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First-line cisplatin,docetaxel,and cetuximab for patients with recurrent or metastatic head and neck cancer:A multicenter cohort study

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World Journal of Clinical Oncology 2022年第2期13卷 147-158页

作者： Agustin Falco mariano Leiva Albano Blanco guido Cefarelli Andres Rodriguez Juan melo Federico Cayol manglio miguel Rizzo Alejandro Sola Hernan Rodriguez montani matias Chacon Diego Enrico Federico Waisberg Department of medical Oncology Head and Neck UnitAlexander Fleming Cancer InstituteBuenos Aires 1428Argentina Department of medical Oncology Alexander Fleming Cancer InstituteBuenos Aires 1426Argentina Department of medical Oncology Hospital Italiano de Buenos AiresBuenos Aires 1199Argentina Department of medical Oncology Hospital Universitario AustralPilar 1629Argentina Department of medical Oncology Fundación Centro Oncológico de Integración RegionalMendoza 5500Argentina Department of medical Oncology Hospital Italiano RosarioSanatorio de la MujerRosario 2001Argentina

BACKGROUND The targeted therapy cetuximab[directed at the epidermal growth factor receptor(EGFR)]in combination with 5-fluorouracil and platinum-based chemotherapy(the EXTREmE regimen)has shown substantial efficacy for patients with recurrent or metastatic squamous cell carcinoma of the head and neck(R/m SCCHN).Thus,this scheme has been established as the preferred first-line option for these ***,more recently,a new strategy combining platinum,taxanes,and cetuximab(the TPEx regimen)has demonstrated similar efficacy with a more favorable toxicity profile in clinical *** To evaluate the safety and efficacy of the TPEx scheme as first-line therapy in advanced SCCHN in a multicenter cohort *** This retrospective multicenter cohort study included patients with histologically confirmed recurrent or metastatic SCCHN treated with first-line TPEx at five medical centers in Argentina between January 1,2017 and April 31,*** consisted of four cycles of docetaxel,cisplatin,and cetuximab followed by cetuximab maintenance *** outcomes and toxicity profiles were collected from medical *** response was assessed by the investigator in accordance with Response Evaluation Criteria in Solid Tumors(version 1.1).Adverse events were graded according to the National Cancer Institute Common Terminology Criteria for Adverse Events(version 4.0).RESULTS Twenty-four patients were *** median age at diagnosis was 58 years(range:36-77 years).The majority of patients(83.3%)received at least four chemotherapy cycles in the initial *** the included group,the overall response rate was 62.5%,and 3 patients achieved a complete response(12.5%).The median time to response was 2.4 mo[95% confidence interval(CI):1.3-3.5].With a median follow-up of 12.7 mo(95%CI:8.8-16.6),the median progression-free survival(PFS)was 6.9 mo(95%CI:6.5-7.3),and the overall survival rate at 12 mo was 82.4%.Patients with documented tumor response s

关键词： Recurrent and/or metastatic head and neck cancer TPEx schema Cetuximab Docetaxel Cisplatin First-line

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The ALmA-QUARKS Survey.Ⅰ.Survey Description and Data Reduction

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Research in Astronomy and Astrophysics 2024年第2期24卷 104-124页

作者：刘训川 Tie Liu Lei Zhu guido Garay Hong-Li Liu Paul Goldsmith Neal Evans Kee-Tae Kim Sheng-Yuan Liu Fengwei Xu Xing Lu Anandmayee Tej Xiaofeng mai Leonardo Bronfman Shanghuo Li Diego mardones Amelia Stutz Ken'ichi Tatematsu Ke Wang Qizhou Zhang Sheng-Li Qin Jianwen Zhou Qiuyi Luo Siju Zhang Yu Cheng Jinhua He Qilao Gu Ziyang Li Zhenying Zhang Suinan Zhang Anindya Saha Lokesh Dewangan Patricio Sanhueza Zhiqiang Shen Shanghai Astronomical Observatory Chinese Academy of SciencesShanghai 200030China Chinese Academy of Sciences South America Center for Astronomy National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China Departamento de Astronomía Universidad de ChileLas Condes7591245 SantiagoChile School of Physics and Astronomy Yunnan UniversityKunming 650091China Jet Propulsion Laboratory California Institute of Technology4800 Oak Grove DrivePasadena CA 91109USA Department of Astronomy The University of Texas at AustinTX 78712-1205USA Korea Astronomy and Space Science Institute 776 Daedeokdae-roYuseong-guDaejeon 34055Republic of Korea Institute of Astronomy and Astrophysics Academia SinicaRoosevelt RoadTaipei 10617China Kavli Institute for Astronomy and Astrophysics Peking UniversityBeijing 100871China Department of Astronomy School of PhysicsPeking UniversityBeijing 100871China Indian Institute of Space Science and Technology Thiruvananthapuram 695547KeralaIndia max Planck Institute for Astronomy Königstuhl 17D-69117 HeidelbergGermany Departamento de Astronomía Universidad de ConcepciónCasilla 160-CConcepciónChile Nobeyama Radio Observatory National Astronomical Observatory of JapanNational Institutes of Natural Sciences462-2 NobeyamaMinamimakiMinamisakuNagano 384-1305Japan Center for Astrophysics∣Harvard&Smithsonian 60 Garden StreetCambridgeMA 02138USA max-Planck-Institut für Radioastronomie Auf dem Hügel 69D-53125 BonnGermany School of Astronomy and Space Sciences University of Chinese Academy of SciencesBeijing 100049China National Astronomical Observatory of Japan 2-21-1 OsawaMitakaTokyo181-8588Japan Yunnan Observatories Chinese Academy of SciencesKunming 650216China Physical Research Laboratory NavrangpuraAhmedabad-380009India Astronomical Science Program The Graduate University for Advanced StudiesSOKENDAI2-21-1 OsawaMitakaTokyo 181-8588Japan University of Science and Technology Korea(UST)217 Gajeong-roYuseong-guDaejeon 34113Republic o

This paper presents an overview of the QUARKS survey,which stands for Querying Underlying mechanisms of massive star formation with ALmA-Resolved gas Kinematics and Structures."The QUARKS survey is observing139 massive clumps covered by 156 pointings at Atacama Large millimeter/submillimeter Array(ALmA)Band 6(λ~1.3 mm).In conjunction with data obtained from the ALmA-ATOmS survey at Band 3(λ~3 mm),QUARKS aims to carry out an unbiased statistical investigation of massive star formation process within protoclusters down to a scale of 1000 *** overview paper describes the observations and data reduction of the QUARKS survey,and gives a first look at an exemplar source,the mini-starburst Sgr B2(m).The wide-b and width(7.5 GHz)and high-angular-resolution(~0."3)observations of the QUARKS survey allow for the resolution of much more compact cores than those could be done by the ATOmS survey,and to detect previously unrevealed fainter filamentary *** spectral windows cover transitions of species including CO,SO,N_(2)D^(+),SiO,H_(30)α,H_(2)CO,CH_(3)CN,and many other complex organic molecules,tracing gas components with different temperatures and spatial *** aims to deepen our understanding of several scientific topics of massive star formation,such as the mass transport within protoclusters by(hub-)filamentary structures,the existence of massive starless cores,the physical and chemical properties of dense cores within protoclusters,and the feedback from already formed high-mass young protostars.

关键词： stars formation-stars kinematics and dynamics-ISm clouds-ISm molecules

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The ALmA-QUARKS Survey.Ⅱ.The ACA 1.3 mm Continuum Source Catalog and the Assembly of Dense Gas in massive Star-Forming Clumps

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Research in Astronomy and Astrophysics 2024年第6期24卷 119-139页

作者：许峰玮 Ke Wang Tie Liu Lei Zhu guido Garay Xunchuan Liu Paul Goldsmith Qizhou Zhang Patricio Sanhueza Shengli Qin Jinhua He mika Juvela Anandmayee Tej Hongli Liu Shanghuo Li Kaho morii Siju Zhang Jianwen Zhou Amelia Stutz Neal JEvans Kee-Tae Kim Shengyuan Liu Diego mardones Guangxing Li Leonardo Bronfman Ken’ichi Tatematsu Chang Won Lee Xing Lu Xiaofeng mai Sihan Jiao James O.Chibueze Keyun Su Viktor L.Tóth Kavli Institute for Astronomy and Astrophysics Peking UniversityBeijing 100871China Department of Astronomy School of PhysicsPeking UniversityBeijing 100871China Shanghai Astronomical Observatory Chinese Academy of SciencesShanghai 200030China Chinese Academy of Sciences South America Center for Astronomy National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China Departamento de Astronomía Universidad de ChileLas Condes7591245 SantiagoChile Jet Propulsion Laboratory California Institute of Technology4800 Oak Grove DrivePasadena CA 91109USA Center for Astrophysics|Harvard&Smithsonian 60 Garden StreetCambridgeMA 02138USA National Astronomical Observatory of Japan National Institutes of Natural Sciences2-21-1 OsawaMitakaTokyo 181-8588Japan Astronomical Science Program The Graduate University for Advanced StudiesSOKENDAI2-21-1 OsawaMitakaTokyo 181-8588Japan School of Physics and Astronomy Yunnan UniversityKunming 650091China Yunnan Observatories Chinese Academy of SciencesKunming 650216China Department of Physics University of HelsinkiPO Box 64FI-00014 HelsinkiFinland Indian Institute of Space Science and Technology Thiruvananthapuram 695547KeralaIndia max Planck Institute for Astronomy Königstuhl 17D-69117 HeidelbergGermany Department of Astronomy Graduate School of ScienceThe University of Tokyo7-3-1 HongoBunkyo-kuTokyo 113-0033Japan max-Planck-Institut für Radioastronomie Auf dem Hügel 6953121 BonnGermany Departamento de AstronomÂıa Universidad de ConcepcionCasilla 160-CConcepci onChile Department of Astronomy The University of Texas at AustinTexas 78712-1205USA Korea Astronomy and Space Science Institute 776 Daedeokdae-roYuseong-guDaejeon 34055Republic of Korea Institute of Astronomy and Astrophysics Academia SinicaRoosevelt RoadTaipei 10617TaiwanChina South-Western Institute for Astronomy Research Yunnan UniversityKunming 650091China Korea Astronomy and Space Science Institute 776 Daedeok-daeroYuseong-guDaejeon 34055Republic of

Leveraging the high resolution,sensitivity,and wide frequency coverage of the Atacama Large millimeter/submillimeter Array(ALmA),the QUARKS survey,standing for“Querying Underlying mechanisms of massive star formation with ALmA-Resolved gas Kinematics and Structures”,is observing 139 massive starforming clumps at ALmA Band 6(λ~1.3 mm).This paper introduces the Atacama Compact Array(ACA)7 m data of the QUARKS survey,describing the ACA observations and data *** multiwavelength data,we provide the first edition of QUARKS atlas,offering insights into the multiscale and multiphase interstellar medium in high-mass star *** ACA 1.3 mm catalog includes 207 continuum sources that are called ACA *** gas kinetic temperatures are estimated using three formaldehyde transitions with a non-LTE radiation transfer model,and the mass and density are derived from a dust emission *** ACA sources are massive(16–84 percentile values of 6–160 m_(⊙)),gravity-dominated(m∝R^(1.1))fragments within massive clumps,with supersonic turbulence(m>1)and embedded star-forming *** find a linear correlation between the masses of the fragments and the massive clumps,with a ratio of 6%between the *** considering fragments as representative of dense gas,the ratio indicates a dense gas fraction(DGF)of 6%,although with a wide scatter ranging from 1%to 10%.If we consider the QUARKS massive clumps to be what is observed at various scales,then the size-independent DGF indicates a self-similar fragmentation or collapsing mode in protocluster *** the ACA data over four orders of magnitude of luminosity-to-mass ratio(L/m),we find that the DGF increases significantly with L/m,which indicates clump evolutionary *** observed a limited fragmentation at the subclump scale,which can be explained by a dynamic global collapse process.

关键词： stars:formation ISm:kinematics and dynamics ISm:clouds stars:protostars

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A new method for validation of quantitative measurement by intravascular ultrasound in vivo

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Chinese medical Journal 1997年第12期 56-56页

作者： Fengqi Liu, Junbo Ge, Dietrich Baumgart, michael Haude, guido Caspari, Günter Grge, Beate Eick and Raimund Erbel

Studies in vitro show that intravascular ultrasound (IVUS) underestimates vessel and lumen dimensions. In order to validate IVUS measurement in vivo, we conducted a comparative study during catheterization in fifty patients. The patients underwent IVUS examinations for the purpose of diagnosis or treatment of coronary artery disease. The IVUS system was a 3.5 F, 20 mHz IVUS catheter (Sonicath catheter of Boston Scientific Co.) and a Hewlett Packard console. After examination of the coronary artery, the IVUS probe was withdrawn back into the guiding catheter to measure the average lumen diameter of the guiding catheter (8 F, Cordis). This measurement in vivo (VI) was compared with the true lumen diameter provided by the manufac Department of Cardiology, University of Essen, Essen, Germany (Liu FQ, Ge JB, Baumgart D, Haude m, Caspari G, Grge G, Eick B and Erbel R) turer (mA) and determined by on line quantitative angiography (HICOR, Siemens) (HI). In addition, the IVUS measurement in vitro (VT) was also taken with the same guiding catheter in waterbath at 37℃. The results showed that IVUS underestimated the true lumen diameter by 2.2%±2.6% in vivo, by 3.1%±1.8% in vitro, while HICOR owerestimated the true lumen diameter by 23.0%±6.8%. There was no difference between the IVUS measurements in vivo and in vitro. In summary, IVUS was very accurate for the measurement of a 8 F guiding catheter in vivo with only a minor underestimation, and IVUS measurement was far more reliable than the on line quantitative angiography.

关键词： A new method for validation of quantitative measurement by intravascular ultrasound in vivo

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中国南海短指软珊瑚Sinularia sp.化学成分的研究

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中国天然药物 2003年第4期1卷 193-195页

作者：贾睿郭跃伟侯惠欣 mollo Ernesto Cimino guido 中国科学院上海生命科学研究院药物研究所国家新药研究重点实验室南京大学附属鼓楼医院南京210008 Istituto di Chimica Biomolecolare

从短指软珊瑚Sinulariasp .中首次分离得到三个倍半萜类化合物 ,根据其理化性质及波谱学分析 ,分别鉴定为 4β ,10α 香兰木二醇 (1)、6 愈创木烯 4α ,10 β 二醇 (2 )、(1′E ,5′E) 5 (2′ ,6′ 二甲辛烷基 1′ ,5′ ,7′ 三烯基 ... 详细信息

从短指软珊瑚Sinulariasp .中首次分离得到三个倍半萜类化合物 ,根据其理化性质及波谱学分析 ,分别鉴定为 4β ,10α 香兰木二醇 (1)、6 愈创木烯 4α ,10 β 二醇 (2 )、(1′E ,5′E) 5 (2′ ,6′ 二甲辛烷基 1′ ,5′ ,7′ 三烯基 ) 3 羧基呋喃 (3 ) 。

关键词：中国南海短指软珊瑚 Sinularia sp. 化学成分倍半萜类化合物

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Immunity:研究开发出最优的HIV疫苗递送模式

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现代生物医学进展 2017年第27期17卷 I0003-I0003页

作者： matthias Pauthner Colin Havenar-Daughton Devin Sok Joseph P. Nkolola Raiza Bastidas Archana V. Boopathy Diane G. Carnathan Abishek Chandrashekar Kimberly m. Cirelli Christopher A. Cottrell Alexey m. Eroshkin Javier Guenaga Kirti Kaushik Daniel W. Kulp Jinyan Liu Laura E. mcCoy Aaron L. Oom Gabriel Ozorowski Kai W. Post Shailendra K. Sharma Jon m. Steichen Steven W. de Taeye Talar Tokatlian Alba Torrents de la Peña Salvatore T. Butera Celia C. LaBranche David C. montefiori guido Silvestri Ian A. Wilson Darrell J. Irvine Rogier W. Sanders William R. Schief Andrew B. Ward Richard T. Wyatt Dan H. Barouch Shane Crotty Dennis R. Burton University of California San Diego La Jolla CA 92093 USA

HIV已不再占据头条新闻。这主要是因为抗逆转录病毒药物的成功开发已将HIV病毒感染导致的艾滋病（AIDS）转化为一种慢性的可控制的疾病。然而。当前在全世界大约0．367亿名HIV感染者中，仅约一半的人能够获得控制这种病毒所需的药物。... 详细信息

HIV已不再占据头条新闻。这主要是因为抗逆转录病毒药物的成功开发已将HIV病毒感染导致的艾滋病（AIDS）转化为一种慢性的可控制的疾病。然而。当前在全世界大约0．367亿名HIV感染者中，仅约一半的人能够获得控制这种病毒所需的药物。与此同时。新的HIV感染率持续保持在非常高的水平，这突出强调了需要开发一种预防性疫苗。然而，几十年来。

关键词： HIV感染者研究开发疫苗递送病毒感染逆转录病毒艾滋病感染率

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Boceprevir or telaprevir in hepatitis C virus chronic infection:The Italian real life experience

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World Journal of Hepatology 2016年第22期8卷 949-956页

作者： Antonio Ascione Luigi Elio Adinolfi Pietro Amoroso Angelo Andriulli Orlando Armignacco Tiziana Ascione Sergio Babudieri Giorgio Barbarini michele Brogna Francesco Cesario Vincenzo Citro Ernesto Claar Raffaele Cozzolongo Giuseppe D’Adamo Emilio D’Amico Pellegrino Dattolo massimo De Luca Vincenzo De maria massimo De Siena Giuseppe De Vita Antonio Di Giacomo Rosanna De marco Giorgio De Stefano Giulio De Stefano Sebastiano Di Salvo Raffaele Di Sarno Nunzia Farella Laura Felicioni Basilio Fimiani Luca Fontanella Giuseppe Foti Caterina Furlan Francesca Giancotti Giancarlo Giolitto Tiziana Gravina Barbara Guerrera Roberto Gulminetti Angelo Iacobellis michele Imparato Angelo Iodice Vincenzo Iovinella Antonio Izzi Alfonso Liberti Pietro Leo Gennaro Lettieri Ileana Luppino Aldo marrone Ettore mazzoni Vincenzo messina Roberto monarca Vincenzo Narciso Lorenzo Nosotti Adriano maria Pellicelli Alessandro Perrella guido Piai Antonio Picardi Paola Pierri Grazia Pietromatera Francesco Resta Luca Rinaldi mario Romano Angelo Rossini maurizio Russello Grazia Russo Rodolfo Sacco Vincenzo Sangiovanni Antonio Schiano Antonio Sciambra Gaetano Scifo Filomena Simeone Annarita Sullo Pierluigi Tarquini Paolo Tundo Alfredo Vallone Depart-ment of medicine Center for Liver Diseases "Buon Consiglio" -Fatebenefratelli Hospital Internal medicine Unit Second University of Naples VI Division of Infectious Diseases Cotugno Hospital AORN "Ospedali dei Colli" Division of Gastro- enterology Casa Sollievo Sofferenza Hospital IRCCS Division of Infectious Diseases Belcolle Hospital IX Division of Infectious Diseases Cotugno Hospital AORN "Ospedali dei Colli" Clinical of Infectious Disease University of Sassari Infectious Disease IRCCS San matteo Division of Infectious Diseases and Liver Unit "G. Iazzolino" Hospital Division of Infectious Diseases "Annunziata" Hospital Depart-ment of Internal medicine Umberto I Hospital Internal medicine Ospedale Evangelico Villa Betania Division of Gastroenterology IRCCS "S.de Bellis" Hospital Internal medicine Unit Pescara-Penne Hospital Gastroenterology Unit Marcianise Hospital Liver Unit AORN Cardarelli Liver Unit Policlinico "Mater Domini" Service of medical Day Hospital "Rummo" Hospital Internal medicine Regina Margherita Hospital Division of Gastroenterology "Annunziata" Hospital Infectious Disease Matera Hospital First Division of Infectious Diseases Cotugno Hospital AORN "Ospedali dei Colli" Division of Infectious Diseases AO Melacrino- Bianchi-Morelli Infectious and Tropical Disease Policlinico Umberto I Division of Infectious Disease Maria SS Addolorata Hospital Division of Infectious Diseases S. Anna and S. Sebastiano Hospital Outpatients Service for Liver Diseases "Loreto Crispi" Hospital V Division of Infectious Diseases Cotugno Hospital AORN "Ospedali dei Colli" Department of medical Surgical Neurological Geriatric and Metabolic Sciences Second Univer-sity of Naples Liver Unit Policlinico Casilino medicine and Health Unit for Prisoners Belcolle Hospital Internal medicine Unit "Ascalesi" Hospital Gastrointestinal and Liver Department National Institute for Health Migration and Poverty Liver Unit Azienda Ospedaliera San Camillo Forlanini VII Division of Infectious Diseases

AIm: To check the safety and efficacy of boceprevir/telaprevir with peginterferon/ribavirin for hepatitis C virus(HCV) genotype 1 in the real-world settings. mETHODS: This study was a non-randomized, observational, prospective, multicenter. This study involved 47 centers in Italy. A database was prepared for the homogenous collection of the data, was used by all of the centers for data collection, and was updated continuously. All of the patients enrolled in this study were older than 18 years of age and were diagnosed with chronic infection due to HCV genotype 1. The HCV RNA testing was performed using COBAS-Taq man2.0(Roche, LLQ 25 IU/m L). RESULTS: All consecutively treated patients were included. Forty-seven centers enrolled 834 patients as follows: male 64%; median age 57(range 18-78), of whom 18.3% were over 65; mean body mass index 25.6(range 16-39); genotype 1b(79.4%); diagnosis of cirrhosis(38.2%); and fibrosis F3/4(71.2%). The following drugs were used: Telaprevir(66.2%) and PEG-IFN-alpha2a(67.6%). Patients were na?ve(24.4%), relapsers(30.5%), partial responders(14.8%) and null responders(30.3%). Overall, adverse events(AEs) occurred in 617 patients(73.9%) during the treatment. Anemia was the most frequent AE(52.9% of cases), especially in cirrhotic. The therapy was stopped for 14.6% of the patients because of adverse events or virological failure(15%). Sustained virological response was achieved in 62.7% of the cases, but was 43.8% in cirrhotic patients over 65 years of age. CONCLUSION: In everyday practice, triple therapy is safe but has moderate efficacy, especially for patients over 65 years of age, with advanced fibrosis, nonresponders to peginterferon + ribavirin.

关键词： Boceprevir Telaprevir Chronic hepatitis Antiviral therapy Peg-interferon Ribavirin

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气候变化预计会减少东亚地区豚草的生物防治效果

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生物多样性 2017年第12期25卷 1285-1294页

作者：孙燕周忠实王瑞 Heinz muller-Scharer Plant Evolutionary Ecology University of Tubingen72076 TuibingenGermany 中国农业科学院植物保护研究所植物病虫害生物学国家重点实验室北京100193 Department of Biology/Ecology&Evolution University of Fribourg1700 FribourgSwitzerland

外来入侵植物对入侵地的生态系统与社会经济可造成严重的威胁。如何控制入侵植物对自然资源的危害,向人类提出了极大的挑战。利用原产地的专食性天敌来控制入侵植物已被广泛证明是一种经济、可持续的生物防治手段。在全球气候变暖的背景... 详细信息

外来入侵植物对入侵地的生态系统与社会经济可造成严重的威胁。如何控制入侵植物对自然资源的危害,向人类提出了极大的挑战。利用原产地的专食性天敌来控制入侵植物已被广泛证明是一种经济、可持续的生物防治手段。在全球气候变暖的背景下,生物防治研究的关键问题是全面了解物种的潜在分布区和传播范围,进而优化入侵植物的生物防治方案。本研究利用生物地理模型,通过预测两种生物防治昆虫和它们的组合在东亚地区的适宜分布区,预测豚草(Ambrosia artemisiifolia)的生物防治区域。豚草原产北美,目前已经入侵全球多个国家和地区。20世纪末,豚草条纹叶甲(Ophraella communa)和豚草卷蛾(Epiblema strenuana)作为豚草的生物防治昆虫从原产地引入到东亚地区。本研究旨在探讨如下问题:(1)在豚草的适宜生长分布区内,有多少区域也同样适宜其两种天敌的生存?(2)在目前和未来的气候背景下,有多少区域适宜豚草生长但是不适宜它的两种天敌生长?(3)在这些适宜豚草生长却不适宜两种昆虫天敌生长的区域内,需要选择哪些特定的生物型进行投放?为此,我们基于入侵植物和两种生物防治昆虫的全球分布记录及其分布点的重要生物气候因子,同时模拟了入侵植物及其两种生物防治天敌在东亚地区的分布范围。排序技术被用来探索气候因子对每个物种的限制作用,同时也用来检验豚草在北美和东亚地区的生态位重叠和相似性。结果表明,在当前和未来的气候背景下,相较于豚草卷蛾,豚草条纹叶甲与豚草的地理分布范围更加吻合(当前气候:40.3%vs.21.6%,未来气候:29.8%vs.20.3%)。气候变化可能会导致两种生物防治天敌(尤其是豚草条纹叶甲)的地理分布与豚草的地理分布的重叠区域减少(42.9%vs.29.9%)。本研究同时提出了温度和降水等气候因子可用于为特殊区域(生物防治天敌未覆盖的豚草分布区)筛选生物防治天敌的相应株系。

关键词：生物防治生物入侵豚草卷蛾生态位重叠豚草条纹叶甲物种分布

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Keratinous and corneous-based products towards circular bioeconomy: A research review

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Environmental Science and Ecotechnology 2024年第6期22卷 25-37页

作者： Giovanni Davide Barone Irene Tagliaro Rodrigo Oliver-Simancas matteo Radice Livia m.Kalossaka michele mattei Antonino Biundo Isabella Pisano Amparo Jiménez-Quero Institute of Biology University of Graz8010GrazAustria Department of materials Science University of Milano-Bicocca20126MilanoItaly Division of Industrial Biotechnology Department of Life SciencesChalmers University of TechnologyGothenburg41296Sweden Department of Biosciences Biotechnology and BiopharmaceuticsUniversity of Bari Aldo MoroVia E.Orabona470125BariItaly Department of Chemistry Molecular Sciences Research HubImperial College LondonW120BZ LondonUnited Kingdom Libera UniversitàInternazionale Degli Studi Sociali“guido Carli” I-00198RomeItaly CIRCC-Interuniversity Consortium Chemical Reactivity and Catalysis Via C.Ulpiani 2770126BariItaly

Keratins and corneous proteins are key components of biomaterials used in a wide range of applications and are potential substitutes for petrochemical-based products. Horns, hooves, feathers, claws, and similar animal tissues are abundant sources of α-keratin and corneous β-proteins, which are by-products of the food industry. Their close association with the meat industry raises environmental and ethical concerns regarding their disposal. To promote an eco-friendly and circular use of these materials in novel applications, efforts have focused on recovering these residues to develop sustainable, non-animal-related, affordable, and scalable procedures. Here, we review and examine biotechnological methods for extracting and expressing α-keratins and corneous β-proteins in microorganisms. This review highlights consolidated research trends in biomaterials, medical devices, food supplements, and packaging, demonstrating the keratin industry's potential to create innovative value-added products. Additionally, it analyzes the state of the art of related intellectual property and market size to underscore the potential within a circular bioeconomic model.

关键词： Alpha-keratin Corneous beta-protein Environmentally sustainable technology Biotechnology Resource recovery

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