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Heterogeneity of mature oligodendrocytes in the central nervous system

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Neural regeneration research 2025年第5期20卷 1336-1349页

作者： Chao Weng Adam m.r.Groh moein Yaqubi Qiao-Ling Cui Jo Anne Stratton G.r.Wayne moore Jack P.Antel Neuroimmunology Unit Montreal Neurological Institute-HospitalDepartment of Neurology and NeurosurgeryMcGill UniversityMontrealQCCanada Department of Neurology Renmin Hospital of Wuhan UniversityWuhanHubei ProvinceChina

mature oligodendrocytes form myelin sheaths that are crucial for the insulation of axons and efficient signal transmission in the central nervous *** evidence has challenged the classical view of the functionally static mature oligodendrocyte and revealed a gamut of dynamic functions such as the ability to modulate neuronal circuitry and provide metabolic support to *** the recognition of potential heterogeneity in mature oligodendrocyte function,a comprehensive summary of mature oligodendrocyte diversity is *** delve into early 20th-century studies by robertson and río-Hortega that laid the foundation for the modern identification of regional and morphological heterogeneity in mature ***,recent morphologic and functional studies call into question the long-assumed homogeneity of mature oligodendrocyte function through the identification of distinct subtypes with varying myelination ***,modern molecular investigations,employing techniques such as single cell/nucleus rNA sequencing,consistently unveil at least six mature oligodendrocyte subpopulations in the human central nervous system that are highly transcriptomically diverse and vary with central nervous system *** and disease related mature oligodendrocyte variation denotes the impact of pathological conditions such as multiple sclerosis,Alzheimer's disease,and psychiatric ***,caution is warranted when subclassifying mature oligodendrocytes because of the simplification needed to make conclusions about cell identity from temporally confined *** studies leveraging advanced techniques like spatial transcriptomics and single-cell proteomics promise a more nuanced understanding of mature oligodendrocyte *** research avenues that precisely evaluate mature oligodendrocyte heterogeneity with care to understand the mitigating influence of species,sex,central nervous system region,age,and disease,

关键词： aging central nervous system diseases electron microscopy heterogeneity immunohistochemistry myelin sheath natural history neuroglia oligodendroglia single-cell gene expression analysis

Coarse to Fine: The role of Severe Plastic Deformation in Advancing Titanium-Based medical Implants - A Comprehensive review

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Journal of Wuhan University of Technology(materials Science) 2025年第1期40卷 295-306页

作者： Dragana r mihajlović Bojan I međo Ivana Lj Cvijović-Alagić Veljko r Djokić Faculty of Technology and metallurgy University of BelgradeKarnegijeva 411120 BelgradeSerbia Vinča Institute of Nuclear Sci-ences-National Institute of the republic of Serbia University of Belgrade11001BeogradSerbia Innovation Centre of the Faculty of Technology and metallurgy Karnegijeva 411120 BelgradeSerbia

This paper describes severe plastic deformation(SPD)procedures,which are utilized to form an ultrafine-grained structure in metallic *** the SPD process,a solid material sample is subjected to very high loads without a significant change in sample *** the present work,the high-pressure torsion(HPT)process,as one of the SPD techniques,which achieves a high degree of deformation and ensures refinement of the microstructure,will be discussed in more *** that grain size control is accepted as a method to obtain materials with desired characteristics,an overview of the properties of ultrafine-grained titanium-based biomaterials to be used in medicine is ***,particular attention is dedicated to the influences of HPT process parameters,primarily hydrostatic pressure,and number of revolutions during torsion,on the grain size and physical and mechanical characteristics(modulus of elasticity,microhardness,and tensile properties),corrosion resistance,and biocompatibility of the titanium-based biomaterials.A review of the literature indicates that titanium-based materials obtained by the SPD process show improved mechanical and physical properties without losing biocompatibility and corrosion resistance,which suggests that these methods of obtaining implants are something that should be further developed in the future.

关键词： high-pressure torsion process ultrafine-grained titanium-based materials electrochemical anodization physical properties mechanical properties

Emerging potential of progranulin-dependent SorCS2 signaling in healthy and diseased nervous systems

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Neural regeneration research 2025年第9期20卷 2591-2593页

作者： Alena Salasova Anders Nykjær Danish research Institute of Translational Neuroscience DANDrITE-Nordic EmBL Partnership for molecular medicine and Centre of Excellence PROMEMODepartment of BiomedicineAarhus UniversityAarhusDenmark

The formation of the mammalian nervous system and its maturation into sensory,motor,cognitive,and behavioral circuits is a complex process that begins during early embryogenesis and lasts until young *** neurodevelopm... 详细信息

关键词： progr jointly CS2

Selecting proper sites for underground dam construction using multi-Attribute Utility Theory in arid and semi-arid regions

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Journal of mountain Science 2023年第1期20卷 197-208页

作者： mohammad Hassan SADEGHIrAVESH Hassan KHOSrAVI Azam abolhasani Department of Environment College of AgricultureTakestan BranchIslamic Azad UniversityTakestanIran Department of reclamation of Arid and mountainous regions Faculty of Natural ResourcesUniversity of TehranTehranIran

Although the construction of underground dams is one of the best methods to conserve water resources in arid and semi-arid regions,applying efficient methods for the selection of suitable sites for subsurface dam construction remains a *** to the costly and time-consuming methods of site selection for underground dam construction,this study aimed to present a new method using geographic information systems techniques and decision-making *** exclusionary criteria including fault,slope,hypsometry,land use,soil,stream,geology,and chemical properties of groundwater were selected for site selection of dam construction and inappropriate regions were omitted by integration and scoring layers in ArcGIS based on the Boolean ***,appropriate sites were prioritized using the multi-Attribute Utility *** to the results of the utility coefficient,seven sites were selected as the region for underground dam construction based on all criteria and experts’*** site of Nazarabad dam was the best location for underground dam construction with a utility coefficient of 0.7137 followed by sites of Akhavan with a utility coefficient of 0.4633 and mirshamsi with a utility coefficient of *** study proposed a new approach for the construction of the subsurface dam at the proper site and help managers and decision-makers achieve sustainable water resources with limited facilities and capital and avoid wasting national capital.

关键词： Prioritization Geographic information system multi-Attribute decision making Arid region

Effects of oil contamination and bioremediation on geotechnical properties of highly plastic clayey soil

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Journal of rock mechanics and Geotechnical Engineering 2021年第3期13卷 653-670页

作者： Araz Salimnezhad Hossein Soltani-Jigheh Ali abolhasani Soorki Department of Civil Engineering Ozyegin UniversityCekmekoyIstanbul34794Turkey Department of Civil Engineering Azarbaijan Shahid Madani UniversityTabrizIran ACECr-research Institute of Applied Sciences Shahid Beheshti UniversityTehranIran

Leakage of oil and its derivatives into the soil can change the engineering behavior of soil as well as cause environmental ***,recovering the contaminated sites into their natural condition and making contaminated materials as both environmentally and geotechnically suitable construction materials need the employment of remediation ***,as an efficient,low cost and environmentalfriendly approach,was used in the case of highly plastic clayey *** better understand the change in geotechnical properties of highly plastic fine-grained soil due to crude oil contamination and bioremediation,Atterberg limits,compaction,unconfined compression,direct shear,and consolidation tests were conducted on natural,contaminated,and bioremediated soil samples to investigate the effects of contamination and remediation on fine-grained soil *** contamination reduced maximum dry density(mDD),optimum moisture content(OmC),unconfined compressive strength(UCS),shear strength,swelling pressure,and coefficient of consolidation of *** addition,contamination increased the compression and swelling indices and compressibility of *** reduced soil contamination by about 50%.moreover,in comparison with contaminated soil,bioremediation reduced the mDD,UCS,swelling index,free swelling and swelling pressure of soil,and also increased OmC,shear strength,cohesion,internal friction angle,failure strain,porosity,compression index,and *** analyses showed that oil contamination does not alter the soil structure in terms of chemical compounds,elements,and constituent *** it decreased the specific surface area of the soil,and the bioremediation significantly increased the mentioned *** resulted in the formation of quasi-fibrous textures and porous and agglomerated *** a result,oil contamination affected the mechanical properties of soil negatively,but bioremediation improved thes

关键词： Oil contamination Bioremediation Geotechnical properties Clay mineralogy Soil microstructure Highly plastic soil Fine-grained clayey soil marl

Security Strategy of Digital medical Contents Based on Blockchain in Generative AI model

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Computers, materials & Continua 2025年第1期82卷 259-278页

作者： Hoon Ko marek r.Ogiela Division of Computer Science and Engineering Sunmoon UniversityAsan31460Republic of Korea AGH University of Krakow Cryptography and Cognitive Informatics LaboratoryKrakow30-059Poland

This study presents an innovative approach to enhancing the security of visual medical data in the generative AI environment through the integration of blockchain *** combining the strengths of blockchain and generative AI,the research team aimed to address the timely challenge of safeguarding visual medical *** participating researchers conducted a comprehensive analysis,examining the vulnerabilities of medical AI services,personal information protection issues,and overall security *** multi faceted exploration led to an indepth evaluation of the model’s performance and ***,the correlation between accuracy,detection rate,and error rate was *** analysis revealed insights into the model’s strengths and limitations,while the consideration of standard deviation shed light on the model’s stability and performance *** study proposed practical improvements,emphasizing the reduction of false negatives to enhance detection rate and leveraging blockchain technology to ensure visual data integrity in medical *** blockchain to generative AI-created medical content addresses key personal information protection *** utilizing the distributed ledger system of blockchain,the research team aimed to protect the privacy and integrity of medical data especially medical *** approach not only enhances security but also enables transparent and tamperproof ***,the use of generative AI models ensures the creation of novel medical content without compromising personal information,further safeguarding patient *** conclusion,this study showcases the potential of blockchain-based solutions in the medical field,particularly in securing sensitive medical data and protecting patient *** proposed approach,combining blockchain and generative AI,offers a promising direction toward more robust and secure medical content *** research and advancements

关键词： Digitalmedical content medical diagnostic visualization security analysis generativeAI blockchain vulnerability pattern recognition

Neurogenesis dynamics in the olfactory bulb:deciphering circuitry organization, function, and adaptive plasticity

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Neural regeneration research 2025年第6期20卷 1565-1581页

作者： moawiah m.Naffaa Department of Psychology and Neuroscience Duke UniversityDurhamNCUSA Department of Cell Biology Duke University School of MedicineDurhamNCUSA

Adult neurogenesis persists after birth in the subventricular zone, with new neurons migrating to the granule cell layer and glomerular layers of the olfactory bulb, where they integrate into existing circuitry as inhibitory interneurons. The generation of these new neurons in the olfactory bulb supports both structural and functional plasticity, aiding in circuit remodeling triggered by memory and learning processes. However, the presence of these neurons, coupled with the cellular diversity within the olfactory bulb, presents an ongoing challenge in understanding its network organization and function. moreover,the continuous integration of new neurons in the olfactory bulb plays a pivotal role in regulating olfactory information processing. This adaptive process responds to changes in epithelial composition and contributes to the formation of olfactory memories by modulating cellular connectivity within the olfactory bulb and interacting intricately with higher-order brain regions. The role of adult neurogenesis in olfactory bulb functions remains a topic of debate. Nevertheless, the functionality of the olfactory bulb is intricately linked to the organization of granule cells around mitral and tufted cells. This organizational pattern significantly impacts output, network behavior, and synaptic plasticity, which are crucial for olfactory perception and memory. Additionally, this organization is further shaped by axon terminals originating from cortical and subcortical regions. Despite the crucial role of olfactory bulb in brain functions and behaviors related to olfaction, these complex and highly interconnected processes have not been comprehensively studied as a whole. Therefore, this manuscript aims to discuss our current understanding and explore how neural plasticity and olfactory neurogenesis contribute to enhancing the adaptability of the olfactory system. These mechanisms are thought to support olfactory learning and memory, potentially through increased

关键词： network adaptability neurogenesis neuronal communication olfactory bulb olfactory learning olfactory memory synaptic plasticity

Antisense oligonucleotides provide optimism to the therapeutic landscape for tauopathies

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Neural regeneration research 2025年第3期20卷 803-804页

作者： Glenn A.Harris Lauren r.Hirschfeld rainwater Charitable Foundation Fort WorthTXUSA

Tauopathies are a group of neurodegenerative diseases characterized by abnormal metabolism of the misfolded tau protein. Tau is encoded by the microtubule-associated protein tau gene(mAPT) and can be classified as either 3-repeat(3r) or 4-repeat(4r) based on the number of repeat domains from alternative splicing of exon 10 of the mAPT gene.

关键词： tau metabolism diseases

mitochondria–cGAS–STING axis is a potential therapeutic target for senescence-dependent inflammaging-associated neurodegeneration

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Neural regeneration research 2025年第3期20卷 805-807页

作者： Josém.Izquierdo Centro de Biología molecular Severo Ochoa(CBm) Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid(CSIC-UAM)MadridSpain

The word “senescence” comes from the Latin senescens, meaning “to begin to age”, and is characterized by a long-lasting but reversible block in proliferation, resulting from stress-induced cell cycle arrest of pre... 详细信息

关键词： Latin potential lasting