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meson-production experiments at COSY-Jülich

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Chinese Physics C 2010年第9期34卷 1263-1268页

作者： m.büscher Institute für Kernphysik and Jülich Center for Hadron Physics

Selected results from experiments at COSY-Jülich are presented： an attempt to measure the mass of the η meson with high precision （ANKE facility）,first steps towards the detection of rare η decays （WASA）,and s... 详细信息

关键词： meson production

Soil: An Extreme Habitat for microorganisms?

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Pedosphere 2004年第2期14卷 137-144页

作者： m.bLTER Institute for Polar Ecology University of Kiel Wischhofstr. 1-3 Bldg. 12 D-24148 Kiel (Germany)

The question is asked whether soils can be regarded as extreme environments with respect to microorganisms. After defining some extreme environments in a general sense, special properties of extreme environments are compared to soil habitats, with special emphasis laid on time frame and localities. In relation to water availability, nutrients and other properties, such places as aggregates can show properties of extreme habitats. These features, which can act at different levels of the system from the community level down to the cellular level, are summarized as stress factors. The latter,where many switches are located leading to different strategies of survival, is described as the most important one. This raises the question of how organisms have adapted to such conditions. The soil system demands a broad spectrum of adaptations and/or adjustments for a highly variable *** soil microorganisms'adaptation can thus be seen as the highest kind of flexibility and is more useful than any other special adaptation.

关键词：土壤环境微生物营养水分

Suitability of lost cores in rheocasting process

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中国有色金属学会会刊：英文版 2010年第S3期20卷 948-953页

作者： H.mICHELS m.büNCK A.büHRIG-POLACZEK Giesserei-Institut RWTH Aachen Intzestraeβ5Aachen 52072Germany

When treated in pressure die casting processes the semi-solid aluminum alloys demand resilient cores which can bear the stress occurring during filling and the final pressure *** design of permanent cores is highly restricted in order to maintain *** cores provide the possibility of complex,undercut geometrical shapes which is mandatory for a variety of casting ***,eligible materials which show appropriate resilience and proper decomposition properties at the same time,and in the upper echelon of cost-effectiveness,are seldom *** the semi-solid process suited between HPdC and GdC regarding the core stress,several common and economically efficient lost core systems could be used.A selection of potentially suitable materials was identified and *** range of testing comprises widespread sand core-systems(amin-pur-coldbox and CO2-water-glass) as well as materials less commonly used,namely salt,plastic and *** types of conditioning are applied to enhance the surface *** mechanical properties of the sand cores are enhanced by different heat treatment methods during *** cores are tested producing a research component cast on a HPdC machine with semi-solid A356 slurry fabricated in the cooling channel *** cast component was analyzed regarding shape stability,core removability and surface as well as the structure *** results show the importance of the surface conditioning for the sand-cores while salt and zinc produce good parts comparable to the reference steel core quality.

关键词： aluminum semi-solid rheocasting cooling channel lost core sand salt zinc plastic

Luminosity determination for the pd reaction at 2.14 GeV with WASA-at-COSY

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Chinese Physics C 2012年第7期36卷 605-609页

作者：郑川 m.büscher P.Fedorets V.Hejny H.Stroher 徐瑚珊袁小华 Institut für Kernphysik Forschungszentrum Jülich Jülich Center for Hadron Physics Forschungszentrum Jülich Institute of modern Physics Chinese Academy of Sciences Institute of modern Physics Fudan University Institute for Theoretical and Experimental Physics State Scientific Center of the Russian Federation

The luminosity for a WASA-at-COSY experiment involving the pd reaction at 2.14 GeV proton- beam energy is determined by the forward pd elastic scattering, which yields an average beam-on-target value of [5.2±0.3（stat）±0.3（syst）] × 10^30 s^-1 cm^-2. In addition, the forward pd elastic-scattering angular distribution is obtained with four-momentum transfer squared -t between 0.16 （GeV/c）2 and 0.78 （GeV/c）2 at this beam energy, which is compared with other experimental data and the pd double scattering model.

关键词： luminosity pd elastic scattering angular distribution double scattering

Thixocasting combination spanners using stainless steel X39Crmo17

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中国有色金属学会会刊：英文版 2010年第S3期20卷 998-1004页

作者： m.büNCK E.SUbASIC A.büHRIG-POLACZEK K.JIANG S.müNSTERmANN J.m.SCHNEIdER K.FICKERT H.J.GüNTHER Foundry Institute at RWTH Aachen University AachenGermany materials Chemistry at RWTH Aachen University AachenGermany HAZET-Hermann Zerver GmbH & Co.KG RemscheidGermany PlaTeG GmbH SiegenGermany

Forging is state-of-the-art for producing hand tools on an industrial *** to high demands on the stiffness and the fracture toughness,high-strength forging steels were used to provide cavity-free components with high mechanical load ***,forging is a cost-effective mass production process but,in spite of all its advantages,it has its limitations,*** the freedom of ***,because of the extreme thermal loading(particularly with regard to permanent moulds) and the frequently unavoidable casting defects,hand tools are not *** means of thixocasting steel,technical difficulties can be reduced and new options are provided which allow the manufacturing of components with much higher complexity than that using *** near-net shape production,manufacturing steps and costs can be ***,steels,which are difficult to forge but nonetheless have high potential for specific applications(such as high strength or corrosion resistant steels),can also be *** cooperation with industrial partners,X39Crmo17 stainless steel combination spanners with 17 mm width across flats were *** dies were designed and optimized by simulation,the hot forming X38CrmoV5 tool steel as well as the molybdenum alloy TZm were selected as the tool *** dies were treated by a plasma nitriding process and subsequently coated with crystalline Al2O3 protective coatings by plasma-enhanced chemical vapor deposition(PECVd).during the experiments,combination spanners were successfully cast in the semi-solid *** parts were heat-treated to enhance the toughness of components,which was subsequently measured by a standardized torque ***,a hypothetical approach of a possible,industrial batch process was carried out using the simulation software mAGmAsoft.

关键词： thixocasting X39Crmo17 steel casting semi-solid mAGmAsoft simulation

Neurogenesis dynamics in the olfactory bulb:deciphering circuitry organization, function, and adaptive plasticity

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Neural Regeneration Research 2025年第6期20卷 1565-1581页

作者： moawiah m.Naffaa department of Psychology and Neuroscience Duke UniversityDurhamNCUSA department of Cell biology Duke University School of MedicineDurhamNCUSA

Adult neurogenesis persists after birth in the subventricular zone, with new neurons migrating to the granule cell layer and glomerular layers of the olfactory bulb, where they integrate into existing circuitry as inhibitory interneurons. The generation of these new neurons in the olfactory bulb supports both structural and functional plasticity, aiding in circuit remodeling triggered by memory and learning processes. However, the presence of these neurons, coupled with the cellular diversity within the olfactory bulb, presents an ongoing challenge in understanding its network organization and function. moreover,the continuous integration of new neurons in the olfactory bulb plays a pivotal role in regulating olfactory information processing. This adaptive process responds to changes in epithelial composition and contributes to the formation of olfactory memories by modulating cellular connectivity within the olfactory bulb and interacting intricately with higher-order brain regions. The role of adult neurogenesis in olfactory bulb functions remains a topic of debate. Nevertheless, the functionality of the olfactory bulb is intricately linked to the organization of granule cells around mitral and tufted cells. This organizational pattern significantly impacts output, network behavior, and synaptic plasticity, which are crucial for olfactory perception and memory. Additionally, this organization is further shaped by axon terminals originating from cortical and subcortical regions. despite the crucial role of olfactory bulb in brain functions and behaviors related to olfaction, these complex and highly interconnected processes have not been comprehensively studied as a whole. Therefore, this manuscript aims to discuss our current understanding and explore how neural plasticity and olfactory neurogenesis contribute to enhancing the adaptability of the olfactory system. These mechanisms are thought to support olfactory learning and memory, potentially through increased

关键词： network adaptability neurogenesis neuronal communication olfactory bulb olfactory learning olfactory memory synaptic plasticity

Additive neurorestorative effects of exercise and docosahexaenoic acid intake in a mouse model of Parkinson’s disease

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Neural Regeneration Research 2025年第2期20卷 574-586页

作者： Olivier Kerdiles méryl-Farelle Oye mintsa mi-mba Katherine Coulombe Cyntia Tremblay VincentÉmond martine Saint-Pierre Clémence Rouxel Line berthiaume Pierre Julien Francesca Cicchetti Frédéric Calon Facultéde pharmacie UniversitéLaval1050 Avenue de la MédecineQuebecQCCanada Axe Neuroscience Centre de recherche du CHU de Québec-UniversitéLaval(Pavillon CHUL)2705 Boulevard LaurierQuebecQCCanada Institute of Nutrition and Functional Foods QuebecQCCanada Optinutribrain International Associated Laboratory(NutriNeuro FranceINAFCanada)QuebecQCCanada Axe Endocrinologie et Néphrologie Centre de recherche du CHU de Québec-UniversitéLavalQuebecQCCanada département de médecine Facultéde MédecineUniversitéLavalQuebecQCCanada département de Psychiatrie et Neurosciences Facultéde MédecineQuebecQCCanada

There is a need to develop interventions to slow or reverse the degeneration of dopamine neurons in Parkinson’s disease after *** that preclinical and clinical studies suggest benefits of dietary n-3 polyunsaturated fatty acids,such as docosahexaenoic acid,and exercise in Parkinson’s disease,we investigated whether both could synergistically interact to induce recovery of the dopaminergic ***,mice received a unilateral stereotactic injection of 6-hydroxydopamine into the striatum to establish an animal model of nigrostriatal *** weeks after lesion,animals were fed a docosahexaenoic acid-enriched or a control diet for the next 8 *** this period,the animals had access to a running wheel,which they could use or *** acid treatment,voluntary exercise,or the combination of both had no effect on(i)distance traveled in the open field test,(ii)the percentage of contraversive rotations in the apomorphine-induction test or(iii)the number of tyrosine-hydroxylase-positive cells in the substantia nigra pars ***,the docosahexaenoic acid diet increased the number of tyrosine-hydroxylase-positive terminals and induced a rise in dopamine concentrations in the lesioned *** to docosahexaenoic acid treatment or exercise alone,the combination of docosahexaenoic acid and exercise(i)improved forelimb balance in the stepping test,(ii)decreased the striatal dOPAC/dopamine ratio and(iii)led to increased dopamine transporter levels in the lesioned *** present results suggest that the combination of exercise and docosahexaenoic acid may act synergistically in the striatum of mice with a unilateral lesion of the dopaminergic system and provide support for clinical trials combining nutrition and physical exercise in the treatment of Parkinson’s disease.

关键词： 6-hydroxydopamine dopamine dopamine transporter exercise neurorestoration Parkinson’s disease polyunsaturated fatty acids omega-3

SbL-JP-0004:A promising dual inhibitor of JAK2 and PI3KCd against gastric cancer

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Oncology Research 2025年第1期33卷 235-243页

作者： HASSAN m.OTIFI department of Pathology College of MedicineKing Khalid UniversityAbha62521Saudi Arabia

background:Gastric cancer(GC)remains a global health burden and is often characterized by heterogeneous molecular profiles and resistance to conventional *** phosphoinositide 3-kinase and PI3K and Janus kinase(JAK)signal transducer and activator of transcription(JAK-STAT)pathways play pivotal roles in GC progression,making them attractive targets for therapeutic ***:This study applied a computational and molecular dynamics simulation approach to identify and characterize SbL-JP-0004 as a potential dual inhibitor of JAK2 and PI3KCd *** and SNU-5 GC cells were used for in vitro ***:SbL-JP-0004 exhibited a robust binding affinity for JAK2 and PI3KCd kinases,as evidenced by molecular docking scores and molecular dynamics *** interactions and Gibbs binding free energy estimates confirmed stable and favorable interactions with target ***-JP-0004 displayed an half-maximal inhibitory concentration(IC_(50))value of 118.9 nm against JAK2 kinase and 200.9 nm against PI3KCd ***-JP-0004 exhibited potent inhibition of cell proliferation in KATOIII and SNU-5 cells,with half-maximal growth inhibitory concentration(GI50)values of 250.8 and 516.3 nm,respectively.A significant elevation in the early phase apoptosis(28.53%in KATOIII cells and 26.85%in SNU-5 cells)and late phase apoptosis(17.37%in KATOIII cells and 10.05%in SNU-5 cells)were observed with SbL-JP-0004 treatment compared to 2.1%and 2.83%in their respective ***:The results highlight SbL-JP-0004 as a promising dual inhibitor targeting JAK2 and PI3KCd kinases for treating GC and warrant further preclinical and clinical investigations to validate its utility in clinical settings.

关键词： Gastric cancer(GC) dual inhibition JAK2 PI3KCd SbL-JP-0004 molecular docking molecular dynamics simulation

mitochondria–cGAS–STING axis is a potential therapeutic target for senescence-dependent inflammaging-associated neurodegeneration

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Neural Regeneration Research 2025年第3期20卷 805-807页

作者： Josém.Izquierdo Centro de biología molecular Severo Ochoa(Cbm) Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid(CSIC-UAM)MadridSpain

The word “senescence” comes from the Latin senescens, meaning “to begin to age”, and is characterized by a long-lasting but reversible block in proliferation, resulting from stress-induced cell cycle arrest of pre... 详细信息

关键词： Latin potential lasting