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作者： m.sasse m.Boehne I.Forstmeyer N.Richter F.Lehner H.K?ditz T.Kaussen K.Seidemann T.Jack Department of Pediatric Cardiology and Intensive Care medicine Hannover Medical School Department of General Visceral and Transplantation Surgery Hannover Medical School

Introduction: Liver transplantation（LT） in children has undergone significant changes over the last years. Especially the use of split and living donor transplants even for infants has led to new challenges in pre-and post-operative care. Systemic inflammatory response syndromes（SIRS, sepsis） as well-known complications after LT have not yet been systematically examined in the pediatric population. methods: We analyzed clinical data of 39 pediatric liver transplant recipients regarding potential risk factors for post-transplant SIRS and sepsis. Secondly, the prognostic impact of SIRS and sepsis on post-transplant clinical course, patient and transplant-survival has been analyzed. Results: 64% of patients developed either SIRS（n = 16, 41%） or sepsis（n = 9, 23%） within 30 days after transplantation. No pre-transplant risk factors for increased susceptibility for SIRS or sepsis could be identified. Secondary closure of the abdomen（p = 0.045） and secondary biliary reconstruction（p = 0.043） were associated with a higher incidence of sepsis and were associated with significantly prolonged mechanical ventilation times in the presence of sepsis（p = 0.001）. Patients with sepsis, but not SIRS, stayed significantly longer on PICU（p = 0.021） and suffered from higher mortality（n = 3 versus 0;p = 0.0006）. All deaths within 30 days of transplantation were due to septic multiorgan failure. Neither early SIRS nor sepsis were associated with loss of transplant function. Conclusions: SIRS and sepsis are frequent events after pediatric liver transplantation. Sepsis increased length of PICU-stay and mortality significantly and prolonged duration of mechanical ventilation. Secondary biliary reconstruction and closure of the abdomen could be identified as potential risk factors for sepsis.

关键词： Liver Transplantation SIRS Sepsis Risk Factors Pediatric

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Intestinal Staple Line Reinforcement Using matriStem

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Surgical Science 2015年第2期6卷 65-70页

作者： Kent C. sasse David Warner Sean m. Ward Walter mandeville Rebecca Evans Department of Physiology & Cell Biology University of Nevada School of Medicine Reno USA

Background: Staple line reinforcement material has been demonstrated to raise the burst pressure threshold after linear intestinal stapling. Numerous bioprosthetic materials have been utilized in surgical practice. Porcine urinary bladder matrix (ACell, Inc.) is an extracellular matrix material derived from porcine bladder used to reinforce surgically repaired soft tissue, and facilitate the body’s regenerative capacity. Objective: This study represents the first evaluation of urinary bladder matrix in gastrointestinal staple line reinforcement. methods: Pathogen-free pigs underwent midline laparotomy under general anesthesia. Small intestinal division was performed with an endoscopic linear stapler. Nineteen intestinal divisions were performed with urinary bladder matrix staple line reinforcement, and twenty divisions were unreinforced. Staple lines were then subjected to burst pressure analysis by intraluminal infusion of dyed Krebs solution at an infusion rate of 20 ml·min-1 under manometric monitoring. Upon visible staple line extravasation, intraluminal pressure was recorded. Results: Intestinal staple lines reinforced with urinary bladder matrix exhibited significantly higher burst pressure threshold (p mmHg, compared to 61 ± 37 mmHg for unreinforced staple lines. Conclusion: Staple line reinforcement using urinary bladder matrix acutely improves burst pressures of intestinal staple lines when compared with unreinforced staple lines. Its regenerative properties may confer a long-term advantage to staple line reinforcement. These findings, along with previous findings of constructive remodeling in the presence of urinary bladder matrix in treatment of the gastrointestinal system, suggest that UBm may serve a role in gastrointestinal staple line reinforcement.

关键词： Surgical Staples Extracellular matrix Porcine Urinary Bladder matrix Surgical Anastomosis Small Intestine

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Relevance of SIRS and Sepsis in Pediatric Liver Transplantation

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Journal of Biosciences and medicines 2021年第1期9卷 131-145页

作者： m. sasse m. Boehne I. Forstmeyer N. Richter F. Lehner H. Köditz T. Kaussen K. Seidemann T. Jack Department of Pediatric Cardiology and Intensive Care medicine Hannover Medical School Hannover Germany Department of General Visceral and Transplantation Surgery Hannover Medical School Hannover Germany Department of General and Visceral Surgery Helios Klinikum Hildesheim Germany

Introduction: Liver transplantation (LT) in children has undergone significant changes over the last years. Especially the use of split and living donor transplants even for infants has led to new challenges in pre- and post-operative care. Systemic inflammatory response syndromes (SIRS, sepsis) as well-known complications after LT have not yet been systematically examined in the pediatric population. methods: We analyzed clinical data of 39 pediatric liver transplant recipients regarding potential risk factors for post-transplant SIRS and sepsis. Secondly, the prognostic impact of SIRS and sepsis on post-transplant clinical course, patient and transplant-survival has been analyzed. Results: 64% of patients developed either SIRS (n = 16, 41%) or sepsis (n = 9, 23%) within 30 days after transplantation. No pre-transplant risk factors for increased susceptibility for SIRS or sepsis could be identified. Secondary closure of the abdomen (p = 0.045) and secondary biliary reconstruction (p = 0.043) were associated with a higher incidence of sepsis and were associated with significantly prolonged mechanical ventilation times in the presence of sepsis (p = 0.001). Patients with sepsis, but not SIRS, stayed significantly longer on PICU (p = 0.021) and suffered from higher mortality (n = 3 versus 0;p = 0.0006). All deaths within 30 days of transplantation were due to septic multiorgan failure. Neither early SIRS nor sepsis were associated with loss of transplant function. Conclusions: SIRS and sepsis are frequent events after pediatric liver transplantation. Sepsis increased length of PICU-stay and mortality significantly and prolonged duration of mechanical ventilation. Secondary biliary reconstruction and closure of the abdomen could be identified as potential risk factors for sepsis.

关键词： Liver Transplantation SIRS Sepsis Risk Factors Pediatric

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运用CFD模拟高效牵伸装置的气流特征

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国际纺织导报 2014年第6期42卷 38-40页

作者： E.S.Südhoff C.sasse S.T.Garcia T.Gries 杨婷婷亚琛工业大学纺织技术研究所

现代新型纺纱工艺的发展,要求提高前道牵伸的速度。喷气纺纱中高效牵伸装置的生产速度可达450 m/min。新型纺纱工艺代替传统纺纱,要求新的纺纱系统必须具有足够的加工稳定性。由于前罗拉的高速旋转,牵伸装置产生的气流场可能对牵伸装置... 详细信息

现代新型纺纱工艺的发展,要求提高前道牵伸的速度。喷气纺纱中高效牵伸装置的生产速度可达450 m/min。新型纺纱工艺代替传统纺纱,要求新的纺纱系统必须具有足够的加工稳定性。由于前罗拉的高速旋转,牵伸装置产生的气流场可能对牵伸装置中的纤维通道产生反作用,进而影响成纱质量。德国亚琛工业大学纺织技术研究所(ITA)采用流体仿真模拟方法表征罗拉输出的气流。通过检测不同的生产速度来研究其对牵伸装置中气流的影响。

关键词：高效牵伸装置 CFD模拟气流特征

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