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Hormone-ba.ed pha.ma.othera.y for meta.olic dysfunction-a.socia.ed fa.ty liver disea.e

medica. Review 2024年第2期4卷 158-168页

作者： Za.a.Siu Wa.Chui Ya.ia. Xue a.min Xu Sta.e Key La.ora.ory of Pha.ma.eutica. Biotechnology The University of Hong KongHong Kong SARChina Depa.tment of medicine The University of Hong KongHong Kong SARChina School of Biomedica. Sciences The University of Hong KongHong Kong SARChina Sta.e Key La.ora.ory of Pha.ma.eutica. Biotechnology The University of Hong Kong999077Hong Kong SARChina Depa.tment of medicine The University of Hong Kong999077Hong Kong SARChina Depa.tment of Pha.ma.ology a.d Pha.ma.y The University of Hong Kong999077Hong Kong SARChina

meta.olic dysfunction-a.socia.ed fa.ty liver disea.e(ma.LD)ha. rea.hed epidemic proportions globa.ly in pa.a.lel to the rising preva.ence of *** its significa.t burden,there is no a.proved pha.ma.othera.y specifica.ly ta.lored for this *** potentia. drug ca.dida.es for ma.LD ha.e encountered setba.ks in clinica. tria.s,due to sa.ety concerns or/a.d insufficient thera.eutic ***,severa. investiga.iona. drugs tha. mimic the a.tions of endogenous meta.olic hormones,including thyroid hormone receptorβ(THRβ)a.onists,fibrobla.t growth fa.tor 21(FGF21)a.a.ogues,a.d gluca.on-like peptide-1 receptor a.onists(GLP-1Ra.),showed promising thera.eutic effica.y a.d excellent sa.ety *** them,resmetirom,a.liver-ta.geted THRβ-selective a.onist,ha. met the prima.y outcomes in a.levia.ion of meta.olic dysfunction-a.socia.ed stea.ohepa.itis(ma.H),the a.va.ced form of ma.LD,a.d liver fibrosis in pha.e-3 clinica. *** hormone-ba.ed pha.ma.othera.ies not only exhibit va.ied degrees of thera.peutic effica.y in mitiga.ing hepa.ic stea.osis,infla.ma.ion a.d fibrosis,but a.so improve meta.olic ***more,these three hormona. a.onists/a.a.ogues a.t in a.complementa.y ma.ner to exert their pha.ma.ologica. effects,suggesting their combined thera.ies ma. yield synergistic thera.eutic *** in-depth studies on the intrica.e interpla. a.ong these meta.olic hormones a.e impera.ive for the development of more effica.ious combina.ion thera.ies,ena.ling precision ma.a.ement of ma.LD a.d its a.socia.ed comorbidities.

关键词： meta.olic hormones meta.olic dysfunctiona.socia.ed stea.ohepa.itis(ma.H) liver fibrosis biopha.ma.eutica. development clinica. tria.s

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Photometric Studies of EV Cnc a.d a. Cnc in the Open Cluster m67

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Resea.ch in a.tronomy a.d a.trophysics 2024年第8期24卷 196-211页

作者： ma.a.ha.Ra.i G. K.Srira. Deblina.La.iri Vija.a.a. Depa.tment of a.tronomy Osmania UniversityHyderabad 500007India

Conta.t bina.ies a. va.ious sta.es of evolution unveil va.ious opera.ing mecha.isms tha. drive *** report the photometric a.d period va.ia.ion a.a.ysis of two conta.t bina.ies EV Cnc a.d a. Cnc in open cluster *** observed the cluster from the JCBT 1.3 m telescope a.d utilized TESS a.d Kepler *** photometric solutions of EV Cnc a.d a. Cnc revea.ed a.ma.s ra.io of q~0.41 a.d~0.15 with a. inclina.ion of i=42°a.d87°*** solutions suggest tha. EV Cnc is proba.ly a.semi-deta.hed a.d a. Cnc is a.deep low-ma.s ra.io conta.t *** study of O-C va.ia.ion a.a.ysis indica.es tha. for both systems,the period is increa.ing which suggests the ma.s tra.sfer is occurring from seconda.y to *** the ca.e of a. Cnc a.d ba.ed on simula.ions by ra.domly va.ying the time of minima.to fit the LITE solution,we noted the third body orbita. period to be a.ound P_(3)=26.82±2.54 yr,which is different from ea.lier reported va.ues a.d conclude tha. future observa.ions a.e required to confirm this *** compa.e these two systems with other simila. conta.t bina.ies to get a. estima.e of the fina. configura.ion of the respective systems.

关键词： (sta.s)bina.ies(including multiple) close-(sta.s)bina.ies eclipsing-sta.s a.tivity

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First-principles ca.cula.ions to investiga.e structura.,electronic,ma.netic,optica. a.d thermodyna.ic properties of RE_(2)Rh_(3)Ge(RE=Pr,Sm)

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Journa. of Ra.e Ea.ths 2024年第7期42卷 1385-1393,I0007页

作者： a.Eza.er R.ma.rour m.Ha.edoun J.Kha.ba.h a.Rezzouk a.Hourma.a.la. N.Benza.our K.Bouslykha.e La.ora.ory of Solid Physics Faculty of Sciences Dhar El MehrazSidi Mohamed Ben Abdellah UniversityBP 1796FezMorocco Equipe de Physique du Solide LaboratoiresLIPIEcole Normale SupérieureBensoudaFèsMorocco

In this pa.er,we a.a.yzed the physica. cha.a.teristics of the terna.y a.loys RE_(2)Rh_(3)Ge(RE=Pr a.d Sm)using the first principles ca.cula.ion ba.ed on functiona. density theory integra.ed in the Wien2k *** ca.cula.ed forma.ion energies of Pr_(2)Rh_(3)Ge a.d Sm_(2)Rh_(3)Ge a.e−5.3827 a.d−5.2782 eV/a.om,respectively,showing tha. these a.loys ma. exist *** results of the ba.d structure a.d density of sta.es indica.e tha. a.l of the compounds tested a.e ma.netic meta.s,a.d their ma.netism is mostly rela.ed to the contribution of Pr a.d Sm *** tota. ma.netic moments of Pr_(2)Rh_(3)Ge a.d Sm_(2)Rh_(3)Ge a.e 4.07245 a.d 11.16161μB/f.u,*** pa.a.eters such a. hea. ca.a.ity a. consta.t pressure,entropy,Debye tempera.ure,la.tice volume,compressibility coefficients,a.d Grüneisen pa.a.eter a.loys were ca.cula.ed using the Gibbs a.gorithm a.d studied in depth over a.la.ge tempera.ure ra.ge of 0-900 *** Debye tempera.ure increa.es with increa.ing pressure a.d decrea.es with decrea.ing ***,the Debye tempera.ures ca.cula.ed a. p=0 GPa.a.d T=300 K a.e equa. to be 342 a.d 322 K for Pr_(2)Rh_(3)Ge a.d Sm_(2)Rh_(3)Ge,*** optica. cha.a.teristics such a. the rea. a.d ima.ina.y portions of the dielectric function,the a.sorption coefficient,the energy-loss function,a.d the refra.tive index were investiga.ed a.d discussed in more depth.

关键词： ma.netic meta.s Functiona. density theory Density of sta.es ma.netic moment Optica. a.d thermodyna.ic properties Ra.e ea.ths

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Influence of cerium ions on structure-dependent ma.netic properties of Ba.Sr m-type hexa.errite na.ocrysta.s

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Journa. of Ra.e Ea.ths 2024年第2期42卷 364-372,I0005页

作者： Ra. a.Pa.a. Sunil m.Pa.a.ge P.m.Dighe Sher Singh meena.a.0}h Ga.-Sehemi mehbooba.i Pa.nipa.a.Sa.tosh S.Ja.ha. Depa.tment of Physics ArtsCommerce and Science CollegeAhmednagar413711MaharashtraIndia Depa.tment of Physics Shri Krishna MahavidyalayaGunjotiDistOsmanabad413606MaharashtraIndia Pa.ma.hri Vikhe Pa.il College of a.ts Science and CommercePravaranagarA/P.Loni(Kd)Tal.RahataDistAhmednagar413713MaharashtraIndia Solid Sta.e Physics Division Bhabha Atomic Research CentreMumbai400085MaharashtraIndia Depa.tment of Chemistry King Khalid UniversityAbha61413Saudi Arabia Depa.tment of Physics D.S.M's ArtsCommerce and Science CollegeJintur431509MaharashtraIndia

The present study is a.systema.ic effort to investiga.e the structure-sensitive ma.netic pa.a.eters of Ce^(3+) substituted Ba.Sr hexa.errite na.ocrysta.s chemica.ly formula.ed a. Ba.(0.5)Sr_(0.5)Ce_(x)Fe_(12-x)O_(19) where x=0.0-0.2 with Δx=*** hexa.errite powders were prepa.ed using the sol-gel self-ignition route a.d structura.ly cha.a.terized by mea.s of powder X-ra. diffra.tion a.d Fourier tra.sform infra.ed *** crea.ion of the m-type hexa.errite pha.e within the synthesized sa.ples wa. revea.ed from the Rietveld refinement of the X-ra. *** occurrence of a.seconda.y pha.e of CeO_(2) wa. revea.ed within the hexa.errites for the substitution,x> *** refined X-ra. diffra.tion da.a.were utilized to compute the la.tice pa.a.eters,X-ra. density,a.d la.tice pa.a.eter *** crysta. structure plotted from the refined XRD da.a.revea.s the occupa.cy of the ions a. different la.tice *** XPS da.a.of the hexa.errite were a.a.yzed to confirm the oxida.ion sta.es of the constituent *** na.ocrysta.line na.ure of the hexa.errites wa. revea.ed from the crysta.lite sizes ca.cula.ed using Scherer's *** a.a.ysis of FTIR spectra.confirms tha. only a.fra.tion of Ce^(3+)a.commoda.ed in the la.tice a.d the rema.ning Ce content reside in the form of the CeO_(2) *** morphology of the hexa.errites wa. a.a.yzed from the FESEm profiles of the ferrite *** ma.netic beha.ior study wa. performed by a.a.yzing the Curie tempera.ure,hysteresis loops,a.d hyperfine intera.tions by mea.s of susceptibility,V.S.m,a.d mossba.er spectroscopy,*** hexa.errites with increa.ing coercivity,decrea.ing sa.ura.ion ma.netiza.ion,a.d decrea.ing Curie tempera.ure a.e reported in the *** substituted Ce^(3+)ions inhibit the gra.n growth a.d crea.e la.tice imperfections giving rise to hexa.errites with tuned ma.netic pa.a.eters suita.le for different a.plica.ions.

关键词： Ba.Sr hexa.errite Ce^(3+)substitution XPS Sa.ura.ion ma.netiza.ion Coercivity m?ssba.er spectroscopy

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a.sembly of functiona. ca.boxymethyl cellulose/polyethylene oxide/a.a.a.e TiO_(2) na.ocomposites a.d tuning the dielectric rela.a.ion, optica., a.d photoluminescence performa.ces

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Journa. of Semiconductors 2024年第7期45卷 26-38页

作者： a.ma. m.Isma.l a.eer a.Reffa.e Fa.zy G.El Desouky Spectroscopy Depa.tment Physics Research InstituteNational Research CentreGizaCairo 12622Egypt microwa.e Physics a.d Dielectrics Depa.tment National Research CentreDokkiCairoEgypt Solid Sta.e Physics Depa.tment Physics Research InstituteNational Research CentreGizaCairo 12622Egypt

Na.ocomposite films consisting of ca.boxymethyl cellulose,polyethylene oxide(CmC/PEO),a.d a.a.a.e tita.ium diox-ide(TO)were produced by the use of sol-gel a.d solution ca.ting ***2 na.ocrysta.s were effectively incorpora.ed into CmC/PEO polymers,a. shown by X-ra. diffra.tion(XRD)a.d a.tenua.ed tota. reflecta.ce fourier tra.sform infra.ed(a.R-FTIR)*** roughness growth is a. high levels of TO na.ocrysta.s(TO NCs),which mea.s increa.ing a.tive sites a.d defects in CmC/*** differentia. sca.ning ca.orimetry(DSC)thermogra.s,the cha.ge in gla.s tra.sition tempera.ure(Tg)va.-ues verifies tha. the polymer blend intera.ts with TO *** increment proportions of TO NCs ha.e a.nota.le impa.t on the dielectric performa.ces of the na.ocomposites,a. *** electrica. properties of the CmC/PEO/TO na.ocomposite undergo significa.t *** na.ocomposite films exhibit a.red a.tera.ion in the a.sorption edge a. the concentra.ion of TO NCs increa.es in the polymer *** decline in the energy ga. is rea.ily a.pa.ent a. the weight percenta.e of TO NCs *** photoluminescence(PL)emission spectra.indica.e tha. the sites of the luminescence pea. ma.imums show slight va.ia.ion;pea.s get wider,while their intensities decrea.e dra.a.ica.ly a. the concentra.ion of TO *** na.ocomposite ma.eria.s show potentia. for multifunctiona. a.plica.ions including optoelectronics,a.tireflection coa.ings,pho-toca.a.ysis,light emitting diodes,a.d solid polymer electrolytes.

关键词： a.a.a.e TiO_(2) CmC/PEO na.ocomposites optica. photoluminescent electrica. optoelectronics

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Swift XRT a.a.ysis of Type II-P Supernova.SN 2008ij

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Interna.iona. Journa. of a.tronomy a.d a.trophysics 2024年第3期14卷 220-229页

作者： SH. m. Sheha.a.a.med m. Foua. R. m. Sa.ir a. a. Sha.er Na.iona. Resea.ch Institute of a.tronomy a.d Geophysics (NRIa.) Helwan Egypt

This study investiga.es the X-ra. properties a.d evolution of Type II supernova. (SNe II) observed by Swift, exa.ining va.ia.ions a.ong supernova. a.d exploring their X-ra. cha.a.teristics over time. We present the first X-ra. study of the Type IIp supernova.SN 2008ij using da.a.from the Swift X-ra. mission. This investiga.ion focuses on its spectra. properties, identifying a. X-ra. flux of 1.20 (+0.11, −0.10) × 10−13 erg/cm2/s a.d a.pla.ma.tempera.ure of 4.76 (+1.22, −0.83) keV. Our study ma.ks a. a.va.cement in understa.ding SN 2008ij, providing crucia. results into its X-ra. emission cha.a.teristics. These results la. the groundwork for future studies of Type IIp supernova., offering a.founda.ion for exploring their evolutiona.y a.d physica. processes.

关键词： X-Ra. Core Colla.se Supernova Swift (XRT) Observa.ions

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Cha.a.teristics of β-La.ta.a.e Synthesis in E. coli a.d K. pneuma.ie Stra.ns in Nosocomia. Infections

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a.va.ces in microbiology 2024年第1期14卷 25-30页

作者： Sa.dra.din a. a.a.ishiza.eh Sa.ya.din a. a.a.ishiza.eh ma.a.ma. m. Da.udov Depa.tment of Infectious Disea.es Azerbaijan Medical University Baku Azerbaijan Depa.tment of Pha.ma.eutica. Technology a.d ma.a.ement Azerbaijan Medical University Baku Azerbaijan Depa.tment of Ora. a.d ma.illofa.ia. Surgery Azerbaijan Medical University Baku Azerbaijan

Ba.kground: Recently micro-orga.isms tha. synthesize extended-spectrum β-la.ta.a.e (ESBLs) were increa.ed. The peculia.ities of ESBL synthesis of Escherichia.coli a.d Klebsiella.pneumonia. stra.ns tha. ca.se nosocomia. urina.y tra.t infections, surgica. site infections a.d pneumonia.in surgica. clinic were studied. ESBL synthesis were observed 38.9% of E. coli stra.ns obta.ned from urine, 92.3% of stra.ns obta.ned from surgica. site infections, a.d 50% of stra.ns obta.ned from sputum. ESBL synthesis were observed 37.5% of K. pneumonia. stra.ns obta.ned from urine, 85.7% of stra.ns obta.ned from surgica. site infections, a.d 60% of stra.ns obta.ned from sputum. Different levels of ESBL synthesize of E. coli a.d K. pneumonia. stra.ns isola.ed from different pa.tern is discussed. Conclusion. ESBL synthesis is common in E. coli a.d K. pneumonia. stra.ns, which ca.se nosocomia. infections. The frequency of occurrence of ESBL s synthesis a.ong of these stra.ns depends on clinica. forms of nosocomia. infections.

关键词： Nosocomia. Infectious a.ents β-La.ta.a.e Synthesis E. coli a.d K. pneumonia.

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Simulta.eous a.sorption of a.ueous Pb2+, Cu2+, Zn2+, a.d Cd2+ Using Surfa.ta.t-modified a.d Unmodified a.tiva.ed Ca.bon in a.Fixed Bed Column

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Journa. of Enca.sula.ion a.d a.sorption Sciences 2024年第1期12卷 1-24页

作者： morufu a. Ola.unji Ka.oru a. Sa.a. a.0}hi m. Evuti Depa.tment of Chemica. Engineering University of Abuja Abuja Nigeria Na.iona. a.ency for Science a.d Engineering Infra.tructure (Na.ENI) Abuja Nigeria

The goa. of this work is to improve the simulta.eous remova. of Pb2+, Cu2+, Zn2+, a.d Cd2+ ions from synthetic wa.tewa.er in a.fixed bed column by incorpora.ing sodium dodecyl sulfa.e (SDS) onto the surfa.e of a.tiva.ed ca.bon ma.e from coconut shells. The a.tiva.ed ca.bons were cha.a.terized using Fourier tra.sform infra.ed spectroscopy (FT-IR) a.d sca.ning electron microscopy-energy dispersive x-ra. (SEm-EDX). The a.sorption column dyna.ics were studied by va.ying the flow ra.es (5, 10 a.d 15 mL/min), bed heights (10, 15 a.d 20 cm), a.d initia. concentra.ions (50, 150, a.d 250 mg/L). The a.tiva.ed ca.bon ha. a.pore volume of 0.715 cm3/g a.d a.BET-specific surfa.e a.ea.of 1410 m2/g. Sodium dodecyl sulfa.e (SDS) surfa.ta.t incorpora.ion onto the surfa.e of the a.tiva.ed ca.bon enha.ces its ca.a.ity for simulta.eous a.sorption of Pb2+, Cu2+, Zn2+, a.d Cd2+ from the a.ueous medium. The a.finity of the hea.y meta.s to both unmodified (a.) a.d modified (a.-SDS) a.tiva.ed ca.bons followed the order of Pb2+ > Cu2+ > Zn2+ > Cd2+. The dyna.ic a.sorption of the column depends on the flow ra.e, bed height, initia. meta. concentra.ion, a.d SDS surfa.e modifica.ion. With a.5 mL/min flow ra.e, a.20 cm bed height, a.d a.50 mg/L initia. meta. concentra.ion, a.ma.imum brea.-through time of 150 minutes for the unmodified a.tiva.ed ca.bon (a.) a.d 180 minutes for the SDS-modified a.tiva.ed ca.bon (a.-SDS) wa. rea.hed.

关键词： a.sorption Surfa.ta.t-modified a.tiva.ed Ca.bon multicomponent Brea.through a.sorption Ca.a.ity Fixed Bed Column

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Frequency-dependent viscoela.ticity effects on the wa.e a.tenua.ion performa.ce of multi-la.ered periodic founda.ions

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a.plied ma.hema.ics a.d mecha.ics(English Edition) 2024年第3期45卷 407-424页

作者： m.Sa.I m.Va.ILIFa.D m.J.ma.mOODI Fa.ulty of Civil Water&Environmental EngineeringShahid Beheshti UniversityTehran ***Iran Fa.ulty of mecha.ica. a.d Energy Engineering Shahid Beheshti UniversityTehran ***Iran

In this pa.er,la.ered periodic founda.ions(LPFs)a.e numerica.ly exa.ined for their responses to longitudina. a.d tra.sverse modes in the time a.d frequency *** different unit-cells,i.e.,2-la.er,4-la.er,a.d 6-la.er unit-cells,comprising concrete/rubber,concrete/rubber/steel/rubber,a.d concrete/rubber/steel/rubber/lea./rubber ma.eria.s,respectively,a.e ta.en into ***,the viscoela.ticity beha.ior of the rubber is modeled with two fa.tors,i.e.,a.frequency-independent(FI)loss fa.tor a.d a.linea. frequency-dependent(FD)loss *** the extra.tion of the complex dispersion curves a.d the identifica.ion of the ba.d ga.s(BGs),the simula.ions of wa.e tra.smission in the time a.d frequency doma.ns a.e performed using the COmSOL *** pa.a.etric studies eva.ua.e the effects of the rubber viscoela.ticity models on the dispersion curves a.d the wa.e tra.smission for the longitudina. a.d tra.sverse *** results show tha. considering the rubber viscoela.ticity enha.ces the wa.e a.tenua.ion ***,the tra.sverse-mode da.ping is more sensitive to the viscoela.ticity model tha. its longitudina. *** 6-la.er unit-cell LPF exhibits the lowest BG,ra.ging from 4.8 Hz to 6.5 Hz.

关键词： la.ered meta.a.eria. periodic founda.ion complex dispersion curve wa.e tra.smission dia.ra.

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Gla.zma.n Thromba.thenia. ma.a.ing Gingiva. Bleeding Triggered by Tooth Eruption—a.Ra.e Ca.e Report

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Ca.e Reports in Clinica. medicine 2024年第8期13卷 283-291页

作者： Na.la.a. a.dulra.ma. mota. a. a.ia.Na.a.a. a.delwa.a. ma.a. m. musta.a Depa.tment of Pedia.ric Dentistry University of Khartoum Khartoum Sudan Depa.tment of Pedia.ric Dentistry National Ribat University Khartoum Sudan Depa.tment of Pedia.ric Dentistry a.d Orthodontic Sciences King Khalid University Abha Saudi Arabia

Gla.zma.n thromba.thenia.(GT) is a.ra.e a.d often underdia.nosed congenita. bleeding disorder ca.sed by muta.ions in the genes encoding glycoproteins GPIIb or GPIIIa. resulting in pla.elet dysfunction. Inherited in a. a.tosoma. recessive ma.ner, GT is cha.a.terized by the ina.ility of pla.elets to a.grega.e. Clinica.ly, it presents with mucocuta.eous bleeding, such a. ea.y a.d extensive bruising, severe epista.is, menorrha.ia. gingiva. bleeding, postpa.tum hemorrha.e, a.d unexpected bleeding following procedures, despite a.norma. pla.elet count. We present a.ca.e involving a.6-yea.-old ma.e pa.ient who experienced sponta.eous gingiva. bleeding for the pa.t 4 weeks due to the eruption of his first perma.ent mola.s. The bleeding wa. pa.ticula.ly severe a. night, disrupting the child’s sleep. The pa.ient ha. been dia.nosed with GT a. the a.e of 16 months. Denta. ma.a.ement wa. pursued, a.d the use of tra.exa.ic a.id mouthwa.h, combined with meticulous ora. hygiene, resulted in a. excellent response.

关键词： Gla.zma.n Thromba.thenia Bleeding Tra.exa.ic a.id Epista.is Pla.elet a.grega.ion

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