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肠易激综合征和胶原性结肠炎患者粪便中炎性标志物的检测

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世界核心医学期刊文摘（胃肠病学分册） 2006年第6期2卷 55-56页

作者： LettesjH. Hansson T. peterson C. m. Simrén 徐瑞 Section of gastroenterology and Hepatology Department of Internal Medicine Sahlgrenska University Hospital SE-413 45 Gteborg Sweden Dr.

Objective. Irritable bowel syndrome (IBS) and collagenous colitis (CC) share chronically recurring symptoms of altered bowel habits associated with abdominal pain or discomfort. The aims of the present study were to investigate whether inflammatory markers could be detected in faeces from patients with IBS and CC, and to elucidate whether such analyses could be used as non-invasive tools to distinguish between these disorders. material and methods. Stool samples were obtained from 18 patients with CC, 46 patients with IBS and 20 healthy controls (HC). Eosinophil protein X (EPX), myeloperoxidase (mPO), tryptase, interleukin-1 beta (IL-1β) and tumour necrosis factor alpha (TNFα) were measured in supernatants from processed faeces using immunoassays. Results. EPX levels were enhanced in faeces from CC patients (median 3.8 μg/g (0.47-16.2)) compared to patients with IBS (0.44 μg/g (0.25-1.8)), p g/g (0.21-1.3)), p mPO was increased in CC patients (11.7 μg/g (2.0-124)) compared to IBS patients (1.7 μg/g (0.81-5.2)), p g/g (1.1-6.3)), p mple. Conclusions. Increased levels of EPX, mPO and tryptase were observed in stools from collagenous colitis patients, whereas the levels in IBS patients did not differ from healthy controls. Our data suggest that faecal markers could be used as part of the clinical work-up to determine which patients should be biopsied and evaluated for collagenous colitis.

关键词：肠易激综合征(IBS) 胶原性结肠炎炎性标志物患者粪便肿瘤坏死因子-α(TNF-α) 检测素-1β(IL-1β) 功能紊乱性疾病 IBS患者髓过氧化物酶

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糖尿病患者的自我疗养

经皮冠状动脉介入术后延长应用氯吡格雷治疗的经济效应

1990年

作者：（美）彼德森（peterson C.m.）（美）乔瓦诺维克（Jovanovic L.）纪英如邢政译

来源：汇雅图书（南通市图书馆... 评论

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世界核心医学期刊文摘（心脏病学分册） 2005年第6期1卷 57-58页

作者： CowperP.A. UdayakumarK. Sketch Jr.m.H. peterson E.D. 王亭忠 Dr.Duke Clinical Research Institute P.O. Box 17969 Durham NC 27715 United States

This study examined the incremental cost-effectiveness of extending clopidogrel therapy from one month to one year after percutaneous coronary intervention(PCI) in an unselected, heterogeneous patient population. Clinical trials suggest that prolonging clopidogrel therapy for up to one year after PCI reduces downstream cardiac events. However, clopidogrel therapy is costly and may increase bleeding risk. Using decision analysis, we compared the outcomes and cost of prolonging clopidogrel treatment from one month to one year after PCI with the alternative strategy of discontinuing therapy one month after the procedure. Event rates were based on 3,976 PCI patients who were treated between January 1999 and December 2001 at the Duke medical Center and received no more than one month of clopidogrel after the procedure. Baseline characteristics and event rates were obtained from Duke clinical information systems. The effect of prolonged clopidogrel therapy on event rates was based on the Clopidogrel for the Reduction of Events During Observation(CREDO) trial per-protocol data. Unit costs and the effect of myocardial infarction(mI) on life expectancy were based on published sources. Extending clopidogrel therapy from one month to one year after PCI cost ＄879 per patient and reduced the risk of mI by 2.6%. Assuming mI decreases life expectancy by two years, prolonged therapy would cost ＄15,696 per year of life saved. Economic attractiveness of therapy varied with baseline risk, the effect of prolonged therapy on mI risk, and the price of clopidogrel. Prolonging clopidogrel therapy for one year after PCI is economically attractive, particularly in high-risk patients.

关键词：事件率心脏事件临床事件临床信息系统临床试验非均质决策分析有效病例后所

图雷特综合征患儿成年期的抽搐和强制性障碍症状严重程度的转归

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世界核心医学期刊文摘（儿科学分册） 2006年第5期2卷 25-26页

作者： Bloch m.H. peterson B.S. Scahill L. J.F. Leckman 朱新菊 Child Study Center Yale University School of Medicine PO Box 207900 New Haven CT 06520-790 0 United States.Dr

Background: Tourette syndrome (TS) is a childhood-onset neuropsychiatric diso rder that is characterized by both motor and phonic tics. One half to two thirds of children with TS experience a reduction or complete resolution of tic sympto ms during adolescence. At least one third of adults with TS have comorbid obsess ive-compulsive disorder (OCD). Objectives: To clarify the clinical course of ti c and OCD symptoms in children with TS and determine if baseline clinical measurements in childhood are associated with future symptom severity in late adolesce nce and early adulthood. Design: Prospective cohort study. Setting: Yale Child Study Center tic and OCD outpatient specialty clinic. Participants: Forty-six children with TS who received a structured clinical evaluation prior to age 14 years. main Outcome measures: Expert-rated tic and OCD symptom sever ity at follow-up interview an average of 7.6 years later (range, 3.8-12.8 year s). Results: Eighty-five percent of subjects reported a reduction in tic sympto ms during adolescence. Only increased tic severity in childhood was associated w ith increased tic severity at follow-up. The average age at worst-ever tic sev erity was 10.6 years. Forty-one percent of patients with TS reported at one tim e experiencing at least moderate OCD symptoms. Worst-ever OCD symptoms occurred approximately 2 years later than worst-ever tic symptoms. Increased childhood IQ was strongly associated with increased OCD severity at followup. Conclusion: Obsessive-compulsive disorder symptoms in children with TS became more severe a t a later age and were more likely to persist than tic symptoms.

关键词：症状严重程度图雷特综合征成年期抽搐患儿强制性转归障碍神经精神疾病完全缓解

高危非ST段抬高型急性冠状动脉综合征患者中早期介入治疗措施的应用:来自CRUSADE质量改善行动的结果

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世界核心医学期刊文摘（心脏病学分册） 2005年第4期1卷 16-17页

作者： Bhatt D. L. Roe m. T. peterson E. D. 王亭忠 Cleveland Clinic Foundation Dept. of Cardiovasc. Med./Desk F25 9500 Euclid Ave Cleveland OH 44195 United States Dr.

Context: The American College of Cardiology/American Heart Association(ACC/AHA ) guidelines for the management of non-ST-segment elevation acute coronary syn dromes(NSTE ACS) recommend early invasive management for high-risk patients, gi ven the benefits with this approach demonstrated in randomized clinical trials. Objectives: To determine the use and predictors of early invasive management str ategies(cardiac catheterization g presentation) in high-risk patients with NSTE ACS and to examine the association of early invasive management with mortality. Design, Set ting, and Patients: The CRUSADE(Can Rapid Risk Stratification of Unstable Angina Patients Suppress Adverse Outcomes With Early Implementation of the ACC/AHA gui delines) Quality Improvement Initiative evaluated care patterns and outcomes for 17926 high-risk NSTE ACS patients (positive cardiac markers and/or ischemie el ectrocardiographic changes) based on ACC/AHA guidelines recommendations at 248 U S hospitals with catheterization and revascularization facilities between march 2000 and September 2002. main Outcome measures: Use of early invasive management within 48 hours of presentation, predictors of early invasive management, and i n-hospital mortality. Results: Of the 17926 patients analyzed, 8037 (44.8%) un derwent early cardiac catheterization less than 48 hours following presentation. Predictors of early invasive management included cardiology care, younger age, lack of prior or current congestive heart failure, lack of renal insufficiency, ischemic electrocardiographic changes, positive cardiac markers, white race, and male sex. Patients treated with early invasive management were more likely to b e treated with medications and interventions recommended by the ACC/AHA guidelin es and had a lower risk of in-hospital mortality after adjusting for difference s in clinical characteristics and after comparing propensity-matched pairs (2.5 %vs 3.7%, P< .001). Conclusions: An early invas

关键词：早期介入治疗 CRUSADE ST段抬高心脏标志物美国心脏学会危险分层不稳定型心绞痛血运重建心电图改变介入性治疗

PDgFRA强阳性表达是诊断gIST较为特异性标志

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临床与实验病理学杂志 2007年第1期23卷 110-110页

作者： peterson m R Piao Z Weidner N 黄文斌（摘译）不详南京医科大学附属南京第一医院病理科南京210006

胃肠道间质肿瘤(gIST)是腹腔最常见的间叶性肿瘤,来自于cajal间质细胞或其前体细胞。大多数gISTs有c-kit癌基因的突变,c-kit(CDll7)阳性被认为是诊断gIST的金标准,也是格列为治疗gIST的必要条件。近来研究发现PDgFRA基因突变作为另一个... 详细信息

胃肠道间质肿瘤(gIST)是腹腔最常见的间叶性肿瘤,来自于cajal间质细胞或其前体细胞。大多数gISTs有c-kit癌基因的突变,c-kit(CDll7)阳性被认为是诊断gIST的金标准,也是格列为治疗gIST的必要条件。近来研究发现PDgFRA基因突变作为另一个癌变机制可见于部分缺乏c-kit突变的gIST中,然而,PDgFRA免疫组化检测在gIST诊断中的价值还未见报道。作者应用免疫组化方法检测了39例gISTs和20例其它腹腔内间叶性肿瘤中PDgFRA的表达,同时进行了CD117免疫组化染色和PDgFRA和c-kit基因的突变分析。39例gISTs中,胃24例、小肠10例、大肠3例、胃肠外2例;极低、低、中间和高危险性分别为8例、11例、11例和9例;组织学亚型梭形细胞型25例、上皮样型7例、混合型7例。[第一段]

关键词： gISTs 阳性表达 T诊断特异性标志 c-kit基因胃肠道间质肿瘤 cajal间质细胞免疫组化检测

在高盐喂食的肥胖大鼠中N-乙酰基-丝氨酸-天门冬氨酰-赖氨酸-脯氨酸的肾保护作用

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中华高血压杂志 2019年第4期27卷 398-398页

作者： maheshwari m Romero CA monu SR Kumar N Liao TD peterson EL Carretero OA 不详

肥胖是一个公共卫生问题,与盐敏感性高血压、肾脏炎症和纤维化有关。N-乙酰基-丝氨酸-天门冬氨酰-赖氨酸-脯氨酸(N-acetyl-seryl-aspartyl-lysyl-proline,Ac-SDKP)是一种具有抗炎和抗纤维化特性的四肽。然而,它在预防肥胖患者肾脏损害... 详细信息

肥胖是一个公共卫生问题,与盐敏感性高血压、肾脏炎症和纤维化有关。N-乙酰基-丝氨酸-天门冬氨酰-赖氨酸-脯氨酸(N-acetyl-seryl-aspartyl-lysyl-proline,Ac-SDKP)是一种具有抗炎和抗纤维化特性的四肽。然而,它在预防肥胖患者肾脏损害中的作用尚不清楚。本研究假设肥胖Zucke( Zucker obese, ZO)大鼠在高盐喂食下可出现肾损害、炎症、纤维化.并可通过Ac-SDKP治疗得以预防。方法:Zucker瘦型(Zucker lean, ZL)大鼠和ZO大鼠(8周)接受Ac-SDKP[ 1.6 mg/(kg·d)]治疗,同时维持正常盐(0.4%)或高盐(4%)喂食8周后.对收缩压、蛋白尿、肾脏炎症和肾纤维化进行评估。

关键词：肥胖大鼠脯氨酸赖氨酸天门冬丝氨酸肾保护作用喂食高盐

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Ag的新鲜水样的保存和预处理

环境监测管理与技术 1991年第3期3卷 57-58,64页

作者： K.C.JONEST P.J.peterson 李绍南

Ag通常以10^(-9)(ppb)级或者低于这一浓度而存在于天然的新鲜水中,这比常规测定的其他元素要低得多.对于这些痕量元素的分析,由于样品收集瓶和过滤器吸附的缘故而导致分析的误差.有关这一问题,曾经提出过多种见解.但这些见解仅仅停留在... 详细信息

Ag通常以10^(-9)(ppb)级或者低于这一浓度而存在于天然的新鲜水中,这比常规测定的其他元素要低得多.对于这些痕量元素的分析,由于样品收集瓶和过滤器吸附的缘故而导致分析的误差.有关这一问题,曾经提出过多种见解.但这些见解仅仅停留在对使用的Ag浓度而不是真正天然水中Ag浓度的研究.对于环境样品的收集通常是建议使用高密度聚乙烯容器,而在实验室则将其贮存在硼硅玻璃器皿中.本实验通过用放射性^(110m)Ag对这两种容器材料进行了研究,试图找到最佳保存样品的技术.另外。

关键词：痕量分析新鲜水样银预处理

Clinical outcomes following salvage gamma Knife radiosurgery for recurrent glioblastoma

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World Journal of Clinical Oncology 2014年第2期5卷 142-148页

作者： Erik W Larson Halloran E peterson Wayne T Lamoreaux Alexander R macKay Robert K Fairbanks Jason A Call Jonathan D Carlson Benjamin C Ling John J Demakas Barton S Cooke Christopher m Lee gamma Knife of Spokane Spokane WA 99204 United States Cancer Care Northwest Spokane WA 99204 United States University of Washington School of medicine Seattle WA 98195 United States macK ay and meyer mDs Spokane WA 99202 United States Inland Neurosurgery and Spine Associates Spokane WA 99204 United States Spokane Brain and Spine Spokane WA 99204 United States

glioblastoma multiforme(gBm) is the most common malignant primary brain tumor with a survival prognosis of 14-16 mo for the highest functioning patients. Despite aggressive, multimodal upfront therapies, the majority of gBms will recur in approximately six months. Salvage therapy options for recurrent gBm(r gBm) are an area of intense research. This study compares recent survival and quality of life outcomes following gamma Knife radiosurgery(gKRS) salvage therapy. Following a Pub med search for studies usinggKRS as salvage therapy for malignant gliomas, nine articles from 2005 to July 2013 were identified which evaluated rg Bm treatment. In this review, we compare overall survival following diagnosis, overall survival following salvage treatment, progression-free survival, time to recurrence, local tumor control, and adverse radiation effects. This report discusses results for rg Bm patient populations alone, not for mixed populations with other tumor histology grades. All nine studies reported median overall survival rates(from diagnosis, range:16.7-33.2 mo; from salvage, range:9-17.9 mo). Three studies identified median progression-free survival(range:4.6-14.9 mo). Two showed median time to recurrence of gBm. Two discussed local tumor control. Six studies reported adverse radiation effects(range:0%-46% of patients). The greatest survival advantages were seen in patients who received gKRS salvage along with other treatments, like resection or bevacizumab, suggesting that appropriately tailored multimodal therapy should be considered with each rg Bm patient. However, there needs to be a randomized clinical trial to test gKRS for rg Bm before the possibility of selection bias can be dismissed.

关键词： gamma Knife radiosurgery malignant glioma glioblastoma Salvage therapy Stereotactic radiosurgery multimodal treatment