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Impact of carbimazole combined with vitamin E on testicular injury induced by experimental hyperthyroidism in adult albino rats:oxidative/inflammatory/apoptotic pathways

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Asian Journal of Andrology 2024年第4期26卷 396-401页

作者： Ramadan S Hussein moustafa m Eyada Rashad m mostafa samah m Elaidy Shereen H Elsayed Hany m saad Department of Dermatology College of Medicine Prince Sattam Bin Abdulaziz UniversityAl-Kharj 16242Saudi Arabia Department of Dermatology Andrology and STDsAssiut Police HospitalAssiut 71525Egypt Department of Dermatology Venereology and AndrologyFaculty of MedicineSuez Canal UniversityIsmailia 41522Egypt Department of Andrology and Sexology Faculty of MedicineSuez Canal UniversityIsmailia 41511Egypt Department of clinical Pharmacology Faculty of MedicineSuez Canal UniversityIsmailia 41511Egypt Department of Rehabilitation Sciences Faculty of Health and Rehabilitation SciencesPrincess Nourah bint Abdulrahman UniversityRiyadh 12271Saudi Arabia.

Thyroid hormones play essential roles in spermatogenesis,but their effects on infertile males remain poorly *** study aimed to evaluate the impact of combining carbimazole(cBZ)with vitamin E(VE)on testicular injury induced by experimental hyperthyroidism in adult albino rats,focusing on oxidative,inflammatory,and apoptotic *** this experimental study,64 adult male albino Wistar rats were divided into eight groups:Group I(control-untreated),Group II(cBZ-control),Group III(VE-control),Group IV(cBZ+VE-control),Group V(levothyroxine-induced testicular injury),Group VI(levothyroxine+cBZ-treated),Group VII(levothyroxine+VE-treated),and Group VIII(levothyroxine+cBZ+VE-treated).The study was conducted in the Faculty of medicine,Suez canal University(Ismailia,Egypt).After cervical decapitation,both testes and epididymis were examined histopathologically and *** differences were observed among groups concerning malondialdehyde(mDA),glutathione(GSH),superoxide dismutase(SOD),and catalase(cAT;all Pmerase chain reaction analysis showed significant differences in tumor necrosis factor-α(TNF-α),interleukin-10(IL-10),Bcl-2-associated X protein(BAX),B-cell lymphoma 2 protein(Bcl2),p53,caspase-3,caspase-8,caspase-9,and nuclear factor-kappa B(NF-κB)mRNA levels(all PcBZ alone(Group VI)exhibited testicular side effects,affecting seminiferous tubules and ***,the Group VIII showed improved spermatogenesis and a decrease in testicular side *** addition of VE to the treatment of hyperthyroid rats with cBZ reduced testicular side effects and seminiferous tubular affection when potentially improving *** research is needed to elucidate the underlying mechanisms fully.

关键词： antithyroid drugs testicular injury thyroid gland vitamin E

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cFD-DEm analysis of particle polydispersity on the performance of fluidised bed reactor during silane pyrolysis Author links open overlay panel

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Particuology 2024年第8期91卷 72-87页

作者： Akshayveer Vijay m.Shinde mS2Discovery Interdisciplinary Research Institute Wilfrid Laurier UniversityWaterlooOntarioN2L3C5Canada Department of chemical Engineering Indian Institute of Technology(BHU)Varanasi221005India

A cFD-DEm model is developed for chemical vapour deposition of silane in a fluidized bed reactor to investigate the effect of polydispersity on local phase dynamics,mass and heat transport,as well as the rate of Si *** gas-phase fines formation and heterogeneous deposition on the seed particle,as well as the scavenging effect for Si particle growth,are *** method is first validated against the experimentally measured Si deposition rate,percentage of fine production and minimum fluidisation ***,the properties,primarily particle intermixing,fluidisation behaviour and bubble dynamics along with the deposition process,are analyzed for several polydisperse beds under various operating *** effect of polydispersity of the bed on a fraction of the bubble size,dense phase expansion and interchange coefficient between various phases is thoroughly investigated to establish a correlation with reactor *** results show that broad-Gaussian particle size distribution(PSD)exhibits excellent improvement in fluidisation behaviour,resulting in a high deposition rate,and minimum formation of Si fines.

关键词： cFD-DEm method chemical vapour deposition(cVD) Particle size distribution Silicon Gas-solid fluidized bed

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Advancements in Web3 Infrastructure for the metaverse

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ZTE communications 2024年第2期22卷 1-2页

作者： Victor c.m.LEUNG cAI Wei the Artificial Intelligence Research Institute Shenzhen MSU-BIT University Shenzhen mSU-BIT University Shenzhen University the Wireless Networks and mobile Systems(WiNmoS)Laboratory at UBc the School of Science and Engineering at The chinese University of Hong Kong Shenzhen the Human-crypto Society Laboratory the cUHK(SZ)White matrix Joint metaverse Laboratory

Web3,also known as Web 3.0,has recently been attracting increasing attention from industry and *** the potential of blockchain technologies,Web3 has emerged as a pivotal foundation in the realm of metaverse development,which is considered by many as the next-generation ***,Web3 technologies such as smart contracts and protocols like non-fungible tokens(NFTs)have supported the immersive and content-rich experience of current Web3 metaverse projects.

关键词： Web token attracting

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metrology for sub-Rayleigh-length target positioning in~10^(22)W/cm^(2)laser-plasma experiments

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High Power Laser Science and Engineering 2024年第3期12卷 90-105页

作者： E.A.Vishnyakov A.sagisaka K.Ogura T.Zh.Esirkepov B.Gonzalez-Izquierdo c.D.Armstrong T.A.Pikuz S.A.Pikuz W.Yan T.m.Jeong S.Singh P.Hadjisolomou O.Finke G.m.Grittani m.Nevrkla c.m.Lazzarini A.Velyhan T.Hayakawa Y.Fukuda J.K.Koga m.Ishino K.Kondo Y.miyasaka A.Kon m.Nishikino Y.V.Nosach D.Khikhlukha I.P.Tsygvintsev D.Kumar J.Nejdl D.margarone P.V.sasorov S.Weber m.Kando H.Kiriyama Y.Kato G.Korn K.Kondo S.V.Bulanov T.Kawachi A.S.Pirozhkov ELI Beamlines Facility The Extreme Light Infrastructure ERICDolníBrežanyCzech Republic Kansai Institute for Photon Science(KPSI) QSTKyotoJapan central Laser Facility Rutherford Appleton LaboratorySTFCHarwell OxfordDidcotUK Institute for Open and Transdisciplinary Research Initiatives Osaka UniversityOsakaJapan HB11 Energy Holdings FreshwaterAustralia Key Laboratory for Laser Plasmas(ministry of Education) School of Physics and AstronomyShanghai Jiao Tong UniversityShanghaiChina collaborative Innovation center of IFsa Shanghai Jiao Tong UniversityShanghaiChina Institute of Plasma Physics AScR PragueCzech Republic FZU-Institute of Physics AScR PragueCzech Republic czech Technical University in Prague FNSPEPragueCzech Republic Institute of Laser Engineering Osaka UniversityOsakaJapan Institute of Physics National Academy of Sciences of UkraineKyivUkraine ISTEQ AR YerevanArmenia

Tight focusing with very small f-numbers is necessary to achieve the highest at-focus ***,tight focusing imposes strong demands on precise target positioning in-focus to achieve the highest on-target irradiance We describe several near-infrared,visible,ultraviolet and soft and hard X-ray diagnostics employed in a~10^(22)W/cm^(2)laser±plasma *** used nearly 10 J total energy femtosecond laser pulses focused into an approximately1.3-μm focal spot on 5±20μm thick stainless-steel *** discuss the applicability of these diagnostics to determine the best in-focus target position with approximately 5μm accuracy(i.e.,around half of the short Rayleigh length)and show that several diagnostics(in particular,3ωreflection and on-axis hard X-rays)can ensure this *** demonstrated target positioning within several micrometers from the focus,ensuring over 80%of the ideal peak laser intensity *** approach is relatively fast(it requires 10±20 laser shots)and does not rely on the coincidence of low-power and high-power focal planes.

关键词： laser-plasma interaction precise target positioning spectroscopy ultra-high intensity X-rays

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Synthesis and Thermal characterization of Solar salt-Based Phase change composites with Graphene Nanoplatelets

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Journal of Thermal Science 2024年第2期33卷 491-500页

作者： Pethurajan VIGNESHWARAN saboor SHAIK Sivan SURESH müslüm ARIcI Asif AFZAL Department of Thermal and Energy Engineering School of Mechanical Engineering(SMEC)Vellore Institute of TechnologyVelloreTamil NaduIndia Nanotechnology Research Laboratory Department of Mechanical EngineeringNational Institute of TechnologyTiruchirappalliTamil NaduIndia mechanical Engineering Department Engineering FacultyKocaeli UniversityUmuttepe CampusKocaeli41001Turkey Department of mechanical Engineering P.A.College of Engineering(affiliated to Visvesvaraya Technological UniversityBelagavi)Mangaluru574153India

Thermal energy storage(TES) systems use solar energy despite its irregular availability and day-night temperature *** work reports the thermal characterizations of solar salt-based phase change composites in the presence of graphene nanoplatelets(GNP).Solar salt(60:40 of NaNO_(3):KNO_(3)) possessing phase transition temperature and melting enthalpy of 221.01℃ and 134.58 kJ/kg is proposed as a phase change material(Pcm) for high-temperature solar-based energy storage *** conductivity must be improved to make them suitable for widespread applications and to close the gap between the system needs where they are *** is added at weight concentrations of 0.1%,0.3%,and 0.5% with solar salt using the ball milling method to boost its thermal *** studies indicated the formation of a uniform surface of GNP on solar *** spectrum peaks identified the physical interaction between salt and *** characterization of the composites,such as thermal conductivity,DSc and TGA was carried out for the samples earlier and later 300 thermal cycles.0.5% of GNP has improved the thermal conductivity of salt by 129.67% and after thermal cycling,the enhancement reduced to 125.21% indicating that thermal cycling has a minor impact on thermal *** change temperature decreased by around 2.32% in the presence of0.5% GNP and the latent heat reduced by 4.34% after thermal *** thermograms depicted the composites initiated the weight loss at around 550℃ after which it was *** thermal cycling,the weight loss initiated at ~40℃ lower compared to pure salt,which was found to be a minor *** characterization of solar salt and GNP-based solar salt composites revealed that the composites can be used for enhanced heat transfer in high-temperature solar-based heat transfer and energy storage applications.

关键词： thermal energy storage high temperature solar salt graphene nanoplatelets thermal characterization

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Effect of Fluidic Diode on Performance of Unidirectional Impulse Turbine

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Journal of Thermal Science 2024年第3期33卷 807-814页

作者： DODDAmANI Hithaish ABDUS samad mANABU Takao SHINYA Okuhara m m ASHRAFUL Alam Department of Ocean Engineering Indian Institute of Technology MadrasChennai600036India Department of mechanical Engineering National Institute of TechnologyMatsue CollegeShimane6908518Japan center of Support Practical Education National Institute of TechnologyMatsue CollegeShimane6908518Japan Department of Transportation Engineering Osaka Sangyo UniversityDaito5748530Japan

A pair of unidirectional turbines(UT)can operate in oscillatory airflow without additional ***,this arrangement suffers from poor flow rectification.A fluidic diode(FD)offers variable hydrodynamic resistance based on the flow direction,and this can be coupled with UT to improve flow *** this work,a numerical investigation on the effect of FD with UT is presented using the commercial fluid dynamics software ANSYS Fluent 16.1 with k-ωSST turbulence closure *** domains of UT and FD are numerically validated individually with experimental ***,both are coupled to obtain the combined effect,and these results are compared with the analytical *** was observed that coupling FD with UT improved the unit's performance at the lower flow coefficient(mance decreased as the flow coefficient *** to the diode's presence,fluid leaving the turbine experiences higher resistance at a higher flow coefficient,which decreases the overall performance of the combined unit.

关键词： wave energy oscillating water column unidirectional impulse turbine fluidic diode flow rectification

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Old-growth mixed dipterocarp forests show variable losses and gains in aboveground biomass and standing carbon over forty years

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Forest Ecosystems 2024年第1期11卷 14-23页

作者： Sisira Ediriweera champika Bandara Tithira Lakkana Shanika Jayasinghe David Woodbury Arun Dayanandan B.m.P.Singhakumara Xiangcheng mi I.A.U.N.Gunatilleke c.V.S.Gunatilleke mark sashton Department of Science and Technology Uva Wellassa UniversityBadullaSri Lanka The Forest School Yale School of the EnvironmentYale UniversityNew HavenCT06511USA Department of Forestry and Environmental Science University of Sri JayewardenepuraNugegodaSri Lanka State Key Laboratory of Vegetation and Environmental change Institute of BotanyChinese Academy of SciencesBeijing100093China Botany Department University of PeradeniyaPeradeniyaSri Lanka

Background:No studies have documented long-term trends in aboveground biomass(AGB)for mixed-dipterocarp forests(mDF),the dominant rain forest type in tropical wet equatorial *** our study,we sought to document such trends over forty years across three sites representing lowland to lower montane ***:To do this,we established fifty 100 m×25 m plots in 1978 across three sites sampled along an elevation gradient,identified as mature old-growth *** measured trees for diameter at breast height that we identified to species and *** took wood samples to calculate species wood-specific *** re-measured plots in 1998 and again in ***:We show standing AGB for all sites combined to be 517.52 mg·ha^(-1)in 1978,but this declined by 17%over 40 years to 430.11 mg·ha^(-1).No differences exist among sites in AGB primarily because of considerable within site variation;but interactions of time with site show declines across sites were not uniform,one remained about the *** few species represented a high proportion of the AGB with the top five species comprising between 34%and 65%,depending upon site and year *** species,mesua nagassarium,represented a disproportionately large amount of AGB and decline over time,particularly at the low elevation ***:Our results are directly relevant to estimating AGB and standing carbon sequestered in *** study is the first to demonstrate varying but overall,declining trends in amounts of AGB among forests making predictions of biomass and standing carbon in mDF difficult over wide regions.

关键词： Western ghats Shorea spp. Southeast Asia Sri Lanka Tropical rain forest Wood specific gravity

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cooperative Target Fencing of multiple Vehicles for a General Target with connectivity Preservation and collision Avoidance

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Journal of Systems Science & complexity 2024年第1期37卷 136-151页

作者： PAN Zini cHEN Ben m Department of mechanical and Automation Engineering The Chinese University of Hong KongHong KongChina

In this paper,the authors study the cooperative target-fencing problem for n-dimensional systems and a target with a general *** using the velocity of the vehicles,a position feedback control law is proposed to fence the general target into the convex hull formed by the ***,the dynamics of each vehicle is described by a double-integrator *** potential functions are designed to guarantee connectivity preservation of the communication network and collision avoidance among the *** proposed approach can deal with a target whose trajectory is any twice continuously differentiable function of *** effectiveness of the result is verified by a numerical example.

关键词： multi-agent systems networked systems target fencing

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The ccD instrument background of the SmILE SXI

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Earth and Planetary Physics 2024年第1期8卷 15-24页

作者： m.W.J.Hubbard O.Hetherington D.J.Hall T.W.Buggey S.Parsons T.Arnold A.Holland c.Pagani S.Sembay centre for Electronic Imaging The Open UniversityMilton KeynesMK76AAUK X-ray and Observational Astronomy Group Department of Physics&AstronomyUniversity of LeicesterLE17RHUK

The Esa and cAS SmILE mission orbit is highly elliptical and will pass through multiple radiation *** Soft X-ray Imager(SXI)instrument aboard has a radiation shutter door designed to close when the surrounding radiation flux is *** shutter door will close when passing below an altitude threshold to protect against trapped particles in the Earth’s Van Allen ***,two radiation environments can be approximated based on the shutter door position:open and *** instrument background for the ccDs(charge-coupled Devices)that form the focal plane array of the SXI were evaluated for the two *** to the correlation of the space environment with the solar cycle,the solar minima and maxima,the background was also evaluated at these two *** results demonstrated that the highest instrument background will occur during solar minima due to the main contributing source being Galactic cosmic Rays(GcRs).It was also found that the open background was highest for solar minima and that the closed background was highest during solar *** is due to the radiation shutter door acting as a scattering centre and the changes in the energy flux distribution of the GcRs between the two solar extremes.

关键词： instrument background X-ray astronomy space radiation

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comparison of methods for deriving phenotypes from incomplete observation data with an application to age at puberty in dairy cattle

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Journal of Animal Science and Biotechnology 2024年第2期15卷 535-545页

作者： melissa A.Stephen chris R.Burke Jennie E.Pryce Nicole m.Steele Peter R.Amer Susanne meier claire V.c.Phyn Dorian J.Garrick DairyNZ Ltd 605 Ruakura RoadHamilton 3240New Zealand AL Rae centre for Genetics and Breeding-massey University RuakuraHamilton 3214New Zealand Agriculture Victoria Research AgriBioCentre for AgriBioscienceBundooraVictoria 3083Australia School of Applied Systems Biology La Trobe UniversityBundooraVictoria 3083Australia AbacusBio DunedinNew Zealand

Background many phenotypes in animal breeding are derived from incomplete measures,especially if they are challenging or expensive to measure *** include time-dependent traits such as reproductive status,or *** measures for these traits result in phenotypes that are subject to left-,interval-and rightcensoring,where phenotypes are only known to fall below an upper bound,between a lower and upper bound,or above a lower bound *** we compare three methods for deriving phenotypes from incomplete data using age at first elevation(>1 ng/mL)in blood plasma progesterone(AGEP4),which generally coincides with onset of puberty,as an example *** We produced AGEP4 phenotypes from three blood samples collected at about 30-day intervals from approximately 5,000 Holstein–Friesian or Holstein–Friesian×Jersey cross-bred dairy heifers managed in 54 seasonal-calving,pasture-based herds in New *** used these actual data to simulate 7 different visit scenarios,increasing the extent of censoring by disregarding data from one or two of the three *** methods for deriving phenotypes from these data were explored:1)ordinal categorical variables which were analysed using categorical threshold analysis;2)continuous variables,with a penalty of 31 d assigned to right-censored phenotypes;and 3)continuous variables,sampled from within a lower and upper bound using a data augmentation *** credibility intervals for heritability estimations overlapped across all methods and visit scenarios,but estimated heritabilities tended to be higher when left censoring was *** sires with at least 5 daughters,the correlations between estimated breeding values(EBVs)from our three-visit scenario and each reduced data scenario varied by method,ranging from 0.65 to *** estimated breed effects also varied by method,but breed differences were smaller as phenotype censoring *** Our results indicate that using

关键词： cattle Gibbs sampler markov-chain monte carlo(mcmc) Puberty

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