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Autoantibodies against beta cells to predict early insulin requirements in pediatric patients with clinically diagnosed type 2 diabetes

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World Journal of Diabetes 2024年第8期15卷 1717-1725页

作者： Jorge m molina Patricia G medina rita A Gomez Julia r Herrera Nancy L martínez Brenda Hernández Yesenia García Department of Endocrinology Children’s Hospital Federico GomezMexico 06720Mexico National medical Center"Siglo XXI" UMAE Hosp EspecialidadesUnidad Invest Med Epidemiol ClinMexican Social Security InstituteMexico 06720Mexico research Division UMAE Hospital de EspecialidadesCentro Médico Nacional Siglo XXIMexican Institute of Social SecurityMexico 06720Mexico Epidemiology research Unit in Endocrinology and Nutrition Federico Gómez Children’s HospitalMexico 06720Mexico Department of Endocrinology Comprehensive Health Unit for Trans PersonsMexico 11340Mexico

BACKGrOUND Autoimmunity has emerged as a probable disease modifier in patients with clinically diagnosed type 2 diabetes mellitus(T2Dm),that is,patients who have insulin resistance,obesity,and other cardiovascular risk factors,suggesting that the presence of glutamic acid decarboxylase(anti-GAD65),islet antigen 2(anti-IA2),and zinc transporter 8(anti-Zn8T)antibodies could have deleterious effects on beta cell function,causing failure and earlier requirement for insulin *** To evaluate anti-GAD65,anti-IA2 and anti-Zn8T as predictors of early insulin requirement in adolescents with a clinical diagnosis of *** This was a case–control study in patients with clinically diagnosed with T2Dm(68 cases and 64 controls with and without early insulin dependence respectively),male and female,aged 12–18 ***,blood pressure,glucose,insulin,C-peptide,glycated hemoglobin A1c,and lipid profiles were *** was used to measure anti-GAD65,anti-IA2,and anti-Zn8T *** statistics,Pearson'sχ2 test,Student's t test,and logistic regression was performed.Pred statistically *** There were 132 patients(53.8%female),with a mean age was 15.9±1.3 years,and there was a disease evolution time of 4.49±0.88 *** presence of anti-GAD65,anti-IA2,and anti-Zn8T positivity was found in 29.5%,18.2%,and 15.9%,*** the groups by early or no insulin dependence showed that the group with insulin had a higher frequency of antibody positivity:anti-GAD65 odds ratio(Or):2.42(1.112–5.303,P=0.026);anti-IA2:Or:1.55(0.859–2.818,P=0.105);and anti-Zn8T:Or:7.32(2.039–26.279,P=0.002).CONCLUSION Anti-GAD65 positivity was high in our ***-GAD65 and anti-Zn8T positivity showed a significantly depleted beta cell reserve phenotype,leading to an increased risk of early insulin dependence.

关键词： Diabetes Obesity Adolescents Autoimmunity Beta cell Insulin requirements

Surface activation of viscose textiles via air,argon,and oxygen dielectric barrier discharge plasma:influence of peak voltage

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Plasma Science and Technology 2024年第7期26卷 134-147页

作者： Shrouk ELASHrY Usama m.rASHED mostafa A.WAHBA Hend m.AHmED Nabil m.ELSIrAGY Plasma Laboratory Physics DepartmentFaculty of scienceTanta UniversityTanta 31527Egypt Physics Department Faculty of Science(Male)Al-Azhar UniversityCairo 11651Egypt Textile research Industrial Division National Research CentreDokkiGiza 12622Egypt

This paper discusses the use of atmospheric pressure dielectric barrier discharge(DBD)plasma treatment to enhance the surface qualities of viscose *** study explores the effects of different plasma gases,discharge voltages,and exposure times on the treated *** findings emphasize the importance of optimizing the plasma's peak voltage to achieve the desired surface treatment *** document also presents data on colour strength,wettability,colour fastness,and tensile strength of the treated fabrics,as well as scanning electron microscopy(SEm)analysis of surface morphology and chemical analysis using fouriertransition infrared spectroscopy(FTIr)and energy dispersive X-ray(EDX).The results show that treatment at a peak voltage of 11.83 k V is more efficient,except for the tensile strength which is enhanced at a peak voltage of 8.92 k *** oxygen plasma treatment significantly improves the colour strength,which exhibits an increase from 11 to *** intensified colour was attributed to the significant influence of electrostatic interactions between the charged hydroxyl groups of the oxygen plasma treated viscose textiles and the dye molecules,which enhance the *** oxygen DBD plasma exhibits a higher ability to enhance the properties of textiles when compared to air and argon *** study presents a sustainable,economical,secure,and ecologically friendly approach to explore new fabrics for specific uses.

关键词： Lissajous diagrams printability wettability tensile strength SEm EDX FTIr

Classification of Conversational Sentences Using an Ensemble Pre-Trained Language model with the Fine-Tuned Parameter

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Computers, materials & Continua 2024年第2期78卷 1669-1686页

作者： r.Sujatha K.Nimala Department of Networking and Communications SRM Institute of Science and TechnologyKattankulathurChengalpattuTamilnadu603203India

Sentence classification is the process of categorizing a sentence based on the context of the *** categorization requires more semantic highlights than other tasks,such as dependence parsing,which requires more syntactic *** existing strategies focus on the general semantics of a conversation without involving the context of the sentence,recognizing the progress and comparing *** ensemble pre-trained language model was taken up here to classify the conversation sentences from the conversation *** conversational sentences are classified into four categories:information,question,directive,and *** classification label sequences are for analyzing the conversation progress and predicting the pecking order of the *** of Bidirectional Encoder for representation of Transformer(BErT),robustly Optimized BErT pretraining Approach(roBErTa),Generative Pre-Trained Transformer(GPT),DistilBErT and Generalized Autoregressive Pretraining for Language Understanding(XLNet)models are trained on conversation corpus with *** tuning approach is carried out for better performance on sentence *** Ensemble of Pre-trained Language models with a Hyperparameter Tuning(EPLm-HT)system is trained on an annotated conversation *** proposed approach outperformed compared to the base BErT,GPT,DistilBErT and XLNet transformer *** proposed ensemble model with the fine-tuned parameters achieved an F1_score of 0.88.

关键词： Bidirectional encoder for representation of transformer conversation ensemble model fine-tuning generalized autoregressive pretraining for language understanding generative pre-trained transformer hyperparameter tuning natural language processing robustly optimized BErT pretraining approach sentence classification transformer models

modified Black Widow Optimization-Based Enhanced Threshold Energy Detection Technique for Spectrum Sensing in Cognitive radio Networks

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Computer modeling in Engineering & Sciences 2024年第3期138卷 2339-2356页

作者： r.Saravanan r.muthaiah A.rajesh School of Computing SASTRA Deemed UniversityThanjavur613401India School of Electrical&Electronics Engineering SASTRA Deemed UniversityThanjavur613401India

This study develops an Enhanced Threshold Based Energy Detection approach(ETBED)for spectrum sensing in a cognitive radio *** threshold identification method is implemented in the received signal at the secondary user based on the square *** proposed method is implemented with the signal transmission of multiple outputs-orthogonal frequency division ***,the proposed method is considered the dynamic detection threshold adjustments and energy identification spectrum sensing technique in cognitive radio *** the dynamic threshold,the signal ratio-based threshold is *** threshold is computed by considering the modified Black Widow Optimization Algorithm(mBWO).So,the proposed methodology is a combination of dynamic threshold detection and *** general threshold-based detection technique has different limitations such as the inability optimal signal threshold for determining the presence of the primary user *** limitations undermine the sensing accuracy of the energy identification ***,the ETBED technique is developed to enhance the energy efficiency of cognitive radio *** projected approach is executed and analyzed with performance and comparison *** proposed method is contrasted with the conventional techniques of theWhale Optimization Algorithm(WOA)and GreyWolf Optimization(GWO).It indicated superior results,achieving a high average throughput of 2.2 mbps and an energy efficiency of 3.8,outperforming conventional techniques.

关键词： Cognitive radio network spectrum sensing noise uncertainty modified black widow optimization algorithm energy detection technique

Logical Image Acquisition and Analysis of Android Smartphones

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Journal of Computer and Communications 2024年第4期12卷 139-152页

作者： Nursel Yalçın Tayfun Yıldırım Department of Computer and Instructional Technologies Education Faculty of Education Gazi University Ankara T&#252rkiye Department of Computer Forensics Institute of Informatics Gazi University Ankara T&#252rkiye

Android smartphones largely dominate the smartphone market. For this reason, it is very important to examine these smartphones in terms of digital forensics since they are often used as evidence in trials. It is possible to acquire a physical or logical image of these devices. Acquiring physical and logical images has advantages and disadvantages compared to each other. Creating the logical image is done at the file system level. Analysis can be made on this logical image. Both logical image acquisition and analysis of the image can be done by software tools. In this study, the differences between logical image and physical image acquisition in Android smartphones, their advantages and disadvantages compared to each other, the difficulties that may be encountered in obtaining physical images, which type of image contributes to obtaining more useful and effective data, which one should be preferred for different conditions, and the benefits of having root authority are discussed. The practice of getting the logical image of the Android smartphones and making an analysis on the image is also included. Although root privileges are not required for logical image acquisition, it has been observed that very limited data will be obtained with the logical image created without root privileges. Nevertheless, logical image acquisition has advantages too against physical image acquisition.

关键词： Android Smartphone Forensics Data Acquisition Data Analysis root Privileges Digital Forensics

Unsteady mHD Casson Nanofluid Flow Past an Exponentially Accelerated Vertical Plate:An Analytical Strategy

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Computer modeling in Engineering & Sciences 2024年第7期140卷 431-460页

作者： T.Aghalya r.Tamizharasi Department of mathematics School of Advanced SciencesVellore Institute of TechnologyVelloreTamilnadu632014India

In this study,the characteristics of heat transfer on an unsteady magnetohydrodynamic(mHD)Casson nanofluid over an exponentially accelerated vertical porous plate with rotating effects were *** flow was driven by the combined effects of the magnetic field,heat radiation,heat source/sink and chemical *** oxide(CuO)and titanium oxide(TiO2)are acknowledged as nanoparticle *** nondimensional governing equations were subjected to the Laplace transformation technique to derive closed-form *** representations are provided to analyze how changes in physical parameters,such as the magnetic field,heat radiation,heat source/sink and chemical reaction,affect the velocity,temperature and concentration *** computed values of skin friction,heat and mass transfer rates at the surface were tabulated for various sets of input *** is perceived that there is a drop in temperature due to the rise in the heat source/sink and the Prandtl *** should be noted that a boost in the thermal radiation parameter prompts an increase in *** increase in the Prandtl number,heat source/sink parameter,time and a decrease in the thermal radiation parameter result in an increase in theNusselt *** computed values of the skin friction,heat andmass transfer rates at the surface were tabulated for various values of the flow *** present results were compared with those of previously published studies andwere found to be in excellent *** research has practical applications in areas such as drug delivery,thermal medicine and cancer treatment.

关键词： Thermal radiation radiative flux nanofluid copper oxide titanium oxide accelerated plate

Storylines of family medicine Ⅴ:ways of thinking—honing the therapeutic self

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Family medicine and Community Health 2024年第S3期12卷 43-51页

作者： William B Ventres Leslie A Stone Johanna F Shapiro Cynthia Haq Jéssica r B Leao Donald E Nease Jr Liz Grant Stewart W mercer John C m Gillies Pablo González Blasco maria Auxiliadora C De Benedetto Graziela moreto marcelo r Levites Jennifer E DeVoe William r Phillips Jane m Uygur Thomas r Egnew Colette S Stanley Family and Preventive medicine University of Arkansas for Medical Sciences College of MedicineLittle RockArkansasUSA Family medicine University of California Irvine School of MedicineIrvineCaliforniaUSA Faculty of medicine University of Sao PauloSao PauloBrazil Family medicine University of Colorado Anschutz Medical Campus School of MedicineAuroraColoradoUSA Usher Institute Edinburgh Medical SchoolUniversity of EdinburghEdinburghUK SOBrAmFA-medical Education and Humanism Sao PauloBrazil Family medicine Oregon Health&Science University School of MedicinePortlandOregonUSA Family medicine University of Washington School of MedicineSeattleWashingtonUSA General Practice Royal College of Surgeons in IrelandDublinIreland General Internal medicine Geriatrics&Palliative MedicineTulane University School of MedicineNew OrleansLouisianaUSA

Storylines of Family medicine is a 12-part series of thematically linked essays with accompanying illustrations that explore the many dimensions of family medicine,as interpreted by individual family physicians and medical educators in the USA and elsewhere around the ***‘Ⅴ:ways of thinking—honing the therapeutic self’,authors present the following sections:‘reflective practice in action’,‘The doctor as drug—Balint groups’,‘Cultivating compassion’,‘Towards a humanistic approach to doctoring’,‘Intimacy in family medicine’,‘The many faces of suffering’,‘Transcending suffering’and‘The power of listening to stories.’may readers feel a deeper sense of their own therapeutic agency by reflecting on these essays.

关键词： illustration dimensions suffering

Classifying moisture sources associated with snowfall in the mountains of Lesotho

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Journal of mountain Science 2024年第6期21卷 1941-1953页

作者： Alexi m.mArINAKI Jennifer m.FITCHETT School of Geography Archaeology and Environmental StudiesUniversity of the WitwatersrandPrivate Bag X3Wits 2050South Africa

An average of eight snowfall events occur each year in the eastern Lesotho *** snowfall events are typically associated with cut-off low(CoLs)systems and mid-latitude ***,the moisture sources of the snowfall are unclassified and *** Hybrid Single-Particle Lagrangian Integrated Trajectory(HYSPLIT)model,an air mass back trajectory model,has been used to evaluate moisture source waters locally in southern Africa and internationally in China and *** study uses HYSPLIT to determine the source moisture of snow in Lesotho.A list of all 82 snowfall events in Lesotho spanning 2017 to 2022 was compiled using the Snow report SA Instagram page,including the date and location of snowfall.A 72-hour back trajectory for each snowfall event was initiated for both Afriski and the whole of *** amounts to models of moisture source trajectories for 28 and 82 snowfall days,*** air mass pathways are classified according to their frequency per snowfall event,per month in the snow season,per year and for the full *** this,associated moisture source regions and dominant air mass trajectories were *** study reports that the air mass trajectories associated with Afriski and Lesotho as a whole are very *** most common pathway of air mass trajectories transporting snow-bearing moisture to Lesotho was an inland trajectory from the northern regions of southern *** pathway makes up 16.6%of all trajectories reported and is associated with the Angola Low,the Congo Air Boundary and the *** High Pressure.

关键词： Eastern Lesotho Highlands Afriski Snow Cut-off Lows HYSPLIT Synoptic Climatology

An Efficient modelling of Oversampling with Optimal Deep Learning Enabled Anomaly Detection in Streaming Data

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China Communications 2024年第5期21卷 249-260页

作者： r.rajakumar S.Sathiya Devi Srinivasa ramanujan Centre SASTRA Deemed UniversityKumbakonamTamil Nadu 612001India University College of Engineering BIT CampusAnna UniversityTiruchirappalli 620024India

recently,anomaly detection(AD)in streaming data gained significant attention among research communities due to its applicability in finance,business,healthcare,education,*** recent developments of deep learning(DL)models find helpful in the detection and classification of *** article designs an oversampling with an optimal deep learning-based streaming data classification(OS-ODLSDC)*** aim of the OSODLSDC model is to recognize and classify the presence of anomalies in the streaming *** proposed OS-ODLSDC model initially undergoes preprocessing *** streaming data is unbalanced,support vector machine(SVm)-Synthetic minority Over-sampling Technique(SVm-SmOTE)is applied for oversampling ***,the OS-ODLSDC model employs bidirectional long short-term memory(Bi LSTm)for AD and ***,the root means square propagation(rmSProp)optimizer is applied for optimal hyperparameter tuning of the Bi LSTm *** ensuring the promising performance of the OS-ODLSDC model,a wide-ranging experimental analysis is performed using three benchmark datasets such as CICIDS 2018,KDD-Cup 1999,and NSL-KDD datasets.

关键词： anomaly detection deep learning hyperparameter optimization oversampling SmOTE streaming data