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m2BPGi for assessing liver fibrosis in patients with hepatitis C treated with direct-acting antivirals

World Journal of Gastroenterology 2020年第21期26卷 2864-2876页

作者： Shereen A Saleh mohamed m Salama marwan m Alhusseini Ghada A mohamed Gastroenterology and Hepatology Unit Department of Internal MedicineFaculty of MedicineAin Shams UniversityCairo 11341Egypt

BACKGROUND Assessing liver fibrosis is important for predicting the efficacy of direct-acting antivirals(DAAs)and patient ***-invasive techniques to assess liver fibrosis are becoming ***,serum mac-2 binding protein glycosylation isomer(m2BPGi)was identified as a non-invasive marker of liver *** To investigate the diagnostic accuracy of m2BPGi in assessing liver fibrosis in patients with chronic hepatitis C(CHC)treated with *** From December 2017 to August 2018,80 treatment-naive adult patients with CHC who were eligible for DAAs therapy were consecutively enrolled in this observational cohort *** 12 weeks,65 patients were treated with sofosbuvir/daclatasvir,and 15 patients were treated with sofosbuvir/daclatasvir and a weight-based dose of ribavirin at knowledge and technology association for hepatitis C management clinic,Cairo,*** measured serum m2BPGi levels,PAPAS index,fibrosis-4(FIB-4)score and liver stiffness measurements(LSm)at baseline and 12 weeks after the end of *** m2BPGi levels were measured using enzyme-linked immunosorbent *** All patients achieved sustained virologic response(SVR12)(100%).Serum m2BPGi levels,LSm,FIB-4 score and PAPAS index decreased significantly at SVR12(Pm m2BPGi levels correlated positively with LSm at baseline and SVR12(Pmpared with the FIB-4 score and PAPAS index,m2BPGi was the best marker to distinguish patients with grade F4 fibrosis(AUC=0.801,Pm grade F0-1 fibrosis(AUC=0.713,P=0.012),patients with grade F3-4 from grade F0-2 fibrosis(AUC=0.730,Pm grade F0-1 fibrosis(AUC=0.763,Pm2BPGi had the greatest AUCs for differentiating patients with grade F4 fibrosis(AUC=0.844,Pm grade F0-2 fibrosis(AUC=0.893,P=0.002),patients with grade F3-4 from grade F0-2 fibrosis(AUC=0.891,P<0.001),and patients with grad

关键词： Hepatitis C virus Liver fibrosis Human mac-2 binding protein Antiviral agents Sustained virologic response Elastography

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T_(m)-Eigenvalues of Odd-Order Tensors

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Communications on Applied mathematics and Computation 2022年第4期4卷 1258-1279页

作者： m.Pakmanesh Hamidreza Afshin Department of mathematics Vali-e-Asr University of RafsanjanRafsanjanIran

In this paper,we propose a definition for eigenvalues of odd-order tensors based on some ***,we define the Schur form and the Jordan canonical form of such tensors,and discuss commuting families of ***,we prove some e... 详细信息

关键词： T_(m)-product T_(m)-eigenvalue T_(m)-Schur form T_(m)-Jordan canonical form Odd-order tensor F_(m)-upper(lower)triangular tensor

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S-band low noise amplifier using 1μm InGaAs/InAlAs/InP pHEmT

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Journal of Semiconductors 2012年第2期33卷 58-63页

作者： Z.Hamaizia N.Sengouga m.C.E.Yagoub m.missous Laboratory of materials Semiconductors and metallic University of Med Khider RF and microwave Research Group School of Electrical Engineering and Computer ScienceUniversity of OttawaOttawa ONKIN 6N5 Canada microelectronic & Nanostructure Group School of Electric and Electronic EngineeringUniversity of ManchesterUK

This paper discusses the design of a wideband low noise amplifier（LNA） in which specific architecture decisions were made in consideration of system-on-chip implementation for radio-astronomy *** LNA design is based on a novel ultra-low noise InGaAs/InAlAs/InP *** and non-linear modelling of this pHEmT has been used to design an LNA operating from 2 to 4 GHz.A common-drain in cascade with a common source inductive degeneration,broadband LNA topology is proposed for wideband *** proposed configuration achieved a maximum gain of 27 dB and a noise figure of 0.3 dB with a good input and output return loss（S11〈—10 dB,S22〈—11 dB）.This LNA exhibits an input 1-dB compression point of-18 dBm,a third order input intercept point of 0 dBm and consumes 85 mW of power from a 1.8 V supply.

关键词： HEmT InGaAs InP SKADS telescope LNA

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Regenerative capacity of müller cells and their modulation as a tool to treat retinal degenerations

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Neural Regeneration Research 2023年第1期18卷 139-140页

作者： Federica m.Conedera Volker Enzmann Advanced microscopy Program Center for Systems BiologyMassachusetts General HospitalBostonMAUSA Wellman Center for Photomedicine Massachusetts General HospitalBostonMAUSA(Conedera FM)Department of OphthalmologyUniversity HospitalUniversity of BernBernSwitzerland Department of Biomedical Research University of BernBernSwitzerland

Vision is one of our most precious senses,and its impairment has a high socio-economic *** the industrialized world,degenerative diseases of the retina lead to vision loss,particularly among the *** degenerations include,for instance,retinitis pigmentosa,age-related macular degeneration,and diabetic *** treatments are evolving to manage late-stage symptoms of retinal degenerations,no effective therapies to recover vision loss *** degeneration often involves loss or damage to specialized neural cells,such as photoreceptors,and their death stimulates the activation and proliferation of müller cells(Salman et al.,2021).

关键词： degeneration diseases impairment

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Effects of the partial replacement of La by m(m=Ce,Ca and Sr) in La_(2-x)m_xCuO_4 perovskites on catalysis of the water-gas shift reaction

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Journal of Natural Gas Chemistry 2010年第6期19卷 567-574页

作者： S.S.maluf E.m.Assaf Institute de Química de So Carlos Universidade de So PauloAv.Trabalhador Socarlense400 So CarlosSP 13560-970Brazil

The performance of La2-x m x CuO4 perovskites （where m=Ce,Ca or Sr） as catalysts for the water-gas shift reaction was investigated at 290℃ and 360℃.The catalysts were characterized by EDS,XRD,N2 adsorption-desorption,XPS and *** XRD results showed that all the perovskites exhibited a single phase （the presence of perovskite structure）,suggesting the incorporation of metals in the perovskite *** XPS and XANES results showed the presence of Cu2＋ on the *** perovskites that exhibited the best catalytic performance were La 2 x Ce x CuO 4 perovskites,with CO conversions of 85% 90%.moreover,these perovskites have higher surface areas and larger amounts of Cu on the *** Ce has a higher filled energy level than the other metals,increasing the energy of the valence band of Ce and providing more electrons for the ***,the La1.80Ca0.20CuO4 perovskite showed a good catalytic performance.

关键词： perovskites water-gas shift reaction lanthanum copper calcium cerium strontium

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Petrology, geochemistry, radioactivity, and m–W type rare earth element tetrads of El Sela altered granites, south eastern desert,Egypt

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Acta Geochimica 2019年第1期38卷 95-119页

作者： A.m.El mezayen m.A.Heikal m.G.El-Feky H.A.Shahin I.K.Abu Zeid S.R.Lasheen Geology Department Faculty of Science Al Azhar University Nuclear material Authority

The southern part of the Eastern Desert of Egypt—about 30 km southwest of Abu-Ramad city—is mainly covered by ophiolitic rocks(Sul Hamed), island arc assemblage, younger granites(muscovite granites of Qash Amer and two mica granites of El Sela), and various acidic and basic dikes. Field, petrological, and geochemical studies indicate that the El Sela shear zone has been subject to hydrothermal and supergene alteration such as kaolinization, albitization, sericitization, and hematitization. It is invaded by quartz ENE–WSW veins associated with hydrothermal alteration accompanied by radioactive mineralization. The investigated younger granitic rocks had very low contents of compatible elements, such as Cr, Ni,and Co; and high contents of incompatible elements, such as Zr, and large ion lithophiles, such as Sr, especially in the El Sela shear zone. major oxide and trace element analyses revealed calc-alkaline affinity and peraluminous *** highly differentiated granitic rocks' lower Zr/Hf and higher Y/Ho than the normal ratio are consistent with hydrothermal alteration. most samples had rare earth element(REE)-patterns with an m-type tetrad effect in the first and fourth segments and a W-type tetrad in the third segment. The average ∑REE in the studied granites was lower than the world granite average; the ratio of light to heavy REEs greater. The main radioactive, uranium-bearing, and uraniferous Fe and mn minerals are uranothorite,autunite, uranophane and autunite as compounds, kasolite,columbite, xenotime, uranophane-bearing zircon and jarosite, silver-bearing pyrite, hematite, and autunite-bearing pyrolusite.

关键词： Geochemistry REE-tetrad effect Radioactive minerals Radiometric measurements Qash Amer El Sela

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A matrix-Vector Operation-Based Numerical Solution method for Linear m-th Order Ordinary Differential Equations:Application to Engineering Problems

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Advances in Applied mathematics and mechanics 2013年第3期5卷 269-308页

作者： m.Aminbaghai m.Dorn J.Eberhardsteiner B.Pichler Institute for mechanics of materials and Structures Vienna University of Technology(TU Wien)Karlsplatz 13/202A-1040 ViennaAustria Linnaeus University Department of Building and Energy TechnologyL¨uckligs Plats 1S-35195 V¨axj¨oSweden

many problems in engineering sciences can be described by linear,inhomogeneous,m-th order ordinary differential equations(ODEs)with variable *** this wide class of problems,we here present a new,simple,flexible,and robust solution method,based on piecewise exact integration of local approximation polynomials as well as on averaging local *** method is designed for modern mathematical software providing efficient environments for numerical matrix-vector operation-based *** on cubic approximation polynomials,the presented method can be expected to perform(i)similar to the Runge-Kutta method,when applied to stiff initial value problems,and(ii)significantly better than the finite difference method,when applied to boundary value ***,we use the presented method for the analysis of engineering problems including the oscillation of a modulated torsional spring pendulum,steady-state heat transfer through a cooling web,and the structural analysis of a slender tower based on second-order beam *** convergence studies provide insight into the satisfying characteristics of the proposed solution scheme.

关键词： Numerical integration polynomial approximation ODE variable coefficients initial conditions boundary conditions stiff equation

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Assessment of lnc RNA GAS5, lnc RNA HEIH, lnc RNA BISPR and its m RNA BST2 as serum innovative non-invasive biomarkers: Recent insights into Egyptian patients with hepatitis C virus type 4

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World Journal of Gastroenterology 2020年第2期26卷 168-183页

作者： Nourhan m El Samaloty marwa I Shabayek Ramy S Ghait Shohda A El-maraghy Sherine m Rizk maha m El-Sawalhi Biochemistry Section PharmacologyToxicology and Biochemistry DepartmentFaculty of Pharmaceutical Sciences and Pharmaceutical IndustriesFuture UniversityCairo 11795Egypt Internal medicine Gastroenterology and Hepatology DepartmentFaculty of MedicineAin Shams UniversityCairo 11566Egypt Biochemistry Department Faculty of PharmacyCairo UniversityCairo 11562Egypt

BACKGROUND Hepatitis C virus(HCV)infection and its consequent complications are undeniably a public health burden worldwide,particularly in *** evidence suggests that many lncRNAs have relevant roles in viral infections and antiviral *** To investigate the expression profiles of circulating lncRNAGAS5,lncRNAHEIH,lncRNABISPR and mRNABST2 in naïve,treated and relapsed HCV Egyptian patients,to elucidate relation to HCV infection and their efficacy as innovative biomarkers for the diagnosis and prognosis of HCV *** One hundred and thirty HCV-infected Egyptian patients and 20 healthy controls were included in this *** lncRNAs and mRNABST2 were measured using quantitative real-time polymerase chain reaction(qRT-PCR).RESULTS Our results indicated that serum lncRNAGAS5 and LncRNABISPR were upregulated,whereas mRNA BST2 and LncRNA HEIH were downregulated in naïve *** contrast,HCV patients treated with sofosbuvir and simeprevir;with sofosbuvir and daclatasvir;or with sofosbuvir,daclatasvir and ribavirin exhibited lower levels of lncRNAGAS5 and lncRNABISPR with higher mRNABST2 compared to naïve ***,patients relapsed from sofosbuvir and simeprevir showed higher levels of these lncRNAs with lower mRNABST2 compared to treated ***5 and lncRNABISPR were positively correlated with viral load and ALT at PmRNABST2 was negatively correlated with viral load at Pment in HCV pathogenesis or antiviral response and highlights their promising roles in diagnosis and prognosis of HCV.

关键词： lncRNA GAS5 lncRNA BISPR mRNA BST2 lncRNA HEIH Hepatitis C Biomarkers

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The Dual Spaces of Sets of Difference Sequences of Order m and matrix Transformations

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Acta mathematica Sinica,English Series 2007年第3期23卷 521-532页

作者： Eberhard mALKOWSKY m.mURSALEEN Suthep SUANTAI Department of mathematics University of GiessenArndtstrasse 2D-35392 GiessenGermany and Department of MathematicsFaculty of Sciences and MathematicsUniversity of NiViegradska 3318000 NiSerbia and Montenegro Department of mathematics Aligarh Muslim UniversityAligarh 202002India and Department of MathematicsFaculty of Science Department of mathematics Chiang Mai UniversityChiang MaiThailand

Let p = （pk）k=0^∞ be a bounded sequence of positive reals, m C N and u be s sequence of nonzero terms. If x = （xk）k=0^∞ is any sequence of complex numbers we write Δ（m）x for the sequence of the m th order differences of x and Δu^（m）X = {x=（x）k=0^∞ uΔ（m）x ∈ X} for any set X of sequences. We determine the α-, β- and γ-duals of the sets Δμ^（m）X for X=co（p）,c（p）,l∞（p） and characterize some matrix transformations between these spaces Δ^（m）X.

关键词： difference sequences dual spaces matrix transformations

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message from Deputy Editor-in-Chief Gabriel m Leung—International Trade and Global Health Protection

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China CDC weekly 2019年第4期1卷 45-46页

作者： Gabriel m Leung China CDC Weekly Dean of medicine The University of Hong KongHong Kong SARChina

It was external trade that first prompted the collection and reporting of surveillance data at the foreign ports from which the US imported *** established Bulletin of the Public Health—the first precursor to the US ... 详细信息

关键词： Trade prompt Health

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