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Clinical applications of the CRISPR/Cas9 genome-editing system: Delivery options and challenges in precision medicine

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Genes & Diseases 2024年第1期11卷 268-282页

作者： mohadeseh Khoshandam Hossein Soltaninejad marziyeh mousazadeh Amir ali Hamidieh Saman Hosseinkhani Department of Reproductive Biology Academic Center for EducationCultureand Research(ACECR)Qom BranchQom ***Iran National Institute of Genetic Engineering and Biotechnology(NIGEB) Tehran 14155-6463Iran Faculty of Interdisciplinary Science and Technology Tarbiat Modares UniversityTehran 14117-13116Iran Pediatric Cell and Gene Therapy Research Center GeneCell&Tissue Research InstituteTehran UniversityofMedical SciencesTehran14155-6559Iran Department of Nanobiotechnology Faculty of Biological SciencesTarbiat Modares UniversityTehran 14117-13116Iran Department of Biochemistry Faculty of Biological SciencesTarbiat Modares UniversityTehran 14117-13116Iran

CRISPR/Cas9 is an effective gene editing tool with broad applications for the pre-vention or treatment of numerous *** depends on CRiSPR(clustered regularly inter-spaced short palindromic repeats)as a bacterial immune system and plays as a gene editing *** to the higher specificity and efficiency of CRISPR/Cas9 compared to other editing ap-proaches,it has been broadly investigated to treat numerous hereditary and acquired ill-nesses,including cancers,hemolytic diseases,immunodeficiency disorders,cardiovascular diseases,visual maladies,neurodegenerative conditions,and a few X-linked ***/Cas9 system has been used to treat cancers through a variety of approaches,with sta-ble gene editing ***,the applications and clinical trials of CRisPR/Cas9 in various illnesses are *** to its high precision and efficiency,CRISPR/Cas9 strategies may treat gene-related illnesses by deleting,inserting,modifying,or blocking the expression of specific *** most challenging barrier to the in vivo use of CRISPR/Cas9 like off-target effects will be *** use of transfection vehicles for CRISPR/Cas9,including viral vectors(such as an Adeno-associated virus(AAV),and the development of non-viral vectors is also considered.

关键词： Clinical trials CRISPR/Cas9 Gene therapy Non-viral vectors Viral vectors

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Conservation laws,Lie symmetries,self adjointness,and soliton solutions for the Selkov–Schnakenberg system

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Communications in Theoretical Physics 2024年第2期76卷 29-44页

作者： Kashif ali Aly R Seadawy Syed T R Rizvi Noor Aziz Department of mathematics COMSATS University IslamabadLahore CampusPakistan mathematics Department Faculty of ScienceTaibah UniversityAl-Madinah Al-Munawarah41411Saudi Arabia

In this article,we explore the famous Selkov–Schnakenberg(SS)system of coupled nonlinear partial differential equations(PDEs)for Lie symmetry analysis,self-adjointness,and conservation ***,miscellaneous soliton solutions like dark,bright,periodic,rational,Jacobian elliptic function,Weierstrass elliptic function,and hyperbolic solutions of the SS system will be achieved by a well-known technique called sub-ordinary differential *** these results are displayed graphically by 3D,2D,and contour plots.

关键词： Selkov-Schnakenberg system Lie symmetry analysis conservation laws adjointness integrability

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Gaussian Backbone-Based Spherical Evolutionary Algorithm with Cross-search for Engineering Problems

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Journal of Bionic Engineering 2024年第2期21卷 1055-1091页

作者： Yupeng Li Dong Zhao ali Asghar Heidari Shuihua Wang Huiling Chen Yudong Zhang College of Computer Science and Technology Changchun Normal UniversityChangchun130032JilinChina School of Surveying and Geospatial Engineering College of EngineeringUniversity of TehranTehranIran School of Computing and mathematical Sciences University of LeicesterLeicesterLE17RHUK Department of Biological Sciences Xi’an Jiaotong-Liverpool UniversitySuzhou215123JiangsuChina Key Laboratory of Intelligent Informatics for Safety and Emergency of Zhejiang Province Wenzhou UniversityWenzhou325035China School of Computer Science and Engineering Southeast UniversityNanjing210096China

In recent years,with the increasing demand for social production,engineering design problems have gradually become more and more *** novel and well-performing meta-heuristic algorithms have been studied and developed to cope with this *** them,the Spherical Evolutionary Algorithm(SE)is one of the classical representative methods that proposed in recent years with admirable optimization ***,it tends to stagnate prematurely to local optima in solving some specific ***,this paper proposes an SE variant integrating the Cross-search mutation(CSm)and Gaussian Backbone Strategy(GBS),called *** this study,the CSm can enhance its social learning ability,which strengthens the utilization rate of SE on effective information;the GBS cooperates with the original rules of SE to further improve the convergence effect of *** objectively demonstrate the core advantages of CGSE,this paper designs a series of global optimization experiments based on IEEE CEC2017,and CGSE is used to solve six engineering design problems with *** final experimental results fully showcase that,compared with the existing well-known methods,CGSE has a very significant competitive advantage in global tasks and has certain practical value in real ***,the proposed CGSE is a promising and first-rate algorithm with good potential strength in the field of engineering design.

关键词： meta-heuristic algorithms Engineering optimization Spherical evolution algorithm Global optimization

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mechanical and magneto-electronic properties of europium lanthanide-based cubic perovskites EuYO_(3)(Y=Cr, mn, Fe): An ab initio study

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Journal of Rare Earths 2024年第3期42卷 562-569,I0005页

作者： Hayat Ullah Azra Sarwar Sajad ali Rabah Khenata Abdelmadjid Bouhemadou Saad Bin-Omran Department of Physics Women University of Azad Jammu&Kashmir Bagh 10250Pakistan Department of Physics Abdul Wali Khan UniversityMardan23200KPPakistan LPQ3m Laboratory Institute of Science and TechnologyUniversity of Mascara29000MascaraAlgeria Laboratory for Developing New materials and Their Characterization Farhat Abbas University Setif l19000SetifAlgeria Department of Physics and Astronomy College of ScienceKing Saud UniversityP.O.Box 2455Riyadh11451Saudi Arabia

Computational calculations using density functional theory(DFT) were performed for the first time using the full potential linearized augmented plane wave plus local orbital method(FP-LAPW + LO) to determine the structural, elastic, electronic and magnetic properties of europium-based cubic perovskites EuYO_(3)(Y=Cr, mn, Fe). The exchange correlation potentials of GGA along with some analytical methods were adopted for the computation of structural and elastic properties. moreover, the GGA + U formalism was also added for obtaining more precise electronic and magnetic properties, particularly to address the Eu-4f and Y-3d orientations in the spin-polarized double cell symmetry. The observed lattice parameters of these compounds are consistent with experiment. The observed bulk moduli predict that EuCrO_(3) is harder and less compressible than EumnO_(3) and EuFeO_(3). The calculated tolerance factors of these compounds are within the cubic symmetry range. Our computed critical radius of EuCrO_(3) shows that EuCrO_(3) has a larger migration energy. Based on their elastic properties, these compounds are ductile in nature. We also computed the thermal properties of these compounds. The band structures and density of states show that these compounds are metallic in character. The lowest ground state energy and magnetic moments of these compounds expose their ferromagnetic nature. The metallic nature and strong ferromagnetism of these compounds make them promising applicants for application in spintronic.

关键词： Perovskites GGA+U Elastic constants Band structure magnetic moments Rare earths

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Exploring the shadow of a rotating charged modmax black hole

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Communications in Theoretical Physics 2024年第2期76卷 89-101页

作者： Khurshid Karshiboev Farruh Atamurotov Ahmadjon Abdujabbarov ali Övgün Anvar Reyimberganov Institute of Theoretical Physics National University of UzbekistanTashkent 100174Uzbekistan New Uzbekistan University Movarounnahr Street 1Tashkent 100000Uzbekistan Central Asian University Milliy Bog'Street 264Tashkent 111221Uzbekistan University of Tashkent for Applied Sciences Str.Gavhar 1Tashkent 100149Uzbekistan Tashkent State Technical University Tashkent 100095Uzbekistan Ulugh Beg Astronomical Institute Astronomy Street 33Tashkent 100052Uzbekistan Institute of Fundamental and Applied Research National Research University TIIAMEKori Niyoziy 39Tashkent 100000Uzbekistan Physics Department Eastern Mediterranean UniversityFamagusta99628 North Cyprusvia Mersin 10Turkey Urgench State University Urgench 220100Uzbekistan

The research presented in this paper discusses the impact that the parameters of charge(Q)and screening factor(γ)have on properties of the horizon and silhouette of rotating charged mod max black holes which were reviewed in[***.J.C(2022)82:1155]recently,building upon previous findings in the ***,the study explores the behavior of null geodesics,which can help us better understand the apparent shape of the black hole’s silhouette,as well as the distortion parameter and approximate radii of the silhouette that are influenced by the aforementioned parameters,and there are some values of parameter Q which corresponds to data from the Event Horizon Telescope(EHT).Notably,we explore the distortion parameter and approximate radii of the silhouette,revealing that while an increase inγleads to a growth in silhouette radius(Rs),it simultaneously reduces the distortion rate(δs).Conversely,heightened Q charge results in a reduction of Rsaccompanied by an increase inδ***,the paper analyzes the effects of the black hole’s parameters on the effective potential and energy emission:the peak value of the energy emission rate experiences a decrease as the screening factor(γ)increases,while it increases with higher values of the charge parameter(Q).

关键词： black hole modmax gravity rotating black hole black hole shadow

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Kaoline-based catalyst for a high stability desulfurization of sour heavy naphtha in a three-phase oscillatory baffled reactor

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Particuology 2024年第1期84卷 249-260页

作者： Hassan m.Hmood Saba A.Gheni Safaa m.R.Ahmed mudheher m.ali Hamid Yonis Saleh mohammed H.mohammed Awad E.mohammed marwan A.mahomood Hiba R.mohammed Ahmed A.Hassan Adam Harvey North Refineries Company Ministry of OilIraq Chemical Engineering Department Tikrit UniversityIraq ministry of Oil Iraq AL-Hawija Technical Institute Northern Technical UniversityMoselIraq School of Engineering Newcastle UniversityUK

To meet the rapidly increasing demand for energy and the dramatic depletion of conventional crude oil,it is imperative to utilize sour *** no coke being produced,oxidative desulfurization(ODS)of naphtha lowers its sulfur content and average molecular *** this article,we outline a method for heavy naphtha non-extractive ODS using a very stable *** technique involves the use of a solid catalyst with oxygen gas as the *** necessitated relatively high mixing intensities;hence a three-phase Oscillatory Baffled Reactor(OBR)was *** catalyst was based on the zeolite ZSm-5,prepared from natural kaolin by a series of delamination and activation steps and impregnated with Fe.A TiO2 nanolayer was applied,using the sol-gel method,to prevent rapid *** reactor performance was evaluated to minimize the sulfur content in the naphtha *** to the protective coating,the sulfur conversion stabilized at 90%.The results of this work establish the use of natural clay-based catalysts in a continuous,three-phase ODS,particularly with regard to proving long-term *** also showed that modest ODS can be achieved using an environmentally friendly oxidant,at mild operating conditions,whilst maintaining stability.

关键词： Natural kaoline Desulfurization Three-phase Oscillatory baffled reactor

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Robust design of sliding mode control for airship trajectory tracking with uncertainty and disturbance estimation

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Journal of Systems Engineering and Electronics 2024年第1期35卷 242-258页

作者： WASIm muhammad ali Ahsan CHOUDHRY mohammad Ahmad SHAIKH Inam Ul Hasan SALEEm Faisal Department of Aeronautics and Astronautics Engineering Institute of Space TechnologyIslamabad 44000Pakistan Department of Electrical Engineering University of Engineering and TechnologyTaxila 47080Pakistan Department of measurements and Control Systems Silesian University of TechnologyGliwice 44-101Poland The Joint Doctoral School Silesian University of TechnologyGliwice 44-100Poland

The robotic airship can provide a promising aerostatic platform for many potential *** applications require a precise autonomous trajectory tracking control for *** has a nonlinear and uncertain *** is prone to wind disturbances that offer a challenge for a trajectory tracking control *** paper addresses the airship trajectory tracking problem having time varying reference path.A lumped parameter estimation approach under model uncertainties and wind disturbances is opted against distributed *** uses extended Kalman filter(EKF)for uncertainty and disturbance *** estimated parameters are used by sliding mode controller(SmC)for ultimate control of airship trajectory *** comprehensive algorithm,EKF based SmC(ESmC),is used as a robust solution to track airship *** proposed estimator provides the estimates of wind disturbances as well as model uncertainty due to the mass matrix variations and aerodynamic model *** stability and convergence of the proposed method are investigated using the Lyapunov stability *** simulation results show that the proposed method efficiently tracks the desired *** method solves the stability,convergence,and chattering problem of SmC under model uncertainties and wind disturbances.

关键词： airship chattering extended Kalman filter(EKF) model uncertainties estimation sliding mode controller(SmC)

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Sacrificial piles as a countermeasure against local scour around underwater pipelines

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Water Science and Engineering 2024年第2期17卷 187-196页

作者： Forough Raeisi Seyed mohammad ali Zomorodiann masih Zolghadr Hazi mohammad Azamathulla Department of Water Engineering Shiraz UniversityShiraz ***Iran Department of Water Sciences Engineering Jahrom UniversityJahrom ***Iran Department of Civil and Environmental Engineering The University of the West IndiesSt.Augustine CampusTrinidad 331310Republic of Trinidad and Tobago

Local scour around pipelines crossing rivers or in marine environments is a significant *** can lead to failure of the pipelines resulting in environmental side effects and economic *** study developed an experimental method to reduce local scour around pipelines with a steady flow of clear water by installing cylindrical and cubical sacrificial *** sizes of sacrificial piles were examined in a linear *** piles were installed on the upstream side of the pipeline at three *** scour depth reduction rates below the pipeline were *** results showed that sacrificial piles could protect a pipeline from local scour.A portion of scoured sediment around the sacrificial piles was deposited beneath the *** sediment accumulation reduced the scour depth beneath the *** of the experimental results demonstrated that the size of piles(d),the spacing between piles,and the distance between the pipe and piles(Xp)were the variables that reduced the maximum scour beneath the pipeline with a diameter of *** the piles with d=0.40D and 0.64D,X_(p)=4OD was the optimal distance to install a group of piles,and cubical piles could mitigate scour more effectively than cylindrical piles under similar *** the piles with d=D,the greatest reduction in scour depth was achieved at X_(p)=50D with any desired spacings between piles,and cylindrical piles in this dimension could protect the pipeline against scour more effectively than cubical piles.

关键词： Clear water River crossing pipeline Local scour Self-burial process Sediment transport

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Combustion characteristics of low-quality lignite for different bed material sphericities in a circulating fluidized bed boiler:A numerical study

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Particuology 2024年第7期90卷 364-382页

作者： Barış Gürel Gülşah Karaca Dolgun Osman İpek ali Keçebaş Department of mechanical Engineering Engineering FacultySüleyman Demirel UniversityÇünürIspartaTurkey Department of Energy Systems Engineering Technology FacultyMuğla SıtkıKoçman UniversityKötekliMenteşeMuğlaTurkey

This study delves into the combustion behavior of various lignite types within a circulating fluidized bed boiler(CFBB),with a primary focus on the impact of different bed material sphericity ratios(0.5,0.7,and 0.9).Utilizing bed material with a sphericity ratio of 0.9 sourced from theÇan power plant and verified through experimentation,the research reveals several key ***,furnace temperatures tended to rise with higher sphericity ratios,albeit with variations between lignite types,particularly highlighting the complexity of this relationship in the case of GLI-Tunçbilek *** levels in the combustion chamber remained consistent across different sphericity ratios,indicating minimal influence on pressure *** combustion efficiency,especially at the bottom of the boiler,was observed at lower sphericity levels(0.5 and 0.7)forÇan lignite,as reflected in CO_(2) mole *** NO_(x) emissions generally decreased with lower sphericity,the sensitivity to sphericity varied by lignite type,with Ilgın lignite showcasing low NO_(x) but high SO_(2) emissions,underscoring the intricate interplay between lignite properties,sphericity,and ***,this study advances our understanding of CFBB combustion dynamics,offering insights valuable for optimizing performance and emissions control,particularly in lignite-based power.

关键词： Circulating fluidized bed boiler Computational particle fluid dynamics method Particle sphericity ratios NO_(x)and SO_(2)emissions Energy production efficiency

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mechanistic insights toward identification and interaction of plant parasitic nematodes:A review

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Soil Ecology Letters 2024年第1期6卷 11-27页

作者： Bisma Jan ali Haider Shah mudasir Ahmad Bhat Arif Tasleem Jan Ishfaq Ahmad Wani ali Asghar Shah Section of microbiology Baba Ghulam Shah Badshah UniversityRajouriJ&K185234India Department of Biotechnology Baba Ghulam Shah Badshah University RajouriJ&K185234India Department of Botany Baba Ghulam Shah Badshah University RajouriJ&K185234India Department of Zoology School of Biosciences and BiotechnologyBaba Ghulam Shah Badshah University RajouriJ&K185234India

Nematode identification serves as an important param-eter to study their behaviour,importance and *** of classical morphometric based identifica-tion methods prove to be lacking due to insufficient knowledge on morphological variations among closely related *** approaches such as DNA and protein-based information,microarray,probing,sequence-based methods and others have been used to supplement morphology-based methods for nematode *** and certain protein-based nematode-associated molecular patterns(NAmPs),can be perceived by the host plants,and can initiate a signalling *** review primarily emphasizes on an updated account of different classical and modern tools used for the identification of *** we also summa-rize the mechanism of some important signalling pathways which are involved in the different plant nematode *** constitute most diverse and least studied group of soil inhabiting *** are ecologically and physiologically important,however,wide range of nematodes show harmful impact on the individuals that live within their *** parasitic nematodes(PPNs)are transparent,pseudocoelomate,free living or parasitic *** lack morphometric identification methods due to insufficient knowl-edge on morphological variations among closely related *** such,molecular approaches such as DNA and protein-based information,microarray,probing,sequence-based methods and others have been used to supplement morphology-based methods for their *** invade the defense response of different plant species,parasitic nematodes have evolved different molecular *** and certain protein-based nematode-associated molecular patterns(NAmPs),can be perceived by the host plants,and can initiate a signaling *** overcome the host confrontation and develop certain nematode feeding sites,some members can inject effectors into

关键词： nematode identification plant nematode interaction DNA fingerprinting nematode-associated molecular patterns signaling path-ways

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