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miniSCIDOm: a scintillator-based tomograph for volumetric dose reconstruction of single laser-driven proton bunches

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High Power Laser Science and Engineering 2024年第2期12卷 41-50页

作者： A.Corvino m.reimold E.Beyreuther F.-E.Brack F.Kroll J.Pawelke J.D.Schilz m.Schneider U.Schramm m.E.P.Umlandt K.Zeil T.Ziegler J.metzkes-Ng Helmholtz-Zentrum Dresden–Rossendorf DresdenGermany Technische Universität Dresden DresdenGermany OncoRay–National Center for Radiation Research in Oncology Faculty of Medicine and University Hospital Carl Gustav CarusTUD Dresden University of TechnologyHelmholtz-Zentrum Dresden–RossendorfDresdenGermany Current affiliation:Institut Curie UniversitéPSLCNRS UMR3347OrsayFrance Current affiliation:Universitätsklinikum Freiburg FreiburgGermany

Laser plasma accelerators(LPAs)enable the generation of intense and short proton bunches on a micrometre scale,thus offering new experimental capabilities to research fields such as ultra-high dose rate radiobiology or material *** spectrally broadband,laser-accelerated proton bunches allow for tailored volumetric dose deposition in a sample via single bunches to excite or probe specific sample *** rising number of such experiments indicates a need for diagnostics providing spatially resolved characterization of dose distributions with volumes of approximately 1 cm^(3) for single proton bunches to allow for fast online *** we present the scintillator-based miniSCIDOm detector for online single-bunch tomographic reconstruction of dose distributions in volumes of up to approximately 1 cm^(3).The detector achieves a spatial resolution below 500μm and a sensitivity of 100 *** detector performance is tested at a proton therapy cyclotron and an LPA proton *** experiments’primary focus is the characterization of the scintillator’s ionization quenching behaviour.

关键词： beam monitoring detectors laser-driven proton beams scintillator-based diagnostics ultra-high dose rate

OCTOPOD:single-bunch tomography for angular-spectral characterization of laser-driven protons

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High Power Laser Science and Engineering 2023年第6期11卷 16-28页

作者： m.reimold S.Assenbaum E.Beyreuther E.Bodenstein F.-E.Brack C.Eisenmann F.Englbrecht F.Kroll F.Lindner U.masood J.Pawelke U.Schramm m.Schneider m.Sobiella m.E.P.Umlandt m.Vescovi K.Zeil T.Ziegler J.metzkes-Ng Helmholtz-Zentrum Dresden-Rossendorf DresdenGermany Technische Universität Dresden DresdenGermany OncoRay-National Center for Radiation Research in Oncology DresdenGermany Ludwig-maximilians-Universität münchen Garching/MünchenGermany Universitätsklinikum Freiburg FreiburgGermany

Laser-plasma accelerated(LPA)proton bunches are now applied for research fields ranging from ultra-high-dose-rate radiobiology to material ***,the capabilities to characterize the spectrally and angularly broad LPA bunches lag behind the rapidly evolving *** OCTOPOD translates the angularly resolved spectral characterization of LPA proton bunches into the spatially resolved detection of the volumetric dose distribution deposited in a liquid *** to 24 multi-pinhole arrays record projections of the scintillation light distribution and allow for tomographic reconstruction of the volumetric dose deposition pattern,from which proton spectra may be *** the OCTOPOD at a cyclotron,we show the reliable retrieval of various spatial dose deposition patterns and detector sensitivity over a broad dose ***,the OCTOPOD was installed at an LPA proton source,providing real-time data on proton acceleration performance and attesting the system optimal performance in the harsh laser-plasma environment.

关键词： laser-plasma acceleration of protons proton detector tomographic reconstruction

脊髓小脑共济失调1、2、3和6型患者多巴胺转运蛋白的正电子发射断层扫描

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世界核心医学期刊文摘（神经病学分册） 2005年第12期1卷 15-15页

作者： Wüllner U. reimold m. Abele m. 江山 Dr.Department of Neurology University of Bonn (UKB) Sigmund Freud Str 25 D-53105 Bonn Germany

Background: The spinocerebellar ataxias (SCAs) are a genetically heterogeneous group of autosomal dominant ataxias: some mutations, including SCA1, SCA2, and SCA3, are multisystemic disorders characterized by a variety of noncerebellar symptoms while others, like SCA6, give rise to a pure cerebellar syndrome. Abstract:Objective: To identify impairments of the dopaminergic system and regional changes of glucose metabolism in SCA1, SCA2, SCA3, and SCA6. methods: We used [11C]d-threo-meth- ylphenidate and [18F]-fluorodeoxyglucose positron emission tomography to identify cerebral dopamine terminal loss and specific regional metabolic patterns in SCA1, SCA2, SCA3, and SCA6. Results: The binding potential of [11C]d-threo-methylphenidate was reduced in the striatum in SCA2 and SCA3; in contrast to patients with Parkinson disease, no increased susceptibility of the putamen was evident. Decreased regional cerebral glucose metabolism was found in the cerebellum of all patients with SCA, the brainstem of SCA1, SCA2, SCA3, the thalamus and putamen of SCA3, and the parietal cortex of patients with SCA2. A trend toward increased regional cerebral glucose metabolism was found in the temporal cortex of all patients with SCA, pronounced in SCA6. Conclusions: Specific biochemical patterns point to different mechanisms of neuronal dysfunction in SCA1, SCA2, SCA3, and SCA6; dopamine terminal loss is severe in SCA2 but distinct from Parkinson disease.

关键词：多巴转运蛋白小脑综合征帕金森病氟脱氧葡萄糖壳核哌甲酯多系统功能紊乱纹状体葡萄糖代谢