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预防医院耐药菌感染--2014年美国

上海预防医学 2017年第2期29卷 163-167页

作者： Lindsey m.Weiner,mPH Scott K.Fridkin,mD Zuleika Aponte-Torres,mPH Lacey Avery,mA Nicole Coffin,mA margaret A.Dudeck,mPH Jonathan R.Edwards,mStat John A.Jernigan,mD Rebecca Konnor,mPH minn m.soe,mBBS,mPH Kelly Peterson L.Clifford mcDonald,mD 刘洪霞(综述) 金克峙(审校) Division of Healthcare Quality Promotion National Center for Emerging and Zoonotic Infectious Diseases CDC. 不详

耐药菌是一种世界性的公共卫生威胁。2013年疾病预防控制中心（CDC）的一项报告概述了美国前18位危急和严重级别的耐药相关的威胁。

关键词：疾病预防控制中心耐药菌感染美国医院公共卫生

Observed characteristics of flow,water mass,and turbulent mixing in the Preparis Channel

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Acta Oceanologica Sinica 2023年第2期42卷 83-93页

作者： Ruijie Ye Feng Zhou Xiao ma Dingyong Zeng Feilong Lin Hongliang Li Chenggang Liu soe moe Lwin Hlaing Swe Win soe Pyae Aung State Key Laboratory of Satellite Ocean Environment Dynamics Second Institute of OceanographyMinistry of Natural ResourcesHangzhou310012China School of Oceanography Shanghai Jiao Tong UniversityShanghai200030China Geology Department Dagon UniversityYangon11422Myanmar National Analytical Laboratory Department of Research Innovation Ministry of EducationYangon11061Myanmar Port and Harbour Engineering Department Myanmar Maritime UniversityYangon11293Myanmar

Preparis Channel is the very important exchange path of energy and materials between the northern Bay of Bengal and Andaman Sea(AS).A set of hydrographic measurements,a microstructure profiler,and a deep mooring were used to determine the characteristics of water masses,turbulent mixing,and flows in the Preparis *** unprecedented short-term mooring data reveal that a deep current in the deep narrow passage(below 400 m)of the Preparis Channel flows toward the Bay of Bengal(BoB)with a mean along-stream velocity of 25.26 cm/s at depth of 540 m;above the deep current,there are a relatively weak current flows toward the AS with a mean along-stream velocity of 15.46 cm/s between 500 m and 520 m,and another weak current flows toward the BoB between 430 m and 500 ***,a sandwiched vertical structure of deep currents(below 400 m)is present in the Preparis *** volume transport below 400 m is 0.06 Sv(1 Sv=106 m^(3)/s)from the AS to the *** the upper layer(shallower than 300 m),the sea water of the AS is relatively warmer and fresher than that in the BoB,indicating a strong exchange through the *** profiler observations reveal that the turbulent diffusivity in the upper layer of the Preparis Channel reaches O(10−4 m^(2)/s),one order larger than that in the interior of the BoB and over the continental slope of the northern *** speculate that energetic high-mode internal tides in the Preparis Channel contribute to elevated turbulent *** addition,a local“hotspot”of turbidity is identified at the deep mooring site,at depth of about 100 m,which corresponds to the location of elevated turbulent mixing in the Preparis Channel.

关键词： deep flow turbulent mixing water mass Preparis Channel

Origin and Evolution of Ultramafic Rocks along the Sagaing Fault, myanmar

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Journal of Earth Science 2023年第1期34卷 122-132页

作者： Tomoaki morishita Hnin min soe Hla Htay Than Htut Lwin Juan miguel Guotana Akihiro Tamura Tomoyuki mizukami Khin Zaw 无 Faculty of Geosciences and Civil Engineering Kanazawa UniversityKanazawa920-1192Japan Lamont-Doherty Earth Observatory Columbia UniversityPalisadesNY10964USA Volcanoes and Earth’s Interior Research Center Japan Agency for Marine-Earth Science and Technology2-15 NatsushimaKanagawa237-0061Japan Geology Department University of MandalayMandalay05092Myanmar Geology Department Dagon UniversityNorth Dagon11422Myanmar Taunggoke Degree College TaunggokeTaunggoke Township07161Myanmar Graduate School of Natural Science and Technology Kanazawa UniversityKanazawaIshikawa920-1192Japan CODES ARC Centre of Excellence in Ore Deposits University of TasmaniaTasmania7001Australia

The active Sagaing fault in myanmar defines the boundary between the Indian Plate and the Eurasian Plate and causes seismic damage in the major cities of myanmar. Small bodies of serpentinite occur along the fault. We for the first time investigated the highly sheared serpentinite bodies in the Sheinmagar area and Yega Inn area along the Sagaing fault. Extensively sheared/brecciated serpentinites and related rocks, such as talc and/or chlorite-bearing rocks contains small rock fragments of serpentinites. Serpentine texture and mineral chemistry indicate that the protolith of these serpentinites were mainly harzburgite with minor amounts of dunite, some of which are cut by gabbroic veins. No shape-preferred orientation of the antigorite is present, indicating that the serpentinization was occurred under relatively static conditions. Protolith and serpentine minerals are similar to those of the jadeitite-bearing serpentinites in the north of the Sagaing fault(the Jade mine belt). Chemical variations of spinels in the studied area are within the compositional range of forearc peridotites and those in the mantle section of nearby ophiolites. After the formation of antigorite serpentinite under static conditions, these serpentinites were subsequently, but locally deformed, probably due to the activity of the Sagaing fault, resulting in the formation of serpentinite schist/brecciated rock. The presence of the less-deformed antigorite serpentinite in the sheared/brecciated zone indicates the strain localization mainly along the surrounding serpentine-talc(±chlorite) schistose rocks, which is probably formed by the reaction between serpentinite and country rocks. Further studies are needed to better understand whether the distribution of serpentinized peridotites cause variations in the activity of the Sagaing fault.

关键词： Sagaing fault serpentinite deformation ophiolite

An Adaptive Response Compensation Technique for the Constant-Current Hot-Wire Anemometer

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Open Journal of Fluid Dynamics 2013年第2期3卷 95-108页

作者： soe minn Khine Tomoya Houra masato Tagawa Department of mechanical Engineering Nagoya Institute of Technology Nagoya Japan

An adaptive response compensation technique has been proposed to compensate for the response lag of the constant-current hot-wire anemometer (CCA) by taking advantage of digital signal processing technology. First, we have developed a simple response compensation scheme based on a precise theoretical expression for the frequency response of the CCA (Kaifuku et al. 2010, 2011), and verified its effectiveness experimentally for hot-wires of 5 μm, 10 μm and 20 μm in diameter. Then, another novel technique based on a two-sensor probe technique—originally developed for the response compensation of fine-wire thermocouples (Tagawa and Ohta 1997;Tagawa et al. 1998)—has been proposed for estimating thermal time-constants of hot-wires to realize the in-situ response compensation of the CCA. To demonstrate the usefulness of the CCA, we have applied the response compensation schemes to multipoint velocity measure- ment of a turbulent wake flow formed behind a circular cylinder by using a CCA probe consisting of 16 hot-wires, which were driven simultaneously by a very simple constant-current circuit. As a result, the proposed response compensation techniques for the CCA work quite successfully and are capable of improving the response speed of the CCA to obtain reliable measurements comparable to those by the commercially-available constant-temperature hot-wire anemometer (CTA).

关键词： Flow measurement Hot-Wire Anemometer Turbulent Flow Constant-Current Hot-Wire Anemometer Response Compensation Frequency Response Time-Constant multipoint measurement Digital Signal Processing

Epipelagic mesozooplankton communities in the northeastern Indian Ocean off myanmar during the winter monsoon

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Acta Oceanologica Sinica 2023年第6期42卷 57-69页

作者： Ping Du Dingyong Zeng Feilong Lin Sanda Naing Zhibing Jiang Jingjing Zhang Di Tian Qinghe Liu Yuanli Zhu soe moe Lwin Wenqi Ye Chenggang Liu Lu Shou Feng Zhou Key Laboratory of marine Ecosystem Dynamics Second Institute of OceanographyMinistry of Natural ResourcesHangzhou 310012China State Key Laboratory of Satellite Ocean Environment Dynamics Second Institute of OceanographyMinistry of Natural ResourcesHangzhou 310012China Port and Harbour Engineering Department Myanmar Maritime UniversityYangon 11293Myanmar Geology Department Dagon UniversityYangon 11422Myanmar

The northern Andaman Sea off myanmar is one of the relatively high productive regions in the Indian *** abundance,biomass and species composition of mesozooplankton and their relationships with environmental variables in the epipelagic zone(~200 m)were studied for the first time during the Sino-myanmar joint cruise(February 2020).The mean abundance and biomass of mesozooplankton were(1916.7±1192.9)ind./m3and(17.8±7.9)mg/m3,respectively.A total of 213 species(taxa)were identified from all *** omnivorous Cyclopoida Oncaea venusta and Oithona *** the top two dominant *** mesozooplankton communities were determined via cluster analysis:the open ocean in the Andaman Sea and the Bay of Bengal(Group A),the transition zone across the Preparis Channel(Group B),and nearshore water off the Ayeyarwady Delta and along the Tanintharyi Coast(Group C).Variation partitioning analysis revealed that the interaction of physical and biological factors explained 98.8%of mesozooplankton community spatial variation,and redundancy analysis revealed that column mean chlorophyll a concentration(CmCHLA)was the most important explanatory variable(43.1%).The abundance and biomass were significantly higher in Group C,the same as CmCHLA and column mean temperature(CmT)and in contrast to salinity,and CmT was the dominant *** taxon spatial variations were controlled by CmCHLA,salinity and *** study suggested that mesozooplankton spatial variation was mainly regulated by physical processes through their effects on *** physical processes were simultaneously affected by heat loss differences,freshwater influx,eddies and depth.

关键词： mesozooplankton myanmar epipelagic zone physical processes water column mean chlorophyll a

干旱-遮荫复合胁迫对大豆生长及代谢途径的影响

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干旱-遮荫复合胁迫对大豆生长及代谢途径的影响

作者： Haymarn soe myint 四川农业大学

学位级别：硕士

干旱、遮荫等逆境威胁作物正常发育。玉米-大豆间套作系统中,由于高位作物玉米的遮荫和玉米-大豆行的水分亏缺,大豆同时遭受光照和水分的限制。目前,已有很多对单一环境胁迫的研究,但关于复合胁迫的研究尚不深入。本研究旨在探讨遮荫和... 详细信息

干旱、遮荫等逆境威胁作物正常发育。玉米-大豆间套作系统中,由于高位作物玉米的遮荫和玉米-大豆行的水分亏缺,大豆同时遭受光照和水分的限制。目前,已有很多对单一环境胁迫的研究,但关于复合胁迫的研究尚不深入。本研究旨在探讨遮荫和干旱复合胁迫对大豆生理特性、抗氧化系统、激素浓度和代谢群体的影响。试验以WW+NL(充足灌溉+正常光照)为对照,设置5个处理,分别命名为:m+NL(中度干旱+正常光照)、S+NL(重度干旱+正常光照)、WW+S(充足灌溉+遮荫)、m+S(中度干旱+遮荫)和S+S(重度干旱+遮荫)。主要研究结果如下:与单一水分亏缺相比,遮荫和复合胁迫下的大豆植株株高均有不同程度的增加;单株叶面积随水分亏缺程度的增加而逐渐减小。而重度干旱+遮荫处理大豆的比叶面积最大。与C103相比,ND12具有较高的生物量、单株叶面积和比叶面积,但株高较低。与单一水分亏缺相比,复合胁迫提高了ND12和C103的光合速率、气孔导度、蒸腾速率和水分利用效率;复合胁迫下的气孔开度高于单一胁迫下的气孔开度。由于超氧化物歧化酶(SOD)、过氧化物酶(POD)和过氧化氢酶(CAT)等抗氧化酶含量的提高,与C103相比,ND12中mDA含量的降低,对氧化损伤有更好的保护作用。在m+S和S+S下,SOD、POD和CAT含量均呈上升趋势,而在m+NL和S+NL下则呈下降趋势。mDA含量以S+NL最高,其次为m+N L、S+S、m+S和WW+S。对植物激素浓度的分析表明,两个大豆品种的叶片脱落酸含量均在S+NL下达到最大。然而,在m+S和S+S处理下,大豆叶片脱落酸含量显著降低。此外,单一荫蔽和水分胁迫下,大豆叶片中茉莉酸含量降低;而复合胁迫下,ND12中的茉莉酸含量高于C103。在WW+S条件下,ND12和C103中吲哚-3-乙酸含量最高,分别为9.86μg g FW和14.11μg g FW。此外,氨基酸积累量与植物对复合胁迫的抗性有关,在复合胁迫下,天冬酰胺、谷氨酰胺和组氨酸水平的增加促进了气孔开放。对不同处理大豆根表型的研究表明,与单一胁迫相比,水分亏缺+荫蔽复合胁迫导致了不同的根长、根径和根体积的产生。m+S和S+S的根系形态表现优于m+NL和S+NL,且ND12的根系形态优于C103。叶片的代谢组学分析表明,干旱-荫蔽复合胁迫下,脱落酸生物合成量的变化可能导致叶片形态生理的改善,从而避免清除活性氧。然而,与其他处理相比,在中度水分亏缺+遮荫处理下,脱落酸生物合成量最高。油菜素甾体类化合物的生物合成在两个大豆品种的根系中都有显著变化,这可能是两个品种根系抗水分和遮荫胁迫的重要途径。根系的代谢组学分析表明,与C103相比,复合胁迫加速了ND12油菜素甾体的生物合成。因此,与单一胁迫相比,复合胁迫可以通过增强植物的防御系统来降低不利于植物代谢的环境胁迫。

关键词：大豆干旱荫蔽代谢组学植物激素

Bt蛋白Cry51Aa1和Cry51Aa2对绿盲蝽的毒性和结合特性分析

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Bt蛋白Cry51Aa1和Cry51Aa2对绿盲蝽的毒性和结合特性分析

作者： Ei Thinzar soe 中国农业科学院

学位级别：硕士

自1996年转基因作物商业化生产以来,表达苏云金芽孢杆菌杀虫蛋白的转基因棉花有效地控制了主要靶标害虫。但是,随着转基因棉花种植后棉田杀虫剂使用量的下降,绿盲蝽(Apolygus lucorum)(Hemiptera:miridae)等次要害虫的种群数量上升。另... 详细信息

自1996年转基因作物商业化生产以来,表达苏云金芽孢杆菌杀虫蛋白的转基因棉花有效地控制了主要靶标害虫。但是,随着转基因棉花种植后棉田杀虫剂使用量的下降,绿盲蝽(Apolygus lucorum)(Hemiptera:miridae)等次要害虫的种群数量上升。另一主要原因是当前种植的Bt作物对刺吸式害虫几乎没有毒性。最近有报道,属于β-成孔蛋白家族的Bt Cry51Aa1和Cry51Aa2蛋白对盲蝽具有的潜在毒性,Cry51Aa1序列修饰的Cry51Aa2突变体(Cry51Aa2.834＿16)对西部牧草盲蝽Lygus Hesperus和美国牧草盲蝽Lygus lineolaris具有很高的毒性。本研究中,我们测定了Cry51Aa1和Cry51Aa2对绿盲蝽***的杀虫活性,并对杀虫机制进行了初步研究。我们通过生物测定检测了Cry51Aa1和Cry51Aa2蛋白对绿盲蝽若虫的毒性,测定了绿盲蝽中肠匀浆液、中肠酶液、胰蛋白酶或胰凝乳蛋白酶对Cry51Aa1和Cry51Aa2原毒素的活化,利用ELISA法测定了绿盲蝽中肠蛋白与Cry51Aa1和Cry51Aa2的结合能力,通过Ligand blot法明确了Cry51Aa1和Cry51Aa2原毒素和活化毒素与绿盲蝽中肠受体蛋白的结合,并利用配体垂钓和LC-mS/mS进一步分析了可能的受体蛋白种类。主要结果如下:Cry51Aa1原毒素蛋白是在携带全长基因的重组Bt菌株BmB171表达获得,。通过离子交换层析法纯化产生的Bt原毒素蛋白,纯化后的Cry51Aa1原毒素蛋白大约35 k Da。具有His-tag的重组Cry51Aa2在p ET30a＿51Aa2质粒构建的载体转化至BL21(DE3)感受态细胞中表达,表达的重组蛋白用Ni柱纯化,利用肠激酶消化切去重组Cry51Aa2蛋白N末端的His标签区域,再次用离子交换层析法纯化,纯化的Cry51Aa2毒素约为35 k Da。1.利用混合饲料法进行生物测定,结果表明,绿盲蝽若虫对Cry51Aa1和Cry51Aa2毒素都很敏感,且Cry51Aa1(LC=11.87μgml)原毒素毒性高于Cry51Aa2原毒素(LC=61.34μgml)。***51Aa1和Cry51Aa2毒素都能够被胰蛋白酶和胰凝乳蛋白酶活化,活化的Cry51Aa1和Cry51Aa2毒素大小为25 k Da左右。当毒素与绿盲蝽中肠匀浆液或中肠酶液一起孵育后,用Western blot进行检测,也得到了相同的结果。此外,我们发现了60 k Da的Cry51Aa1和Cry51Aa2毒素的自二聚体。绿盲蝽若虫取食亚致死剂量的原毒素1小时后,间隔不同时间收集中肠,通过蛋白免疫印迹(Western blot)分析原毒素在体内的活化进程,结果发现绿盲蝽取食原毒素1小时,在3小时和6小时后取样,Cry51Aa1和Cry51Aa2原毒素部分被活化,同时有原毒素、预活化和活化毒素三种形式;在12、24或48小时后取样,Cry51Aa1和Cry51Aa2原毒素被完全活化。***分析结果表明,绿盲蝽若虫中肠蛋白能够与Cry51Aa1和Cry51Aa2毒素结合,结合能力与浓度有关。当使用100 n m和200 n m的Cry51Aa1时,结合能力随着中肠浓度的增加而增加,并在中肠蛋白20μg时结合能力达到最高。但是,当Cry51Aa125n m和50 n m时,与中肠蛋白的结合能力较低。所检测的Cry51Aa2,浓度为25、50、100和200 n m时,随中肠蛋白浓度的增加结合能力增加,与20μg和30μg中肠蛋白结合能力最高。20μg中肠蛋白与Cry51Aa1特异性结合的解离常数(kd)为248.6±47.4n m,与Cry51Aa2的解离常数为113.8±25.4 n m。*** blot分析结果显示,原毒素和活化的Cry51Aa1毒素主要与绿盲蝽中肠上分子大小约25 k Da的蛋白结合。与Cry51Aa2原毒素和活化的毒素与中肠蛋白的结合主要也显示出相同的条带,而且与活化的Cry51Aa2还与一个约50 k Da的蛋白结合。5.通过pull-down分析能够结合Cry51Aa1和Cry51Aa2原毒素的绿盲蝽中肠蛋白。切下在SDS-PAGE检测中结合的蛋白条带,并通过LC-mS/mS分析鉴定。在所有鉴定出的蛋白中,与两种毒素都结合的共有15种质膜蛋白,包括ABCA3、ABCB6、ABCC7、ABCD1、ABCG1、ABCG4(86.8 k Da)、ABCF1和一种氨肽酶等蛋白;还鉴定到分别与Cry51Aa1和Cry51Aa2特异性结合的质膜蛋白各24个,其中与Cry51Aa2结合的片段中包含两个氨肽酶和ABCF2蛋白等,与Cry51Aa2结合的片段中含ABCB

关键词：苏云金芽胞杆菌绿盲蝽 Cry51Aa1 Cry51Aa2 毒性结合蛋白

玉米（Zea mays L.）与大豆（Glycine max）不同间作模式的资源利用率及饲草产量与饲料品质的研究

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玉米（Zea mays L.）与大豆（Glycine max）不同间作模式的资源利...

作者： mAW NI soe HTET 西北农林科技大学

学位级别：硕士

间作种植是农业生产中重要种植模式,与单作种植模式相比,间作种植有利于资源利用率及作物生产水平的提高。玉米与间作豆科作物也有助于青贮饲料粗蛋白水平的增加。玉米间作豆科作物通过优化种植结构、增加生物多样性,进而提高大田种植效... 详细信息

间作种植是农业生产中重要种植模式,与单作种植模式相比,间作种植有利于资源利用率及作物生产水平的提高。玉米与间作豆科作物也有助于青贮饲料粗蛋白水平的增加。玉米间作豆科作物通过优化种植结构、增加生物多样性,进而提高大田种植效率,最终实现综合效果显著超过单作模式。粮豆间作模式可以改善大田资源环境,如光照条件,土壤水分和温度,减少病虫害损失,抑制杂草生长,降低生产风险,增加农民收入。另外,通过玉米间作大豆作物,又可以增加饲草产量、改善饲料品种,提高土壤肥力。因此,研究玉米-大豆不同间作模式的资源利用效率以及饲草产量和青贮饲料品质变化规律对实现农牧结合具有重要的理论指导价值。论文采用裂区完全随机区组设计,设五个处理,研究了玉米-大豆不同间作种植模式光、水资源的变化特征,以及饲草产量及青贮饲料的营养成分变化规律。研究结果表明:玉米与大豆间作模式可以显着增加鲜生物量和干物质生产,实现资源利用效率提高,如光合有效辐射(PAR)和土壤水分。玉米与大豆间作可以降低由于玉米生长不佳,大豆叶片衰老期间漏光率。,提高光合利用效率。玉米与大豆间作对土壤温度和土壤含水量也有显著影响。五种处理所制作的青贮饲料,醚提取物(EE)、灰分(%)和酸性洗涤纤维(ADF)对饲料营养成分无显著差异(P>0.05);所有间作模式的青贮饲料CP值(1m1s,12.1%;1m2s,12.2%;1m3s,12.4%;2m1s,12.1%),NDF和ADF含量均高于单作玉米青贮饲料;1m3s间作模式鲜草产量、干物质产量以及青贮饲料有机酸(Pm3s(1行玉米3行大豆)是适合青贮饲草产量提高和饲料营养品质改善的间作模式。本研究对了解玉米大豆间作效应,掌握玉米与大豆间作后制作青贮饲料的营养成分变化有具有重要意义。

关键词：间作种植模式玉米大豆饲草饲料品质

Aging and menopause reprogram osteoclast precursors for aggressive bone resorption

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Bone Research 2020年第3期8卷 333-342页

作者： Anais marie Julie moller Jean-marie Delaisse Jacob Bastholm Olesen Jonna Skov madsen Luisa matos Canto Troels Bechmann Silvia Regina Rogatto Kent soe Clinical Cell Biology Lillebaelt HospitalUniversity Hospital of Southern Denmark7100 VejleDenmark Department of Regional Health Research University of Southern Denmark5230 Odense MDenmark Department of Clinical Biochemistry and Immunology Lillebaelt HospitalUniversity Hospital of Southern Denmark7100 VejleDenmark Clinical Cell Biology Department of PathologyOdense University Hospital5000 Odense CDenmark Department of Clinical Research University of Southern Denmark5230 Odense MDenmark Department of molecular medicine University of Southern Denmark5230 Odense MDenmark Department of Clinical Genetics Lillebaelt HospitalUniversity Hospital of Southern Denmark7100 VejleDenmark Department of Oncology Lillebaelt HospitalUniversity Hospital of Southern Denmark7100 VejleDenmark OPEN Odense Patient data Explorative NetworkOdense University Hospital5000 Odense CDenmark

Women gradually lose bone from the age of〜35 years,but around menopause,the rate of bone loss escalates due to increasing bone resorption and decreasing bone formation levels,rendering these individuals more prone to developing *** increased osteoclast activity has been linked to a reduced estrogen level and other hormonal ***,it is unclear whether intrinsic changes in osteoclast precursors around menopause can also explain the increased osteoclast ***,we set up a protocol in which CD14f blood monocytes were isolated from 49 female donors(40-66 years old).Cells were differentiated into osteoclasts,and data on differentiation and resorption activity were *** multiple linear regression analyses combining in vitro and in vivo data,we found the following:(1)age and menopausal status correlate with aggressive osteoclastic bone resorption in vitro;(2)the type I procollagen N-terminal propeptide level in vivo inversely correlates with osteoclast resorption activity in vitro;(3)the protein level of mature cathepsin K in osteoclasts in vitro increases with age and menopause;and(4)the promoter of the gene encoding the dendritic cell-specific transmembrane protein is less methylated with *** conclude that monocytes are"reprogrammed"in vivo,allowing them to"remember"age,the menopausal status,and the bone formation status in vitro,resulting in more aggressive *** discovery suggests that this may be mediated through DNA *** suggest that this may have clinical implications and could contribute to understanding individual differences in age-and menopause-induced bone loss.

关键词： osteoclast menopause osteoporosis