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EVALUATION OF CREEP PROPERTIES FOR 316FR STEEL THICK PLATE WELDmENT USING mINIATURE CREEP SPECImEN

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Acta metallurgica Sinica(English Letters) 2004年第4期17卷 369-374页

作者： H.Hongo m.Yamazaki T.Watanabe T.Tanabe m.tabuchi Y.monma National Institute for materials Science Materials Information Technology Station Tsukuba Ibaraki 305-0047 JapanNational Institute for Materials Science Materials Information Technology Station Tsukuba Ibaraki 305-0047 JapanNational Institute for Materials Science Materials Information Technology Station Tsukuba Ibaraki 305-0047 JapanNational Institute for Materials Science Materials Information Technology Station Tsukuba Ibaraki 305-0047 JapanNational Institute for Materials Science Materials Information Technology Station Tsukuba Ibaraki 305-0047 JapanKochi University of Technology Tosayamada Kochi 782-8502 Japan

Evaluation of creep properties of the welded joint through taking local fluctuation of the mechanical properties into consideration is experimentally or analytically seldom carried out. The purposes of the present study are to examine the surface strain distribution in the weld metal of a full thickness welded joint specimen and subsequently to investigate the local variation in the properties of the all-weld metal part of the joint using miniature specimens. A welded joint was prepared for 316FR steel plates by gas tungsten arc welding process using mod. 316L filler wire. Creep tests were conducted at 823K in air using full thickness large welded joint specimens, HAZ and all-weld metal miniature specimens. From the results obtained, it is concluded that the creep properties of multi-layer welded joints strongly depend on the location of specimen sampling.

关键词： creep properties weld metal welded joint stainless steel 316FR

Suppression of fibrosis in human pterygium fibroblasts by butyrate and phenylbutyrate

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International Journal of Ophthalmology(English edition) 2017年第9期10卷 1337-1343页

作者： Yuka Koga Noriaki maeshige Hiroto tabuchi mikiko Uemura michiko Aoyama-Ishikawa makoto miyoshi Chikako Katakami makoto Usami Division of Nutrition and metabolism Department ofBiophysicsKobe University Graduate School of Health SciencesTomogaoka 7-10-2Suma-kuKobeJapan Department of Rehabilitation Science Kobe University Graduate School of Health SciencesTomogaoka 7-10-2Suma-kuKobeJapan Department of Ophthalmology Saneikai Tsukazaki HospitalWaku 68-1Aboshi-kuHimejiJapan Department of Nutrition Kobe University HospitalKobe University School of MedicineKusunoki-cho 7-5-2Chuo-kuKobeJapan

AIm：To evaluate the antifibrogenic effects of butyrate or phenylbutyrate,a chemical derivative of butyrate,in human pterygium ***：Human pterygium fibroblasts obtained from patient pterygium tissue were treated with butyrate or phenylbutyrate for *** ofα-smooth muscle actin,collagen I,collagen III and matrix metalloproteinase-1m RNA was measured by quantitative real-time reverse transcription polymerase chain reaction,and acetylated histone was evaluated by Western ***：Butyrate inhibitedα-smooth muscle actin,type III collagen and matrix metalloproteinase-1 expressions,and phenylbutyrate inhibited types I and III collagen and matrix metalloproteinase-1 expressions without changing cell viability as well as both of these increased histone *** results suggested that butyrate and phenylbutyrate suppress fibrosis through a mechanism involving histone deacetylase ***：This indicates that butyrate or phenylbutyrate have antifibrogenic effects in human pterygium fibroblasts and could be novel types of prophylactic and/or therapeutic drugs for pterygium,especially phenylbutyrate,which does not have the unpleasant smell associated with butyrate.

关键词： butyrate phenylbutymte pterygium fibroblasts antifibrogenic effect

Changes in choroidal thickness in healthy pediatric individuals: a longitudinal study

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International Journal of Ophthalmology(English edition) 2018年第7期11卷 1179-1184页

作者： Eiko Ohsugi Yoshinori mitamura Kayo Shinomiya masanori Niki Hiroki Sano Toshihiko Nagasawa Yukiko Shimizu Daisuke Nagasato Hitoshi tabuchi Department of Ophthalmology Saneikai Tsukazaki Hospital Department of Ophthalmology Institute of Biomedical Sciences Tokushima University Graduate School

AIm： To investigate the changes in the choroidal thickness in healthy pediatric children in a longitudinal study, and to determine the ocular and systemic parameters that were significantly correlated with the changes in the choroidal thickness. mETHODS： This study included 64 eyes of 34 healthy Japanese children with a mean age（±SD） of 4.4（±0.4）y（range, 3.6-5.8 y） at baseline. Swept-source optical coherence tomography（SS-OCT） was used to record images of the retina and choroid at the baseline and after a mean followup period of about 1.5 y. The 3 D raster scan protocol was used to construct the choroidal thickness map. mean choroidal thickness was calculated for each of the nine sectors of the Early Treatment Diabetic Retinopathy Study grid. Best-corrected visual acuity, axial length, body height, and weight were also measured. Changes in measurements were defined as the baseline values subtracted from the values at the final visit. A generalized estimating equation was used to eliminate the effect of within-subject intereye correlations. RESULTS： The mean central choroidal thickness was significantly reduced during the follow-up period（baseline, 301.8±8.6 μm; final visit, 286.6±8.0 μm, P〈0.001）. The decrease in the choroidal thickness was greatest in the central sector, followed by the sectors of the inner and outer rings. The inner and outer rings had diameters of 1 to 3 mm and 3 to 6 mm, respectively. The changes in the choroidal thickness in the central, inner ring, and outer ring sectors were significantly and negatively correlated with the age, baseline body height, baseline body weight, and elongation of the axial length. CONCLUSION： These results indicate that the choroidal thickness among preschool-aged Japanese children decreased significantly during the follow-up period. The choroidal thinning is significantly associated with the elongation of axial length. These characteristics should be considered in the evaluation of choroidal thickness in younger chi

关键词： choroidal thickness longitudinal study pediatrics swept-source optical coherence tomography

Criteria for versatile GaN mOVPE tool:high growth rate GaN by atmospheric pressure growth

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Journal of Semiconductors 2011年第1期32卷 21-23页

作者： Koh matsumoto Kazutada Ikenaga Jun Yamamoto Kazuki Naito Yoshiki Yano Akinori Ubukata Hiroki Tokunaga Tadanobu Arimura Katsuaki Cho Toshiya tabuchi Akira Yamaguchi Yasuhiro Harada Yuzaburo Ban Kousuke Uchiyama TN-EmC Ltd 2008-2 Wada TamaTokyo 206-0001Japan Business Strategy Planning div.Electronics Group TAIYO NIPPON SANSO Corporation 10 OkuboTsukuba 300-2611Japan Compound-semiconductor Division TAIYO NIPPON SANSO Corp. 6-2 KojimachoKawasaki-shi210-0861Japan

Growth rate has a direct impact on the productivity of nitride LED production. Atmospheric pressure growth of GaN with a growth rate as high as 10/zm/h and also *** growth of 1μm/h by using 4 inch by 11 production scale mOVPE are described. XRD of （002） and （102） direction was 200 arcsec and 250 arcsec, respectively. Impact of the growth rate on productivity is discussed.

关键词： mOVPE GaN: AlGaN atmospheric pressure growth high growth rate

Qualitative Rural Indonesian Study of Diabetes Knowledge, Health Beliefs, and Behaviors in Type 2 Diabetes Patients

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Health 2019年第2期11卷 263-275页

作者： Nice maylani Asril Keiji tabuchi miwako Tsunematsu Toshio Kobayashi masayuki Kakehashi Department of Health Informatics Graduate School of Biomedical and Health Science Hiroshima University Hiroshima Japan Department of Education Faculty of Education Ganesha University of Education Bali Indonesia Department of Health Promotion and Development Science Graduate School of Biomedical and Health Science Hiroshima University Hiroshima Japan Department of General Internal medicine Ishii Memorial Hospital Yamaguchi Japan

This study was aimed at understanding diabetes knowledge, health beliefs, and behaviors among type 2 diabetes patients in Balinese rural areas. The study used the Health Belief model (HBm) in applied thematic analysis. It involved semi-structured focus groups with 20 patients (m = 49.95 years old, SD 6.7). Three themes formulated: poor diabetes knowledge, diabetes perceived as a life burden, and the factors affecting self-efficacy in practicing healthy lifestyle. The poor diabetes knowledge was due to traditional indigenous beliefs and low health literacy. The perception that diabetes is a life burden was related with physical and psychological condition. The factors affecting the self-efficacy were the perceived barriers and external influence. It is need to understand the traditional indigenous beliefs, burdens, and lacking internal intention as the modifying factors of health beliefs. This study suggests that the development of integrated health promotion of diabetes should consider the HBm’s modifying factors in rural areas.

关键词： Type 2 Diabetes Health Beliefs Health Behaviors Health Promotion Rural Areas

Conscious Slower Breathing Predominates Parasympathetic Activity and Provides a Relaxing Effect, in Healthy Japanese Adult Women

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Health 2023年第9期15卷 954-964页

作者： mami Sakurai Ailing Hu Takuji Yamaguchi masahiro tabuchi Yasushi Ikarashi Hiroyuki Kobayashi Department of Hospital Administration Graduate School of Medicine Juntendo University Tokyo Japan Department of Personalized Kampo medicine Graduate School of Medicine Juntendo University Tokyo Japan

Background: The optimal breathing pattern (BP) to effectively regulate autonomic nervous activity is yet to be determined. Objective: We aimed to clarify the effects of four BPs (BP-1, BP-2, BP-3, and BP-4) on autonomic nervous activity and mood changes. methods: Eleven healthy adult female volunteers performed each BP in a sitting position for 5 min in a resting state. The time required for one breathing for BP-1 (30 breaths/min), BP-2 (20 breaths/min), BP-3 (15 breaths/min), and BP-4 (10 breaths/min) were 2 s, 3 s, 4 s, and 6 s, respectively. The inspiratory/expiratory time of one breathing was 1 s/1 s, 1 s/2 s, 2 s/2 s, and 2 s/4 s. The high-frequency component (HF) and low-frequency component (LF)/HF ratio during and before (control) performing a BP were calculated from heart rate variability data recorded using the wearable biometric information tracer m-BIT. Three mood changes, which are, “pleasure—unpleasure”, “relaxation—tension”, and “sleepiness—arousal”, in the subjects were assessed using the visual analog scale (VAS) before and after performing a BP. Results: Slower breathing induced an increase in HF power and a reduction in LF/HF ratio, indicating increased parasympathetic activity and decreased sympathetic dominance. Furthermore, VAS revealed that slower breathing increased the tendency to feel “pleasure”, “relaxation”, and “sleepiness”. Conclusion: Our results suggest that slower breathing predominates parasympathetic activity in the autonomic nervous system, resulting in a relaxing effect. This result may help lay the foundation for deriving breathing methods that efficiently regulate an individual’s autonomic activity.

关键词： Breathing Autonomic Activity Heart Rate Variability Analysis Visual Analog Scale

Boiogito Increases the Synthesis and Secretion of Adiponectin by Promoting Differentiation in Cultured Human Adipocytes

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Health 2023年第12期15卷 1319-1337页

作者： Yuan Gu Ailing Hu Takuji Yamaguchi masahiro tabuchi Yasushi Ikarashi Hiroyuki Kobayashi Department of Personalized Kampo medicine Juntendo University Graduate School of Medicine Tokyo Japan

Boiogito (BOT) ameliorates insulin resistance and diabetes in several animal models;however, the underlying mechanisms for these in vivo effects remain unclear. Thiazolidine derivatives, which are peroxisome proliferator-activated receptor γ (PPARγ) agonists for the treatment of type II diabetes, promote adiponectin production by inducing adipocyte differentiation, thereby reducing insulin resistance. This study aimed to evaluate the effect of BOT on adipocyte differentiation using cultured human visceral preadipocytes (HVPAds) compared with the thiazolidine derivative troglitazone (TRG). We investigated the effects of BOT (0.125 - 1 mg/mL) and TRG (10 μm) on the differentiation of adipocytes treated with or without tumor necrosis factor-α (TNF-α: 5 ng/mL). On day 14 of culture, the following adipocyte differentiation marker levels were measured: intracellular lipids, extracellular (i.e., medium) adiponectin, and intracellular differentiation-related genes (PPARγ, CCAAT/enhancer binding protein, adiponectin, differentiation cluster 36, glucose transporter type 4). BOT and TRG increased factors associated with differentiation including lipid, adiponectin, and differentiation-related gene expression levels compared with the controls. The increases in these differentiation markers were inhibited by the PPARγ antagonist GW9662 (20 μm). Furthermore, TNF-α decreased all differentiation marker levels. The decreases in differentiation markers were inhibited by BOT and TRG;however, these inhibitory effects were blocked by GW9662. The results suggest that BOT increases the synthesis and secretion of adiponectin by promoting differentiation similar to TRG. This study is the first to demonstrate that adipocyte differentiation-promoting activity is a mechanism for the beneficial effects of BOT on diabetes and insulin resistance.

关键词： Adipocyte Adiponectin Boiogito Differentiation Troglitazone

Relationship between Pectic Substances and Strand Separation of Cooked Spaghetti Squash--Part 2. Changes in Firmness, Histological Structure and Pectic Substances during Soaking in Pectin Extractants

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Journal of Food Science and Engineering 2014年第4期4卷 228-235页

作者： Kayoko Ishii Ai Teramoto Hiroko Kuwada Chihiro Nakazaki Yuri Jibu mayumi tabuchi michiko Fuchigami Department of Nutrition and Life Science Fukuyama University Fukuyama Hirosima-ken 729-0292 Japan Department of Health and Nutrition Kanto Gakuin University Yokohama Kanagawa-ken 236-8501 Japan Department of Nutritional Science Okayama Prefectural University Soja Okayama-ken 719-1197 Japan

The flesh of spaghetti squash separates into strands when cooked. The purpose of this paper is to investigate the cause of strand separation （during cooking） by soaking for 24 h at 35 ℃ in solutions with three kinds of pectin extractant. The changes in strand separation, firmness, histological structure and the pectin of flesh during soaking in 0.01 N HCI solution （pH 2.0）, 0.035 m ammonium oxalate solution （pH 4.0） or 2% sodium hexametaphosphate solution （pH 4.0） were investigated. When flesh was soaked in the HCI solution, the separation into strands and removal of calcium and magnesium were greater than that soaked in other pectin extractants. High methoxyl pectin was extracted by soaking in HC1 solution （pH 2.0） due to removal of polyvalent cations. This result shows that high methoxyl pectin glues strands together in the flesh of spaghetti squash. The shape of the cells which constituted strands was round; on the other hand, that of cells surrounded strands was elongated. When cooked in boiling water or soaked at pH 2.0, the shape of the former cells was maintained, but the latter cells, which contributed to adhesion between strands, broke down. Thus, the flesh separated into strands. When flesh was boiled for 15-30 min, pectin degraded and dissolved in the cooking solution; consequently, the flesh separated into strands and also the middle lamella of cell walls of strands separated. However, pectin remaining in strands maintained their crispness.

关键词： Spaghetti squash pectin texture histological structure strand separation soaking pectin extractant.

Transient receptor potential vanilloid 4-dependent calcium influx and ATP release in mouse and rat gastric epithelia

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World Journal of Gastroenterology 2016年第24期22卷 5512-5519页

作者： Hiroshi mihara Nobuhiro Suzuki Ammar Abdullkader Boudaka Jibran Sualeh muhammad makoto Tominaga Yoshiaki tabuchi Toshiro Sugiyama Department of Gastroenterology Graduate School of Medicine and Pharmaceutical Sciences University of Toyama Division of Cell Signaling Okazaki Institute for Integrative Bioscience (National Institute for Physiological Sciences) National Institutes of Natural Sciences Department of Physiology College of Medicine and Health Sciences Sultan Qaboos University Life Science Research Center University of Toyama

AIm: To explore the expression of transient receptor potential vanilloid 4(TRPV4) and its physiological meaning in mouse and rat gastric epithelia. mETHODS: RT-PCR and immunochemistry were used to detect TRPV4 m RNA and protein expression in mouse stomach and a rat normal gastric epithelial cell line(RGE1-01), while Ca2+-imaging and electrophysiology were used to evaluate TRPV4 channel activity. ATP release was measured by a luciferin-luciferase assay. Gastric emptying was also compared between WT and TRPV4 knockout mice. RESULTS: TRPV4 m RNA and protein were detected in mouse tissues and RGE1-01 cells. A TRPV4-specific agonist(GSK1016790A) increased intracellular Ca2+ concentrations and/or evoked TRPV4-like current activities in WT mouse gastric epithelial cells andRGE1-01 cells, but not TRPV4 KO cells. GSK1016790 A or mechanical stimuli induced ATP release from RGE1-01 cells while TRPV4 knockout mice displayed delayed gastric emptying in vivo. CONCLUSION: TRPV4 is expressed in mouse and rat gastric epithelium and contributes to ATP release and gastric emptying.

关键词： Transient receptor potential vanilloid 4 Stomach gastric emptying ATP