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培美曲塞加铂类联合或不联合帕博利珠单抗对初治转移性非鳞状NSCLC患者的疗效与安全性分析：KEYNOTE-189研究方案指定的最终分析

中国肺癌杂志 2022年第6期25卷 443-456页

作者：周彩存 Delvys RODRíGUEZ-ABREU S.F.POWELL m.J.HOCHmAIR S.GAD GEEL E.ESTEBAN E.FELIP G.SPERANZA F.De ANGELIS m.DómINE S.Y.CHENG H.G.BISCHOFF N.PELED m.reck R.HUI E.B.GARON m.BOYER T.KURATA J.YANG m.C.PIETANZA F.SOUZA m.C.GARASSINO 同济大学附属上海市肺科医院肿瘤科 medical Oncology Complejo Hospitalario Universitario Insular Materno-Infantil de Gran CanariaUniversidad de Las Palmas de Gran Canaria Oncology Sanford Health 4. Department of Respiratory and Critical Care MedicineKarl Landsteiner Institute of Lung Research and Pulmonary Oncology Thoracic Oncology Karmanos Cancer InstituteWayne State University Department of medical Oncology Hospital Universitario Central de Asturias medical Oncology Department Vall d'Hebron UniversityVall d'Hebron Institute of Oncology (VHIO) 8. Centre Integre de Cancerologie de la MontérégieH?pital Charles-Le Moyne 9. Medical Oncology DepartmentHospital Universitario Fundacidn Jiménez DiazIIS-FJD Sunnybrook Health Sciences Centre Thoraxklinik Heidelberg Department of Oncology Shaare Zedek Medical Center LungenClinic Airway Research Center NorthGerman Center for Lung Research Department of medical Oncology Westmead Hospital and University of Sydney Department of medicine David Geffen School of Medicine at UCLA Department of medical Oncology Chris O'Brien Lifehouse Department of Thoracic Oncology Kansai Medical University Hospital merck & Co. Inc. Fondazione IRCCS Istituto Nazionale dei Tumori University of Chicago medicine & Biological Sciences Knapp Center for Biomedical Discovery

背景在KEYNOTE-189此项Ⅲ期研究(NCT02578680)中,与安慰剂联合培美曲塞加铂类相比,帕博利珠单抗联合培美曲塞加铂类化疗(培美曲塞-铂类)显著改善了初治转移性非鳞状非小细胞肺癌(non-small cell lung cancer,NSCLC)患者的总生存期(over... 详细信息

背景在KEYNOTE-189此项Ⅲ期研究(NCT02578680)中,与安慰剂联合培美曲塞加铂类相比,帕博利珠单抗联合培美曲塞加铂类化疗(培美曲塞-铂类)显著改善了初治转移性非鳞状非小细胞肺癌(non-small cell lung cancer,NSCLC)患者的总生存期(overall survival,OS)和无进展生存期(progression-free survival,PFS)。本研究报告了研究方案指定的最终分析的疗效结局,包括从培美曲塞-铂类交叉至帕博利珠单抗治疗的患者,以及完成35个周期(约2年)帕博利珠单抗治疗组的疗效。方法符合条件的患者以2:1随机分配至帕博利珠单抗,每3周一次,200 mg (n=410)或安慰剂(n=206)(共35周期,约2年),加上4个周期的培美曲塞(500 mg/m~2)和由研究者选择的每3周顺铂(75 mg/m~2)或卡铂(曲线下面积5 mg/min/mL)治疗,随后使用培美曲塞直至疾病进展。若符合纳入标准,分配至安慰剂联合培美曲塞加铂类治疗的患者可在疾病进展时转向帕博利珠单抗治疗。主要研究终点为OS和PFS。结果中位随访31.0个月,无论PD-L1的表达水平如何,与安慰剂联合培美曲塞-铂类治疗相比,帕博利珠单抗联合培美曲塞-铂类治疗可使患者的OS[风险比(hazard ratio,HR)为0.56;95%可信区间(confidence interval,CI) 0.46-0.69]和PFS (HR=0.49;95%CI:0.41-0.59)显著获益。接受帕博利珠单抗联合培美曲塞-铂类治疗的患者客观缓解率(objective response rate,ORR)(48.3%vs 19.9%)和第二次/后续无进展生存期(PFS2;HR=0.50;95%CI:0.41-0.61)均得到改善。安慰剂联合培美曲塞-铂类组的84例患者(40.8%)交叉至帕博利珠单抗治疗组。72.1%的接受帕博利珠单抗联合培美曲塞-铂类的患者和66.8%的接受安慰剂联合培美曲塞-铂类的患者发生了3级-5级不良事件。56例患者完成了35个周期(约2年)的帕博利珠单抗治疗;ORR为85.7%,53例(94.6%)患者存活至数据截止时间。结论与安慰剂联合培美曲塞-铂类治疗相比,帕博利珠单抗联合培美曲塞-铂类可持续提高疗效,且安全性可控。该研究结果支持将帕博利珠单抗联合培美曲塞-铂类作为初治转移性非鳞状NSCLC患者的一线治疗方案。

关键词：帕博利珠单抗化疗非鳞状非小细胞肺癌

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非小细胞肺癌的一线免疫治疗

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中国肺癌杂志 2022年第10期25卷 771-783页

作者：刘思阳 martin reck Jordi REmON matthew D.HELLmANN 广东省人民医院肿瘤中心广东省医学科学院广东省肺癌研究所 Lung Clinic Grosshansdorf Airway Research Center North German Center of Lung Research 3. Department of Medical Oncology Centro Integral Oncologico Clara Campal (HM-CIOCC) Hospital HM Delfos HM Hospitales memorial Sloan Kettering Cancer Center and Weill Cornell medical College

过去十年内，转移性非小细胞肺癌（metastatic non-small-cell lung cancer, m NSCLC）的治疗取得了关键性进展，大大提高了患者的生存率。尤其是一线/二线治疗策略中针对程序性死亡受体1(programmed cell death protein 1, PD-1)、程... 详细信息

过去十年内，转移性非小细胞肺癌（metastatic non-small-cell lung cancer, m NSCLC）的治疗取得了关键性进展，大大提高了患者的生存率。尤其是一线/二线治疗策略中针对程序性死亡受体1(programmed cell death protein 1, PD-1)、程序性死亡配体1(programmed death ligand-1, PD-L1)和细胞毒性T淋巴细胞相关蛋白4受体（cytotoxic T-lymphocyteassociated protein 4, CTLA-4）等的特异性抗体惊艳亮相，使部分患者生存期明显延长。尽管抗PD-1和PD-L1疗法的免疫检查点抑制剂（immune checkpoint inhibitor, ICI）起初主要是作为二线治疗的单药治疗，但最近已转向作为晚期一线治疗的联合疗法，早期肺癌也已将免疫治疗纳入临床范式。如今，除了具有靶向基因突变的m NSCLC外，几乎所有的m NSCLC患者都在一线接受PD-1或PD-L1治疗。在此，我们报告了m NSCLC一线免疫治疗的现状以及当前为患者选择最佳免疫治疗方案所面临的挑战。

关键词：细胞肺癌免疫治疗细胞毒

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Solid phase microextraction chemical biopsy tool for monitoring of doxorubicin residue during in vivo lung chemo-perfusion

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Journal of Pharmaceutical Analysis 2021年第1期11卷 37-47页

作者： Barbara Bojko Nikita Looby mariola Olkowicz Anna Roszkowska Bogumiła Kupcewicz Pedro reck dos Santos Khaled Ramadan Shaf Keshavjee Thomas K.Waddell German Goomez-Rios marcos Tascon Krzysztof Gorynski marcelo Cypel Janusz Pawliszyn Department of Chemistry University of WaterlooWaterlooON M1B 6G3Canada Department of Pharmacodynamics and molecular Pharmacology Faculty of PharmacyCollegium Medicum in BydgoszczNicolaus Copernicus University in Torun85-089BydgoszczPoland Jagiellonian Centre for Experimental Therapeutics(JCET) Jagiellonian University30-348 KrakowPoland Department of Pharmaceutical Chemistry Medical University of Gdansk80-416GdanskPoland Department of Inorganic and Analytical Chemistry Faculty of PharmacyCollegium Medicum in BydgoszczNicolaus Copernicus University in Torun85-089BydgoszczPoland University Health Network-TGH TorontoON M5G 2C4Canada

Development of a novel in vivo lung perfusion(IVLP)procedure allows localized delivery of high-dose doxorubicin(DOX)for targeting residual micrometastatic disease in the ***,DOX delivery via IVLP requires careful monitoring of drug level to ensure tissue concentrations of this agent remain in the therapeutic window.A small dimension nitinol wire coated with a sorbent of biocompatible morphology(Bio-SPmE)has been clinically evaluated for in vivo lung tissue extraction and determination of DOX and its key *** in vivo Bio-SPmE-IVLP experiments were performed on pig model over various(150 and 225 mg/m^(2))drug doses,and during human clinical *** patients with metastatic osteosarcoma were treated with a single 5 and 7 μg/mL(respectively)dose of DOX during a 3-h *** both pig and human cases,DOX tissue levels presented similar trends during *** lung tissue concentrations of drug ranged between 15 and 293 μg/g over the course of the IVLP *** addition to DOX levels,Bio-SPmE followed by liquid chromatography-mass spectrometry analysis generated 64 metabolic features during endogenous metabolite screening,providing information about lung status during drug ***-time monitoring of DOX levels in the lungs can be performed effectively throughout the IVLP procedure by in vivo Bio-SPmE chemical biopsy ***-SPmE also extracted various endogenous molecules,thus providing a real-time snapshot of the physiology of the cells,which might assist in the tailoring of personalized treatment strategy.

关键词： In vivo solid phase microextraction metabolite profiling Spatial resolution Therapeutic drug monitoring Tissue analysis

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核、膜蛋白的基因能抑制禽类流感病毒及其重组株的繁殖

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中国医学科学院学报 1986年第1期8卷 1-6页

作者：田淑芳,Buckler-White AJ,London WT,reck LJ,Chanock Rm,murphy BR 中国预防医学中心病毒研究所 Laboratory of Infectious Diseases National Institute of Allergy Infectious Diseases NIH USA National Institute of Neurological Communicative Disorders Stroke NIH USA. Laboratory of Infectious Diseases National Institute of Allergy Infectious Diseases NIH USA Laboratory of Infectious Diseases National Institute of Allergy Infectious Diseases NIH USA Laboratory of Infectious Diseases National Institute of Allergy Infectious Diseases NIH USA

对人流感病毒A/Udorn/72（H3N2）株与禽类流感病毒A/mallard/NY/78/（H2N2）重组后的重组株分析表明,仅含禽类病毒的核蛋白（NP）或膜蛋白（m）的RNA片段的重组株,在松鼠猴的呼吸道繁殖是受限制的。另外。仅有禽类的RNAl和NS基因的重组... 详细信息

对人流感病毒A/Udorn/72（H3N2）株与禽类流感病毒A/mallard/NY/78/（H2N2）重组后的重组株分析表明,仅含禽类病毒的核蛋白（NP）或膜蛋白（m）的RNA片段的重组株,在松鼠猴的呼吸道繁殖是受限制的。另外。仅有禽类的RNAl和NS基因的重组株（Clone 12）在松鼠猴的气管内的繁殖也明显受限制,而只具有其中一个基因的Clone 9, Clone 2, 则限制就不明显。由此表明,禽类流感病毒的NP和m基因在宿主范围的繁殖限制中起主要作用,而RNAI和SN基因的结合,同样起着繁殖受限制作用。

关键词：禽类流感病毒基因重组繁殖性状

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Insights into CODE-DE–Germany’s Copernicus data and exploitation platform

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Big Earth Data 2019年第4期3卷 338-361页

作者： Tobias Storch Christoph reck Stefanie Holzwarth Bert Wiegers Nico mandery Ulrich Raapea Christian Strobl Rouven Volkmann martin Böttcher Andreas Hirner Johanna Senft Nicolae Plesia Thomas Kukuk Stephan meissl Jens-Rainer Felske Thomas Heege Vanessa Keuck michael Schmidt Helmut Staudenrausch Earth Observation Center(EOC) German Aerospace Center(DLR)WeßlingGermany T-Systems SfR GmbH BonnGermany Brockmann Consult GmbH GeesthachtGermany GAF AG MunichGermany EOX IT Services GmbH ViennaAustria Werum Software&Systems AG LüneburgGermany EOmAP GmbH&Co.KG SeefeldGermany Programme Strategy Space R&D German Aerospace Center(DLR)CologneGermany Space Administration German Aerospace Center(DLR)BonnGermany

This article presents and analyses the modular architecture and capabilities of CODE-DE(Copernicus Data and Exploitation Platform–Deutschland,***),the integrated German operational environment for accessing and processing Copernicus data and products,as well as the methodology to establish and operate the *** march 2017,CODE-DE has been online with access to Sentinel-1 and Sentinel-2 data,to Sentinel-3 data shortly after this time,and since march 2019 with access to Sentinel-5P *** products are available and accessed by 1,682 registered users as of march *** this period 654,895 products were downloaded and a global catalogue was continuously updated,featuring a data volume of 814 TByte based on a rolling archive concept supported by a reload mechanism from a long-term *** November 2017,the element for big data processing has been operational,where registered users can process and analyse data themselves specifically assisted by methods for value-added product *** 195,467 core and 696,406 memory hours,982,948 products of different applications were fully automatically generated in the cloud environment and made available as of march *** features include an improved visualization of available Sentinel-2 products,which are presented within the catalogue client at full 10 m resolution.

关键词： Big earth data big data processing online data access Sentinel Copernicus CODE-DE collaborative ground segment

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Fungal diversity notes 367-490:taxonomic and phylogenetic contributions to fungal taxa

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Fungal Diversity 2016年第5期80卷 1-270页

作者： Kevin D.Hyde Sinang Hongsanan Rajesh Jeewon D.Jayarama Bhat Eric H.C.mcKenzie E.B.Gareth Jones Rungtiwa Phookamsak Hiran A.Ariyawansa Saranyaphat Boonmee Qi Zhao Faten Awad Abdel-Aziz mohamed A.Abdel-Wahab Supharat Banmai Putarak Chomnunti Bao-Kai Cui Dinushani A.Daranagama Kanad Das monika C.Dayarathne Nimali Ide Silva Asha J.Dissanayake mingkwan Doilom Anusha H.Ekanayaka Tatiana Baptista Gibertoni Aristóteles Góes-Neto Shi-Ke Huang Subashini C.Jayasiri Ruvishika S.Jayawardena Sirinapa Konta Hyang Burm Lee Wen-Jing Li Chuan-Gen Lin Jian-Kui Liu Yong-Zhong Lu Zong-Long Luo Ishara S.manawasinghe Patinjareveettil manimohan Ausana mapook Tuula Niskanen Chada Norphanphoun moslem Papizadeh Rekhani H.Perera Chayanard Phukhamsakda Christian Richter AndréL.C.mde A.Santiago E.Ricardo Drechsler-Santos Indunil C.Senanayake Kazuaki Tanaka T.m.D.S.Tennakoon Kasun m.Thambugala Qing Tian Saowaluck Tibpromma Benjarong Thongbai Alfredo Vizzini Dhanushka N.Wanasinghe Nalin N.Wijayawardene Hai-Xia Wu Jing Yang Xiang-Yu Zeng Huang Zhang Jin-Feng Zhang Timur S.Bulgakov Erio Camporesi Ali H.Bahkali mohammad A.Amoozegar Lidia Silva Araujo-Neta Joseph F.Ammirati Abhishek Baghela R.P.Bhatt Dimitar Bojantchev Bart Buyck Gladstone Alves da Silva Catarina Letícia Ferreira de Lima Rafael JoséVilela de Oliveira Carlos Alberto Fragoso de Souza Yu-Cheng Dai Bálint Dima Tham Thi Duong Enrico Ercole Fernando mafalda-Freire Aniket Ghosh Akira Hashimoto Sutakorn Kamolhan Ji-Chuan Kang Samantha C.Karunarathna Paul m.Kirk Ilkka Kytovuori Angela Lantieri Kare Liimatainen Zuo-Yi Liu Xing-Zhong Liu Robert Lücking Gianfranco medardi Peter E.mortimer Thi Thuong Thuong Nguyen Itthayakorn Promputtha K.N.Anil Raj mateus A.reck Saisamorn Lumyong Seyed Abolhassan Shahzadeh-Fazeli marc Stadler mohammad Reza Soudi Hong-Yan Su Takumasa Takahashi Narumon Tangthirasunun Priyanka Uniyal Yong Wang Ting-Chi Wen Jian-Chu Xu Zhong-Kai Zhang Yong-Chang Zhao Jun-Liang Zhou Lin Zhu Institute of Biotechnology and Germplasm Resources Key Lab of Southwestern Crop Gene Resources and Germplasm Innovation Ministry of AgricultureYunnan Provincial Key Laboratory of Agricultural BiotechnologyYunnan Academy of Agricultural SciencesKunming 650223YunnanPeople’s Republic of China Key Laboratory of Plant Diversity and Biogeography of East Asia Kunming Institute of BotanyChinese Academy of SciencesKunming 650201YunnanPeople’s Republic of China Center of Excellence in Fungal Research Mae Fah Luang University333 M.1T.ThasudMuangChiang Rai 57100Thailand State Key Laboratory of mycology Institute of MicrobiologyChinese Academy of SciencesNo 31st West Beichen RoadChaoyang DistrictBeijing 100101People’s Republic of China Department of Botany and microbiology College of ScienceKing Saud UniversityP.O.Box:2455Riyadh1145Saudi Arabia Department of Botany and microbiology Faculty of ScienceSohag UniversitySohag 82524Egypt Faculty of Agriculture and Life Sciences Hirosaki University3 Bunkyo-choHirosakiAomori 036-8561Japan The United Graduate School of Agricultural Sciences Iwate University18-8 Ueda 3 ChomeMorioka 020-8550Japan Guizhou Key Laboratory of Agricultural Biotechnology Guizhou Academy of Agricultural SciencesXiaohe DistrictGuiyang CityGuizhou Province 550006People’s Republic of China School of Science Mae Fah Luang UniversityChiang Rai 57100Thailand Department of Plant Pathology College of AgricultureGuizhou UniversityGuiyang 550025GuizhouPeople’s Republic of China Department of Botany Goa UniversityTaleigãoGoaIndia No.128/1-J Azad Housing SocietyCurcaGoa Velha 403108India Department of Biology Faculty of ScienceChiang Mai UniversityChiang Mai 50200Thailand World Agroforestry Centre East and Central AsiaKunming 650201YunnanPeople’s Republic of China Centre of mountain Ecosystem Studies Kunming Institute of BotanyChinese Academy of SciencesKunming 650201YunnanPeople’s Republic of China Department of microbial Drugs Helmholtz Centre for Infection Res

This is a continuity of a series of taxonomic papers where materials are examined,described and novel combinations are proposed where necessary to improve our traditional species concepts and provide updates on their *** addition to extensive morphological descriptions and appropriate asexual and sexual connections,DNA sequence data are also analysed from concatenated datasets(rDNA,TEF-a,RBP2 and b-Tubulin)to infer phylogenetic relationships and substantiate systematic position of taxa within appropriate *** new species or combinations are being proposed,we apply an integrative approach(morphological and molecular data as well as ecological features wherever applicable).Notes on 125 fungal taxa are compiled in this paper,including eight new genera,101 new species,two new combinations,one neotype,four reference specimens,new host or distribution records for eight species and one alternative *** new genera introduced in this paper are Alloarthopyrenia,Arundellina,Camarosporioides,Neomassaria,Neomassarina,Neotruncatella,Paracapsulospora and *** new species are Alfaria spartii,Alloarthopyrenia italica,Anthostomella ravenna,***,Arthrinium paraphaeospermum,Arundellina typhae,Aspergillus koreanus,Asterina cynometrae,Bertiella ellipsoidea,Blastophorum aquaticum,Cainia globosa,Camarosporioides phragmitis,Ceramothyrium menglunense,Chaetosphaeronema achilleae,Chlamydotubeufia helicospora,Ciliochorella phanericola,Clavulinopsis aurantiaca,Colletotrichum insertae,Comoclathris italica,Coronophora myricoides,Cortinarius fulvescentoideus,***,***,***,Cunninghamella gigacellularis,Cyathus pyristriatus,Cytospora cotini,Dematiopleospora alliariae,***,Diaporthe aseana,***,Distoseptispora multiseptata,***,***,Dothiora buxi,Emericellopsis persica,Gloniopsis calami,Helicoma guttulatum,Helvella floriforma,***,Hermatomyces subiculosa,Ju

关键词： Ascomycota Basidiomycota Dothideomycetes mortierellomycotina mucoromycotina Pezizomycetes Phylogeny Taxonomy New genus New species New host records

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Fungal diversity notes 253-366:taxonomic and phylogenetic contributions to fungal taxa

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Fungal Diversity 2016年第3期78卷 1-237页

作者： Guo Jie Li Kevin D.Hyde Rui Lin Zhao Sinang Hongsanan Faten Awad Abdel-Aziz mohamed A.Abdel-Wahab Pablo Alvarado Genivaldo Alves-Silva Joseph F.Ammirati Hiran A.Ariyawansa Abhishek Baghela Ali Hassan Bahkali michael Beug D.Jayarama Bhat Dimitar Bojantchev Thitiya Boonpratuang Timur S.Bulgakov Erio Camporesi marcela CBoro Oldriska Ceska Dyutiparna Chakraborty Jia Jia Chen K.W.Thilini Chethana Putarak Chomnunti Giovanni Consiglio Bao Kai Cui Dong Qin Dai Yu Cheng Dai Dinushani A.Daranagama Kanad Das monika C.Dayarathne Eske De Crop Rafael J.V.De Oliveira Carlos Alberto Fragoso de Souza JoséIde Souza Bryn T.m.Dentinger Asha J.Dissanayake mingkwan Doilom E.Ricardo Drechsler-Santos masoomeh Ghobad-Nejhad Sean P.Gilmore Aristóteles Góes-Neto michałGorczak Charles H.Haitjema Kalani Kanchana Hapuarachchi Akira Hashimoto mao Qiang He John K.Henske Kazuyuki Hirayama maria J.Iribarren Subashini C.Jayasiri Ruvishika S.Jayawardena Sun Jeong Jeon Gustavo H.Jerônimo Ana L.Jesus E.B.Gareth Jones Ji Chuan Kang Samantha C.Karunarathna Paul m.Kirk Sirinapa Konta Eric Kuhnert Ewald Langer Haeng Sub Lee Hyang Burm Lee Wen Jing Li Xing Hong Li Kare Liimatainen Diogo Xavier Lima Chuan Gen Lin Jian Kui Liu Xings Zhong Liu Zuo Yi Liu J.Jennifer Luangsa-ard Robert Lücking H.Thorsten Lumbsch Saisamorn Lumyong Eduardo m.Leaño Agostina V.marano misato matsumura Eric H.C.mcKenzie Suchada mongkolsamrit Peter E.mortimer Thi Thuong Thuong Nguyen Tuula Niskanen Chada Norphanphoun michelle A.O’malley Sittiporn Parnmen Julia Pawłowska Rekhani H.Perera Rungtiwa Phookamsak Chayanard Phukhamsakda Carmen L.A.Pires-Zottarelli Olivier Raspé mateus A.reck Sarah C.O.Rocha AndréL.C.m.Ade Santiago Indunil C.Senanayake Ledo Setti Qiu Ju Shang Sanjay K.Singh Esteban B.Sir Kevin V.Solomon Jie Song Prasert Srikitikulchai marc Stadler Satinee Suetrong Hayato Takahashi Takumasa Takahashi Kazuaki Tanaka Li Ping Tang Kasun m.Thambugala Donnaya Thanakitpipattana michael K.Theodorou Benjarong Thongbai Tuksaporn Thummarukcharoen Qing Tian Saowaluck Tibpromma Annemieke State Key Laboratory of mycology Institute of MicrobiologyChinese Academy of SciencesNo 31st West Beichen RoadChaoyang DistrictBeijing 100101People’s Republic of China Centre of Excellence in Fungal Research and School of Science Mae Fah Luang UniversityChiang Rai 57100Thailand Key Laboratory for Plant Diversity and Biogeography of East Asia Kunming Institute of BotanyChinese Academy of ScienceKunming 650201YunnanPeople’s Republic of China Department of Botany and microbiology College of ScienceKing Saud UniversityP.O.Box:2455Riyadh 1145Saudi Arabia Department of Botany and microbiology Faculty of ScienceSohag UniversitySohag 82524Egypt ALVALAB C/La Rochela nº47E-39012 SantanderSpain micolab Programa de Pós-Graduação em Biologia de FungosAlgas e PlantasDepartamento de BotânicaUniversidade Federal de Santa CatarinaCampus Universitário TrindadeCEP:88040-900 FlorianópolisSanta CatarinaBrazil Department of Biology University of WashingtonBox 351800SeattleWA 98195-1800USA Guizhou Key Laboratory of Agricultural Biotechnology Guizhou Academy of Agricultural SciencesGuiyang 550006GuizhouPeople’s Republic of China National Fungal Culture Collection of India(NFCCI) Biodiversity and Palaeobiology GroupMACS’Agharkar Research InstituteG.G.Agarkar RoadPune 411004India PO Box 116 HusumWA 98623-0116USA Formerly Department of BotanyGoa UniversityGoaIndia No.128/1-J Azad Housing SocietyCurcaP.O.Goa Velha 403108India *** 345 Shipwatch LaneHerculesCA 94547USA microbe Interaction Laboratory(BmIT) BIOTECNational Science and Technology Development Agency(NSTDA)113 Thailand Science ParkThanon PhahonyothinTombon Khlong NuengAmphoeKhlong LuangPathum Thani 12120Thailand Academy of Biology and Biotechnology Southern Federal UniversityRostov-on-Don 344090Rostov regionRussia A.m.B.Gruppo micologico Forlivese BAntonio“Cicognani” Via Roma Forlì Italy 18 A.M.B.Circolo Micologico“Giovanni Carini”C.P.314BresciaItaly Societàper gli Studi Naturalistici della Romagna C.P.144Bagnacavallo

Notes on 113 fungal taxa are compiled in this paper,including 11 new genera,89 new species,one new subspecies,three new combinations and seven reference *** geographic and taxonomic range of fungal taxa are *** the Ascomycota the new genera Angustospora(Testudinaceae),Camporesia(Xylariaceae),Clematidis,Crassiparies(Pleosporales genera incertae sedis),Farasanispora,Longiostiolum(Pleosporales genera incertae sedis),multilocularia(Parabambusicolaceae),Neophaeocryptopus(Dothideaceae),Parameliola(Pleosporales genera incertae sedis),and Towyspora(Lentitheciaceae)are *** introduced species are Angustospora nilensis,Aniptodera aquibella,Annulohypoxylon albidiscum,Astrocystis thailandica,Camporesia sambuci,Clematidis italica,Colletotrichum menispermi,***,Comoclathris pimpinellae,Crassiparies quadrisporus,Cytospora salicicola,Diatrype thailandica,Dothiorella rhamni,Durotheca macrostroma,Farasanispora avicenniae,Halorosellinia rhizophorae,Humicola koreana,Hypoxylon lilloi,Kirschsteiniothelia tectonae,Lindgomyces okinawaensis,Longiostiolum tectonae,Lophiostoma pseudoarmatisporum,moelleriella phukhiaoensis,***,mucoharknessia anthoxanthi,multilocularia bambusae,multiseptospora thysanolaenae,Neophaeocryptopus cytisi,Ocellularia arachchigei,***,Ochronectria thailandica,Ophiocordyceps karstii,Parameliola acaciae,***,Parastagonospora cumpignensis,Pseudodidymosphaeria phlei,Polyplosphaeria thailandica,Pseudolachnella brevifusiformis,Psiloglonium macrosporum,Rhabdodiscus albodenticulatus,Rosellinia chiangmaiensis,Saccothecium rubi,Seimatosporium pseudocornii,***,Sigarispora ononidis and Towyspora *** combinations are provided for Eutiarosporella dactylidis(sexual morph described and illus trated)and Pseudocamarosporium ***,illustrations and/or reference specimens are designated for Aposphaeria corallinolutea,Cryptovalsa ampelina,Dothiorella vidmadera,Ophiocordyceps formosana,P

关键词： Ascomycota Basidiomycota Neocallimastigomycota Oomycota.Zygomycota Phylogeny Taxonomy New genus New species

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