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Parental Occupational Exposure and Risk of Acute Leukemia in Children: A Tunisian Population-Based Case-Control Study

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International Journal of Clinical medicine 2016年第3期7卷 193-203页

作者： H. Kalboussi y. Ben youssef I. Bougmiza F. Aloui A. Aloui W. Boughattas m. maoua A. Brahem S. Chatti O. El maalel F. Debbabi A. Khlif N. mrizak Occupational medicine and Occupational Pathologies Department Farhat Hached Teaching Hospital Sousse Tunisia Hematology Department Farhat Hached Teaching Hospital Sousse Tunisia Community medicine Department Faculty of Medicine of Sousse University of Sousse Sousse Tunisia

Background: In recent decades, the incidence of children’s hematological malignancies has been increasing worldwide including Tunisia. Their severity is reflected in the importance of the medical, social and economic impact. This increase remains fully unexplained, and the involvement of genetic, environmental and occupational factors is strongly suspected. materials and methods: Our study was a cross-sectional survey of the type case-control conducted in the University Hospital of Farhat Hached of Sousse during the period ranging between 1 July 2011 and 30 June 2012, and which included children with acute leukemia compared to children unharmed by neoplastic disease. Cases and controls were matched by age and gender. Our objective was to describe the socio-occupational characteristics of the parents of children with acute leukemia and to identify potential occupational factors implicated in the genesis of acute leukemia. Results: The number of acute leukemia cases in the Hematology Service and day hospital of the University Hospital of Farhat Hached during the study period was 66 cases divided into in 40 boys and 26 girls with a sex ratio of 1.53. Our cases and controls were matched by age and gender. The risk of incidence of leukemia in children from smoking fathers was higher (p = 0.02, OR = 2.24, IC = [1.11 - 4.52]). The risk of incidence of leukemia in children from alcoholic fathers was higher with p = 0.009, OR = 3.9;CI = [1.33 - 11.39]. After adjusting different variables, the difference persisted significantly with pa = 0.03 and ORa = 3.5, ICa = [1.09 - 11.6]. 25.7% of cases had a family history of blood disease and neoplasia, whereas no control presented that. The difference was statistically significant (p = 0.006, OR = 1.46, IC = [1.38 - 1.56]). The parental occupational exposures associated to the occurrence of acute leukemia in children were pesticides with a statistically significant difference (p = 0.03, OR = 2.94, IC = [1.06 - 8.13]). This difference

关键词： Occupational medicine Hematology Leukemia Children Case Control Survey

花生荚果与种子相关性状QTL定位及与环境互作分析

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The Salt Overly Sensitive （SOS） Pathway： Established and Emerging Roles

作物学报 2021年第10期47卷 1874-1890页

作者：孟鑫浩张靖男崔顺立 Charles y.Chen 穆国俊侯名语杨鑫雷刘立峰华北作物改良与调控国家重点实验室 / 河北省种质资源重点实验室 / 河北农业大学河北保定 071001 奥本大学作物、土壤与环境科学系美国奥本 36849

花生荚果、种子性状与产量紧密相关,是重要的农艺性状.为挖掘与荚果、种子性状紧密连锁的分子标记,本研究以大果品种冀花5号和小果美国资源m130组配衍生的315个家系RIL8群体为材料,利用SSR、AhTE、SRAP和TRAP等标记构建了一张包含363个... 详细信息

花生荚果、种子性状与产量紧密相关,是重要的农艺性状.为挖掘与荚果、种子性状紧密连锁的分子标记,本研究以大果品种冀花5号和小果美国资源m130组配衍生的315个家系RIL8群体为材料,利用SSR、AhTE、SRAP和TRAP等标记构建了一张包含363个多态性位点的遗传连锁图谱.该图谱共包含21个连锁群,总长为1360.38 cm,标记间平均距离为3.75 cm.利用完备区间作图法对2017—2018年5个环境的荚果、种子相关性状进行数量性状基因座(quantitative trait locus,QTL)分析,共鉴定到97个与荚果、种子性状相关的QTL,可解释的表型变异为2.36％～12.15％,分布在A02、A05、A08、A09、B02、B03、B04、B08和B09等9条染色体上.其中,9个与荚果长相关,13个与荚果宽相关,14个与荚果厚相关,11个与种子长相关,14个与种子宽相关,13个与种子厚相关,13个与百果重相关,10个与百仁重相关;4个主效QTL分别为qPWA08.1、qPTA08.3、qPTA08.4和qSWB08.5,可解释的表型变异分别为10.02％、11.06％、12.15％和11.97％;45个稳定表达的QTL在3个以上环境可被重复检测;连锁群A02、A08、B02、B04和B08上存在QTL聚集区.另外,检测到15对上位性QTL,可解释的表型变异为10.23％～51.84％.研究结果将为花生荚果、种子性状的分子标记辅助育种提供重要的理论依据.

关键词：花生荚果种子 QTL QTL×E

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molecular Plant 2013年第2期6卷 275-286页

作者： Hongtao Ji José m. Pardo Giorgia Batelli michael J. Van Oosten Ray A. Bressan Xia Li The State Key Laboratory of Plant Cell and Chromosome Engineering Center of Agricultural Resources Research Institute of Genetics andDevelopmental Biology Chinese Academy of Sciences Shijiazhuang Hebei 050021 PR China Instituto de Recursos Naturales y Agrobiologia Consejo Superior de Investigaciones Cientificas Sevilla-41012 Spain CNR Institute of Plant Genetics (CNR-IGV) Via Universita' i33 80055 Portici Italy Department of Agricultural Engineering and Agronomy University of Naples Federico II Via Universit~ 100 80055 Portici Italy Center for Plant Environmental Stress Physiology Purdue University West Lafayette IN 47907-2010 USA Department Biological Sciences King Abdulaziz University Kingdom of Saudi Arabia

Soil salinity is a growing problem around the world with special relevance in farmlands. The ability to sense and respond to environmental stimuli is among the most fundamental processes that enable plants to survive. At the cellular level, the Salt Overly Sensitive （SOS） signaling pathway that comprises SOS3, SOS2, and SOS1 has been proposed to mediate cellular signaling under salt stress, to maintain ion homeostasis. Less well known is how cellularly heterog- enous organs couple the salt signals to homeostasis maintenance of different types of cells and to appropriate growth of the entire organ and plant. Recent evidence strongly indicates that different regulatory mechanisms are adopted by roots and shoots in response to salt stress. Several reports have stated that, in roots, the SOS proteins may have novel roles in addition to their functions in sodium homeostasis. SOS3 plays a critical role in plastic development of lateral roots through modulation of auxin gradients and maxima in roots under mild salt conditions. The SOS proteins also play a role in the dynamics of cytoskeleton under stress. These results imply a high complexity of the regulatory networks involved in plant response to salinity. This review focuses on the emerging complexity of the SOS signaling and SOS protein functions, and highlights recent understanding on how the SOS proteins contribute to different responses to salt stress besides ion homeostasis.

关键词： auxin ion homeostasis root system architecture salt stress the SOS signaling pathway.

超加工食品消费增加成年人患高血压的风险:一项系统综述和荟萃分析

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中华高血压杂志 2023年第6期31卷 600-600页

作者： Wang m Du X Huang W Xu y 刘青

近年来,超加工食品(ultra-processed foods,UPF)对健康的影响引起广泛关注。然而,UPF与高血压之间的关系尚不清楚,该荟萃分析旨在分析两者的关系。方法:研究者系统性地搜索了Pubmed、Embase和Cochrane图书馆,查找截至2022年1月31日发表...

近年来,超加工食品(ultra-processed foods,UPF)对健康的影响引起广泛关注。然而,UPF与高血压之间的关系尚不清楚,该荟萃分析旨在分析两者的关系。方法:研究者系统性地搜索了Pubmed、Embase和Cochrane图书馆,查找截至2022年1月31日发表的所有相关研究。纳入了9项观察性研究,涉及参与者111594人。荟萃分析的结果显示,较高的UPF消耗量显著增加了高血压的风险(OR=1.23;95%CI 1.11～1.37;P=0.034)。

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Filling the Gaps to Solve the Extensin Puzzle

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molecular Plant 2018年第5期11卷 645-658页

作者： Eliana marzol Cecilia Borassi mauro Bringas Ana Sede Diana Rosa Rodriguez Garcia Luciana Capece Jose m. Estevez Fundacion Instituto Leloir and Instituto de Investigaciones Bioquimicas de Buenos Aires (IIBBA-CO.NICEr) Avenida Patricias Argentinas 435 Buenos AiresCP C1405BWE Argentina Departamento de Quimica Inorganica Analitica y Quimica Fisica Facultad de Ciencias Exactas y Naturales Universidad de Buenos Aires (INQUIMAE-CONICET)Buenos Aires CP C1428EGA Argentina Instituto de Investigaciones en Ingenierfa Genetica y Biologia molecular Dr. Hector Torres (INGEBI-CONICET) Vuelta de Obligado 2490 Buenos Aires C1428ADNArgentina

Extensins （EXTs） are highly repetitive plant O-glycoproteins that require several post-translational modifi- cations （PTms） to become functional in plant cell walls. First, they are hydroxylated on contiguous proline residues; then they are O-glycosylated on hydroxyproline and serine. After secretion into the apoplast, O-glycosylated EXTs form a tridimensional network organized by inter- and intra-Tyr linkages. Recent studies have made significant progress in the identification of the enzymatic machinery required to process EXTs, which includes prolyl 4-hydroxylases, glycosyltransferases, papain-type cysteine endopeptidases, and peroxidases. EXTs are abundant in plant tissues and are particularly important in rapidly expanding root hairs and pollen tubes, which grow in a polar manner. Small changes in EXT PTms affect fastgrowing cells, although the molecular mechanisms underlying this regulation are unknown. In this review, we highlight recent advances in our understanding of EXT modifications throughout the secretory pathway, EXT assembly in cell walls, and possible sensing mechanisms involving the Catharanthus roseus cell surface sensor receptor-like kinases located at the interface between the apoplast and the cytoplasmic side of the plasma membrane.

关键词： Arabidopsis thaliana cysteine endopeptidases extensins glycosyltransferases peroxidases prolyl 4-hydroxylases

Rotational Bands in 169Re

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ImP & HIRFL Annual Report 2002年 31-31页

作者： m.Oshima,y.Toh,m.Koizumi,A.Osa,T.Hayakawa,y.Hatsukawa,T.Shizuma,m.Sugawara Japan Atomic Energy Research Institute Japan. Japan Atomic Energy Research Institute Japan. Japan Atomic Energy Research Institute Japan. Japan Atomic Energy Research Institute Japan. Japan Atomic Energy Research Institute Japan. Japan Atomic Energy Research Institute Japan. Japan Atomic Energy Research Institute Japan. Chiba Institute of Technology Japan.

High-spin states in 169Re have been investigated by means of in-beam 7-ray spectroscopy techniques with the 144Sm(28Si, 1p2n) 169Re reaction. X-γ and γ-γ-t coincidences, 7-ray anisotropies, and DCO ratios were measured. A strongly coupled band based on the 9/2-[514] Nilsson state and a decoupled band built on the h9/2 intruder proton orbital (nominally 1/2- [541]) have been established. The AB neutron crossings are observed at hω=0.23 and 0.27 meV for the 9/2-[514] and 1/2-[541] bands, respectively. The difference between the

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Dispersal behavior of yellowjacket （Vespula germanica） queens

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Insect Science 2018年第1期25卷 109-116页

作者： maite masciocchi Andres S. martinez Aria J. Pereira Jose m. Villacide Juan C. Corley CONICET CCT Comahue INTA Grupo de Ecologia de Poblaciones de Insectos INTA EEA Bariloche Argentina Centro Regional Universitario Bariloche U. N. del Comahue Bariloche 8400 Argentina

Understanding the factors that affect animal dispersal behavior is important from both *** and applied perspectives. Dispersal can have clear evolutionary and ecological consequences, but for normative insect pests, dispersal capacity can also help to explain invasion success. Vespula germanica is a social wasp that, in the last century, has successfully invaded several regions of the world, showing one of the highest spread rates reported for a nonnative insect. In contrast with nonsocial wasps, in social species, queens are responsible for population redistribution and spread, as workers are sterile. For V. germanica, it has been observed that queen flight is limited to 2 distinct periods： early autumn, when new queens leave the nest to mate and find sheltered places in which to hibernate, and spring when new colonies are founded. Our aim was to study the flight behavior of V. germanica queens by focusing on the different periods in which dispersal occurs, characterizing as well the potential contribution of queen flight （i.e., distance） to the observed geographical spread. Our results suggest that the distances flown by nonover- wintered queens is greater than that flown by overwintered individuals, suggesting that the main queen dispersal events would occur before queens enter hibernation. This could relate to a behavioral trait of the queens to avoid the inbreeding with related drones. Additionally, given the short distances flown and remarkable geographical spread observed, we provide evidence showing that queen dispersal by flight is likely to contribute proportionately less to population spread than human-aided factors.

关键词： flight potential German wasps hibernation invasive wasps social insect

The nature of transition from adakitic to non-adakitic magmatism in a slab window setting:A synthesis from the eastern Pontides,NE Turkey

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Geoscience Frontiers 2013年第4期4卷 353-375页

作者： yener Eyuboglu m.Santosh Francis O.Dudas Enver Akaryali Sun-Lin Chung Kemal Akdag Osman Bektas Department of Geological Engineering.Karadeniz Technical University School of Earth Sciences and Resources.China University of Geosciences(Beijing) Department of Earth.Atmospheric and Planetary Sciences.massachusetts Institute of Technology Department of Geological Engineering.Gumushane University Department of Geosciences National Taiwan University

The eastern Pontides orogenic belt provides a window into continental arc magmatism in the Alpine-Himalayan belt. The late mesozoic-Cenozoic geodynamic evolution of this belt remains controversial. Here we focus on the nature of the transition from the adakitic to non-adakitic magmatism in the Kale area of Gumushane region in NE Turkey where this transition is best preserved. The adakitic lithologies comprise porphyries and hyaloclastites. The porphyries are represented by biotite-rich andesites, hornblende-rich andesite and dacite. The hayaloclastites represent the final stage of adakitic activity and they were generated by eruption/intrusion of adakitic andesitic magma into soft carbonate mud. The non-adakitic lithologies include basaltic-andesitic volcanic and associated pyroclastic rocks. Both rock groups are cutting by basaltic dikes representing the final stage of the Cenozoic magmatism in the study area. We report zircon U-Pb ages of 48.71 ± 0.74 ma for the adakitic rocks, and 44.68 ± 0.84 ma for the non-adakitic type, suggesting that there is no significant time gap during the transition from adakitic to non-adakitic magmatism. We evaluate the origin, magma processes and tectonic setting of the magmatism in the southern part of the eastern Pontides orogenic belt. Our results have important bearing on the late mesozoic-Cenozoic geodynamic evolution of the eastern mediter- ranean region.

关键词： AdakiteGeochemistryZircon U-Pb geochronologymagma tectonicsEastern Pontides

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π-Extension and chlorination of non-fullerene acceptors enable more readily processable and sustainable high-performance organic solar cells

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Journal of Energy Chemistry 2023年第4期79卷 321-329页

作者： Ning Su Jianhua Chen mengran Peng Guoping Li Robert m.Pankow Ding Zheng Junqiao Ding Antonio Facchetti Tobin J.marks Department of Chemical Science and Technology Yunnan UniversityKunming 650500YunnanChina Department of Chemistry and the materials Research Center Northwestern UniversityEvanstonIL 60208USA

Organic solar cells(OSCs)processed without halogenated solvents and complex treatments are essential for future ***,we report three novel small molecule acceptors(NFAs)consisting of a y6-like core but withπ-extended naphthalene with progressively more chlorinated end-capping groups and a longer branched chain on the Nitrogen *** NFAs exhibit good solubilities in nonchlorinated organic solvents,broad optical absorptions,closeπ-πstacking distances(3.63–3.84A),and high electron mobilities(~10^(-3)cm^(2)V^(-1)s^(-1)).The o-xylene processed and as-cast binary devices using Pm6 as the donor polymer exhibit a PCE increasing upon progressive chlorination of the naphthalene end-capping group from 8.93%for yN to 14.38%for yN-Cl to 15.00%for *** similarly processed ternary OSCs were fabricated by employing yN-Cl and yN-2Cl as the third component of Pm6:CH1007 blends(PCE=15.75%).Compared to all binary devices,the ternary Pm6:CH1007:yN-Cl(1:1:0.2)and Pm6:CH1007:yN-2Cl(1:1:0.2)cells exhibit significantly improved PCEs of 16.49%and15.88%,respectively,which are among the highest values reported to date for non-halogenated solvent processed OSCs without using any additives and blend post-deposition treatments.

关键词： Non-fullerene acceptors Non-chlorinated organic solvents Organic solar cells

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