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Biofabrication of nanocomposite-based scaffolds containing human bone extracellularmatrix for the differentiation of skeletal stem and progenitor cells

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Bio-design and manufacturing 2024年第2期7卷 121-136页

作者： Yang-Hee Kim Janos m.Kanczler Stuart Lanham Andrew Rawlings marta Roldo Gianluca Tozzi Jonathan I.dawson Gianluca Cidonio Richard O.C.Oreffo Faculty of medicine Bone and Joint Research GroupCentre for Human DevelopmentStem Cells and RegenerationInstitute of Developmental SciencesUniversity of SouthamptonSouthampton SO166YDUK School of Pharmacy and Biomedical Science University of PortsmouthPortsmouth PO12DTUK School of Engineering Faculty of Engineering and ScienceUniversity of GreenwichGreenwich ME44TBUK Center for Life Nano-and Neuro-Science(CLN2S) Italian Institute of Technology00161 RomeItaly

Autograft or metal implants are routinely used in skeletal ***,they fail to provide long-term clinical resolution,necessitating a functional biomimetic tissue engineering *** use of native human bone tissue for synthesizing a biomimeticmaterial inkfor three-dimensional(3d)bioprintingof skeletal tissueis anattractivestrategyfor ***,human bone extracellular matrix(bone-ECm)offers an exciting potential for the development of an appropriate microenvironment for human bone marrow stromal cells(HBmSCs)to proliferate and differentiate along the osteogenic *** this study,we engineered a novel material ink(LAB)by blending human bone-ECm(B)with nanoclay(L,Laponite®)and alginate(A)polymers using extrusion-based *** inclusion of the nanoﬁller and polymeric material increased the rheology,printability,and drug retention properties and,critically,the preservation of HBmSCs viability upon *** composite of human bone-ECm-based 3d constructs containing vascular endothelial growth factor(VEGF)enhanced vascularization after implantation in an ex vivo chick chorioallantoic membrane(CAm)*** inclusion of bone morphogenetic protein-2(BmP-2)with the HBmSCs further enhanced vascularization and mineralization after only seven *** study demonstrates the synergistic combination of nanoclay with biomimetic materials(alginate and bone-ECm)to support the formation of osteogenic tissue both in vitro and ex vivo and offers a promising novel 3d bioprinting approach to personalized skeletal tissue repair.

关键词： Extracellular matrix Nanoclay Bone 3d bioprinting

Viscoelastic potential flow instability theory of Rivlin-Ericksen electrified fluids of cylindrical interface

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Journal of Ocean Engineering and Science 2024年第4期9卷 311-316页

作者： d.m.mostafa department of mathematics College of ScienceQassim UniversityPO Box 6644Buraidah 51452Saudi Arabia department of mathematics Faculty of EducationAin Shams UniversityRoxyCairoEgypt

A linear electrohydrodynamic Kelvin-Helmholtz instability of the interface between two viscoelastic Rivlin-Ericksen fluids enclosed by two concentric horizontal cylinders has been studied via the viscoelastic potential flow *** dispersion equation of complex coefficients for asymmetric disturbance has been obtained by using normal mode *** stability criteria are analyzed theoretically and illustrated *** imaginary part of growth rate is plotted versus the wave *** influences of dynamic viscoelastic,uniform velocities,Reynolds number,electric field,dynamic viscosity,density fluids ratio,dielectric constant ratio and inner fluid fraction on the stability of the system are *** study finds its significance in Ocean pipelines to transfer oil or gas such as Eastern Siberia-Pacific Ocean oil pipeline.

关键词： Rivlin-Ericksen fluid Cylindrical flow Viscoelastic potential flow Electrohydrodynamics stability

Numerical calculation of Z-scan measurements for nonlinear media with large phase shift

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Optoelectronics Letters 2024年第3期20卷 177-182页

作者： m.d.Zidan A.Allahham department of Physics Atomic Energy Commission of SyriaP.O.Box 6091DamascusSyria

We have reported the characteristics of a Z-scan for the poly(azaneylylidene-acylene)(dAZA) polymer, as nonlinear medium with a large nonlinear phase shift using continuous-wave(CW) laser beam. It has been verified that the Fresnel diffraction model is applicable for analyses of Z-scan measurements with dAZA polymer at high laser power. It was found that Z-scan curves with peak-to-valley features appear as the applied light intensity increases in the case of a large nonlinear phase shift. The Z-scan experiments were carried out using a CW laser to verify the theoretical calculations in the case of a large nonlinear phase shift model. Our results show good agreements between the experimental data and the proposed theoretical models.

关键词： nonlinear phase media

Enhancement of coercivity,permeability,and dielectric properties of Co_(0.2)Zn_(0.3)Ni_(0.5)Eu_(x)Fe_(2-x)O_(4) ferrites for memory and high frequency devices

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Journal of Rare Earths 2024年第6期42卷 1128-1135,I0005页

作者： I.Sardar m.d.Hossain m.S.Sikder m.N.I.Khan m.R.Rahman Physics discipline Khulna UniversityKhulna9208Bangladesh department of Physics Khulna University of Engineering&TechnologyKhulna9203Bangladesh department ofComputer Science and Engineering Northern University of Business&Technology KhulnaKhulna9100Bangladesh material Science division Atomic Energy CentreDhaka1000Bangladesh

Spinel cubic ferrites have huge applications in me mory and high frequency *** the improvement of these modern devices,the magnetic coercivity,permeability,and dielectric properties of a ferrite are the important *** article focuses on improving the magnetic coercivity,magnetic permeability,and dielectric properties of Co_(0.2)Zn_(0.3)Ni_(0.5)Eu_(x)Fe_(2-x)O_(4) ferrites,where x=0.00,0.06,and *** X-ray diffraction(XRd),Fourier transform infrared spectroscopy(FTIR),field emission scanning electron microscopy(FESEm),energy dispersive X-ray(EdX),vibrating sample magnetometer(VSm),and an impedance analyzer were used to characterize the structural,magnetic,and dielectric properties of the *** XRd patterns indicate the formation of spinel cubic structure of the samples with a secondary peak(EuFeO_(3))for Eu doped *** densities and porosities of the samples follow an inverse trend,where the doped samples’lattice parameters are increased with the increment of rare earth Eu *** FTIR analysis also proves the spinel cubic phase of the *** average grain size of the ferrites is obtained via FESEm images,and it is increased from 121 to 198 *** analysis confirms that doping of the Eu content also changes other hysteresis loop properties of Co_(0.2)Zn_(0.3)Ni_(0.5)Eu_(x)Fe_(2-x)O_(4) ***,the coercivity of the Eu doped samples is greater than that of the mother alloy(x=0.00).The EdX study shows that there is no impurity contamination in the *** permeability and dielectric measurements show an improved quality factor of the Eu-doped samples with low magnetic and dielectric *** dependent resistivity and impedance analysis also show the improved *** the observed properties of the samples,all the investigated ferrites might be strong candidates for potential applications in memory devices,magnetic sensors,and high frequency applications.

关键词： Ferrites Raree arths Coercivity Permeability EdX Resistivity

Highly toxic Aβ begets more Aβ

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Neural Regeneration Research 2024年第9期19卷 1871-1872页

作者： merc m.Kemeh Noel d.Lazo Gustaf H.Carlson School of Chemistry and Biochemistry Clark UniversityWorcesterMAUSA

Alzheimer’s disease(Ad)is the most common form of dementia-the 7th leading cause of death *** the tissue level,Ad is characterized by the presence of extracellular amyloid plaques that are comprised primarily of the amyloid-βpeptide(Aβ),and by intraneuronal neurofibrillary tangles composed of *** genetics of early-onset Ad and longitudinal brain-imaging studies of late-onset Ad indicate that extracellular Aβdeposition,in general,precedes neurofibrillary tangle formation in neurons(Hampel et al.,2021;Young-Pearse et al.,2023).

关键词： Aβ tau Alzheimer death

The multi-impurity system in CdSe nanoplatelets:electronic structure and thermodynamic properties

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Communications in Theoretical Physics 2024年第3期76卷 165-173页

作者： d A Baghdasaryan V A Harutynyan E m Kazaryan H A Sarkisyan Russian-Armenian University H Emin 1230051YerevanArmenia Institute of Applied Problems of Physics 25 Nersisyan St0014YerevanArmenia

This paper theoretically studies the impurity states and the effects of impurity concentration and configuration on the optical,electrical,and statistical properties of CdSe nanoplatelets(NPLs).An image charge-based model of electron-impurity interaction is *** charge-carrier energy spectra and corresponding wave functions depending on the impurity number and configuration are *** electron binding energies are calculated for different NPL *** is shown that the image charge-based interaction potential that arises due to the dielectric constants mismatch is much stronger than the interaction potential that does not take such a mismatch into ***,it is demonstrated that the binding energies are increasing with the number of *** calculate the canonical partition function using the energy levels of the electron,which in turn is used to obtain the mean energy,heat capacity,and entropy of the non-interacting electron *** thermodynamic properties of the non-interacting electron gas that depend on the geometric parameters of the NPL,impurity number,configuration,and temperature are studied.

关键词： nanoplateletes thermodynamic properties impurity states

Predictor-corrector Fdm analysis of mHd darcy-Forchheimer flow of a micropolar fluid with viscous dissipation and heterogeneoushomogeneous

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Propulsion and Power Research 2024年第2期13卷 257-272页

作者： d.Thenmozhi m.Eswara Rao department of mathematics Saveetha School of EngineeringSIMATSChennaiTamilnaduIndia

This research delves into an intricate exploration ofﬂuid dynamics within heat transfer systems,with a speciﬁc focus on enhancing our understanding and improving system efﬁ*** a sophisticated mathematical model,the study incorporates micropolarﬂuid dynamics,micro rotational effects,laminarﬂow characterized by the darcy-Forchheimer model,inertia effects,and chemical reactions within a heat transfer system featuring boundary layer *** mathematical framework consists of partial differential equations(PdEs),and the study utilizes advanced numerical techniques,including the(PC4-Fdm)Predictor-Corrector Finite difference method and the shooting method,to solve these govern-ing *** inclusion of quantized mesh points and analysis of convergence using 4th orderﬁnite difference methods enhances the precision of the obtained *** param-eters are scrutinized to draw meaningful *** heterogeneous parameter reveals an increasing trend inﬂuid concentration,while the homogeneous parameter indicates a collision effect leading to a decrease inﬂuid *** Eckert number,associated with viscous dissipation,exhibits a correlation with decreasedﬂuid temperature and increasedﬂuid *** rotation parameters suggest a parallel increase inﬂuid velocity and a marginal decrease inﬂuid ***,the darcy-Forchheimer parameter,reﬂective of inertial effects,showcases an increase inﬂuid temperature and decrease in velocity in the convection *** the industrial implications,the study underscores the signiﬁcance of convection heat transfer systems in the context of ***ﬁndings offer valuable insights for optimizing heating and cooling processes in diverse industrial applications,ranging from power plants to waste heat recovery units and pharmaceutical industries.ª2024 The *** services by Elsevier *** behalf of KeAi Communications ***.

关键词： Predictor-corrector micropolarﬂuid magnetohydrodynamics(mHd) Viscous dissipation Homogeneous-heterogeneous

Role of homologous recombination/recombineering on human adenovirus genome engineering:Not the only but the most competent solution

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Engineering microbiology 2024年第1期4卷 90-107页

作者： Lisa-marie dawson montaha Alshawabkeh Katrin Schröer Fatima Arakrak Anja Ehrhardt Wenli Zhang Virology and microbiology Center for Biomedical Education and Research(ZBAF)School of MedicineFaculty of HealthWitten/Herdecke UniversityStockumer Str.1058453 WittenGermany

Adenoviruses typically cause mild illnesses,but severe diseases may occur primarily in immunodeficient individuals,particularly ***,adenoviruses have garnered significant interest as a versatile tool in gene therapy,tumor treatment,and vaccine vector *** the past two decades,the advent of recombineering,a method based on homologous recombination,has notably enhanced the utility of adenoviral vectors in therapeutic *** review summarizes recent advancements in the use of human adenoviral vectors in medicine and discusses the pivotal role of recombineering in the development of these ***,it highlights the current achievements and potential future impact of therapeutic adenoviral vectors.

关键词： Adenoviral vector Gene therapy Homologous recombination Oncolytic virus Vaccine vector

In_(2)O_(3)/Bi_(19)Br_(3)S_(27)S型异质结增强光催化CO_(2)还原

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Science China materials 2024年第2期67卷 514-523页

作者：卞玉琴何厚伟 Graham dawson 张金锋代凯 Laboratory of Green and Precise Synthetic Chemistry and Applications Ministry of EducationAnhui Province Key Laboratory of Pollutant Sensitive Materials and Environmental RemediationAnhui Province Key Laboratory of Intelligent Computing and ApplicationsAnhui Province Industrial Generic Technology Research Center for Alumics MaterialsHuaibei Normal UniversityHuaibei 235000China department of Chemistry Xi’an Jiaotong Liverpool UniversitySuzhou 215123China

近年来,半导体催化剂因其较强的氧化还原能力和较好的稳定性而受到广泛关注.然而,光生电子和空穴对易复合和低氧化性导致单一半导体催化剂难以实现实际应用.深入研究表明,S型异质结具有独特的电子和空穴分离机理、强大的氧化还原能力和... 详细信息

近年来,半导体催化剂因其较强的氧化还原能力和较好的稳定性而受到广泛关注.然而,光生电子和空穴对易复合和低氧化性导致单一半导体催化剂难以实现实际应用.深入研究表明,S型异质结具有独特的电子和空穴分离机理、强大的氧化还原能力和较强的载流子分离驱动力.本研究以在In_(2)O_(3)纳米球上生长的Bi_(19)Br_(3)S_(27)纳米花为原料,采用水热法合成了In_(2)O_(3)/Bi_(19)Br_(3)S_(27)梯形异质结.这种梯形异质结有效地促进了光生电荷载流子的分离和转移.结果表明,In_(2)O_(3)/Bi_(19)Br_(3)S_(27)复合材料对CO_(2)的还原产率高达28.36μmol h^(-1)g^(-1),分别是In_(2)O_(3)和Bi_(19)Br_(3)S_(27)的19和3.5倍.此外,通过原位漫反射红外傅里叶变换光谱对参与光催化反应的中间体进行了研究,揭示了光催化还原CO_(2)的反应过程.本工作为构建S型异质结光催化剂增强CO_(2)催化还原的方法提供了较好的研究思路.

关键词： photocatalytic CO_(2)reduction S-scheme heterojunction In_(2)O_(3) Bi_(19)Br_(3)S_(27)