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Wildfire severity alters soil microbial exoenzyme production and fungal abundances in the southern Appalachian mountains

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Pedosphere 2024年第5期34卷 865-878页

作者： megan L.SCHILL Richard BAIRD Shawn P.BROWN allison m.VEACH Department of Integrative Biology University of Texas at San Antonio Biochemistry Molecular Biology Entomology and Plant Pathology Department Mississippi State University Department of Biological Sciences The University of Memphis

Climate change has increased drought frequency and duration that are exacerbated by increased temperatures globally. This effect has, and will continue,to increase fire occurrence across many regions of North America. In the southern Appalachian mountains, wildfires with high burn severity occurred in 2016due to increased drought and human activity. To investigate the effects of burn severity on soil physicochemical properties, microbial extracellular enzyme production, and microbial abundances in a temperate region, surface soils (0–15 cm) were collected from two sites (the Great Smoky mountains National Park in Tennessee and the Nantahala National Forest in North Carolina, USA) spanning lightly, moderately, and severely burned areas, accompanied by adjacent unburned locations that act as controls. The soil samples were collected at three time points between 2017 and 2019 (i.e., 0.5, 1, and 2.5 years post-fire)among burn severity plots. Total hydrolytic enzyme production varied over time, with severe burn plots having significantly lower enzyme production at 2.5years post-fire. Individual enzymes varied among burn severities and across time post-fire. Light burn plots showed greater carbon-specific (β-glucosidase and β-xylosidase) and phosphorus-specific (acid phosphatase) enzyme activities at 0.5 years post-fire, but this effect was transient. At 2.5 years post-fire, theβ-xylosidase and acid phosphatase activities were lower in severe or moderate burn plots relative to the controls. In contrast, the activity of nitrogen-specific enzyme leucyl aminopeptidase was the lowest in severe burn plots at 0.5 years post-fire, but was the lowest in light burn plots at 2.5 years post-fire. The fungi:bacteria ratio declined with burn severity, indicating that fungi are sensitive or less resilient to high burn severity during recovery. These results suggest that wildfires alter trajectories for soil microbial structure and function within a 2.5-year timeframe, which potentially

关键词： 16S rRNA burn severity extracellular enzyme fungi:bacteria ratio internal transcribed spacer microbial structure

A precise monitoring of snow surface height in the region of Lambert Glacier basin-Amery Ice Shelf,East Antarctica

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Science China Earth Sciences 2005年第1期48卷 100-111页

作者： I.allison Australian Antarctic Division and Antarctic Climate and Ecosystems CRC

The net surface snow accumulation on the Antarctic ice sheet is determined by a combination of precipitation, sublimation and wind redistribution. We present a one-year record of hourly snow-height measurements at LGB69 (70°50'S, 77°04'E, 1850 m a.s.l.). east side of Lambert Glacier basin (LGB), and 4 year record at G3 (70°53'S, 69°52'E, 84 m a.s.l.), Amery Ice Shelf (AIS). The measurements were made with ultrasonic sensors mounted on automatic weather stations installed at two sites. The snow accumulation at LGB69 is approximately 70 cm. Throughout the winter, between April and September, there was little change in surface snow height (SSH) at the two sites. The negative SSH change is due to densification at LGB69, and is due to both ablation and densification at G3. The strongest accumulation at two sites occurred during the period between October and march (accounting for 101.6% at LGB69), with four episodic increasing events occurring during 2002 for LGB69, and eight events during 1999-2002 for G3 (2 to 3 events per year). At LGB69, these episodic events coincided with obvious humidity 'pulses' and decreases of incoming solar radiation as recorded by the AWS. Observations of the total cloud amount at Davis station, 160 km NNE of LGB69, showed good correlation with major accumulation events recorded at LGB69. There was an obvious anti-correlation between the lowest cloud height at Davis and the daily accumulation rate at LGB69. Although there was no correlation over the total year between wind speed and accumulation at LGB69, large individual accumulation events are associated with episodes of strong wind (>7 m/s), we estimate drift snow may contribute to total SSH up to 35%. Strong accumulation events at LGB69 are associated with major storms in the region and inland transport of moist air masses from the coast.

关键词： Antarctica, Lambert Glacier basin, Amery Ice Shelf, accumulation, katabatic wind.

Complete response to radiation therapy of orbital metastasis from hepatocellular carcinoma

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World Journal of Gastroenterology 2009年第47期15卷 6000-6003页

作者： allison m Quick mark Bloomston Edward Y Kim Nathan C Hall Nina A mayr Department of Radiation medicine Arthur G.James Cancer HospitalThe Ohio State University Medical CenterColumbusOH 43210 United States Department of Surgical Oncology The Ohio State University Medical CenterColumbusOH 43210 United States Department of Radiology The Ohio State University Medical CenterColumbusOH 43210United States

The incidence of hepatocellular carcinoma(HCC)is increasing in the United States,and 50%-75%o patients with HCC will develop metastatic disease Orbital metastases from HCC are extremely *** report the case of a 52-year-old male with known metastatic HCC,who presented with severe proptosis and *** orbital mass was identified on magnetic resonance imaging(mRI)and confirmed to have hypermetabolic activity on positron emission tomography/computed *** received a palliative course of external beam radiation therapy to the right *** modulated radiation therapy (ImRT)was used to allow sparing of critical norma tissues in close proximity to the *** month after completion of ImRT to 58 Gray in 30 fractions delivered over 6 wk,the patient had a complete clinical,radiologic(mRI)and symptomatic response The patient continues to have local control in the orbi 1.7 years after therapy *** critical norma structures were kept below the tolerance dose using ImRT,and no toxicities were observed.

关键词： Hepatocellular carcinoma Eye neoplasms metastasis Intensity modulated radiation therapy Palliative therapy

Transient occult cardiotoxicity in children receiving continuous beta-agonist therapy

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World Journal of Pediatrics 2014年第4期10卷 324-329页

作者： Christopher L Carroll melinda Coro allison Cowl Kathleen A Sala Craig m Schramm Department of Pediatrics Connecticut Children's Medical CenterHartfordCTUSA

Background:Continuous beta-agonist therapy,typically in the form of inhaled albuterol,is the first line therapy for the treatment of acute and severe bronchospasm in *** this treatment is commonly used,concerns about cardiotoxicity have been *** aimed to investigate the cardiotoxic effects of continuous beta-agonist therapy in ***:We conducted a retrospective review of children admitted to the intensive care unit(ICU)between may 2008 and April 2009,who were treated with continuous beta-agonist therapy(intravenous and nebulized).Results:Twenty of the 36 children treated with continuous albuterol had repeated serum troponin-T and lactate levels *** patients(55%)were also treated with continuous intravenous *** levels of troponin-T levels were found in 25%of children,and elevated lactate levels were found in 60%.However,all returned to normal levels within 48 hours of ICU admission,despite continued beta-agonist *** children experienced arrhythmias during *** was no association between intravenous terbutaline use and elevated troponin-T[odds ratio(OR),1.3;95%CI,0.2-10.3]or with elevated serum lactate(OR,0.6;95%CI,0.1-3.7).There was also no association between elevated troponin-T or lactate and ICU or hospital length of ***:In this small study,a significant proportion of children had elevated serum troponin-T and lactate levels while receiving inhaled continuous beta-agonist therapy,irrespective of intravenous ***,these abnormal values all returned to normal within 48 hours of ICU admission and were not associated with increased duration of hospitalization.

关键词： asthma beta-agonist pediatric

Newfound physiological function of FAIm protein offers hope of novel disease-modifying therapy for Alzheimer's disease

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Neural Regeneration Research 2023年第12期18卷 2677-2679页

作者： allison RBalaj Hiroaki Kaku Department of Investigative medicine Western Michigan University Homer Stryker M.D.School of MedicineKalamazooMIUSA

Introduction of Fas apoptosis inhibitory molecule(FAIm): FAIm was originally discovered in FASresistant mouse primary B lymphocytes in 1999, and was thought of as a FAS-apoptosis inhibitor based on overexpression studies(Schneider et al., 1999). FAIm is an approximately 20 k Da intracellular protein, but a subsequent study identified an alternatively spliced form.

关键词： al. Alzheimer lymphocytes

Co-delivery of PARP and PI3K inhibitors by nanoscale metal-organic frameworks for enhanced tumor chemoradiation

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Nano Research 2019年第12期12卷 3003-3017页

作者： megan J.Neufeld allison N.DuRoss madeleine R.Landry Hayden Winter Andrea m.Goforth Conroy Sun Department of Pharmaceutical Sciences College of PharmacyOregon State UniversityPortlandOregon 97201USA Department of Chemistry Portland State University1719 SW 10th AvePortlandOregon 97201USA Department of Radiation medicine Oregon Health&Science University3181 S.W.Sam Jackson Park RdPortlandOregon 97239USA

Due to their complementary activity,the use of DNA damage repair(DDR)inhibitors during radiotherapy(RT)has yielded promising ***,this approach is often hindered by toxicity and poor in vivo stability of the DDR in *** scale metal-organic frameworks(nmOFs)represent an emerging class of crystalline materials which exhibit advantageous properties over traditional nanomaterials and demonstrate great potential in ***,a unique,synergistic treatment strategy for enhancing the therapeutic efficacy of RT vianmOF-mediated drug delivery and RT enhancement was evaluated.A nmOF containing the high-Zelement Hf and the ligand 1,4-dicarboxybenzene(Hf-BDC)was synthesized and loaded with the two DDR inhibitor drugs,talazoparib and buparlisib(TB@Hf-BDC-PEG).TB@Hf-BDC-PEGaugmented RT by increasing reactive oxygen species generation and thus DNA damage of which repair was inhibited *** enhancement was demonstrated in vivo where the combination of concurrent radiation with in travenous TB@Hf-BDC-PEG administration resulted in improved tumor control and increased ***,no apparent toxicity was observed with nmOF treatment,supporting its potential as an attractive candidate over traditional nano *** work provides the first report of nmOFs employed to enhance thetherapeutic response to RT through DDR inhibitor delivery and physical radiation dose enhancement.

关键词： nano scale metal-organic frameworks chemoradiotherapy DNA damage repair inhibitors drug delivery radiation dose enhancement

models to predict injury, physical fitness failure and attrition in recruit training: a retrospective cohort study

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military medical Research 2020年第4期7卷 391-400页

作者： Robin m.Orr Bruce S.Cohen Stephen C.allison Lakmini Bulathsinhala Edward J.Zambraski mark Jaffrey Tactical Research Unit Bond University2 Promethean WayGold CoastRobinaQLD 4226Australia United States Army Research Institute for Environmental medicine NatickMA 01760USA Defence Science and Technology Group Port MelbourneVIC 3207Australia

Background:Attrition rate in new army recruits is higher than in incumbent *** the current study,we identified the risk factors for attrition due to injuries and physical fitness failure in recruit training.A variety of predictive models were ***:This retrospective cohort included 19,769 Army soldiers of the Australian Defence Force receiving recruit training during a period from 2006 to *** them,7692 reserve soldiers received a 28-day training course,and the remaining 12,077 full-time soldiers received an 80-day training *** data included anthropometric measures,course-specific variables,injury,and physical fitness *** regression was used to develop a variety of models to predict the rate of attrition due to injuries and physical fitness *** area under the receiver operating characteristic curve was used to compare the performance of the ***:In the overall analysis that included both the 28-day and 80-day courses,the incidence of injury of any type was 27.8%.The 80-day course had a higher rate of injury if calculated per course(34.3%vs.17.6%in the 28-day course),but lower number of injuries per person-year(1.56 vs.2.29).Fitness test failure rate was significantly higher in the 28-day course(30.0%vs.12.1%).The overall attrition rate was 5.2%and 5.0%in the 28-day and 80-day courses,*** fracture was common in the 80-day course(n=44)and rare in the 28-day course(n=1).The areas under the receiver operating characteristic curves for the course-specific predictive models were relatively low(ranging from 0.51 to 0.69),consistent with"failed"to"poor"predictive *** course-combined models performed somewhat better than the course-specific models,with two models having AUC of 0.70 and 0.78,which are considered"fair"predictive ***:Attrition rate was similar between 28-day and 80-day *** comparison to the 80-day full course,the 28-day course had a lower rat

关键词： military training Predictive modelling Risk management Soldier

THE GEANT4 VISUALIZATION SYSTEm—A mULTI-DRIVER GRAPHICS SYSTEm

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International Journal of modeling, Simulation, and Scientific Computing 2013年第S1期4卷 1-19页

作者： JOHN allison LAURENT GARNIER AKINORI KImURA JOSEPH PER School of Physics and Astronomy The University of Manchester ManchesterM139PLUK and GEANT4 Associates International Ltd.9 Royd Terrace Hebden BridgeHX77BTUK John Laboratoire de l’Acc´el´erateur Lin´eaire 91898 Orsay cedexFrance Ashikaga Institute of Technology 268-1 Omae-choAshikaga CityTochigi 326-8558Japan SLAC National Accelerator Laboratory 2575 Sand Hill RoadMenlo ParkCA 94025-7015USA

From the beginning,the Geant4 Visualization System was designed to support several simultaneous graphics systems written to common abstract ***,it has matured into a powerful diagnostic and presentational *** comes with a library of models that may be added to the current scene and which include the representation of the Geant4 geometry hierarchy,simulated trajectories and user-written hits and *** workhorse is the OpenGL suite of drivers for X,Xm,Qt,and *** is an Open Inventor *** can be exported in special graphics formats for offline viewing in the DAWN,VRmL,HepRApp and gmocren *** can be generated through OpenGL,Open Inventor,DAWN and ***4’s own tracking algorithms are used by the Ray *** all drivers support all features but all drivers bring added functionality of some *** paper describes the interfaces and details the individual drivers.

关键词： Geant4 simulation radiation modeling graphics ray tracing.

Study of Aerosol Direct and Indirect Effects and Auto-conversion Processes over the West African monsoon Region Using a Regional Climate model

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Advances in Atmospheric Sciences 2018年第2期35卷 182-194页

作者： Zeinab SALAH Ahmed SHALABY allison L. STEINER Ashraf S. ZAKEY Ritesh GAUTAm mohamed m. ABDEL WAHAB The Egyptian meteorological Authority Cairo 11784 Egypt University of michigan Department of Climate and Space Sciences and Engineering Ann Arbor M148109-2143 USA Centre of Studies in Resources Engineering and Interdisciplinary Program in Climate Studies Indian Institute of Technology Bombay Bombay 400076 India Cairo University Department of Astronomy Space Science and Meteorology Giza 12613 Egypt Environmental Defense Fund Washington DC 20009 USA

This study assesses the direct and indirect effects of natural and anthropogenic aerosols （e.g., black carbon and sulfate） over West and Central Africa during the West African monsoon （WAm） period （June-July-August）. We investigate the impacts of aerosols on the amount of cloudiness, the influences on the precipitation efficiency of clouds, and the associated radiative forcing （direct and indirect）. Our study includes the implementation of three new formulations of auto-conversion parameterization [namely, the Beheng （BH）, Tripoli and Cotton （TC） and Liu and Daum （R6） schemes] in RegCm4.4.1, besides the default model＇s auto-conversion scheme （Kessler）. Among the new schemes, BH reduces the precipitation wet bias by more than 50% over West Africa and achieves a bias reduction of around 25% over Central Africa. Results from detailed sensitivity experiments suggest a significant path forward in terms of addressing the long-standing issue of the characteristic wet bias in RegCm. In terms of aerosol-induced radiative forcing, the impact of the various schemes is found to vary considerably （ranging from -5 to -25 W m-2）.

关键词： aerosol, cloud West African monsoon auto-conversion RegCm