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Identification of Cu in <i>Crassostrea virginica</i>Tissue Using the Technique of Laser-Induced Breakdown Spectroscopy (LIBS)

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Optics and Photonics Journal 2021年第3期11卷 51-62页

作者： Xochitl Patricia Urrutia-meza Fabio Felipe chalé-Lara Rogelio Ortega-Izaguirre Instituto Politécnico Nacional Centro de Investigación en Ciencia Aplicada y Tecnología Avanzada U. Altamira Altamira México

The analysis of metals in aquatic organisms is of great importance due to the health problems they can cause to be consumed by human beings. In this study, the Laser-Induced Plasma Spectroscopy (LIBS) technique is evaluated as an alternative method to identify Cu in Crassostrea virginica oysters’ tissue. It focuses on the characterization of oysters caught a natural bank and the identification of different Cu concentrations. To carry out experimentation, oyster samples were collected in autumn (October 2017) and spring (may 2018) from San Andres Lagoon, Aldama, Tamaulipas. A single pulse Nd:YAG laser (1064 nm) was used, and tissue was contaminated with 0, 2, 10, 20, 50, and 100 μg/g of Cu. In tissue were identified atomic lines for Ca, Cr, mg, mn, Na, N, O, and H. However, the intensities of emission lines for autumn samples were greater than spring samples. Cu emission lines at 324.6, 327.1, 510.3, 515.1, and 521.5 nm were found for contaminated pills. The intensity of emission lines showed a linear increase with the concentration;whereby, they can be used as calibration curves to quantify Cu concentrations in oyster tissue.

关键词： LIBS Crassostrea virginica Heavy metals

Computational aerodynamic analysis on perimeter reinforced(PR)-compliant wing

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Chinese Journal of Aeronautics 2013年第5期26卷 1093-1105页

作者： N.I.Ismail A.H.Zulkifli m.Z.Abdullah m.Hisyam Basri Norazharuddin Shah Abdullah Faculty of m.chanical Engineering Universiti Teknologi MARA40450 Shah AlamSelangorMalaysia School of m.chanical Engineering Universiti Sains MalaysiaEngineering Campus14300 Nibong TebalPenangMalaysia School of materials and mineral Resources Engineering Universiti Sains MalaysiaEngineering Campus14300 Nibong TebalPenangMalaysia

Abstract Implementing the morphing technique on a micro air vehicle （mAV） wing is a very chal- lenging task, due to the mAWs wing size limitation and the complex morphing m.chanism. As a result, understanding aerodynamic characteristics and flow configurations, subject to wing structure deformation of a morphing wing mAV has remained obstructed. Thus, this paper presents the investigation of structural deformation, aerodynamics performance and flow formation on a pro- posed twist morphing mAV wing design named perimeter reinforced （PR）-compliant wing. The numerical simulation of two-way fluid structure interaction （FSI） investigation consist of a quasi- static aeroelastic structural analysis coupled with 3D incompressible Reynolds-averaged Navier- Stokes and shear-stress-transport （RANS-SST） solver utilized throughout this study. Verification of numerical method on a rigid rectangular wing achieves a good correlation with available exper- imental results. A comparative aeroelastic study between PR-compliant to PR and rigid wing per- formance is organized to elucidate the morphing wing performances. Structural deformation results show that PR-compliant wing is able to alter the wing＇s geometric twist characteristic, which has directly influenced both the overall aerodynamic performance and flow structure behavior. Despite the superior lift performance result, PR-compliant wing also suffers from massive drag penalty, which has consequently affected the wing efficiency in general. Based on vortices investigation, the results reveal the connection between these aerodynamic performances with vortices formation on PR-comoliant wing.

关键词： Aerodynamics Aeroelasticity Fluid structure interaction micro air vehicle (mAV) morphing wing

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梦游快照

汽车生活 2011年第10期 42-43页

作者： cham Jensen 张萌

如果第一次接触雷内·马格利特的画,你会清晰地感觉到,似乎有什么重要的玄机被你漏掉了。这正是我们第一次看到摄影师川岛高拍摄的加州高速公路照片＂Everybody Is Dreaming＂时的感觉。再仔细看一眼,恍然大悟：所有的车子都是红色的!... 详细信息

如果第一次接触雷内·马格利特的画,你会清晰地感觉到,似乎有什么重要的玄机被你漏掉了。这正是我们第一次看到摄影师川岛高拍摄的加州高速公路照片＂Everybody Is Dreaming＂时的感觉。再仔细看一眼,恍然大悟：所有的车子都是红色的!随后我们才知道,

关键词：快照高速公路摄影师

Rethinking the architecture design of data center networks

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Frontiers of Computer Science 2012年第5期6卷 596-603页

作者： Kaishun WU Jiang XIAO Lionel m. NI National Engineering Research Center of Digital Life State-Province Joint Laboratory of Digital Home Interactive Applications School of Physics and Engineering Sun Yat-sen University Guangzhou 510006 China Department of Computer Science and Engineering Hong Kong University of Science and Technology Hong Kong China

In the rising tide of the Internet of things, more and more things in the world are connected to the Internet. Recently, data have kept growing at a rate more than four times of that expected in moore＇s law. This explosion of data comes from various sources such as mobile phones, video cameras and sensor networks, which often present multidi- mensional characteristics. The huge amount of data brings many challenges on the management, transportation, and pro- cessing IT infrastructures. To address these challenges, the state-of-art large scale data center networks have begun to provide cloud services that are increasingly prevalent. How- ever, how to build a good data center remains an open chal- lenge. Concurrently, the architecture design, which signifi- cantly affects the total performance, is of great research inter- est. This paper surveys advances in data center network de- sign. In this paper we first introduce the upcoming trends in the data center industry. Then we review some popular design principles for today＇s data center network architectures. In the third part, we present some up-to-date data center frame- works and make a comprehensive comparison of them. Dur- ing the comparison, we observe that there is no so-called op- timal data center and the design should be different referring to the data placement, replication, processing, and query pro- cessing. After that, several existing challenges and limitations are discussed. According to these observations, we point out some possible future research directions.

关键词： data center networks switch-based networks,direct networks hybrid networks

Germline BRCA2 variants in advanced pancreatic acinar cell carcinoma:A case report and review of literature

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World Journal of Gastroenterology 2022年第45期28卷 6421-6432页

作者： cha Len Lee Spring Holter Ayelet Borgida Anna Dodd Stephanie Ramotar Robert Grant Kristy Wasson Elena Elimova Raymond W Jang malcolm moore Tae Kyoung Kim Korosh Khalili Carol-Anne moulton Steven Gallinger Grainne m O’Kane Jennifer J Knox Division of medical Oncology and Hematology Wallace McCain Center for Pancreatic CancerPrincess Margaret Cancer CentreToronto M5G1Z5ONCanada Department of medical Imaging Wallace McCain Center for Pancreatic CancerPrincess Margaret Cancer CentreToronto M5G1Z5ONCanada Hepatobiliary/Pancreatic Surgical Program Wallace McCain Center for Pancreatic CancerPrincess Margaret Cancer CentreToronto M5G1Z5ONCanada

BACKGROUND Pancreatic acinar cell carcinoma(PACC)is a rare *** to 45%of PACCs have alterations in the DNA damage repair pathway and 23%harbor rearrangements in the BRAF or RAF1 *** present a PACC case with a germline BRCA2 likely pathogenic variant(LPV)to highlight the impact of genomic testing on treatment decisions and patient *** our larger case series,we provide clinic-based information on additional 10 PACC patients treated in our *** SUmmARY A 70-year-old male was diagnosed with advanced *** presentation,he was cachectic with severe arthralgia despite prednisolone and a skin rash that was later confirmed to be *** was treated with modified FOLFIRINOX(mFFX)with the knowledge of the germline BRCA2 *** 11 cycles of mFFX,a computed tomography(CT)scan demonstrated significant tumor response in the pancreatic primary and hepatic metastases,totaling 70%from baseline as per Response Evaluation Criteria in Solid *** of the skin panniculitis was also *** identified two additional PACCs with druggable targets in our case *** data contribute to practical evidence for the value of germline and somatic profiling in the management of rare diseases like *** This patient and others in our larger case series highlight the importance of genomic testing in PACC with potential utility in personalized treatment.

关键词： Pancreatic acinar carcinoma BRCA Polyadenosine diphosphate-ribose polymerase inhibitor Case report

Comparison of micromorphological Features of Two Agricultural Cultivated Soils in Guanzhong Areas, Shaanxi Province, China

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Agricultural Sciences in China 2007年第9期6卷 1089-1098页

作者： PANG Jiang-li QIU Hai-yan HUANG Chun-chang cha Xiao-cun ZHANG Xu College of Tourism and Environmental Sciences Shaanxi Normal University Xi＇an 710062 P.R.China State Key Laboratory of Loess and Quaternary Geology Institute of Earth Environment Chinese Academy of Sciences （CAS） Xi＇an 710075. P.R.China

By comparing micromorphological features of irrigated and non-irrigated soils in Guanzhong areas, China, this paper tries to illustrate the influences of farming management methods on the soil-forming process. The micromorphology was observed under a petrographic microscope and its image was quantificationally measured by Nikon NISBR 2.2 software. Both irrigated and non-irrigated soils have the same soil profile pattern, Ap1- AP2- BC, but the former has a more obvious profile dissimilation. The minerals assemblage of soil profiles A and B are very similar, which is mainly composed of Q and P1. Compared with non-irrigated soil, grains of irrigated soil remarkably decrease in length, area, eqdiameter, perimeter, elongation, roundness, and C/F10μm ratio; voids are characterized by more regular void shape and more smooth void wall; there is more abundant residual clay and small amount of illuvial clay. All results in this study suggest that the farming management method has influences on soil profile dissimilation and micromorphology. Agricultural irrigation could strengthen the degree of weathering, make smaller and rounder soil grains, cause a significant increase of residual clay and appearance of illuvial clay. But no significant change has been observed in the minerals assemblage of coarse grains.

关键词： micromorphology irrigation Guanzhong areas

Reversal of pulmonary vein remodeling after catheter ablation of atrial fibrillation

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Journal of Geriatric Cardiology 2016年第2期13卷 163-168页

作者： Jia-Hui WU Hung-Kei LI Daniel m Couri Philip A Araoz Ying-Hsiang Lee chang-Sheng mA Douglas L Packer Yong-mei cha Department of Cardiology Beijing Anzhen Hospital Capital Medical University Beijing Institute of Heart Lung and Blood Vessel Diseases Beijing China Heart Rhythm Specialists Phoenix Arizona USA Prairie Cardiovascular Consultants Ltd. Springfield Illinois USA Department of Radiology Mayo Clinic Rochester Minnesota USA Department of Cardiovascular medicine Mackay Memorial Hospital Taipei Taiwan China Division of Cardiovascular Diseases Mayo Clinic Rochester Minnesota USA

Background Pulmonary veins （PV） and the atria undergo electrical and structural remodeling in atrial fibrillation （AF）. This study aimed to determine PV and left atrial （LA） reverse remodeling after catheter ablation for AF assessed by chest computed tomography （CT）. methods PV electrophysiologic studies and catheter ablation were performed in 63 patients （68% male; mean ± SD age： 56 ± 10 years） with symptomatic AF （49% paroxysmal, 51% persistent）. Chest CT was performed before and 3 months after catheter ablation. Results At baseline, patients with persistent AF had a greater LA volume （91 ±29 cm3 vs. 66 ± 27 cm3; P = 0.003） and mean PV ostial area （241 ＋ 43 mm2 vs. 212 ± 47 mm2; P = 0.03） than patients with paroxysmal AF. There was no significant correlation between the effective refractory period and the area of the left superior PV ostium. At 3 months of follow-up after ablation, 48 patients （76%） were AF free on or off antiarrhythmic drugs. There was a significant reduction in LA volume （77 ±31 cm3 to 70 ± 28 cm3; P 〈 0.001） and mean PV ostial area （224 ± 48 mm2 to 182 ± 43 mm2; P 〈 0.001）. Patients with persistent AF had more reduction in LA volume （11.8 ± 12.8 cm3 vs. 4.0 ± 11.2 cm3; P = 0.04） and PV ostial area （62 mm2 vs. 34 mm2; P = 0.04） than those who have paroxysmal AF. The reduction of the averaged PV ostial area was significantly correlated with the reduction of LA volume （r = 0.38, P = 0.03）. Conclusions Catheter ablation of AF improves structural remodeling ofPV ostia and left atrium. This finding is more apparent in patients with persistent AF treated by catheter ablation.

关键词： Ablation Atrial fibrillation Computed tomography Left atrium Pulmonary vein isolation Pulmonary vein ostial area

L-Palmitoylcarnitine potentiates plasmin and tPA to inhibit thrombosis

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Natural Products and Bioprospecting 2023年第1期13卷 171-180页

作者： Juan Yang Lina cha Yepeng Wang Quan Zhang Xiaopeng Tang Jianlin Shao Zilei Duan Department of Anesthesiology First Affiliated Hospital of Kunming Medical UniversityKunming 650032China State Key Laboratory of Drug Research Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China College of Life Sciences Nanjing Agricultural UniversityNanjing 210095China Small molecule Drugs Sichuan Key Laboratory Institute of Materia MedicaSchool of PharmacyChengdu Medical CollegeChengdu 610500China School of Basic medicine Qingdao UniversityQingdao 266071ShandongChina

L-Palmitoylcarnitine(L-PC)is an important endogenous fatty acid *** classical biological functions are involved in the regulations of membrane molecular dynamics and theβ-oxidation of fatty *** plasma long-chain acylcarnitines showed the association of venous thrombosis,implying anticoagulant activity of the metabolites and inspiring us to investigate if and how L-PC,a long-chain acylcarnitine,takes part in *** we show that L-PC exerted anti-coagulant effects by potentiating the enzymatic activities of plasmin and tissue plasminogen activator(tPA).L-PC directly interacts with plasmin and tPA with an equilibrium dissociation constant(KD)of 6.47×10^(-9)and 4.46×10^(-9)m,respectively,showing high *** mouse model,L-PC administration significantly inhibited FeCl_(3)-induced arterial *** also mitigated intracerebral thrombosis and inflammation in a transient middle cerebral artery occlusion(tmCAO)mouse model.L-PC induced little bleeding *** results show that L-PC has anti-thrombotic function by potentiating plasmin and tPA.

关键词： L-palmitoylcarnitine Coagulation Plasmin Tissue-type plasminogen activator Thrombosis

Intra and extra pelvic multidisciplinary surgical approach of retroperitoneal sarcoma:Case series report

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World Journal of Clinical Cases 2022年第27期10卷 9693-9702页

作者： Heekyoung Song Jung Hwan Ahn Yuyeon Jung Jae Yeon Woo Jimin cha Yang-Guk Chung Keun Ho Lee Department of Obstetrics and Gynecology Incheon St.Mary’s HospitalCollege of MedicineThe Catholic University of KoreaSeoul 06591South Korea Department of Obstetrics and Gynecology Seoul St.Mary’s HospitalCollege of MedicineThe Catholic University of KoreaSeoul 06591South Korea Department of Orthopaedic Surgery Seoul St.Mary’s HospitalCollege of MedicineThe Catholic University of KoreaSeoul 06591South Korea

BACKGROUND Retroperitoneal sarcoma(RPS) is a rare malignancy arising from mesenchymal cells that most commonly presents as an abdominal mass and is associated with poor *** several studies have assessed the survival benefits of wide excision,few have reported detailed methods for achieving wide excision in patients with *** To describe our experience with multidisciplinary surgical resection of RPS using intra-and extra-pelvic *** multidisciplinary surgery is an anatomical approach that combines intra-and extra-peritoneal access within the same surgery to achieve complete RPS *** retrospective review of the records of patients who underwent multidisciplinary surgery for RPS analyzed surgical and survival *** Eight patients underwent 10 intra-and extra-pelvic surgical resections,and their median mass size was 12.75 cm(range,6-45.5 cm).Using an intrapelvic approach,laparoscopy-assisted surgery was performed in four cases and laparotomy surgery in *** an extrapelvic approach,ilioinguinal and posterior approaches were used in four cases each,and the prone position and midline skin incision were shared in *** patients’ RPS masses were removed completely,and four achieved R0 resection through intra-and extra-pelvic *** median estimated blood loss was 2000 m L(range,300-20000 m L) and the median hospitalization was 12.6 d(range,9-69 d).Reoperation was needed in two patients(one for wound necrosis and the other for bowel perforation and wound necrosis).The median overall survival rate and median progression-free survival were 64.6 and 13.7 mo,*** RPS is therapeutically challenging because of its location and high risk of ***,intra-and extra-pelvic surgical approaches can improve the macroscopic security of the surgical margin.

关键词： margins of excision Retroperitoneal neoplasms Sarcoma