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Experimental evidence of obesity as a risk factor for severe acute pancreatitis

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World Journal of Gastroenterology 2009年第42期15卷 5260-5265页

作者： Jean-Louis Frossard Pierre Lescuyer Catherine m Pastor Service of Gastroenterology Geneva University HospitalsGeneva 1205Switzerland Laboratory of pathophysiology and molecular imaging Geneva University HospitalsGeneva 1205Switzerland Service of Genetics and Central Laboratory Geneva University HospitalsGeneva 1205Switzerland

The incidence of acute pancreatitis, an inflammation of the pancreas, is increasing worldwide. Pancreatic injury is mild in 80%-90% of patients who recover without complications. The remaining patients may develop a severe disease with local complications such as acinar cell necrosis, abscess and remote organ injury including lung injury. The early prediction of the severity of the disease is an important goal for physicians in management of patients with acute pancreatitis in order to optimize the therapy and to prevent organ dysfunction and local complications. For that purpose, multiple clinical scale scores have been applied to patients with acute pancreatitis. Recently, a new problem has emerged： the increased severity of the disease in obese patients. However, the mechanisms by which obesity increases the severity of acute pancreatitis are unclear. Several hypotheses have been suggested：（1） obese patients have an increased inflammation within the pancreas; （2） obese patients have an increased accumulation of fat within and around the pancreas where necrosis is often located; （3） increase in both peri- and intra-pancreatic fat and inflammatory cells explain the high incidence of pancreatic inflammation and necrosis in obese patients; （4） hepatic dysfunction associated with obesity might enhance the systemic inflammatory response by altering the detoxiflcation of inflammatory mediators; and （5） ventilation/perfusion mismatch leading to hypoxia associated with a low pancreatic flow might reduce the pancreatic oxygenation and further enhance pancreatic injury. Recent experimental investigations also show an increased mortality and morbidity in obese rodents with acute pancreatitis and the implication of the adipokines leptin and adiponectin. Such models are important to investigate whether the inflammatory response of the disease is enhanced by obesity. It is exciting to speculate that manipulation of the adipokine milieu has the potential to influence the severi

关键词： Acute pancreatitis Obesity Adiponectin leptin

Experimental Analysis of an Innovative High Efficiency Aluminium Billet Heater

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Journal of Iron and Steel Research International 2012年第S2期19卷 653-657页

作者： m.Bullo F.Dughiero m.Forzan m.Zerbetto lep Laboratory for ElectroheatDepartment of Industrial Engineering Università di Padova InovalabSrl

The paper presents the design procedure of a novel aluminum billet heater based upon the concept of inducing eddy-currents by rotating permanent magnets around a fixed *** industrial scale prototype has been realized following the directions of the described design procedure which is based upon numerical Finite Elements *** comparisons between the results of numerical models with experimental ones are also presented.

关键词： induction heating permanent magnet finite element method

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THE Z BOSON

Chinese Physics C 2016年第10期40卷 603-609页

作者： m.W. Griinewald A. Gurtu U. College Dublin and U. Ghent Formerly Tata Inst.

Precision measurements at the Z-boson resonance using electron-positron colliding beams began in 1989 at the SLC and at lep. During 1989-95, the four lep experiments （AlepH, DELPHI, L3, OPAL） made high-statistics studies of the production and decay properties of the Z. Although the SLD experiment at the SLC collected much lower statistics,

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ANOmALOUS W/Z QUARTIC COUPLINGS （QGCS）

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Chinese Physics C 2016年第10期40卷 602-603页

作者： m.W. Griinewald A. Gurtu U. College Dublin Formerly Tata Inst.

Quartic couplings, WWZZ, WWZγ WWγγ, and ZZγγ, were studied at lep and Tevatron at energies at which the Standard model predicts negligible contributions to multiboson production. Thus, to parametrize limits on these couplings, an effective theory approach is adopted which supplements the Standard model Lagrangian with higher dimensional operators which include quartic couplings. The lep collaborations chose the lowers dimensional representation of operators （dimension 6） which presumes the SU（2）xU（1） gauge symmetry is broken by means other than the conventional Higgs scalar doublet [1-3].

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Adoption of mating disruption for controlling the Grape berry moth,Endopiza viteana(Clemens)(lep.,Tortricidae) in Ontario,Canada

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Adoption of mating disruption for controlling the Grape berr...

Reversal of maternal obesity attenuates hypoxia and improves placental development in the preeclamptic-like BPH/5 mouse model

International Conference:Technology Transfer in Biological Control:From Research to Practice

作者： R.m.TRImBLE Pest management Research Centre Vineland Agriculture and Agri-Food CanadaVineland StationP.O.Box 6000OntarioL0R 2E0 Canada

The grape berry moth,Endopiza viteana(Clemens),is the most important insect pest of grapes in Eastern North *** the Niagara peninsula of Ontario,*** has three generations of actively feeding larvae per year. Traditionally,an average of three annual applications of organophosphorous insecticide have been used to control *** 1992,a sex pheromone-

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生物细胞(英文) 2023年第9期47卷 2051-2058页

作者： DANIELLA m.ADAmS KALIE F.BECKERS JULIET P.FLANAGAN VIVIANE C.L.GOmES CHIN-CHI LIU JENNY L.SONES Veterinary Clinical Sciences School of Veterinary MedicineLouisiana State UniversityBaton RougeLAUSA Pennington Biomedical Research Center Louisiana State UniversityBaton RougeLAUSA Small Animal Clinical Sciences College of Veterinary MedicineMichigan State UniversityEast LansingMIUSA

Background:Women with obesity have higher risk of adverse pregnancy outcomes,including preeclampsia(PE).Late-gestational hypertension,aberrant fetoplacental development,and fetal growth restriction(FGR),hallmarks of PE,are observed spontaneously in BPH/5 *** to obese preeclamptic women,BPH/5 mice have higher visceral white adipose tissue(WAT)and circulating *** hypothesized that attenuation of maternal obesity and serum.leptin in pregnant BPH/5 mice will improve fetoplacental development by decreasing hypoxia markers and leptin expression at the maternal-fetal ***:To test this hypothesis,BPH/5 mice were fed ad libitum(lib)and pair-fed(PF)to C57 ad lib controls beginning at embryonic day(e)***-related genes,hypoxia inducible factor(Hif)1α,stem cell factor(Scf),heme oxygenase-1(Ho-1),leptin(lep),and leptin receptor(lepR)were assessed in e7.5 implantation ***:BPH/5 ad lib had 1.5 to 2-fold increase in Hif1α,Scf,and Ho-1 mRNA and a greater than 3-fold increase in leptin mRNA vs.C57 that was attenuated with *** leptin promoted Hif1αand Ho-1 mRNA expression in e7.5 decidua in *** hypoxic conditions in vitro did not change decidual leptin ***,BPH/5 PF mice demonstrated improved fetal and placental outcomes later in gestation,with greater placental vascular area by e18.5 and attenuation of ***:In conclusion,pair-feeding BPH/5 mice beginning at conception may improve placental vasculature formation via decreased leptin and hypoxia-associated markers in this *** investigations are needed to better determine the effect of hypoxia and leptin on pregnancy outcomes in obese pregnant women.

关键词： Preeclampsia BPH/5 leptin Hypoxia

The Journal of the American Board of Family medicine论文摘要汇编——家庭医生提供在线诊疗服务的普遍程度和影响因素

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中国全科医学 2020年第7期23卷 848-848页

作者： PEABODY m R DAI m L TURNER K 本刊编辑部 From the American Board of Family medicine Lexington KY (MRP MD LEP) Department of Health Services Research Management and Policy University of Florida Gainesville FL (KT ARM) Department of Family and Community medicine University of Kentucky Lexington KY (LEP) Department of Family medicine and Community Health University of Florida Gainesville FL (AGM). mpeabody@***. Department of Family medicine and Community Health University of Florida Gainesville FL (AGM).

目的近年来,远程医疗的使用有所增加。作为远程医疗的一部分,在线诊疗服务涉及家庭医生或其他临床医生通过网络或电子通信系统对患者进行评估和管理。目前,尚不清楚全国初级保健医生提供在线诊疗服务的普遍程度,以及影响该服务使用率的... 详细信息

目的近年来,远程医疗的使用有所增加。作为远程医疗的一部分,在线诊疗服务涉及家庭医生或其他临床医生通过网络或电子通信系统对患者进行评估和管理。目前,尚不清楚全国初级保健医生提供在线诊疗服务的普遍程度,以及影响该服务使用率的因素。本研究旨在探索家庭医生提供在线诊疗服务的普遍程度和影响因素。方法在全国范围内,对7 580名执业家庭医生进行横断面人口统计调查问卷研究。计算双变量统计数据,并进行逻辑回归分析,以确定与提供在线诊疗服务相关的医生层面因素和诊所层面因素。结果在线诊疗服务的总提供率为9.3%(702/7 580)。与私人执业医师相比,在学术卫生中心/师资诊所[OR=1.73,95%CI(1.03,2.91)]、管理式护理/健康维持组织诊所[OR=9.79,95%CI(7.05,13.58)]、医院/卫生系统所有的医疗诊所(不包括管理式护理/健康维持组织诊所)[OR=2.50,95%CI(1.83,3.41)]、职场诊所[OR=2.28,95%CI(1.43,3.63)]或联邦诊所(军队、退伍军人管理局/国防部)[OR=4.49,95%CI(2.93,6.89)]执业的医师更有可能提供在线诊疗服务。没有诊所所有权[OR=0.44,95%CI(0.28,0.68)]和拥有诊所部分股权[OR=0.29,95%CI(0.12,0.71)]的医师与独自拥有诊所的医师相比,提供在线诊疗服务的概率较低。结论只有不到10%的家庭医生提供在线诊疗服务。在健康维持组织诊所和退伍军人管理局执业的医师(即定额模型与无定额模型)更有可能提供在线诊疗服务。这表明能否报销可能是影响家庭医生提供在线诊疗服务的主要因素。

关键词：家庭医生逻辑回归分析初级保健医生卫生系统医疗诊所诊疗服务临床医生远程医疗

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甘肃靖远、景泰早石炭世维宪期植物群

古生物学报 2005年第2期44卷 175-202页

作者：吴秀元王军张宜 I.m.STEVANOVIC-WALLS H.W.PFEFFERKORN 中国科学院南京地质古生物研究所南京210008 Department of Earth and Environmental Science University of Pennsylvanian Philadelphia PA 19104-6316USA

祁连山和河西走廊区石炭纪地层发育,动植物化石丰富,是研究我国海陆交互相石炭系的重要地区。臭牛沟组系袁复礼(1925)所建,标准地点在甘肃武威西南35 km的臭牛沟,据其中的腕足类和珊瑚化石的研究,确定其时代为早石炭世维宪期(Visean)。... 详细信息

祁连山和河西走廊区石炭纪地层发育,动植物化石丰富,是研究我国海陆交互相石炭系的重要地区。臭牛沟组系袁复礼(1925)所建,标准地点在甘肃武威西南35 km的臭牛沟,据其中的腕足类和珊瑚化石的研究,确定其时代为早石炭世维宪期(Visean)。研究材料来自甘肃景泰和靖远的早石炭世臭牛沟组,这里的臭牛沟组厚约120 m左右,由泥质页岩夹煤线、粉砂岩及薄层泥灰岩、灰岩组成,为潮间潟湖相至滨海沼泽相及泥炭沼泽相沉积。含丰富的植物化石,主要分子有:Sublepidodendron sp., lepidodendron ciyaoense sp. nov., lep jingyuanense ***., lepidodendron volkmannianum, lep. gansuense sp. nov., lep. shanyangense, lep. cf. aolungpulukense,lep. sp.1, lep. sp.2, Cathaysiodendron jingyuanense, C. cf. incertum, Stigmaria ficoides, lepidostrobophyl lum cf. lanceolatum, L. rotundifoliumsp. nov., lepidostrobussp. 1, L. sp.2, Bothrodendron ruchengense, Ar chaeocalamites scrobiculatus, Hamatophyton verticillatum, Cardiopteridium spetsbergense, C. podozamioides,Triphyllopteris collombiana , Triphyllopteris sp. ( cf. T. lescuriana Lesquereux), Rhacopteris sp.,

关键词：早石炭世植物群景泰臭牛沟组 sp. 植物化石下石炭统海陆交互相地层发育河西走廊甘肃武威珊瑚化石泥质页岩泥炭沼泽下伏地层孢子化石上覆地层牙形石带贵州罗甸腕足类孢子带石炭纪祁连山石炭系泥灰岩

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抗麻风菌特异性酚糖脂IgA抗体的研究

中国麻风杂志 1993年第2期9卷 71-74页

作者：曹元华和泉真藏川津邦雄 m.D.Amiruddin A.m.Choudhury 烟野研太郎藤原刚中国医学科学院皮肤病研究所日本国立多摩研究所印度尼西亚Hasanuddin大学孟加拉国达卡麻风病院孟加拉国基督教麻风中心日本奈良大学自然科学教室

摘要用NT—P—BSA/ELISA检测抗麻风菌特异性酚糖脂的IgA抗体。检查血清1156份(其中麻风373例,麻风家内接触者81例,职业接触者11例,结核患者144例,正常孕妇120例,正常对照427例)。取截断值为0.040(OD)时,本法的特异性为95.6％,敏感性为6... 详细信息

摘要用NT—P—BSA/ELISA检测抗麻风菌特异性酚糖脂的IgA抗体。检查血清1156份(其中麻风373例,麻风家内接触者81例,职业接触者11例,结核患者144例,正常孕妇120例,正常对照427例)。取截断值为0.040(OD)时,本法的特异性为95.6％,敏感性为63.O％。麻风患者与非麻风人群之间的阳性率差异非常显著(Pm呈非常显著的正相关。与Igm抗体相比,看来IgA抗体检测在麻风血清学研究方面的应用价值不大。

关键词：麻风血清诊断抗体 ELISA