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Real-World Safety and Performance of Saline Nasal Spray Products for Nasal Cleansing and Reducing Obstruction of the Nasal Cavity

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Open Journal of Respiratory Diseases 2023年第4期13卷 65-79页

作者： mathieu m. Albasser Gary Smith mariane Ballerini Fernandes nisha Patel Petr Novak martina Hagen GSK Consumer Healthcare SARL a Haleon company Nyon Switzerland Haleon Weybridge Surrey UK GSK Kingston upon Thames London UK Haleon Prague Czech Republic

Background and Objectives: Three post-marketing clinical follow-up studies were performed in Europe to confirm the safety and performance of four nonprescription, nasal cleansing medical devices: Otrivin Sea Water (OSW) pressurized spray, OSW with aloe vera (OSWAV), Otrisal 0.74% NaCl metered-Dose Spray (mDS), and Prorhinel spray. material and methods: Observational, single-arm, retrospective studies consisting of a single online questionnaire were performed between July 2021 and December 2021. Eligible participants were adults who used the device or supervised use of the device in a participant under 18 years of age within 6 months of completing the questionnaire. Demographics, safety, and device performance were assessed. Results: Based on questionnaires submitted on OSW (n = 556), OSWAV (n = 555), Otrisal mDS (n = 555), and Prorhinel (n = 555), proportions of users who reported safety events were 1.8% for OSW, 2.3% for OSWAV, 1.4% for Otrisal mDS, and 2.0% for Prorhinel. Proportions of users who indicated they were satisfied or very satisfied with device performance ranged from 72.0% - 89.0% across all devices. Device performance for all products was also supported for additional preventative and symptomatic uses through exploratory analyses. Conclusions and Significance: These data confirm device safety and performance of OSW, OSWAV, Otrisal mDS, and Prorhinel for their intended uses.

关键词： Saline Solution Sodium Chloride Common Cold Allergens Postmarketing Product Surveillance

Jointly Optimized Spatial Histogram UNET Architecture(JOSHUA)for Adipose Tissue Segmentation

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Biomedical Engineering Frontiers 2022年第1期3卷 248-261页

作者： Joshua K.Peeples Julie F.Jameson nisha m.Kotta Jonathan m.Grasman Whitney L.Stoppe Alina Zare Department of Electrical and Computer Engineering University of FloridaGainesvilleFL 32611USA Department of Chemical Engineering University of FloridaGainesvilleFL 32611USA J.Crayton Pruitt Family Department of Biomedical Engineering University of FloridaGainesvilleFL 32611USA Department of Biomedical Engineering New Jersey Institute of TechnologyUniversity HeightsNewarkNJ 07102USA

*** aim to develop a machine learning algorithm to quantify adipose tissue deposition at surgical sites as a function of biomaterial *** *** our knowledge,this study is the first investigation to apply convolutional neural network(CNN)models to identify and segment adipose tissue in histological images from silk fibroin biomaterial *** designing biomaterials for the treatment of various soft tissue injuries and diseases,one must consider the extent of adipose tissue *** this work,we analyzed adipose tissue accumulation in histological images of sectioned silk fibroin-based biomaterials excised from rodents following subcutaneous implantation for 1,2,4,or 8 *** strategies for quantifying adipose tissue after biomaterial implantation are often tedious and prone to human bias during *** used CNN models with novel spatial histogram layer(s)that can more accurately identify and segment regions of adipose tissue in hematoxylin and eosin(H&E)and masson’s trichrome stained images,allowing for determination of the optimal biomaterial *** compared the method,Jointly Optimized Spatial Histogram UNET Architecture(JOSHUA),to the baseline UNET model and an extension of the baseline model,attention UNET,as well as to versions of the models with a supplemental attention-inspired mechanism(JOSHUA+and UNET+).*** inclusion of histogram layer(s)in our models shows improved performance through qualitative and quantitative *** results demonstrate that the proposed methods,JOSHUA and JOSHUA+,are highly beneficial for adipose tissue identification and *** new histological dataset and code used in our experiments are publicly available.

关键词： injuries implantation Spatial

Evaluation of Combined Effect of micronutrients (ZnSO₄ + Borax) and Fungicides to Control the Purple Blotch Complex of Onion (Allium cepa)

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American Journal of Plant Sciences 2016年第5期7卷 715-723页

作者： Hasan Ali Hosna Ara Chowdhury nisha md. Belal Hossain md. Rafiqul Islam Department of Plant Pathology Sher-e-Bangla Agricultural University Dhaka Bangladesh

Ten different treatments viz. T0 = Control, T1 = micronutrients (ZnSO4 + Borax), T2 = Rovral 50 WP + micronutrients, T3 = Dithane m-45 + micronutrients, T4 = Ridomil Gold + micronutrients, T5 = Cupravit + micronutrients, T6 = Rovral 50 WP, T7 = Dithane m-45, T8 = Ridomil Gold and T9 = Cupravit were evaluated against the purple blotch complex disease of onion caused by Alternaria porri and Stemphylium vesicarium in field condition for bulb yield. In lab condition, all the tested chemical fungicides (Rovral 50 WP, Dithane m-45, Ridomil Gold mZ-72 and Cupravit 50 WP) significantly reduced mycelial growth of both pathogens. Among the fungicides, Rovral 50 WP @ 0.2% reduced the highest radial mycelial growth followed by Dithane m-45 @ 0.45% and Ridomil Gold mZ-72 @ 0.2% compared to control. In field experiment, application of Rovral 50 WP @ 0.2% along with micronutrients showed significant effect in reducing disease incidence and severity which significantly increased bulb yield and yield contributing characters.

关键词： Onion Purple Blotch Complex micronutrients Fungicides

Immuno-contraceptive potential of sperm specific LDHC<sub>4</sub>and SPAm-1 (PH-20) sub units in dog

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Open Journal of Animal Sciences 2012年第4期2卷 265-280页

作者： Ranjna S. Cheema nisha Vashishat Amrit K. Bansal Gaurav Bakhri Vinod Kumar Gandotra Department of Veterinary Gynaecology and Obstetrics Guru Angad Dev Veterinary and Animal Sciences University Ludhiana India Department of Veterinary Gynaecology and Obstetrics Guru Angad Dev Veterinary and Animal Sciences University Ludhiana India Department of Zoology Punjab Agricultural University Ludhiana India Division of Biochemistry National Dairy Research Institute Karnal India

PH-20 (Spam-1) antigen appears to be a bi-functional sperm plasma membrane protein with hyaluronidase activity and its role is related to cumulus penetration as well as zona binding. (LDH-C4) is a key enzyme, distributed specifically in testis and is highly immunogenic, function of which relates to energy metabolism and capacitation of the sperm. Therefore, in this study, we observed the effect of purified native PH-20 and LDH-C4 antigens on sperm function and morphology in dog. Native PH-20 (46, 32 kDa) and LDH-C4 (36, 30, 28) sub units, purified from dog sperm SDS- extracts were used to test as immunocontraceptive candidates in stray dog. Dogs 1, 2, 3, 4, 5/6 and 7/8 were immunized with 46, 32, 36, 30/28, 46/32, 36/30/28 kDa sub units respectively by i/m route and semen was analysed at weekly intervals. High titre of 3200 - 6400 was achieved in all dogs after three boosters. Immune response in treated dogs was confirmed by increase in Ig level in blood serum and reaction of partially purified serum Ig of immunized dogs with respective antigens in double immune diffusion and immunoblots. Immunization of dogs either with individual PH-20/ LDHC sub units or pooled PH-20/LDHC4 sub units showed a significant effect on sperm count, percent motility, viability, HOST and sperm morphology. All the sperm parameters declined to a significant level (p mained low than that of the recommended values for fertile dog semen till 175 DPI. The incubation of spermatozoa in HOS solution in the presence of anti-PH-20 and anti-LDHC Ig significantly reduced the percent HOS positive spermatozoa. A significant decline (p ≤ 0.05) in acrylamide penetration assay was also observed in the presence of anti 46 and 30/28 kDa Ig. Since percent motility, sperm count, HOST and percent normal spermatozoa in immunized dogs were significantly less than that of recommended fertile dog semen, it can be concluded that PH-20 (46/32 kDa) and LDHC4 (36/30/28 kDa) sub units

关键词： Immunocontraception Dog Sperm LDHC4 PH-20

基于Worldview-3与Sentinel-1 SAR数据的草原矿区复垦植被生物量反演方法研究

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地学前缘 2021年第4期28卷 219-228页

作者：刘艳慧杨晓宇包妮沙顾晓薇东北大学资源与土木工程学院辽宁沈阳110819 中国地震局第二监测中心陕西西安710000 东北大学智慧水利与资源环境科技创新中心辽宁沈阳110819

利用多源遥感数据定量反演矿区复垦植被生物量是高效、动态、大面积监测土地复垦和生态恢复效果的必要手段之一。本文以内蒙古草原露天煤矿为研究区,联合遥感光学与雷达数据各自的优势,探索基于Worldview-3(WV-3)与Sentinel-1 SAR数据... 详细信息

利用多源遥感数据定量反演矿区复垦植被生物量是高效、动态、大面积监测土地复垦和生态恢复效果的必要手段之一。本文以内蒙古草原露天煤矿为研究区,联合遥感光学与雷达数据各自的优势,探索基于Worldview-3(WV-3)与Sentinel-1 SAR数据的矿区复垦植被生物量反演方法,选择主成分小波变换(W-PCA)算法对WV-3与Sentinel-1 SAR数据进行融合,揭示波段反射率、植被指数、后向散射系数及纹理特征等参数与生物量之间的相关关系,建立多变量的生物量反演模型,并分析不同生物量模型的空间不确定性。结果表明:(1)通过W-PCA算法得到融合后的图像,信息熵的提高反映了融合图像与光学WV-3图像相比具有更多的细节信息,平均梯度的提高反映了融合图像与Sentinel-1 SAR图像相比具有更高的清晰度和更丰富的纹理信息。融合后的第8波段相关系数最高、光谱扭曲度最低、光谱保真度最高。(2)通过相关性分析,发现增强型植被指数(EVI)、归一化植被指数(NDVI)、VH极化、VH均值纹理以及融合后第8波段与生物量显著正相关。WV-3的NDVI与Sentinel-1的VH mE建模精度(R 2=0.8340,RmSE=16.4646 g/m^(2),Ac=81.52%)最高,融合后的第8波段验证精度(R 2=0.7983,RmSE=22.8283 g/m^(2),Ac=74.64%)最高。(3)基于不同模型的残差不确定性分析,Sentinel-1 SAR数据变量建立的模型估测结果更容易出现高估及饱和现象,两者联合变量建立的模型可实现优势互补,利用融合数据建立的模型明显改善生物量小于40 g/m^(2)时的高估计现象以及生物量大于100 g/m^(2)时的两者饱和现象,其不确定性降低2.42~9.68 g/m^(2)。因此,利用光学和雷达遥感融合能够有效提高复垦植被生物量的估算精度,为草原矿区复垦植被精细监测提供有效的数据支持。

关键词：草原矿区复垦植被 Worldview-3 Sentinel-1 SAR 数据融合生物量反演

草原露天煤矿区土壤粒径分布及热红外辐射特征研究

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地理与地理信息科学 2018年第2期34卷 27-33页

作者：李诗朦包妮沙刘善军雷尚彬东北大学灾害遥感与数字矿山研究所辽宁沈阳110819 中交天津港航勘察设计研究院有限公司天津300456

土壤质地是矿区植被恢复及土地复垦的关键,该文选择土壤粒径作为反映矿区土壤质地的重要指标之一,以伊敏露天煤矿区域为研究区,通过分析原地貌围栏、放牧和矿区不同复垦年限土地利用下土壤粒径分布与发射率光谱的关系,探究不同土壤粒径... 详细信息

土壤质地是矿区植被恢复及土地复垦的关键,该文选择土壤粒径作为反映矿区土壤质地的重要指标之一,以伊敏露天煤矿区域为研究区,通过分析原地貌围栏、放牧和矿区不同复垦年限土地利用下土壤粒径分布与发射率光谱的关系,探究不同土壤粒径分布在热红外光谱的敏感波段,进而构建支持向量机模型,预测土壤粒径分布。结果表明:1)复垦土壤粗砂粒含量高,细砂粒含量低,且发射率低于原地貌土壤;2)土壤粗砂粒含量与土壤热红外发射率在8~13μm上呈显著负相关,粗粉粒含量和细砂粒含量分别在8.2~10.5μm波段和11~13μm波段与发射率呈显著正相关;3)采用径向核函数-支持向量机模型对土壤粒径分布进行预测,相比粗粉粒含量和细砂粒含量,粗砂粒预测精度最高(建模精度R2=0.91,RmSE=4.30%,RPD=3.28;验证精度R2=0.65,RmSE=7.71%,RPD=1.71)。研究结果为草原煤矿区利用热红外光谱技术预测土壤粒径分布提供了理论依据和技术支撑。

关键词：草原煤矿区复垦土壤土壤粒径热红外光谱支持向量机

基于无人机大样方草地植被覆盖度及生物量估算方法研究

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生态环境学报 2018年第11期27卷 2023-2032页

作者：刘艳慧蔡宗磊包妮沙刘善军东北大学测绘遥感与数字矿山研究所辽宁沈阳110819 吉林省水利水电勘测设计研究院吉林长春130012

为了探讨与分析无人机大样方估算草地植被覆盖度的可行性及植被覆盖度与生物量的相关性,利用大疆Phantom3Professiona无人机获取呼伦贝尔草甸草原60 m×60 m大样方数据,利用开关中值滤波及基于维纳滤波的小波变换对图像进行去噪处理,并... 详细信息

为了探讨与分析无人机大样方估算草地植被覆盖度的可行性及植被覆盖度与生物量的相关性,利用大疆Phantom3Professiona无人机获取呼伦贝尔草甸草原60 m×60 m大样方数据,利用开关中值滤波及基于维纳滤波的小波变换对图像进行去噪处理,并用直方图均衡化进行图像增强,构建过绿指数与颜色指数,根据最大熵原理,建立植被覆盖度与背景的双阈值目标函数,采用遗传算法寻找最佳分割阈值,从而估算草地植被覆盖度。结合野外同步实地照相法获取1 m×1 m样方数据,利用t检验及计算均方根误差验证基于无人机大样方估算草地植被覆盖度的精度。结果表明,利用过绿植被指数基于遗传算法的最大熵法估算无人机大样方草地植被覆盖度的精度较高(t检验P值为0.272,均方根误差为6.635 6);株高及覆盖度的交叉变量构建的拟合方程效果(R2为0.853 6,RmSE为2.442 0g·m-2,估算精度为83.41%)优于单一变量拟合方程。利用无人机数据及最大熵-遗传算法不仅可以快速、准确、高效地获取植被地面信息,同时也可以为遥感估算植被覆盖度提供地面验证,从而提高植被覆盖度估算模型的精度及模型验证的准确性。

关键词：草地植被覆盖度生物量无人机大样方最大熵法遗传算法

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1种小型污水处理填料生物转盘的设计与实验

水处理技术 2018年第12期44卷 101-103页

作者：张尊举金泥沙张仁志河北环境工程学院河北秦皇岛066102

以农村家庭为设计单元,研究设计了1种小型一体化污水处理装置——填料生物转盘。装置设计体积流量为0.5 m3/d,由进水区、生化反应区和沉淀区组成。装置采用生物膜法工艺,结合生物滤池和生物转盘的特点,设计填料生物转盘,结构紧凑、运行... 详细信息

以农村家庭为设计单元,研究设计了1种小型一体化污水处理装置——填料生物转盘。装置设计体积流量为0.5 m3/d,由进水区、生化反应区和沉淀区组成。装置采用生物膜法工艺,结合生物滤池和生物转盘的特点,设计填料生物转盘,结构紧凑、运行简单、费用少,避免了农村污水处理常见的问题。同时,实验研究表明,该装置运行稳定,对COD、BOD_5,SS、NH_3-N的去除效率均达到87%以上,处理后的出水水质能够达到河北省地方标准DB 13/2171-2015一级B的要求。

关键词：农村家庭污水处理装置填料生物转盘生物膜法

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气-固循环流化床换热器的传热性能与压降

化学工业与工程 2021年第3期38卷 36-48页

作者：姜峰韩妮莎齐国鹏王锦锦李修伦天津大学化工学院天津300072 天津职业大学生物与环境工程学院天津300410

为强化气相换热,将流化床换热防垢节能技术和气相换热过程相结合,设计并构建了一套气-固循环流化床换热装置。以空气和玻璃珠颗粒作为工质,利用热电阻和差压传感器,系统地考察了颗粒加入量、空气流量和热通量等操作参数对于其传热性能... 详细信息

为强化气相换热,将流化床换热防垢节能技术和气相换热过程相结合,设计并构建了一套气-固循环流化床换热装置。以空气和玻璃珠颗粒作为工质,利用热电阻和差压传感器,系统地考察了颗粒加入量、空气流量和热通量等操作参数对于其传热性能和压降的影响。研究结果表明,玻璃珠颗粒的加入可以明显地强化气相的传热。实验范围内,最大的传热增强因子为33.4%,所对应的操作参数为ε=1.5%,Vg=19.78 m3·h^(-1)和q=1 kW·m^(-2),相应的压降比率不超过2.5%。传热增强因子随颗粒加入量和空气流量的增加呈现出波动的趋势。空气流量较低时,传热增强因子随着热通量的增加而增大;随着空气流量的增加,热通量对传热增强因子的影响减小。构建了操作参数对传热性能和压降影响的三维图,以利于选择适宜的操作参数范围。研究结果有利于流化床换热防垢节能技术在气相换热过程中的应用。

关键词：强化传热气-固两相流循环流化床换热器压降