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Remodeling Tumor Immune microenvironment by Using Polymer-Lipid-manganese Dioxide Nanoparticles with Radiation Therapy to Boost Immune Response of Castration-Resistant Prostate Cancer

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Research 2024年第3期2023卷 83-96页

作者： Abdulmottaleb e.Zetrini HoYin Lip Azhar Z.Abbasi Ibrahim Alradwan Taksim Ahmed Chunsheng He Jeffrey T.Henderson Andrew m.Rauth Xiao Yu Wu Advanced Pharmaceutics and Drug Delivery Laboratory Leslie Dan Faculty of PharmacyUniversity of TorontoM5S 3M2TorontoONCanada. Departments of medical Biophysics and Radiation Oncology University of TorontoM5G 1L7TorontoONCanada.

Despite substantial progress in the treatment of castration-resistant prostate cancer (CRPC), including radiation therapy and immunotherapy alone or in combination, the response to treatment remains poor due to the hypoxic and immunosuppressive nature of the tumor microenvironment. Herein, we exploited the bioreactivity of novel polymer–lipid manganese dioxide nanoparticles (PLmDs) to remodel the tumor immune microenvironment (TIme) by increasing the local oxygen levels and extracellular pH and enhancing radiation-induced immunogenic cell death. This study demonstrated that PLmD treatment sensitized hypoxic human and murine CRPC cells to radiation, significantly increasing radiation-induced DNA double-strand breaks and ultimately cell death, which enhanced the secretion of damage-associated molecular patterns, attributable to the induction of autophagy and endoplasmic reticulum stress. Reoxygenation via PLmDs also polarized hypoxic murine RAW264.7 macrophages toward the m1 phenotype, enhancing tumor necrosis factor alpha release, and thus reducing the viability of murine CRPC TRAmP-C2 cells. In a syngeneic TRAmP-C2 tumor model, intravenous injection of PLmDs suppressed, while radiation alone enhanced recruitment of regulatory T cells and m.e.oid-derived suppressor cells. Pretreatment with PLmDs followed by radiation down-regulated program.e. death-ligand 1 and promoted the infiltration of antitumor CD8+ T cells and m1 macrophages to tumor sites. Taken together, TIme modulation by PLmDs plus radiation profoundly delayed tumor growth and prolonged median survival compared with radiation alone. These results suggest that PLmDs plus radiation is a promising treatment modality for improving therapeutic efficacy in radioresistant and immunosuppressive solid tumors.

关键词： RAW264.7 alone treatment

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抗PD-1免疫疗法与雄激素剥夺疗法联合可显著增强诱导转移性去势敏感前列腺癌的免疫浸润

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中国临床药理学杂志 2024年第1期40卷 51-51页

作者： HAWLeY J e OBRADOVIC A Z DALLOS m C 孟海峰

引自:HAWLeY J e,OBRADOVIC A Z,DALLOS m C,et ***-PD-1 immunotherapy with androgen depriva⁃tion therapy induces robust immune infiltration in metastatic castration-sensitive prostate cancer[J].Cancer Cell,2023,41(11):1972-1988.研究表明,与其他恶性肿瘤比较,原发性和去势抗性前列腺癌症(CRPC)的肿瘤微环境(Tme)缺乏免疫浸润。尽管雄激素剥夺疗法(ADT)可以在局部性前列腺癌中诱导复杂的免疫浸润,但在转移性去势敏感性前列腺癌(mCSPC)中Tme的组成、ADT或其它治疗方法在这方面的作用尚不明确。研究者对参与Ⅱ期临床试验(NCT03951831)患者的转移灶进行了全面的单细胞RNA测序(scRNA-seq)分析,该试验评估了标准化疗激素疗法联合抗PD-1免疫疗法的疗效。研究者基于蛋白质活性对Tme亚群进行了纵向分析,揭示了在多个转移灶中的免疫亚群。研究者还观察到这些免疫亚群对治疗反应的动态变化以及与临床结果具有相关性。本研究揭示了一种具有治疗耐药性、转录不同的肿瘤亚群,该亚群在治疗难治性患者中细胞数量增加。

关键词： Ⅱ期临床试验肿瘤微环境免疫疗法标准化疗前列腺癌临床结果激素疗法去势

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内循环流化床生物质气化过程的神经网络模型

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太阳能学报 2007年第12期28卷 1354-1359页

作者：马隆龙陈平原晓华阴秀丽吴创之颜涌捷华东理工大学中国科学院广州能源研究所中国科学院可再生能源与天然气水合物重点实验室广东省新能源和可再生能源研究开发与应用重点实验室广州510640

基于BP人工神经网络原理,利用mATLAB神经网络工具箱,以实验得到的57组气化实验数据作为样本,建立了一个以加料量和送风量为输入变量,以燃气热值、产气率、碳转化率和气化效率为输出变量,用于描述连续稳定气化过程的内循环流化床生物质... 详细信息

基于BP人工神经网络原理,利用mATLAB神经网络工具箱,以实验得到的57组气化实验数据作为样本,建立了一个以加料量和送风量为输入变量,以燃气热值、产气率、碳转化率和气化效率为输出变量,用于描述连续稳定气化过程的内循环流化床生物质气化模型。对模型的隐层节点数和训练周期改变对模拟结果的影响进行了分析,发现当隐层节点数为20,训练步骤为50步,模型的4个输出变量的模拟结果与实验结果相关系数均超过0.95;同时对该模型的预测能力进行了考察,模型预测结果与实验结果吻合良好,证明了该模型具有较强的泛化能力,为生物质内循环流化床气化系统的优化设计和自动控制提供新思路。

关键词：生物质气化内循环流化床 BP神经网络

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Frequency-dependent viscoelasticity effects on the wave attenuation performance of multi-layered periodic foundations

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Applied mathematics and mechanics(english edition) 2024年第3期45卷 407-424页

作者： m.SAFI m.VAKILIFARD m.J.mAHmOODI Faculty of Civil Water&Environmental EngineeringShahid Beheshti UniversityTehran ***Iran Faculty of mechanical and energy engineering Shahid Beheshti UniversityTehran ***Iran

In this paper,layered periodic foundations(LPFs)are numerically examined for their responses to longitudinal and transverse modes in the time and frequency *** different unit-cells,i.e.,2-layer,4-layer,and 6-layer unit-cells,comprising concrete/rubber,concrete/rubber/steel/rubber,and concrete/rubber/steel/rubber/lead/rubber materials,respectively,are taken into ***,the viscoelasticity behavior of the rubber is modeled with two factors,i.e.,a frequency-independent(FI)loss factor and a linear frequency-dependent(FD)loss *** the extraction of the complex dispersion curves and the identification of the band gaps(BGs),the simulations of wave transmission in the time and frequency domains are performed using the COmSOL *** parametric studies evaluate the effects of the rubber viscoelasticity models on the dispersion curves and the wave transmission for the longitudinal and transverse *** results show that considering the rubber viscoelasticity enhances the wave attenuation ***,the transverse-mode damping is more sensitive to the viscoelasticity model than its longitudinal *** 6-layer unit-cell LPF exhibits the lowest BG,ranging from 4.8 Hz to 6.5 Hz.

关键词： layered metamaterial periodic foundation complex dispersion curve wave transmission diagram

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变质矿床的成因分类

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长春地质学院学报 1993年第1期23卷 16-25页

作者： IO.m.索柯洛夫 m.e.萨利耶俄罗斯科学院前寒武纪地质和地质年代学研究所

本文溯本求源,讨论了变质成矿作用学说的建立、变质作用及变质成矿作用研究的几个历史阶段和现状,对以往的变质矿床分类做了分析,论证了本分类的理论前提,在该分类中划分出前变质、流变质(peo-)①和正变质矿床。

关键词：变质矿床成因分类成矿作用

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Assessment of the piroxicam-incited model of synchronized colitis in T-cell receptor alpha chain-deficient mice

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Animal models and experimental medicine 2024年第4期7卷 533-543页

作者： maximo e.Lange Danisa m.Bescucci Valerie F.Boras Tony montina G.Douglas Inglis douglas inglis 11 lethbridge research and development centre agriculture and agri-food canadalethbridgealbertacanada alberta health services chinook regional hospitallethbridgealbertacanada department of chemistry and biochemistry university of lethbridgelethbridgealbertacanada southern alberta genome sciences centre university of lethbridgelethbridgealbertacanada

Background:A multitude of mouse models are utilized to emulate and study intestinal inflammation.T-cell receptor alpha chain(TCRα)-deficient mice are used as a model of spontaneous colitis that has similarities with human ulcerative ***,colitis is triggered late in the life of the mouse(age:4-5 months),and inflammation does not develop at the same time in different mice.A previously conducted study reported that the administration of the drug piroxicam triggered predictable and early colitis in TCRα-deficient mice at the age of 6-8 ***,a detailed characterization of ensuing inflammation was not ***:We conducted an in-depth examination of piroxicam-triggered colitis in TCRα-deficient mice,with emphasis on spatial histopathologic changes and analysis of expression of inflammatory ***,we tested amelioration of colitis with ***:We confirmed that piroxicam induced a time-prescribed colitis and did so in the proximal colon as well as the cecum of TCRα-deficient *** adminis-tration was observed to induce epithelial hyperplasia,goblet cell loss,and leukocyte infiltration with occasional ulceration.A Swiss roll technique was used to examine the colon and cecum in its ***,we observed that inflammation was mul-tifocal segmental,with areas of tissue damage in between healthy *** addition,we observed variability in the severity of inflammation among replicate animals and treatments,and that the administration of dexamethasone only partially ameliorated inflammation in the proximal ***:Piroxicam consistently induced multifocal segmental colitis in the proxi-mal colon and cecum,although the degree of inflammation was reduced in the ***,spatial variability in inflammation in the large intestine and the inter-replicate variation in the severity of inflammation must be taken into consideration when utilizing this murine model of synchronized colitis.

关键词： colon dexamethasone histology induction inflammation knockout

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农村生物质气化燃气分散供暖经济和环境效益分析

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农业工程学报 2014年第14期30卷 213-218页

作者：周卫红陈冠益马隆龙颜蓓蓓夏宗鹏天津大学环境科学与工程学院天津300072 辽宁科技大学土木工程学院鞍山114051 天津大学内燃机燃烧学国家重点实验室天津300072 中国科学院广州能源研究所广州510640 天津大学中低温热能高效利用教育部重点实验室天津300072

为了充分利用农业废弃物资源,改善北方农村冬季供暖条件,该文对生物质气化燃气分散式供暖技术进行了经济和环境效益分析,探讨其在农村供暖中的可行性。生物质气化分散式供暖具有节约能源、减少大气污染、温度调节方便等优点。通过借鉴... 详细信息

为了充分利用农业废弃物资源,改善北方农村冬季供暖条件,该文对生物质气化燃气分散式供暖技术进行了经济和环境效益分析,探讨其在农村供暖中的可行性。生物质气化分散式供暖具有节约能源、减少大气污染、温度调节方便等优点。通过借鉴天然气分散式供暖的研究成果和对生物质气分散式供暖进行分析,结果表明采取分段式控温、分房间控温和建筑物节能改造等手段可将供暖费用降到合理水平,基本与城市供暖费用相同。通过该文分析可知生物质气化燃气分散式供暖可以作为农村供暖的一种新模式。

关键词：农村地区生物质气化燃气分散式供暖

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effect of biochar on the metabolome of soybean seedlings

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Oil Crop Science 2024年第1期9卷 60-68页

作者： Nathalia e.Silva mariana G.Aguilar Osania e.Ferreira Gleicia m.Paulino Jaqueline C.L.Carvalho Lúcia P.S.Pimenta Alan R.T.machado Programa de Pos-graduaçao em Ciencias Ambientais Universidade do Estado de Minas GeraisFrutalMinas Gerais38202-436Brazil Departamento de Química Universidade Federal de Minas GeraisMinas GeraisBelo Horizonte31270-901Brazil Departamento de engenharia Aplicada e Tecnologias Ambientais Universidade do Estado de Minas GeraisJoao MonlevadeMinas Gerais35930-314Brazil Departamento de Ciencias exatas Universidade do Estado de Minas GeraisJoao MonlevadeMinas Gerais35930-314Brazil

The use of biochar can have several effects on plant germination,depending on raw material,preparation method and application ***,the molecular mechanisms that lead to those results have yet to be *** aim of this research was to improve the understanding of these mechanisms by characterizing the metabolic effects of sugarcane bagasse biochar on soybean *** types of biochars were prepared by pyrolysis at 300℃(SCB300),400℃(SCB400)and 600℃(SCB600).Then,each one was mixed into sand at 1%,3%,5%(w/w)dose,*** experiment was performed in 8 days of incubation,when the num.e. of germinated seeds and the average radicle length were *** evaluate the metabolome,the dry biomass(DB)was subjected to extraction with a mixture of methanol-d4 and D2O(1:1 v/v).The extracts were submitted to metabolomics analysis by Proton Nuclear magnetic *** Relative Germination,Relative Average Radicle Growth and Germination Index increased in all treatments compared to *** the other hand,the DB increased in all treatments,except for SCB300,at doses of 1%and 3%w/*** metabolites(alanine,asparagine,acetic acid,citric acid,glycerol,fatty acids and sucrose)were identified and quantified in DB extracts as the most influential finding for the separation of *** together,these results strongly suggested that biochars accelerated the catabolism of triacylglycerols to sucrose and induced a slight osmotic stress.

关键词： Germination metabolomics 1H NmR Pyrolysis Sugarcane bagasse

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engineering of efficient visible light photocatalysts:Ti_(1-x+y)Cu_(x)La_(y)O_(2)(x=0.03;y=0,0.005,0.01) compositions

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Journal of Rare earths 2024年第3期42卷 497-505,I0003页

作者： S.m.Yakout A.m.Youssef Inorganic Chemistry Department National Research Centre(NRC)El Buhouth StDokkiCairo12622Egypt

In dye-photocatalysis, widening the wavelengths absorption range of catalysts as well as aborting the recombination of the photoexcited charge carriers(electrons-holes pairs) are of paramount *** the current study, we report the photocatalytic characteristics of four compositions composed of TiO_(2),Ti_(0.97)Cu_(0.03)O_(2), Ti_(0.965)Cu_(0.03)La_(0.005)O_(2)and Ti_(0.96)Cu_(0.03)La_(0.01)O_(2)powders for two harmful dyes(Congo red and methylene blue). The X-ray diffraction technique verified the configuration of mixed anatase and rutile phases in pure TiO_(2)and Ti_(0.97)Cu_(0.03)O_(2)powders while Ti_(0.965)Cu_(0.03)La_(0.005)O_(2)and Ti_(0.96)Cu_(0.03)La_(0.01)O_(2)powders possess anatase phase only. The changes of the band gap structure and dimensions of the unit cell volume of TiO_(2)confirm the substitution of Ti^(4+)sites by Cu^(2+)and La^(3+)ions. Remarkable widening of wavelengths absorption with formation of long absorption tails were found in TiO_(2)(3.13 e V) through insertion of La^(3+)plus Cu^(2+)ions. Ti_(0.965)Cu_(0.03)La_(0.005)O_(2)and Ti_(0.96)Cu_(0.03)La_(0.01)O_(2)samples exhibit a visible light band gap of 2.3 and 2.7 e V, respectively. Based on Sem images, incorporation of Cu^(2+)and La^(3+)ions influences the surface morphology of TiO_(2). The resulting Ti_(0.97)Cu_(0.03)O_(2), Ti_(0.965)Cu_(0.03)La_(0.005)O_(2)and Ti_(0.96)Cu_(0.03)La_(0.01)O_(2)powders present enhanced photocatalytic activity towards Congo red dye degradation compared to pure one under natural solar spectrum. The best Ti_(0.96)Cu_(0.03)La_(0.01)O_(2)catalyst exhibits superior photocatalytic activity of 96% for 10 ppm CR dye in 20 min as well as above average photocatalytic efficiency of 63% for 30 ppm CR dye in 120 min. As well, it showed acceptable photodegradation activity of 52% for 30 ppm mB solution in 140 min of sunlight irradiation. The heightened photodegradation efficiency of Ti_(0.96)Cu_(0.03)La_(0.01)O_(2)catalyst can be clarified in terms of higher ch

关键词： Semiconductor TiO_(2) Rare earths Congo red methylene blue Solar spectrum Photodegradation

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Cu-Fe基双孔载体催化剂结构和低碳醇合成反应性能

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物理化学学报 2012年第8期28卷 1964-1970页

作者：刘建国定明月王铁军马隆龙中国科学院可再生能源与天然气水合物重点实验室广州510640 中国科学院研究生院北京100049

采用超声浸渍法制备了Cu、Fe双活性组元改性的双孔载体(m)催化剂, 采用N2物理吸附、H2程序升温还原/脱附(H2-TPR/TPD)、X 射线衍射(XRD)等表征手段考察了催化剂中Cu-Fe的相互作用, 并在固定床反应器中评价了Cu/Fe摩尔比的改变对低碳醇... 详细信息

采用超声浸渍法制备了Cu、Fe双活性组元改性的双孔载体(m)催化剂, 采用N2物理吸附、H2程序升温还原/脱附(H2-TPR/TPD)、X 射线衍射(XRD)等表征手段考察了催化剂中Cu-Fe的相互作用, 并在固定床反应器中评价了Cu/Fe摩尔比的改变对低碳醇合成反应性能的影响. 结果表明: 小孔硅溶胶浸渍在大孔硅凝胶中可形成具有不同纳米孔径结构的双孔载体, 增加小孔硅溶胶的含量可促使双孔载体中小孔纳米结构尺寸变小. Fe/Cu摩尔比的增加有利于铜物种在载体表面的分散, 促进了表层CuO和Fe2O3的还原, 加强了双孔载体内孔道与铜铁氧化物之间的相互作用, 促使了单质铜的分散和铁碳化物的生成. CO加氢反应活性和低碳醇时空收率随着Fe/Cu摩尔比的逐渐增加呈现增加的变化趋势. 当Fe/Cu摩尔比增加到30/20时,Cu-Fe基双孔载体催化剂的CO转化率增加到46%, 低碳醇的时空收率增加到0.21 g·mL-1·h-1, C2+OH/CH3OH 质量比达到 1.96.

关键词：低碳混合醇合成:Cu—Fe基催化剂:双孔载体: 时空收率: 高级醇选择性

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