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Cardiac implications in myasthenia gravis

World Journal of Clinical Cases 2024年第26期12卷 5863-5867页

作者： praveen reddy Elmati Gowthami Sai Kogilathota Jagirdhar Salim Surani Department of Anesthesiology Saint Clair HospitalDoverNJ 07801United States Department of medicine Saint Michaels Medical CenterNewarkNJ 07107United States Department of medicine and Pharmacology Texas A&M UniversityCollege StationTX 77843United States

This editorial aimed to consolidate the current evidence in literature on the association between myasthenia gravis(mG)and cardiac involvement,focusing on the impact of thymoma,antistriational antibodies,and late-onset ***,the study aimed to explore the influence of genetic differences among populations on the association with cardiac *** conducted a review of existing literature in Pubmed and Google Scholar to find relevant studies on cardiac involvement in *** created search criteria using a combination of free text words,including mG,antistriational antibodies,thymectomy,cardiomyopathy,myocarditis,arrhythmias,autonomic *** articles published in English language were analyzed and *** findings indicate a strong association between thymoma,myasthenic crisis,antistriational antibodies,and late-onset mG with cardiac *** study also revealed that genetic differences among populations influence the risk of cardiac disease and electrocardiography(ECG)abnormalities in mG *** dysfunctions altered cardiac autonomic response and increased susceptibility to arrhythmias and sudden cardiac death in mG *** study supports the significance of thymoma,antistriational antibodies,and late-onset mG as key factors associated with cardiac involvement in mG *** emphasizes the importance of ECG as the initial test in managing mG patients,particularly in the perioperative period,to identify and genetic testing if needed to address their cardiac risk effectively.

关键词： myasthenia gravis Antistriational antibodies Thymectomy Cardiomyopathy myocarditis Arrhythmias Autonomic dysfunction

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remimazolam in intensive care unit:Potential applications and considerations

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World Journal of Critical Care medicine 2024年第3期13卷 25-31页

作者： praveen reddy Elmati Teja Nagaradona Gowthami Sai Kogilathota Jagirdhar Salim Surani Department of Anesthesiology Saint Clair HospitalDoverNJ 07801United States School of medicine St George UniversityGranada SW170BDWest Indies Department of medicine Saint Michaels Medical CenterNewarkNJ 07107United States Department of medicine&Pharmacology Texas A&M UniversityCollege StationTX 77843United States

This manuscript explores the potential use of remimazolam in the intensive care unit(ICU)and critical care units,considering its pharmacological characteristics,clinical applications,advantages,and comparative effectiveness over current sedatives and *** reviewed existing Pubmed and Google Scholar literature to find relevant studies on remimazolam in *** created search criteria using a combination of free text words,including remimazolam,critical care,intensive care,sedation,anesthesia,pharmacokinetics,and *** articles published in the English language were analyzed and *** is an ultra-short-acting benzodiazepine derivative promising for sedation and *** is a safer option for hemodynamically unstable,elderly,or liver or kidney *** also has comparable deep sedation properties to propofol in the ***,it reduces post-procedural delirium and patient comfort and reduces the need for additional sedatives in pediatric *** conclusion,remimazolam is an excellent alternative to current sedatives and anesthetics in the *** cost is comparable to that of current *** research on its long-term safety in the ICU and its broader application and incorporation into routine use is necessary.

关键词： remimazolam Intensive care Critical care Anesthesia Sedation mechanical ventilation Benzodiazepine

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An Efficient Sound and Data Steganography Based Secure Authentication System

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Computers, materials & Continua 2021年第4期67卷 723-751页

作者： Debajit Datta Lalit Garg Kathiravan Srinivasan Atsushi Inoue G.Thippa reddy m.praveen kum.r reddy K.ramesh Nidal Nasser School of Computer Science and Engineering Vellore Institute of Technology(VIT)Vellore632014India Faculty of Information and Communication Technology University of MaltaMsidaMSD2080Malta School of Information Technology and Engineering Vellore Institute of Technology(VIT)Vellore632014India Department of Information Systems&Business Analytics Eastern Washington UniversitySpokaneWA99202USA Department of Computer Science Karnataka State Akkamahadevi Women’s UniversityVijayapuraIndia College of Engineering Alfaisal UniversityRiyadh1153Saudi Arabia

The prodigious advancements in contemporary technologies have also brought in the situation of unprecedented ***,the pin-based security system is an inadequate mechanism for handling such a *** reason is that hackers use multiple strategies for evading security systems and thereby gaining access to private *** research proposes to deploy diverse approaches for authenticating and securing a connection amongst two devices/gadgets via sound,thereby disregarding the pins’manual ***,the results demonstrate that the proposed approaches outperform conventional pin-based authentication or Qr authentication ***,a random signal is encrypted,and then it is transformed into a wave file,after which it gets transmitted in a short burst via the device’s ***,the other device/gadget captures these audio bursts through its microphone and decrypts the audio signal for getting the essential data for ***,this model requires two devices/gadgets with speakers and a microphone,and no extra hardware such as a camera,for reading the Qr code is *** first module is tested with realtime data and generates high scores for the widely accepted accuracy metrics,including precision,recall,F1 score,entropy,and mutual information(mI).Additionally,this work also proposes a module helps in a secured transmission of sensitive data by encrypting it over images and other *** steganographic module includes two-stage encryption with two different encryption algorithms to transmit data by embedding inside a *** encryption algorithms and their combinations are taken for this system to compare the resultant file *** these systems engender high accuracies and provide secure connectivity,leading to a sustainable communication ecosystem.

关键词： Cyber-attacks signals privacy security organization encryption decryption authentication effective communication steganography

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Association of non-alcoholic fatty liver and metabolic-associated fatty liver with COVID-19 outcomes:A systematic review and metaanalysis

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World Journal of Gastroenterology 2023年第21期29卷 3362-3378页

作者： Gowthami Sai Kogilathota Jagirdhar rakhtan K Qasba Harsha Pattnaik Kaanthi rama Akshat Banga Shiva Teja reddy Anna Carolina Flumignan Bucharles rahul Kashyap praveen reddy Elmati Vikas Bansal Yatinder Bains Theodore DaCosta Salim Surani Department of medicine Saint Michaels Medical CenterNewarkNJ 07102United States Department of medicine Green Life Medical College and HospitalDhaka 1205Bangladesh Department of medicine Lady Hardinge Medical CollegeNew Delhi 110001India Department of medicine Gandhi Medical CollegeTelangana 500003India Department of medicine Sawai Man Singh Medical CollegeJaipur 302004RajistanIndia Department of medicine Universidade PositivoCuritiba 81290-000PRBrazil research WellSpan HealthYorkPA 17403United States Department of Interventional Pain medicine University of LouisvilleLouisvilleKY 40292United States Department of Internal medicine Mayo ClinicRochesterMN 55902United States Department of Gastroenterology Saint Michaels Medical CenterNewarkNJ 07102United States Department of medicine Texas A&M UniversityCollege StationTX 77843United States

BACKGrOUND Non-alcoholic fatty liver disease(NAFLD)and metabolic-associated fatty liver disease(mAFLD)are on the rise like any other liver disease,and tend to affect 25%of the United States *** impact of NAFLD and mAFLD on patients with coronavirus disease 2019(COVID-19)remains *** To identify the association of NAFLD and mAFLD with mortality,hospitalization,hospital length of stay,and supplemental oxygen utilization in COVID-19 *** A systematic review of literature on Cochrane,Embase,Pubmed,ScienceDirect,and Web of Science databases was conducted from January 2019 to July *** that evaluated NAFLD/mAFLD using laboratory methods,noninvasive imaging,or liver biopsy were *** study protocol was registered in PrOSPErO(ID CrD42022313259)and PrISmA guidelines were *** National Institutes of Health quality assessment tool was used to assess the quality of the *** analysis was conducted using software rev man version *** stability of the results was assessed using sensitivity *** Thirty-two studies with 43388 patients were included in the meta-analysis of whom 8538(20%)patients were observed to have *** were 42254 patients from 28 studies included in the mortality analysis.A total of 2008 patients died from COVID-19;837(10.52%)in the NAFLD group and 1171(3.41%)in the non-NAFLD *** odds ratio(Or)was 1.38 for mortality with a 95%confidence interval(95%CI)=0.97-1.95 and P=0.07.A total of 5043 patients from eight studies were included in the hospital length of stay *** were 1318 patients in the NAFLD group and 3725 patients in the non-NAFLD group.A qualitative synthesis showed that the mean difference in hospital length of stay was about 2 d between the NAFLD and non-NAFLD groups with a 95%CI=0.71-3.27 and P=*** hospitalization rates,the Or was 3.25 with a 95%CI of 1.73-6.10 and P=*** supplemental oxygen utilization,the Or was 2.04 with a 95%CI of 1.17-3.5

关键词： Non-alcoholic fatty liver Fatty liver Coronavirus COVID-19 metabolic-associated fatty liver

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