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放射学实践 1986年第4期3卷 149-152页

作者： Von m.reiser N.Rupp H.Zacher O.Paar R.Aigner 高育璈中国人民解放军总医院

关节内注射造影剂C T扫描,使对疑有髌骨软骨病者的术前诊断更为容易,这种方法比关节窥镜检查经济,且诊断准确性较高.手术适应证的确定除了临床所见外还要了解软骨变性改变的程度.

关键词：关节造影病人手术图象造影剂 X光乳剂软骨病维生素D缺乏病 CT

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高时间分辨率的动态mRI对比增强灌注模式在鉴别一过性骨髓水肿综合征与缺血性骨坏死中的诊断价值

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国际医学放射学杂志 2017年第4期 464-465页

作者： T.Geith T.Niethammer S.milz O.Dietrich m.reiser A.Baur-melnyk 张鹏 Department of Clinical Radiology Ludwig-Maximilians University Munich Campus Grosshadern

摘要目的前瞻性研究动态mRI对比增强灌注模式在量化一过性骨髓水肿综合征与缺血性骨坏死的诊断价值。材料与方法该研究获得机构伦理委员会批准,所有病人均签署知情同意书。32例病人(男21例、女11例,平均年龄48岁,26例髋关节、10例膝关节...

摘要目的前瞻性研究动态mRI对比增强灌注模式在量化一过性骨髓水肿综合征与缺血性骨坏死的诊断价值。材料与方法该研究获得机构伦理委员会批准,所有病人均签署知情同意书。32例病人(男21例、女11例,平均年龄48岁,26例髋关节、10例膝关节)均进行3 T常规mR成像及动态对比增强三维扰相梯度回波序列扫描。进一步基于平均通过时间(mTT)影像与血浆流量(PF)图进行定量、定性分析。

关键词：

颈椎mRI:二维T2加权快速自旋回波、二维准T2加权梯度返回波、三维T2加权可变翻转角度快速自旋回波序列的比较

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国际医学放射学杂志 2009年第3期 301-302页

作者： T.meindl S.Wirth S.Weckbach O.Dietrich m.reiser S.O.Schoen-berg 卞读军 Department of Clinical Radiology University Hospitals MunichZiemssenstrasse 180336 MunichGermany

比较颈椎mR成像各向同性三维高分辨T2加权mR序列和它的重建传统序列。采用1.5T mR设备对15名志愿者颈椎进行矢状和横断面三维T2加权mR序列、矢状和横断面二维T2加权mR序列、矢状和横断面二维准T2加权mR序列扫描。由矢状面三维数据重建... 详细信息

比较颈椎mR成像各向同性三维高分辨T2加权mR序列和它的重建传统序列。采用1.5T mR设备对15名志愿者颈椎进行矢状和横断面三维T2加权mR序列、矢状和横断面二维T2加权mR序列、矢状和横断面二维准T2加权mR序列扫描。由矢状面三维数据重建产生横断面(3D mPRT2W)影像。以体模和在体形式评价这些序列的信噪比和图像均匀度。评价颈椎10个解剖结构的可见度和伪影。统计学分析采用Cohen's kappa、Wilcoxon配对、t检验。

关键词： 3D mRI 颈椎 T2加权空间

磁共振图像人体正常解剖结构:采用0.35 T超导磁铁检查 Ⅰ:一般成像特点、面颅、颈、心脏和纵隔

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放射学实践 1986年第1期 1-7页

作者： Von m.reiser ,N.Rupp ,R.Petsch ,H.J.Heller ,P.Lukas ,B.Allgayer ,罗汉超同济医科大学附属协和医院

在显示面颅、颈部、心脏和纵隔的结构方面,mR可提供新的和重要的资料.不必改变患者体位而直接显示冠状面、矢状面和斜位断层图像,是mR优于只能作轴位断层的CT之处,并能借此更好地作出空间定位.各器官具有高对比反差,彼此能区别开来.检... 详细信息

在显示面颅、颈部、心脏和纵隔的结构方面,mR可提供新的和重要的资料.不必改变患者体位而直接显示冠状面、矢状面和斜位断层图像,是mR优于只能作轴位断层的CT之处,并能借此更好地作出空间定位.各器官具有高对比反差,彼此能区别开来.检查参数能明显影响图像对比和信噪比.通过计算相对信号强度和弛豫时间,能获得上述这些区别的数量差异.

关键词：信号强度 mR 弛豫时间图像面颅纵隔胸膜间间隙胸磁共振心脏

风湿性关节病的磁共振体层照像术(正常与增生变厚的滑膜图象)

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放射学实践 1987年第4期 135-138页

作者： von m.reiser K.Lehner J.Zacher N.Rupp K.Heizer F.Weigert 陈王善继苏州医学院

对风湿性关节病活动性和预后的定量测定方法迄今仅得部分解决。晚期的骨质改变可由常规X线诊断得以证实。但病变早期的软组织炎症性改变用目前的方法(临床检查,X线软组织摄影,干板X线摄影,同位素扫描,超声检查,热象图,关节造影术)不能... 详细信息

对风湿性关节病活动性和预后的定量测定方法迄今仅得部分解决。晚期的骨质改变可由常规X线诊断得以证实。但病变早期的软组织炎症性改变用目前的方法(临床检查,X线软组织摄影,干板X线摄影,同位素扫描,超声检查,热象图,关节造影术)不能获得准确、理想的诊断。早期渗出性与增生性滑膜炎的鉴别,以及关节腔积液,纤维素沉积,与关节囊膜增生变厚的鉴别对滑膜切除术的适应症和预后均十分重要。本文目的是阐述用mR断层照像如何显示慢性多发性关节炎的关节改变,及mR对显示软组织的改变有何优越性。

关键词：滑膜层增厚隐窝关节病关节囊风湿性图象体层

An orally-available monovalent SmAC mimetic compound as a broad-spectrum antiviral

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Protein & Cell 2024年第1期15卷 69-75页

作者： miao mei maria_Antonietta Impagnatiello Jun Jiao Ulrich reiser Ulrike Tontsch-Grunt Ju Zhang Paul Nicklin Bingke Yu Yu Wang Yuan He Xu Tan Tsinghua-Peking Center for Life Sciences Beijing Advanced Innovation Center for Structural BiologyBeijing Frontier Research Center for Biological StructureMOE Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical BiologySchool of Pharmaceutical SciencesTsinghua UniversityBeijing 100084China Chinese Institutes for medical Research Beijing 100069China Boehringer Ingelheim RCV GmbH&Co KG ViennaAustria College of Life Sciences and Oceanography Shenzhen UniversityShenzhen 518060China Research Beyond Borders Boehringer IngelheimBiberach an der RissGermany Research Beyond Borders Boehringer IngelheimShanghai 200120China

DearEditor,The coronavirus disease 2019(COVID-19)pandemic caused great global morbidity and mortality concurrent with astronomical socioeconomic damages and *** now,the culpable pathogen,SARS-CoV-2,has infected over 6 hundred million people resulting in more than 6 million deaths worldwide(WHO SARSCoV-2 cases).There is an urgent need for rapid development of effective and affordable therapeutics for COVID-19 patients.

关键词： mortality spectrum compound

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管腔内对比增强超声(IA-CEUS)评价唾液腺阻塞性疾病和分泌失调

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国际医学放射学杂志 2011年第4期 408-408页

作者： P.Zengel A.Berghaus C.Weile m.reiser D.A.Clevert 任宇婧 Department of Otorhinolaryngology Head and Neck SurgeryGrosshadern Medical CenterLudwig-Maximilians-University of Munich

唾液腺阻塞性疾病是一种常见疾病,主要是由涎石病、导管狭窄、异物或其他更少见的病因引起的。分泌失调是唾液腺的另一种常见疾病,主要和干燥综合征或放射治疗后损伤有关。现有的几种诊断工具可以对这两种疾病进行分

关键词：对比增强超声唾液腺分泌失调干燥综合征

C19mC miRNA-520G induces SP100 antiviral gene transcription and inhibits melanin production in skin cutaneous melanoma

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Genes & Diseases 2024年第1期11卷 60-63页

作者： Goodwin G.Jinesh marian T.Smallin Nino mtchedlidze Isha Godwin marco Napoli Nicole Hackel manali S.Phadke Avani A.Deshpande Xiaobo Li John H.Lockhart Jaden R.Baldwin Suehelay Acevedo-Acevedo Yifeng Gao michelle A.reiser Keiran S.m.Smalley Elsa R.Flores Andrew S.Brohl Department of molecular Oncology H.Lee Moffitt Cancer Center&Research InstituteTampaFL 33612USA molecular medicine Program H.Lee Moffitt Cancer Center&Research InstituteTampaFL 33612USA Saveetha medical College ChennaiTamil Nadu 602105India Tumor Biology Department H.Lee Moffitt Cancer Center&Research InstituteTampaFL 33612USA Sarcoma Department H.Lee Moffitt Cancer Center&Research InstituteTampaFL 33612USA

SP100 is an antiviral protein that restricts the productive stage of human papillomavirus(HPV)and multiple other viruses,and viruses in turn block sUmO-1-mediated stabilization of SP100 and promotes its degradation(Table S1).Interferon(IFN)signaling could still produce more SP100 through transcription to counteract viruses.1 Viruses also disable the transcriptional up-regulation of SP100 to achieve persistent infection in hosts.

关键词： SP100 melanoma stabilization

Sperm banking before gonadotoxic treatment:is it worth the effort?

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Asian Journal of Andrology 2021年第5期23卷 490-494页

作者： Kilian Vomstein Elisabeth reiser Germar m Pinggera Peter Toerzsoek Susanne Deininger Thomas Kriesche Wolfgang Biasio Lukas Lusuardi Bettina Toth Department of Gynecological Endocrinology and Reproductive medicine Medical University InnsbruckInnsbruck 6020Austria Department of Urology Medical University InnsbruckInnsbruck 6020Austria Department of Urology and Andrology University Hospital of SalzburgSalzburg 5020Austria

We aimed to compare the sperm quality in different cancer types and benign diseases before gonadotoxic treatment,and assess the usage rate of cryopreserved sperm for assisted reproductive treatment(ART).This retrospective study was conducted at two university clinics between January 2008 and July 2018.A total of 545 patients suffering from cancer or benign diseases were included in the *** pretreatment sperm analyses were based on the World Health Organization(WHO)*** with testicular malignancy(Tm)showed a significantly lower sperm count(median[interquartile range]:18.7×10^(6)[5.3×10^(6)-43.0×10^(6)]ml^(-1);P=0.03)as well as total sperm count(42.4×10^(6)[13.3×10^(6)-108.5×10^(6)]per ejaculate;P=0.007)compared to other malignant and benign *** addition,patients with nonseminomatous Tm showed the lowest sperm count(14.3×10^(6)[6.0×10^(6)-29.9×10^(6)]ml^(-1),vs seminomas:16.5 x 106[4.6×10^(6)-20.3×10^(6)]ml^(-1);P=0.001).With reference to the WHO 2010 guidelines,approximately 48.0%of the patients with Tm and 23.0%with hematological malignancies(Hm)had *** the observation period,only 29 patients(5.3%)used their frozen sperms for 48 ART cycles,resulting in 15 clinical pregnancies and 10 live *** sperm quality varies with the type of underlying disease,with Tm and Hm patients showing the lowest sperm *** to the observed low usage rate of cryopreserved sperm,further patient interviews and sperm analyses should be included in the routine oncologic protocols to avoid unnecessary storage ***,sperm banking is worth the effort as it provides hope for men who cannot reproduce naturally after gonadotoxic treatment.

关键词： cryopreservation fertility gonadotoxic treatment sperm count testicular disease

Bestimmung des regionalen Blutvolumens (rBV) in meningeomen: Vergleich von Echoplanar-und Gradientenechosequenzen

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Journal of Huazhong University of Science and Technology(medical Sciences) 2004年第6期24卷 610-614页

作者：吴仁华 Roland Bruening Christian Berchtenbreiter Jügen Weber 郎志谨 maximilian reiser Abteilung für Radiologie Medizinische Fakultt der Universitt ShantouShantou 515041ChinaInstitut für Diagnostische RadiologieKlinikum GrophadernLudwig-Maximilians-UniversittMünchen 81377Germany Institut für Diagnostische Radiologie Klinikum GrophadernLudwig-Maximilians-UniversittMünchen 81377Germany Abteilung für Radiologie Medizinische Universitt DalianDalian 116011

Summary: The purpose of this study was to evaluate relative regional blood volume (rCBV) in meningioma and compare the utility of reconstruction using both gradient-echo sequence and echo-planar-imaging (EPI) *** patients with meningiomas were studied on a Siemens 1.5-T scanner. During the gradient-echo sequence (n=12) and EPI sequence (n=6), a bolus ^(0.2 mmol/kg) of Gd-DTPA was injected mechanically with a flow rate of 5 ml/second. Image processing of dynamic data was performed on a pixel-by-pixel basis. The ratio of tumor rCBV/gray matter rCBV was 3.01±1.18 (3.07 ± 1.39 in gradient sequence and 2.84 ± 0.94 in EPI sequence). The ratio of gray matter/ white matter as the reference tissue had a mean of 2.79 ± 0.76 using the FLASH sequence, and a mean of 3.04 ± 1.31 using EPI. These differences were not statistically signifcant (P>0.5, t-test). According to the ratio of tumor rCBV/gray matter rCBV, a mean value, 14.5 ml/100 g, of rCBV in meningiomas was calculated. Compared with gray matter, increased inhomogeneous rCBV was observed in meningioma. Based on the two different sequences, no bias can be observed in our rCBV reconstruction.

关键词： magnetic resonance imaging meningioma blood volume

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