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Interaction between early in ovo stimulation of the gut microbiota and chicken host-splenic changes in gene expression and methylation

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Journal of Animal Science and Biotechnology 2022年第1期13卷 94-105页

作者： A.Dunislawska A.Slawinska m.Gryzinska m.siwek Department of Animal Biotechnology and Genetics UTP University of Science and Technology85-084 BydgoszczPoland Institute of Biological Basis of Animal Production Sub-Department of General and Molecular GeneticsUniversity of Life Sciences in Lublin20-032 LublinPoland

Background:Epigenetic regulation of the gene expression results from interaction between the external environment and transcription of the genetic information encoded in *** CpG regions within the gene promoters lead to silencing of the gene expression in most *** contributing to epigenetic regulation include intestinal microbiota,which in chicken can be potently modified by in ovo *** main aim of this study was to determine global and specific methylation patterns of the spleen under the influence of host-microbiome ***:Fertilized eggs of two genotypes:Ross 308 and Green-legged Partridgelike were in ovo stimulated on d 12 of *** injected compounds were as follows:probiotic-Lactococcus lactis *** IBB477,prebiotic-galactooligosaccharides,and synbiotic-combination of *** were sacrificed on d 42 *** was collected,RNA and DNA were isolated and intended to gene expression,gene methylation and global methylation *** have proved that negative regulation of gene expression after administration of bioactive substances in ovo might have epigenetic *** changes depend on the genotype and the substance administered in ***:Epigenetic nature of microbial reprogramming in poultry and extension of issues related to hostmicrobiome interaction is a new direction of this research.

关键词： Gene expression Host-microbiome immune tissue Interaction methylation level

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GLP1 and GIP are involved in the action of synbiotics in broiler chickens

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Journal of Animal Science and Biotechnology 2018年第2期9卷 451-459页

作者： Pawel Antoni Kolodziejski maciej Sassek Daniela Chalupka Natalia Leciejewska Leszek Nogowski Pawel mackowiak Damian Jozefiak Katarzyna Stadnicka maria siwek marek Bednarczyk Tomasz Szwaczkowski Ewa Pruszynska-Oszmalek Department of Animal Physiology and Biochemistry Poznan University of Life Sciences Department of Animal Nutrition and Feed management Poznan University of Life Sciences Department of Animal Biochemistry and Biotechnology UTP University of Science and Technology Department of Genetics and Animal Breeding Poznan University of Life Sciences

Background: In order to discover new strategies to replace antibiotics in the post-antibiotic era in meat-type chicken production, two new synbiotics were tested:(Lactobacillus salivarius IBB3154 plus galactooligosaccharide(Syn1) and Lactobacillus plantarum IBB3036 plus raffinose family oligosaccharides(Syn2).methods: The synbiotics were administered via syringe, using a special automatic system, into the egg air chamber of Cobb 500 broiler chicks on the 12 thday of egg incubation(2 mg of prebiotics + 105 cfu bacteria per egg).Hatched roosters(total 2,400) were reared on an experimental farm, kept in pens(75 animals per pen), with free access to feed and water. After 42 d animals were slaughtered. Blood serum, pancreas, duodenum and duodenum content were ***: Syn2 increased trypsin activity by 2.5-fold in the pancreas and 1.5-fold in the duodenal content. In the duodenum content, Syn2 resulted in ca 30% elevation in lipase activity and 70% reduction in amylase ***1 and Syn2 strongly decreased expression of m RNA for GLP-1 and GIP in the duodenum and for GLP-1 receptors in the pancreas. Simultaneously, concentrations of the incretins significantly diminished in the blood serum(P mes in the pancreas and in the duodenal content. The results indicate that incretins are involved in the action of Syn1 and Syn2 or that they may even be their target. No changes were observed in key hormones regulating metabolism(insulin, glucagon, corticosterone, thyroid hormones, and leptin) or in metabolic indices(glucose,NEFA, triglycerides, cholesterol). Additionally, synbiotics did not cause significant changes in the activities of alanine and aspartate aminotransferases in broiler chickens. Simultaneously, the activity of alkaline phosphatase and gamma glutamyl transferase diminished after Syn2 and Syn1, ***: The selected synbiotics may be used as

关键词： GIP GLP-1 Incretins In ovo Synbiotics

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工业爆炸的防护

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防爆电机 1996年第2期31卷 39-48,F003页

作者： R.siwek 张永义沈阳市劳动保护技术检测研究所

引言爆炸防护包括可燃性物质的处理中为防止爆炸危险所采取的措施和对为避免或可靠地减少这些危险所采取的保护措施效用的评估。爆炸防护规划对所有可燃性物质的混合物均有效旦各组间是有区别的：a.防止或限制形成危险、爆炸性环境的措... 详细信息

引言爆炸防护包括可燃性物质的处理中为防止爆炸危险所采取的措施和对为避免或可靠地减少这些危险所采取的保护措施效用的评估。爆炸防护规划对所有可燃性物质的混合物均有效旦各组间是有区别的：a.防止或限制形成危险、爆炸性环境的措施；b.防止引燃危险和爆炸性环境的措施。C.将爆炸结果限定在无害程度的结构措施。一般地，从安全观点出发。a项是必须给定的重要措施。在具备充分可靠性的工业实际中，肿X。。；衔’‘。作人；单再，不能采厂油项作为唯～的KH’H入…上只存在可燃件粉尘m，如。。；灼“一山则下旬排低引燃能永高，而已能力便地牧、q。及时l＿作区域，则b项可作为哈一的地0入＼冶＿如不能将己义的：“预防措施”一项。和项b所列的措施川十大备充分可靠性的工业实际，则须系问…C所列的“结构措施”。预防性爆炸防护爆炸防护预防万法的原则是切实排除爆炸扩展所必需的条件。因此，原则上，至少要拆除爆炸危险＞角形的一保边。所以，采用下述任何一种人过必定可防止爆炸：—一避免爆炸记一混合物的出现；一用情性”L体地代大气中的氧气，在真空中作业或采m怕、。树上：—一防止有效引燃源的出现。避免形成爆炸性可燃物质。”空气混合物。可燃性粉尘的爆炸极限取决于粉尘...

关键词：劳动保护管理工业爆炸防爆防护措施

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