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serum outperforms plasma in small extracellular vesicle microRNA biomarker studies of adenocarcinoma of the esophagus

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World Journal of Gastroenterology 2020年第20期26卷 2570-2583页

作者： Karen Chiam George C mayne Tingting Wang David I Watson Tanya s Irvine Tim Bright Lorelle T smith Imogen A Ball Joanne m Bowen Dorothy m Keefe sarah K Thompson Damian J Hussey Discipline of surgery College of Medicine and Public HealthFlinders University of South AustraliaAdelaideSA 5042Australia Flinders Health and medical Research Institute Cancer Program College of Medicine and Public HealthFlinders UniversityAdelaideSA 5042Australia Discipline of surgery The University of AdelaideAdelaideSA 5005Australia Adelaide medical school The University of AdelaideAdelaideSA 5005Australia Faculty of Health sciences The University of AdelaideAdelaideSA 5005Australia

BACKGROUND Circulating microRNAs(miRNAs)are potential biomarkers for many ***,they can originate from non-disease specific sources,such as blood cells,and compromise the investigations for miRNA *** small extracellular vesicles(sEVs)have been suggested to provide a purer source of circulating miRNAs for biomarkers discovery,the most suitable blood sample for sEV miRNA biomarker studies has not been *** To compare the mi RNA profiles between matched serum and plasma s EV preparations to determine their suitability for biomarker *** matched serum and plasma samples were obtained from 10 healthy controls and10 patients with esophageal adenocarcinoma.s EV isolates were prepared from serum and plasma using Exo Quick Tm and quantified using Nano *** was extracted from s EV preparations with the mi RNeasy serum/Plasma kit and profiled using the Taqman Openarray q *** overall mi RNA content and theexpression of specific mi RNAs of reported vesicular and non-vesicular origins were compared between serum and plasma s EV *** diagnostic performance of a previously identified multi-mi RNA biomarker panel for esophageal adenocarcinoma was also *** The overall mi RNA content was higher in plasma s EV preparations(480 mi RNAs)and contained 97.5%of the mi RNAs found in the serum s EV preparations(412 mi RNAs).The expression of commonly expressed mi RNAs was highly correlated(spearman’s R=0.87,Psma and serum s EV preparations,but was consistently higher in the plasma s EV *** blood-cell mi RNAs(hsa-mi R-223-3 p,hsa-mi R-451 a,mi R-19 b-3 p,hsa-mi R-17-5 p,hsa-mi R-30 b-5 p,hsa-mi R-106 a-5 p,hsa-mi R-150-5 p and hsa-mi R-92 a-3 p)were expressed at 2.7 to 9.6 fold higher levels in the plasma s EV preparations compared to serum s EV preparations(Psma s EV preparations,the percentage of protein-associated mi RNAs expressed at relatively higher levels(Ct

关键词： Biomarkers Exosomes Extracellular vesicles Circulating microRNA microRNAs Plasma serum Blood cells Real-time polymerase chain reaction Adenocarcinoma of esophagus

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冠状动脉钙化积分能否作为启动多效复方固定制剂和他汀类药物治疗的指标?

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中华高血压杂志 2013年第11期21卷 1079-1080页

作者： Bittencourt m C Blaha m J Blankstein R martin s s 叶鹏(审校) 机构不详

多效复方固定制剂（polypill）是由多种药物组成的固定复方片剂，其优点是能够同时降胆固醇、降血压，减少心血管疾病（cardiovascular disease，CVD）和脑卒中风险。印度多效固定复方制剂研究（the Indianpolycap study，TIPs）显示，p... 详细信息

多效复方固定制剂（polypill）是由多种药物组成的固定复方片剂，其优点是能够同时降胆固醇、降血压，减少心血管疾病（cardiovascular disease，CVD）和脑卒中风险。印度多效固定复方制剂研究（the Indianpolycap study，TIPs）显示，polypill能降低62％的CVD和42％的脑卒中发生风险[1]。伊朗多效固定复方制剂研究（thepoly-Irantrial）显示，和安慰剂组相比，polypill降低收缩压5mmHg（1mmHg=0．133kPa）、低密度脂蛋白胆固醇（low density lipoprotein cholesterol，LDL-C）0．46mmol／L，相当于降低34％的CVD和21％的缺血性脑卒中风险口[2]。

关键词：复方制剂冠状动脉钙化积分复方片剂药物治疗低密度脂蛋白胆固醇 polypill 他汀类缺血性脑卒中

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“神经精神综合征”:一例与双相情感障碍相关的病例报告（英文）

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上海精神医学 2018年第1期30卷 52-55页

作者： Ali m Das s Dept. of Psychiatry National Institute of Mental Health and Neurosciences

白塞氏病是一种炎症性疾病,特点是复发性口腔溃疡(OU)、生殖器溃疡(GU)、和葡萄膜炎,该疾病可以发展为神经行为综合征,也定义为"神经精神综合征"。根据血管或器质性病变,其表现可以是多样的。由于文献稀缺,有关共病白塞氏病的精神疾病... 详细信息

白塞氏病是一种炎症性疾病,特点是复发性口腔溃疡(OU)、生殖器溃疡(GU)、和葡萄膜炎,该疾病可以发展为神经行为综合征,也定义为"神经精神综合征"。根据血管或器质性病变,其表现可以是多样的。由于文献稀缺,有关共病白塞氏病的精神疾病的管理还没有达成共识。白塞氏病中的双相情感障碍是非常罕见的。在这里,我们陈述一个有关共病白塞氏病的双相情感障碍加重的案例,并且实施了临床和管理方面的挑战。

关键词：白塞氏病神经行为双相情感障碍

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A Case of Benign Chondroblastoma of Anterior mandible and Review of Literature: A Very Rare Presentation

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Case Reports in Clinical medicine 2015年第3期4卷 102-106页

作者： B. s. m. s. siriwardena s. shanmuganathan W. m. Tilakaratne Department of Oral Pathology Faculty of Dental Sciences University of Peradeniya Peradeniya Sri Lanka District General Hospital Kalutara Sri Lanka

Benign chondroblastoma of mandibular bone is an extremely rare tumor. Although 9 cases have been reported in the mandibular condyle in the English literature, to the best of our knowledge this is the first case origin... 详细信息

关键词： mandible Rare Chondroblastoma

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An Efficient Video Inpainting Approach Using Deep Belief Network

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Computer systems science & Engineering 2022年第11期43卷 515-529页

作者： m.Nuthal srinivasan m.Chinnadurai Department of Electronics and Communication Engineering E.G.S.Pillay Engineering CollegeNagapattinam611002TamilnaduIndia Department of Computer science and Engineering E.G.S.Pillay Engineering CollegeNagapattinam611002TamilnaduIndia

The video inpainting process helps in several video editing and restoration processes like unwanted object removal,scratch or damage rebuilding,and *** intends to fill spatio-temporal holes with reasonable content in the *** of the recent advancements of deep learning for image inpainting,it is challenging to outspread the techniques into the videos owing to the extra time *** this view,this paper presents an efficient video inpainting approach using beetle antenna search with deep belief network(VIA-BAsDBN).The proposed VIA-BAsDBN technique initially converts the videos into a set of frames and they are again split into a region of 5*5 *** addition,the VIABAsDBN technique involves the design of optimal DBN model,which receives input features from Local Binary Patterns(LBP)to categorize the blocks into smooth or structured ***,the weight vectors of the DBN model are optimally chosen by the use of BAs ***,the inpainting of the smooth and structured regions takes place using the mean and patch matching approaches *** patch matching process depends upon the minimal Euclidean distance among the extracted sIFT features of the actual and references *** order to examine the effective outcome of the VIA-BAsDBN technique,a series of simulations take place and the results denoted the promising performance.

关键词： Video inpainting deep learning video restoration beetle antenna search deep belief network patch matching feature extraction

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A Conservative Pressure-Correction method on Collocated Grid for Low mach Number Flows

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World Journal of mechanics 2012年第5期2卷 253-261页

作者： s. m. Yahya s. F. Anwer s. sanghi Department of Applied mechanics Indian Institute of Technology Delhi India Department of mechanical Engineering Zakir Husain College of Engineering & Technology Aligarh Muslim University Aligarh India

A novel extension to smAC scheme is proposed for variable density flows under low mach number approximation. The algorithm is based on a predictor—corrector time integration scheme that employs a projection method for the momentum equation. A constant-coefficient Poisson equation is solved for the pressure following both the predictor and corrector steps to satisfy the continuity equation at each time step. The proposed algorithm has second order centrally differenced convective fluxes with upwinding based on Cell Peclet number while diffusive flux are viscous fourth order accurate. spatial discretization is performed on a collocated grid system that offers computational simplicity and straight forward extension to curvilinear coordinate systems. The algorithm is kinetic energy preserving. Further in this paper robustness and accuracy are demonstrated by performing test on channel flow with non-Boussinesq condition on different temperature ratios.

关键词： LEs Non-Boussinesq Low mach Number Turbulent Flow

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柳伊河水电站大坝右岸坝区研究(英文)

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冰川冻土 2004年第S1期26卷 142-150页

作者： s.A. Velikin A.m. snegirev Vilyui Permafrost Research station Permafrost Institute SiberianBranch Russian Academy of Sciences RussiaVilyui Permafrost Research Station Permafrost Institute SiberianBranch Russian Academy of Sciences Russia

In the paper in order to ascertain the condition of the right-bank of the dam at the Vilyui hydroelectric power plant measurements are applied to obtain experimentaldate such as drilling borehole, hydrolocationand so forth. By finding out the distribution of the temperature field some corresponding measures are taken to improve the stability of the dam during the change of the ground temperature. And finally some conclusions are draw to the study.

关键词： right-bank contiguity filtering flow temperature field hydrolocation

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superiority of Conventional Angiography over Doppler Ultrasound in Evaluation of Patients With Carotid Artery stenosis.

Superiority of Conventional Angiography over Doppler Ultraso...

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第二届国际脑血管病高峰论坛

作者： m A Hayee s.Husain s U Khan K m Rahman m H Rahman s m Kibria Department of Neurology Sir Salimullah Medical CollegeDhakaBangladesh Department of stroke & Neuroendovascular Therapy Sir Ganga Ram HospitalNew DelhiIndia

We performed a prospective study to evaluate the accuracy of Doppler ultrasound in identifying patients for carotid intervention in general practice *** patient referred to our endovascular service for diagnostic angiography to evaluate for carotid *** patient was interviewed and examined by a *** consisted of symptomatic patients with 50% stenosis and asymptomatic patients with 60%stenosis by Doppler *** pertaining to demographic and cerebrovascular risk factors and the results of the carotid Doppler ultrasound were *** severity of stenosis on angiograms was measured with North American symptomatic Carotid Endarterectomy Trial criteria by a blinded *** results of both studies were compared to determine the relative accuracy of ultrasound *** 158 patients(mean age,62±7.9 years) who met Doppler ultrasound criteria,20(12%) and 30(18%) patients were found to have 30%to 49%orstenosis by angiography,*** positive predictive value of carotid Doppler ultrasound for identifying appropriate symptomatic candidates for carotid intervention(angiographic stenosis 50%) was 70%,with a false-positive value of 30%.The positive predictive value of carotid Doppler ultrasound for identifying appropriate asymptomatic candidates for carotid intervention (angiographic stenosis 60%) was 59%,with a false-positive value of 41%.In 158 patients who underwent cerebral angiography alone,minor complications were observed in two patients.

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Effect of pH on Crystal size and Photoluminescence Property of ZnO Nanoparticles Prepared by Chemical Precipitation method

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Acta metallurgica sinica(English Letters) 2015年第3期28卷 394-404页

作者： m.Jay Chithra m.sathya K.Pushpanathan PG & Research Department of Physics Government Arts College

The effects of pH value on crystal size and optical property of zinc oxide nanoparticles prepared by chemical precipitation method were *** samples have been characterized by means of X-ray diffraction,scanning electron microscopy,ultraviolet-visible spectrometer and photoluminescence *** X-ray diffraction profile,it is found that the particle size of sample increases from 13.8 to 33 nm when the pH value of the solution was increased from 6 to *** study also shows that the particle size increases with pH *** shape of the zinc oxide nanoparticle has been confirmed by the scanning electron microscopy *** recorded ultraviolet-visible spectrum shows excitonic absorption peaks around 381 *** energy gap of the prepared samples has been determined from the ultraviolet-visible absorption spectrum,effective mass model equation and Tauc＇s *** was found that the energy gap of the prepared samples decreases with increase in pH *** recorded blue shift confirmed the quantum confinement effect in the prepared zinc oxide *** spectrum infers that the increase in pH value shifts the ultraviolet-visible emission but not the violet and green emissions.

关键词： Zinc oxide nanoparticles pH value Crystal structure microstructure Energy gap Photoluminescence

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A Novel synthesis of malic Acid Capped silver Nanoparticles using solanum lycopersicums Fruit Extract

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Journal of materials science & Technology 2013年第4期29卷 317-322页

作者： m.Umadevi m.R.Bindhu V.sathe Department of Physics Mother Teresa Women's UniversityKodaikanal 624 102Tamil NaduIndia UGC-DAE Consortium for scientific Research University CampusKhandwa RoadIndore 452 017India

Integration of green chemistry principles to nanotechnology is one of the key issues in nanoscience research. The development of the concept of green nanoparticle preparation has been growingly needed for environmentally benign metal nanoparticle synthesis protocols to avoid adverse effects in medical applications. Keep this in mind, in the present study, silver nanoparticles were synthesized using solanum lycopersicums fruit extract. The prepared silver nanoparticles were characterized by UV-visible spectroscopy, Fourier transform infrared spectroscopy, Raman spectroscopy, scanning electron microscopy and transmission electron microscopy techniques. The surface plasmon resonance peak was found at 445 nm. The synthesized silver nanoparticles were spherical in shape with the average size of 10 nm. The citric acid present in s. lycopersicums fruit extract acted as reducing agent and malic acid was responsible for capping of the bioreduced silver nanoparticles.

关键词： silver nanoparticles solanum lycopersicums UV--visible spectroscopy Fourier transform infrared spectroscopy Ramanspectroscopy

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