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Phosphate,calcium,and vitamin D signaling,transport,and metabolism in the endometria of cyclic ewes

Journal of Animal Science and Biotechnology 2023年第3期14卷 1012-1025页

作者： Claire Stenhouse makenzie G.Newton Katherine m.Halloran Robyn m.moses Nirvay Sah Larry J.Suva Fuller W.Bazer Departments of Animal Science Texas A&M UniversityKleberg CenterTX 77843‑2471 College StationUSA Veterinary Physiology and Pharmacology Texas A&M UniversityTX 77843 College StationUSA

Background Recent evidence suggests important roles for progesterone(P4)and interferon tau in the regulation of calcium,phosphate,and vitamin D signaling in the uteri of pregnant ***,the effects of P4 and estradiol(e2),with respect to the expression of their receptors PGR and eSR1,respectively,in uterine epithelia on mineral signaling during the estrous cycle has not been *** cycles of mature Suffolk ewes were synchronized,prostaglandin F2αwas administered,and ewes were observed for estrus(designated as Day 0)in the presence of vasectomized *** Days 1,9,or 14 of the estrous cycle,hysterectomies were *** 25-hydroxyvitamin D was more abundant in plasma from ewes on Day 14 than Day 1(Pexpression of fibroblast growth factor receptor 2(FGFR2),a disintegrin and metalloprotease 17(ADAm17),and parathyroid hormone-related protein(PTHrP)mRNAs was greater in endometria on Day 9 compared to Days 1 and 14(Pmilarly,expression of transient receptor potential cation channel subfamily V member 6(TRPV6)mRNA was greater in endometria on Day 9 than Day 1(Pe plasma membrane Ca^(2+)transporting 4(ATP2B4)and S100 calcium binding protein G(S100G)mRNA expression was greater in endometria on Day 14 than on Days 1 and 9(Pendometrial expression of vitamin D receptor(VDR)mRNA was lower on Days 9 and 14 than Day 1(Pexpression of klotho(KL)(Pme P450 family 24 subfamily A member 1(CYP24)(PmRNAs was lower on Day 14 than Days 1 and ***17,FGF23,CYP2R1,CYP27B1,KL,and VDR proteins immunolocalized to the uterine myometrium,blood vessels,and uterine luminal(Le),superficial glandular(sGe),and glandular(Ge)epithelia.S100A9 protein was weakly expressed in the uterine myometrium,Le,sGe,and *** of CYP2R1 and KL proteins in uterine Le and sGe was less on Day 1 than on Days 9 and *** contrast,S100G protein was expressed exclusively by Ge,and immunoreactive S100G protein

关键词： Calcium endometrium Ovine Phosphate Vitamin D

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正确应用标准化整体输血方案处理危及生命的产后出血

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国际输血及血液学杂志 2008年第3期31卷 289-292页

作者： Burtelow m Riley e Druzin m 陈蜀岚成都市四川省人民医院感染管理办公室

产后出血是导致产妇病死率发生的重要原因,而通常可预防的产后出血应定义为分娩后24小时内发生的出血。在这段时期,子宫胎盘血循环每分钟估计有700ml,所以产后正常凝血机制异常导致出血发生而危及生命的现象并不足为奇。产后出血的主要... 详细信息

产后出血是导致产妇病死率发生的重要原因,而通常可预防的产后出血应定义为分娩后24小时内发生的出血。在这段时期,子宫胎盘血循环每分钟估计有700ml,所以产后正常凝血机制异常导致出血发生而危及生命的现象并不足为奇。产后出血的主要原因包括宫缩乏力、病理胎盘植入、胚胎残留、子宫破裂、生产创伤以及现有的或后天的凝血功能异常。当前,人们提倡成分输血,大出血的最优处理方法是一不断发展的概念。产后出血的复苏在概念上与外伤后复苏相类

关键词：应用标准化输血处理危及生命产后出血凝血机制异常血循环血发生可预防分娩后病死率子宫胎盘产妇

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HYPOGLYCemIC ACTIVITY OF FeRULIC ACID AND ReLATeD COmPOUNDS FROm RICe BRAN IN DIABeTIC mICe

HYPOGLYCEMIC ACTIVITY OF FERULIC ACID AND RELATED COMPOUNDS ...

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The Second International Symposium on Natural Antioxidants: molecular mechanisms and Health effects

作者： H.morishita m.Ohnishi T.Tsuno A.Hosodai e.Nomurai H.Taniguchi Faculty of education Wakayama University Department of Pharmaceutical Science Kansai Shinkyu medical College Tsuno Food Industrial Co. Industrial Technology Center of Wakayama Prefecture Industrial Technology Center of Wakayama Prefecture Industrial Technology Center of Wakayama Prefecture

Ferulic acid is a ubiquitous plant constituent that arises from the metabolism of phenylalanine and tyrosine. During the investigation of antioxidant activity of ferulic acid and related compounds in vivo, we found th... 详细信息

关键词： STZ HYPOGLYCemIC ACTIVITY OF FeRULIC ACID AND ReLATeD COmPOUNDS FROm RICe BRAN IN DIABeTIC mICe

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内皮细胞和平滑肌细胞氧化应激时Nrf2／ARe信号通路对抗氧化基因表达的调控:与动脉粥样硬化和先兆子痫的关系

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生理学报 2007年第2期59卷 117-127页

作者： Giovanni e. mann Jorg Niehueser-Saran Alan Watson Ling Gao Tetsuro Ishii Patricia de Winter Richard C. m. Siow 皇家学院医学院心血管分部伦敦SEI 9NH英国筑波大学人类综合科学研究科分子和细胞生理学系茨城3058577日本

动脉粥样硬化、糖尿病、慢性肾功能衰竭和先兆子痫等血管疾病时活性氧(reactive oxygen species,ROS)生成增加,容易导致内皮依赖性血管舒张功能的损害和血管损伤,而细胞可以诱导多种编码Ⅱ相解毒酶和抗氧化蛋白的基因表达,从而减轻ROS... 详细信息

动脉粥样硬化、糖尿病、慢性肾功能衰竭和先兆子痫等血管疾病时活性氧(reactive oxygen species,ROS)生成增加,容易导致内皮依赖性血管舒张功能的损害和血管损伤,而细胞可以诱导多种编码Ⅱ相解毒酶和抗氧化蛋白的基因表达,从而减轻ROS和亲电子物质介导的细胞损伤。一个被称为抗氧化反应元件(antioxidant response element,ARe)或亲电子反应元件(electrophile response element,epRe)的顺式转录调控元件,可以介导诸如亚铁血红素加氧酶1、γ-谷氨酰半胱氨酸合成酶、硫氧还蛋白还原酶、谷胱甘肽-S转移酶和NAD(P)H:苯醌氧化还原酶等基因的转录。其他抗氧化酶,如超氧化物歧化酶、过氧化氢酶和非酶清除剂(如谷胱甘肽)等也参与ROS的清除。转录因子NF-e2相关因子2(nuclear factor-erythroid 2-related factor 2, Nrf2)是属于Cap‘n’Collar家族的转录因子,具有碱性亮氨酸拉链(basic region-leucine zipper,bZIP),它在ARe介导的抗氧化基因表达中起重要的作用。在正常情况下,Kelch样环氧氯丙烷相关蛋白-1(Kelch-like eCH-associated protein-1,Keapl)与Nrf2耦联,并与肌动蛋白细胞骨架结合被锚定于胞浆,但是在半胱氨酸残基发生氧化的情况下,Nrf2和Keapl解耦联,进入细胞核并与ARe结合,从而激活多种抗氧化基因和Ⅱ相解毒酶基因的转录。蛋白激酶C、丝裂原活化蛋白激酶和磷脂酰肌醇-3激酶参与Nrf2／ARe信号转导的调控。本文综述了有关Nrf2／ARe信号转导通路在血管稳态和动脉硬化、先兆子痫等疾病情况下内皮及平滑肌细胞对抗持续性氧化应激中起的作用。

关键词：转录因子NF-e2相关因子2 抗氧化反应元件氧化应激内皮细胞血管平滑肌细胞亚铁血红素加氧酶胱氨酸转运体一氧化氮合酶抗氧化基因 Ⅱ相解毒酶动脉粥样硬化糖尿病先兆子痫

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effects of A Galanin-3 Receptor Antagonist on Neurite Outgrowth

Effects of A Galanin-3 Receptor Antagonist on Neurite Outgro...

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第十五届国际药理学大会

作者： Kachel C.Alan Catapano Jr.Raymond Scott Roderick e.m. Blackburn Thomas P. Helicon Therapeutics Inc. Helicon Therapeutics Inc. Helicon Therapeutics Inc. Helicon Therapeutics Inc.

＜正＞ The neuropeptide Galanin mediates its effects through three known G - protein coupled receptor subtypes GalR1,GalR2 and GalR3,and has been implicated in many physiological processes including feeding behavior,pain and depression. Several studies have demonstrated the ability of Galanin to modulate the central 5 - hydroxytryptamine （5 - HT） function. HT - 2157,a selective GalR3 antagonist,has been shown to increase extracellular levels of 5 - HT in various brain regions . 5 - HT - elicitated 5 - HT1A receptor activation increases neurogenesis and promotes neurite outgrowth which may contribute to its antidepressant effects. In this study,the effects of HT- 2157 on enhancing neurite outgrowth were examined and the mechanisms underlying the modulation of neurite outgrowth were explored in both a PC12 sub - clone and primary mouse neuronal cultures. The results demonstrated that HT2157 significantly enhanced neurite outgrowth of PC12 cells and primary mouse neurons. In addition,HT- 2157 down regulated a transcription represser of the 5 - HT1A receptor gene,indicating that the enhancement of neurite outgrowth by HT - 2157 is mediated via derepression of 5 - HT1A receptor gene expression.

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21世纪的远程启动深水完井

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国外油田工程 1998年第12期14卷 30-31,40页

作者： m.V.Smith e.e.Lowe 申守庆江汉油田钻头厂

本文介绍了一种用于深水完井的新型压力脉冲远程启动系统，通过对该系统的构成和工作原理的说明以及对使用该系统典型实例的回顾，阐述了使用这种新型完井系统所获得的效率和重大成就，以及这种技术所面临的挑战及其应用前景。

关键词：深水完井压力脉冲远程启动完井

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NiWO4 powders prepared via polymeric precursor method for application as ceramic luminescent pigments

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Journal of Advanced Ceramics 2020年第1期9卷 55-63页

作者： Naiara A.LImA Lorena D.S.ALeNCAR máximo SIU-LI Carlos A.C.FeITOSA Alexandre meSQUITA Jean-Claude m’PeKO maria I.B.BeRNARDI Instituto de Física de Sao Carlos Universidade de Sao Paulo13560-970 Sao CarlosSPBrazil Instituto Federal de mato Grosso do Sul IFMS79200-000 AquidauanaMSBrazil Departamento de Física Centro de Ciências Exatas e TecnologiaUniversidade Federal do MaranhaoUFMA65080-805Sao LuisMABrazil Instituto de Geociências e Ciências exatas Departamento de FísicaUniversidade Estadual Paulista13506-900Rio ClaroSPBrazil

Ni WO4 was prepared using the polymeric precursor method and studied in terms of physical and chemical properties to verify its stability for industrial applications as *** characterization was accomplished using thermal analyses,X-ray diffraction(XRD),scanning electron microscopy(Sem),photoluminescence(PL)and UV–Vis spectroscopies,colorimetric coordinates,and Raman *** the temperature,successive exothermic reactions were observed and they are related with thermal decomposition of the organic *** stability was reached at^700℃.The material is verified to become completely free of second phase at^800℃.The end Ni WO4 powders showed an intense charge transfer(CT)-related tail centered in the ultraviolet region,resulting in a yellow *** addition,the powders exhibited broad excitation band and broad deep blue–green emission band,which were enhanced with increasing powders’crystallinity.

关键词： nickel tungstate yellow pigment colorimetric coordinate optical property structural characterization

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根据非线性贝叶斯理论的界面波频散曲线反演

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声学学报 2012年第3期37卷 225-231页

作者：李翠琳 Stan e Dosso Hefeng Dong 中国科学院海洋研究所海洋地质与环境重点实验室青岛266071 中国海洋大学工程学院青岛266100 University of Victoria Victoria V8W 3P6 Canada Norwegian University of Science and Technology NO-7491 Trondheim Norway

通过时频分析法从海底环境噪声数据中提取界面波频散曲线,进而采用非线性贝叶斯反演方法估算海底沉积物厚度、剪切波速度、压缩波速度和密度等参数及其不确定性。参数的最大后验概率(mAP)估计值和边缘概率分布分别通过自适应单纯形模拟... 详细信息

通过时频分析法从海底环境噪声数据中提取界面波频散曲线,进而采用非线性贝叶斯反演方法估算海底沉积物厚度、剪切波速度、压缩波速度和密度等参数及其不确定性。参数的最大后验概率(mAP)估计值和边缘概率分布分别通过自适应单纯形模拟退火法和metropolis-Hastings采样法在各参数先验区间内搜索获得,采用贝叶斯信息准则(BIC)从不同参数化模型中选择最优模型。界面波频散曲线反演结果表明:满足实测数据的最优海底模型结构为3层均匀分布剪切波速度剖面结构,海底深度的反演精度在800m以内,比起压缩波速度和密度,剪切波速度的不确定性更小,对界面波频散曲线更敏感。

关键词：贝叶斯理论曲线反演面波频散非线性剪切波速度贝叶斯信息准则边缘概率分布最大后验概率

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21世纪的远程启动深水完井

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石油石化节能 1998年第12期 30-31+40页

作者： m.V.Smith e.e.Lowe 申守庆江汉油田钻头厂

关键词：深水完井压力脉冲远程启动应用

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GeNeRATION OF RUNAWAY eLeCTRONS AND X-RAYS IS AN ORDINARY PHeNOmeNON IN DIFFUSe DISCHARGeS IN AN INHOmOGeNeOUS eLeCTRIC FIeLD 19th

GENERATION OF RUNAWAY ELECTRONS AND X-RAYS IS AN ORDINARY PH...

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The ⅪⅩ International Conference on Gas Discharges and Their Applications

作者： V F TARASeNKO I D KOSTYRYA D V RYBKA e Kh BAKSHT A G BURACHeNKO m I LOmAeV High Current electronics Institute

ISBN: (纸本)9771003651221

The paper reports the properties of supershort avalanche electron beam(SAeB) and x-ray formed in different gases at pressures from 1 torr up to 1 *** is shown that at a nanosecond discharge in the atmospheric pressure air and SAeB current recording through a small area of the foil the pulse duration behind the foil is no more than 25 ps,but from all surface of foil is about 100 *** A1 foil of thickness 10μm, the number of electrons from the entire foil anode in the atmospheric pressure air was 6.2·10 per pulse and this corresponds to a SAeB amplitude of～100 A at a 100-ps triangular pulse *** is shown that the highest amplitudes of SAeB with pulse duration about 100 ps are attained in helium,hydrogen, and nitrogen at a pressure of about 60,30,and 10 torr,*** the extracted data, estimates show that with the generator SLeP used,optimization of all parameters of the gas diode makes possible a SAeB current amplitude of about 500 A at a helium pressure of 60 torr. As the mode of the beam generation is changed due to the decrease in pressure from the above noted values,one can gradually control the FWHm of the beam current pulse between 100 and 500 ps in all gases studied.

关键词： Pressure electric fields Gases indium RUNAWAY eLeCTRONS positronium foils X-rays pulse duration Air Pressure discharge gas diode

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