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3D kinematicmandiblemodel to designmandibular advancement devices for the treatment of obstructive sleep apnea

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Bio-Design and manufacturing 2021年第1期4卷 22-32页

作者： m.García J.A.cabrera A.Bataller S.Postigo J.J.Castillo Department of mechanical Engineering University of MálagaC/Doctor Ortiz Ramos s/nAmpliación Campus Teatinos29071 MálagaSpain

mandibular advancement devices(mADs)are one of the treatments used for Obstructive sleep apnea(OSA).mADs try to maintain the mandible in an advanced position to keep the upper airways open when *** achieve this goal,most current mADs limit the mouth opening to a few *** study of the kinematic behaviour of the patient’s jaw is essential in order to design devices that allow greater aperture *** this purpose,a 3D multibody model that reproduces jaw movement has been developed in this *** this end,the movement of the lower incisor has been determined by means of a vision system and reflective *** addition,the kinematics of the temporomandibular joint has been ***,the device is designed and printed using a cam-follower *** way,the cam profiles and the followers are optimally designed and positioned for each patient depending on the physiognomy of the jaw and the opening and advancing movement prescribed by the specialist.

关键词： mandibular advancement device 3D mandible kinematics Cam-follower mechanism 3D printed devices

Cancer stem cell plasticity and tumor hierarchy

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World Journal of Stem Cells 2015年第1期7卷 27-36页

作者： marina Carla cabrera Robert E Hollingsworth Elaine m Hurt medImmune LLC Department of Oncology ResearchGaithersburg MD 20878 United States

The origins of the complex process of intratumoral heterogeneity have been highly debated and different cellular mechanisms have been hypothesized to account for the diversity within a tumor. The clonal evolution and cancer stem cell(CSC) models have been proposed as drivers of this heterogeneity. However, the concept of cancer stem cell plasticity and bidirectional conversion between stem and non-stem cells has added additional complexity to these highly studied paradigms and may help explain the tumor heterogeneity observed in solid tumors. The process of cancer stem cell plasticity in which cancer cel s harbor the dynamic ability of shifting from a non-CSC state to a CSC state and vice versa may be modulated by specific microenvironmental signals and cellular interactions arising in the tumor niche. In addition to promoting CSC plasticity, these interactions may contribute to the cellular transformation of tumor cells and affect response to chemotherapeutic and radiation treatments by providing CSCs protection from these agents. Herein, we review the literature in support of this dynamic CSC state, discuss the effectors of plasticity, and examine their role in the development and treatment of cancer.

关键词： Cancer stem cells Stem cell Plasticity Tumor hierarchy microenvironment Immune-mediatedtherapies Epithelial-to-mesenchymal transition

Influence of birth order, birth weight, colostrum and serum immunoglobulin G on neonatal piglet survival

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Journal of Animal Science and Biotechnology 2013年第2期4卷 128-136页

作者： Rafael A cabrera Xi Lin Joy m Campbell Adam J moeser Jack Odle Laboratory of Developmental Nutrition Department of Animal Science North Carolina State University Huvepharma USA Inc. 525 West Park Drive Suite 230 Peachtree City American Protein Corporation Department of Population Health and Pathobiology College of Veterinary Medicine North Carolina State University 101 Polk Hall North Carolina State University

Background： Intake of colostrum after birth is essential to stimulate intestinal growth and function, and to provide systemic immunological protection via absorption of Immunoglobulin G （IgG）. The birth order and weight of 745 piglets （from 75 litters） were recorded during a one-week period of farrowing. Only pigs weighing greater than 0.68 kg birth weight were chosen for the trial. Sow colostrum was collected during parturition, and piglets were bled between 48 and 72 hours post-birth. Piglet serum IgG and colostral IgG concentrations were determined by radial immunodiffusion. Results： Sow parity had a significant （P 〈 0.001） effect on sow colostral IgG concentration, being 5% higher in multiparous females. Sow colostral IgG concentration explained 6% and piglet birth order accounted for another 4% of the variation observed in piglet serum IgG concentration （P 〈 0.05）; however, birth weight had no detectable effect. Piglet serum IgG concentration had both a linear （P 〈 0.05） and quadratic effect （P 〈 0.05） on % survival. Piglets with 1,000 mg/dl serum IgG or less （n=24） had a 67% survival; whereas, piglets with IgG concentrations between 2250 to 2500 mg/dl （n=247） had a 91% survival. Birth order had no detectable effect on survival, but birth weight had a positive linear effect （P 〈 0.05）. Piglets weighing 0.9 kg （n = 107） at birth had a 68% survival rate, and those weighing 1.6 kg （n = 158） had an 89% survival. Conclusion： We found that the combination of sow colostrum IgG concentration and birth order can account for 10% of the variation of piglet serum IgG concentration and that piglets with less than 1,000 mg/dl IgG serum concentration and weight of 0.9 kg at birth had low survival rate when compared to their larger siblings. The effective management of colostrum uptake in neonatal piglets in the first 24 hrs post-birth may potentially improve survival from birth to weaning.

关键词： Birth order Birth weight Immunoglobulin G Colostrum Survivability

On the installation of an in situ large-scale vertical SEALing (VSEAL) experiment on bentonite pellet-powder mixture

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Journal of Rock mechanics and Geotechnical Engineering 2023年第9期15卷 2388-2401页

作者： Nadia mokni Justo cabrera Frédéric Deleruyelle Institut de Radioprotection et de SûretéNucléaire(IRSN) PSE-ENV/SEDRE/LETISFontenay-aux-Roses92260France

Recently,the Institute for Radiological protection and Nuclear Safety(IRSN)has launched VSEAL(Vertical SEALing)project to investigate the impact of gas migration on the long-term performance of bentonite based vertical sealing systems(VSS).The first VSEAL in situ test was emplaced in IRSN’s Underground Research Laboratory(URL)in Tournemire(France)in 2019 and was equipped with 76 wired and wireless *** test is still in progress,but the collected set of data provides already valuable information of the hydro-mechanical behavior of VSS during *** swelling core consists of a mixture of highdensity pellets and powder of mX80 bentonite in a ratio of 80/20(in dry mass).An innovative method was adopted to drill a 1-m diameter and w10-m deep shaft in order to minimize the rock perturbation at the *** a specific protocol was adopted to install the bentonite mixture together with a careful characterization of the core during construction,VSEAL 1 constitutes the unique in situ sealing test with a well-known initial structural distribution of the pellets and the *** heterogeneities occurred within the experiment during the installation process:a damaged zone developed around the shaft walls due to the interruption of the installation operations caused by COVID19 lockdown in France;a technological gap with a variable thickness between the last pellets layer and the top confining lid and a heterogeneous distribution of the bentonite powder at some layers inducing large inter pellets voids close to the bentonite-rock *** injected water volume,relative humidity,water content and swelling pressure in both radial and axial directions were *** of the results showed that the presence of installation-induced heterogeneities led to the generation of preferential flow paths that influenced the swelling pressure evolution at radial and axial directions.

关键词： Bentonite pellet-powder mixture Heterogeneities Technological gap Seals In situ test

DBD-Corona Discharge for Degradation of Toxic Gases

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Plasma Science and Technology 2007年第6期9卷 682-685页

作者： m.PACHECO-PACHECO J.PACHECO-SOTELO H.mORENO-SAAVEDRA J.A.DIAZ-GOmEZ A.mERCADO-cabrera m.YOUSFI National Institute of Nuclear Research OcoyoacacMexico Toluca Institute of Technology TolucaMexico Center of Plasma Physics and their Applications of Toulouse France

The non-thermal plasma technology is a promising technique to treat SO2 and NOx. Chemical radicals produced with this technology can remove several pollutants at atmospheric pressure in a very short period of time simultaneously. Both theoretical and experimental study on SO2 and NOx removal, by a dielectric barrier discharge （DBD） with corona effect, is presented.

关键词： DBD-corona de-NOx process de-SO2 process

Exploratory study of non-invasive,high-resolution functional macular imaging in subjects with diabetic retinopathy

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International Journal of Ophthalmology(English edition) 2021年第1期14卷 57-63页

作者： Thalmon R.Campagnoli Gábor márk Somfai Jing Tian Delia cabrera DeBuc William E.Smiddy Bascom Palmer Eye Institute Miller School of MedicineUniversity of MiamiMiamiFL 33136USA Department of Ophthalmology Semmelweis UniversityFaculty of MedicineBudapestHungary

AIm:To evaluate a high-resolution functional imaging device that yields quantitative data regarding macular blood flow and capillary network features in eyes with diabetic retinopathy(DR).mETHODS:Prospective,cross-sectional comparative case-series in which blood flow velocities(BFVs)and noninvasive capillary perfusion maps(nCPms)in macular vessels were measured in patients with DR and in healthy controls using the Retinal Functional Imager(RFI)***:A total of 27 eyes of 21 subjects were studied[9 eyes nonproliferative diabetic retinopathy(NPDR),9 eyes proliferative diabetic retinopathy(PDR)and 9 controls].All diabetic patients were type *** patients with NPDR and 5 eyes with PDR also had diabetic macular edema(DmE).The NPDR group included eyes with severe(n=3)and moderate NPDR(n=6),and were symptomatic.A significant decrease in venular BFVs was observed in the macular region of PDR eyes when compared to controls(2.61±0.6 mm/s and 2.92±0.72 mm/s in PDR and controls,respectively,P=0.019)as well as PDR eyes with DmE compared to NPDR eyes(2.36±0.51 mm/s and 2.94±1.09 mm/s in PDR with DmE and NPDR,respectively,P=0.01).CONCLUSION:The RFI,a non-invasive imaging tool,provides high-resolution functional imaging of the retinal microvasculature and quantitative measurement of BFVs in visually impaired DR *** isolated diminish venular BFVs in PDR eyes compared to healthy eyes and PDR eyes with DmE in comparison to NPDR eyes may indicate the possibility of more retinal vein compromise than suspected in advanced DR.

关键词： macular blood flow capillary perfusion map non-invasive vascular imaging high-resolution imaging diabetic retinopathy retinal function imager

Six forests in one:Tree species diversity in the Bosque Protector Chongón Colonche,a lowland mountain range in coastal Ecuadorian

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Forest Ecosystems 2022年第6期9卷 725-733页

作者： Oswaldo Jadan David ADonoso Edwin Ponce-Ramírez Franz Pucha-Cofrep Omar cabrera Facultad de Ciencias Agropecuarias Universidad de Cuenca12 de Octubre y Diego de TapiaCuenca010107Ecuador Programa de Doctorado en Conservacion de Recursos Naturales Escuela Internacional de DoctoradoUniversidad Rey Juan CarlosMostolesMadridES-28933Spain Departamento de Biología Escuela Politecnica NacionalLadron de Guevara E11⋅253Quito170525Ecuador Geoforest S.A 12 de febrero y Av.Franklin VegaMacas140150Ecuador Grupo de Investigacion Hidrología y Climatología Universidad Tecnica Particular de LojaSan Cayetano Alto S/NLoja110101Ecuador Brandenburg University of Technology(BTU)Cottbus-Senftenberg 03044CottbusGermany Departamento de Ciencias Biologicas y Agropecuarias Universidad Tecnica Particular de LojaSan Cayetano Alto S/NLoja110101Ecuador

Tropical mountain ranges shape the structure of tree communities and promote highly diverse natural ***“Bosque Protector Chong on-Colonche”(BPCC),an 86,000-ha mountain formation situated on the coast of Ecuador,is biogeographically important for the region by connecting floristic elements of the wet Choco and the dry Tumbesian *** understanding of the factors that model tree and palm diversity and distribution in this mountain range are *** measured and identified all trees and palms(DBH≥10 cm)in 289 plots of0.2 ha,distributed throughout *** used generalized linear models to explain the relationship between forest diversity and structure and climatic variables(temperature,rain,aridity),and *** then used cluster and non-metric multidimensional scale(NmDS)analyses to search for distinct forest communities within the *** partition(varpart)was used to determine which predictor variables best explained these distinct forest communities.A species indicator analysis identified the species most likely to define these distinct forest ***,we carried out a niche modeling approach to identify the potential distribution of these forest communities within *** total,we identified 220 tree and palm species in our *** average number of species per plot was 17.8±5.8,ranging from 3 to 40 *** methods sorted the 289study plots into six different forest communities,three communities in the dry forest and three in the semi-humid Garúa *** and temperature,but not altitude or aridity,explained floristic *** results emphasize the high but little cataloged diversity in the lowland mountain rainforests of coastal Ecuador.

关键词： Chongón-Colonche Climatic variables Dry forest Forest communities Garúa forest

等径通道挤压后TWIP钢力学性能以及微观组织演化（英文）

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材料热处理学报 2016年第11期37卷 86-95页

作者：王雷 BENITO J A CALVO J cabrera J m 西安石油大学材料科学与工程学院陕西西安710065 加泰罗尼亚理工大学工业工程学院材料科学与冶金工程系ETSEIB 加泰罗尼亚理工大学工业工程学院材料科学与冶金工程系EUETIB 曼雷萨科技中心

研究了等径通道挤压技术对于一种低碳高锰孪晶诱导塑性变形(TWIP)钢力学性能,微观结构以及织构性能的影响。微拉伸实验结果表明:TWIP钢维氏硬度值,屈服强度和抗拉强度随挤压道次增长不断升高,而塑性则下降。通过EBSD分析,结果表明经等... 详细信息

研究了等径通道挤压技术对于一种低碳高锰孪晶诱导塑性变形(TWIP)钢力学性能,微观结构以及织构性能的影响。微拉伸实验结果表明:TWIP钢维氏硬度值,屈服强度和抗拉强度随挤压道次增长不断升高,而塑性则下降。通过EBSD分析,结果表明经等径通道挤压,平均晶粒尺度由原始状态下的199.6μm减小到不足1μm,孪晶比例也随之下降。关于ECAP挤压后的织构演化,EBSD结果表明原始状态下的主导织构为Goss和Brass,而在挤压后,逐渐由一道次的A*1和A*2织构向多道次的B/B·织构过渡。这表明了多道次挤压后材料呈现了更加稳定的微观结构。

关键词： TWIP钢等径通道挤压技术(ECAP) 微观结构织构力学性能

多道次等径通道挤压后TWIP钢的本构模型（英文）

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材料热处理学报 2017年第2期38卷 185-190页

研究了通过等径通道挤压技术加工后的诱导孪晶塑性变形钢(TWIP钢)的力学性能,并且通过Ludwik,Hollomon以及Swift三种本构模型对拉伸真实应力应变曲线进行了拟合。实验结果表明:随着挤压道次的增加,屈服强度以及极限抗拉强度不断升高,而... 详细信息

研究了通过等径通道挤压技术加工后的诱导孪晶塑性变形钢(TWIP钢)的力学性能,并且通过Ludwik,Hollomon以及Swift三种本构模型对拉伸真实应力应变曲线进行了拟合。实验结果表明:随着挤压道次的增加,屈服强度以及极限抗拉强度不断升高,而塑性,抗拉韧性不断下降。Ludwik,Hollomon以及Swift三种本构模型对于真实应力应变曲线的拟合程度较好,并且本文给出了各模型中的拟合参数。拟合参数中,本文着重讨论了应变硬化系数n随着挤压道次的升高而降低的原因。

关键词： TWIP钢等径通道挤压技术(ECAP) 力学性能本构模型