or control fatty acid plus 15000 IU/d of vitamin A (control +A group) and followed up ove r 4 years. Seventy percent of the patients in each group were taking vitamin A, 15000 IU/d, prior to entry. We compared rates of decline in ocular function in t he DHA +A vs control +A groups among the subgroups defined by use or nonuse of vitamin A prior to entry. We also determined whether decline in ocular function was related to red blood cell phosphatidylethanolamine docosahexaenoic acid lev el, dietary ω-3 fatty acid intake, or duration of vitamin A use. main outcome measures were Humphrey Field Analyzer visual field sensitivity, 30-Hz electrore tinogram amplitude, and visual acuity. Results: Among patients not taking vitami n A prior to entry, those in the DHA +A group had a slower decline in field sen sitivity and electroretinogram amplitude than those in the control +A group ove r the first 2 years (P=.01 and P=.03, respectively); these differences were not observed in years 3 and 4 of follow-up or among patients taking vitamin A prior to entry. In the entire cohort, red blood cell phosphatidylethanolamine docosah exaenoic acid level was inversely related to rate of decline in total field sens itivity over 4 years (test for trend, P=0.05). This was particularly evident ove r the first 2 years among those not on vitamin A prior to entry (test for trend, P=0.003). In the entire control +A group, dietary ω-3 fatty acid intake was inversely related to loss of total field sensitivity over 4 years (intake,min A supplementation prior to ent r

关键词：视网膜色素变性二十二碳六烯酸群分析视网膜电图视功能棕榈酸视黄酯磷脂酰乙醇胺负相关趋势检验队列研究